以抗抑郁活性为目的的1,3,4-恶二嗪吲哚衍生物的新合成及理化表征

Q4 Pharmacology, Toxicology and Pharmaceutics

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI:10.25258/ijddt.13.3.26

Mahadev Agarwal, Neelam Singla, S.K Singh

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引用次数: 0

摘要

本研究通过结合MAOI的肼段和三环段，合成了一系列具有抗抑郁活性的1,3,4-恶二嗪吲哚类化合物。由氨基酸形成的氯胺酸开始了合成。将其转化为氨基酸酰肼，再与isatin反应制得氨基酸酰肼。最后，在冷硫酸存在下，对含腙化合物进行环化反应。合成的化合物通过质谱、核磁共振策略、傅里叶变换红外光谱、薄层色谱和熔点进行表征和确认。对这些化合物的抗抑郁活性进行了评估。

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Novel Synthesis, Physicochemical Characterization of 1,3,4-Oxadiazinoindole Derivatives for the Purpose of Antidepressant Activity

The present study synthesized a series of 1,3,4-oxadiazinoindole moiety-containing compounds by combining MAOI’s hydrazide moiety and tricyclic moiety having antidepressant activity. The formation of amino acid chloride from amino acids started the synthesis. Further, they were converted into amino acid hydrazide, and then amino acid hydrazones were prepared by reaction of amino acid hydrazide with isatin. Finally, cyclization was acted on hydrazone-containing compounds in the presence of cold H2SO4. Synthesized compounds are characterized and confirmed via mass spectroscopy, 1H-nuclear magnetic resonance strategies, fourier transform infrared spectroscopy, thin layer chromatography, and melting point. The compounds were evaluated for antidepressant activity.

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来源期刊

International Journal of Drug Delivery Technology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.70

自引率

0.00%

发文量

期刊介绍： International Journal of Drug Delivery Technology (IJDDT) provides the forum for reporting innovations, production methods, technologies, initiatives and the application of scientific knowledge to the aspects of pharmaceutics, including controlled drug release systems, drug targeting etc. in the form of expert forums, reviews, full research papers, and short communications.