具有抗菌活性的Co3O4尖晶石纳米颗粒的合成与表征

Q4 Pharmacology, Toxicology and Pharmaceutics
Mustafa Hammadi, Rulla Sabah, Esam H Hummadi
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引用次数: 0

摘要

纳米颗粒作为抗生素在医学领域的应用非常广泛。人们已经发现,金属氧化物纳米颗粒,如Co3O4,对耐抗生素的细菌有效。大肠杆菌和葡萄球菌会引起肠道疾病和其他疾病。本研究采用共沉淀法制备Co3O4纳米颗粒。利用扫描电镜(SEM)、x射线衍射(XRD)和傅里叶变换红外光谱(FTIR)对纳米氧化物进行了分析。XRD图验证了Co3O4晶体匹配。SEM还显示了Co3O4纳米颗粒的形貌。通过x射线测定,Co3O4的平均直径约为37.08 nm。能量色散的EDX图显示,纳米Co3O4纯度很高。无论是单独使用还是与头孢氨苄联合使用,这些金属氧化物纳米颗粒都显示出对金黄色葡萄球菌和大肠杆菌的抗菌效果。与单独使用头孢氨苄相比,这些Co3O4纳米颗粒具有较高的生长抑制作用。这些结论发现头孢氨苄与Co3O4的存在具有较高的生长抑制作用。Co3O4纳米颗粒的抗菌活性有待进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Synthesis and Characterization of Co3O4 Spinel Nanoparticles with Antibacterial Activity
Nanoparticles are abundant and usable in the medical field as an antibiotic. It has been found that metal oxide nanoparticles, such as Co3O4, are efficient against bacteria that are resistant to antibiotics. Escherichia and Staphylococcus bring on enteric sickness and other illnesses. This study used co-precipitation to create Co3O4 nanoparticles. SEM, X-ray diffraction (XRD), and Fourier-transform infrared (FTIR) spectroscopy were used to analyze these oxide nanoparticles. The XRD pattern validated the Co3O4 crystalline match. SEM also showed the morphology of Co3O4 nanoparticles. As determined by X-rays, Co3O4 has an average diameter of around 37.08 nm. The Co3O4 nanoparticles were highly pure, showed by an energy-dispersive EDX pattern. Both on their own and in conjunction with cephalexin, these metal oxide nanoparticles demonstrated antibacterial efficacy against S. aureus and E. coli. These Co3O4 nanoparticles showed high growth inhibition compared with using cephalexin individually. These conclusions found that the presence of cephalexin with Co3O4 showed high growth inhibition. The antibacterial activity of Co3O4 nanoparticles should be subjected for further studies.
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来源期刊
International Journal of Drug Delivery Technology
International Journal of Drug Delivery Technology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
0.70
自引率
0.00%
发文量
0
期刊介绍: International Journal of Drug Delivery Technology (IJDDT) provides the forum for reporting innovations, production methods, technologies, initiatives and the application of scientific knowledge to the aspects of pharmaceutics, including controlled drug release systems, drug targeting etc. in the form of expert forums, reviews, full research papers, and short communications.
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