Fabrication of Transdermal Gel Embedded with Solid Lipid Nanoparticles of Indomethacin

Q4 Pharmacology, Toxicology and Pharmaceutics

International Journal of Drug Delivery Technology Pub Date : 2023-03-25 DOI:10.25258/ijddt.13.1.66

Amina Hajwani, Afreen Khan, Numan Ansari, Nazir Zerdi, Mohd Hassan Baig

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引用次数: 0

Abstract

Rheumatoid/osteoarthritis is one of the most common causes for lacking behind in the health sector. Medication in the form of tablets are already available in the market but has disadvantages. When these medicines are taken orally it cause heartburn and discomfort. The introduction of transdermal drug delivery is expected to solve this problem of side eff ects associated with oral delivery of drug. In the present study, indomethacin was loaded in solid lipid nanoparticles (SLN) which are then embedded in Carbopol gel for transdermal application. The solvent evaporation ultrasonication method was used for making SLNs. The formulation was evaluated for various parameters such as ; particle size and zeta potential of SLN using zetasizer as an instrument and gel formulations were evaluated for pH, spreading coeffi cient, viscosity, visual appearance and clarity. Gel-embedded SLN formulation was found to be a potential transdermal drug delivery system for NSAIDs like indomethacin to treat ailments like rheumatoid arthritis or osteoarthritis.

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吲哚美辛固体脂质纳米颗粒包埋透皮凝胶的制备

类风湿/骨关节炎是卫生部门缺乏支持的最常见原因之一。市场上已经有片剂形式的药物，但有缺点。当这些药物口服时，会引起胃灼热和不适。经皮给药的引入有望解决口服给药的副作用问题。在本研究中，将吲哚美辛装入固体脂质纳米颗粒(SLN)中，然后将其嵌入卡波波尔凝胶中进行透皮应用。采用溶剂蒸发超声法制备单晶硅纳米粒子。对配方进行了各种参数的评价，如;以zetasizer为工具对SLN的粒径和zeta电位进行了pH、扩散系数、粘度、视觉外观和透明度的评价。凝胶嵌入的SLN制剂被发现是一种潜在的经皮给药系统，用于治疗类风湿性关节炎或骨关节炎等疾病，如吲哚美辛等非甾体抗炎药。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Drug Delivery Technology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.70

自引率

0.00%

发文量

期刊介绍： International Journal of Drug Delivery Technology (IJDDT) provides the forum for reporting innovations, production methods, technologies, initiatives and the application of scientific knowledge to the aspects of pharmaceutics, including controlled drug release systems, drug targeting etc. in the form of expert forums, reviews, full research papers, and short communications.