混合配体(姜黄素和N2O2型偶氮化合物)新配合物[Ni II, Hg II和La III]的合成、表征、生物活性和热研究

Q4 Pharmacology, Toxicology and Pharmaceutics

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI:10.25258/ijddt.13.3.42

Muna A Shakir, Wurood A Jaafar, Malath K Rasheed

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引用次数: 0

摘要

本研究通过4-氨基苯乙酮与4-甲氧基苯胺在低温、浓盐酸和10% NaNO2中反应制得化合物[L]。姜黄素、几种过渡金属配合物(Ni (II)、La (III)、Hg (II))和化合物[L]在乙氧氢中结合生成新的配合物。利用紫外-可见光谱、红外光谱、AA、热重-差示量分析、电导率、氯离子含量和元素分析(CHNS)对产物的结构进行了表征。利用配合物对真菌、金黄色葡萄球菌(G+)、假单胞菌(G-)、大肠杆菌(G-)和变形杆菌(G-)具有生物活性。根据上述方法的结果，给出了八面体公式作为每个创建复合体的几何结构。

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Synthesis, Characterization, Biological Activity and Thermal Study of New Complexes [Ni II, Hg II and La III] from Mixed Ligands (Curcumin and Azo compounds type N2O2)

The compound [L] was produced in the current study through the reaction of 4-aminoacetophenon with 4-methoxyaniline in the cold, concentrated HCl with 10% NaNO2. Curcumin, several transition metal complexes (Ni (II), La (III), and Hg (II)), and compound [L] were combined in EtOH to create new complexes. UV-vis spectroscopy, FTIR, AA, TGA-DSC, conductivity, chloride content, and elemental analysis (CHNS) were used to describe the structure of produced complexes. Biological activities against fungi, S. aureus (G+), Pseudomonas (G-), E. coli (G-), and Proteus (G-) were demonstrated using complexes. Depending on the outcomes of the aforementioned methods, octahedral formulas were given as the geometrical structures for each created complex.

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来源期刊

International Journal of Drug Delivery Technology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.70

自引率

0.00%

发文量

期刊介绍： International Journal of Drug Delivery Technology (IJDDT) provides the forum for reporting innovations, production methods, technologies, initiatives and the application of scientific knowledge to the aspects of pharmaceutics, including controlled drug release systems, drug targeting etc. in the form of expert forums, reviews, full research papers, and short communications.