Design of Mouth Dissolving Polyherbal Films for Dental Caries

Oral disease is still a major public health problem across the globe in developed countries as well as developing countries. Dental caries is one of humans’ oldest and most prevalent diseases or conditions of factor situations. The present study was designed to evaluate the antimicrobial potential of polyherbal film containing extracts of Annona squamosa L, Mentha piperita and Acalypha indica leaves against Streptococcus mutans. The mouth-dissolving poly herbal films were formulated with 1% (OF1), 2% (OF2) and 3% (OF3) extract concentrations. OF3 produced better results than OF1 and OF2 in folding endurance, disintegration time and dissolution time. The antimicrobial properties of the polyherbal films and standard marketed formulations S1 and S2 mouthwash were evaluated against the dental pathogen, S. mutans. OF3 produced a zone of inhibition 18.3 ± 0.21 mm compared to S2 which produced an inhibition zone of 27.0 ± 0.24 mm, whereas S1 has not shown any zone of inhibition. These results indicated that the mouth dissolving poly herbal films could be effective in the treatment of dental caries and gingivitis.