International Journal of Drug Delivery Technology最新文献

{"title":"Development and Evaluation of Herbal Shampoo as an Antifungal Formulation","authors":"Milind Dyagatwar, Bhushan Pimple, Mohini Kuchekar, Suvarna Vadje, Siddhant Gaikwad, Vanita Bhurkunde, Harshal Tare, Deshraj Chumbhale","doi":"10.25258/ijddt.13.3.23","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.23","url":null,"abstract":"The herbal shampoo is a normal hair care solution used to clear out grease, debris and dandruff, stimulating hair growth and strength. It also gives the hair a glossy appearance and smoothness, reducing tenderness. This research aims to develop an herbal shampoo and assess its physical and chemical properties with an eye toward ensuring its safety and effectiveness. Moreover, it also aims to replace hazardous synthetic chemicals and with safe natural ones. Herbal shampoo was formulated using plants viz Tea, ashwagandha, sandalwood and Nagarmotha which compared with the marketed formulation. Various physicochemical tests were carried out, like visual inspection, pH, detergency, dirt dispersion, determination of foam, viscosity and stability evaluation, and antimicrobial activity. It was observed that prepared herbal shampoo had good cleansing properties and was very efficient in controlling the growth of Candida and Malassezia fungi.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135866579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation Development and Evaluation of Herbal Tablet of Diplocyclos palmatus (L.) Jeffry","authors":"Sumeet Dwivedi1, Devendra S. Lodhi, Deepak Kumawat, Pradeep Golani, Anup K. Chakraborty, Rekha Bisht","doi":"10.25258/ijddt.13.3.09","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.09","url":null,"abstract":"Diplocyclos palmatus (L.) Jeffry. (Shivlingi), is a plant in the Cucurbitaceae family that has been utilized extensively in indigenous medicine due to its purported biological properties. The goal of the current study was to formulate herbal tablets for the treatment of inflammation that contained a hydro-alcoholic extract of D. palmatus (L.) Jeffry. The formulated herbal tablet underwent IP evaluation, and all the results were found satisfactory.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a Newly Formulated Anti-Inflammatory Ointment from Ficus religiosa Root Bark","authors":"Jyothisree G, S. Umadevi","doi":"10.25258/ijddt.13.3.05","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.05","url":null,"abstract":"The basis of the medical system is medicinal herbs. Herbal combinations for therapeutic alignment often include botanical components. This work aims to make an anti-inflammatory ointment from the Ficus religiosa root bark and test the medicine using a novel HPTLC technique. The flavonoid component from the hydroalcoholic extract was separated by column chromatography. The mobile phase used was a mixture of toluene, ethyl acetate, and methanol in the ratio 04:04:02. By using the fusion method to create a straightforward ointment from this separation, it was discovered that the formulation’s physicochemical properties were all within acceptable bounds. The mobile phase for the HPTLC study included toluene, ethyl acetate, formic acid, and methanol (3:3:0.8:0.2), and the wavelength was 280 nm. Using albino mice and the Carrageenan-induced paw edema method, the anti-inflammatory effect was assessed. Rf value is discovered to be 0.86, 0.88, and 0.89 for simple ointment, fractionate, and standard quercetin, respectively. According to ICH criteria, the HPTLC method was validated, and all parameters were within acceptable ranges. The created ointment can be used in a straightforward manner to alleviate inflammation. In comparison to NSAIDS, the topical formulation showed good anti-inflammatory action in carrageenan-induced paw edema.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Lipid Profile and Sexual Hormones in Women with Polycystic Ovarian Syndrome at Al-Najaf Province","authors":"Abdul-Samad U Hassan, Ameer N. K","doi":"10.25258/ijddt.13.3.27","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.27","url":null,"abstract":"Background: A multiple-factorial condition influencing females’ reproductive years is polycystic ovarian syndrome (PCOS). This study aims to investigate lipid profiles and sex hormones, and DHEA hormones related to patients suffering from PCOS. Method: In this investigation, the sex hormones, lipid profile and DHEA hormone of 45 females in their reproductive years who were suffering from PCOS were compared to those of 45 women who were healthy and of a similar age. Results: Our results showed that the mean ± standard deviation of triglyceride parameter is higher than others parameters in both women patients with polycystic syndrome (73.2 ± 147.3 mg/dl) and control (57.9 ± 123.7 mg/dl) groups with highly significant difference (p-value < 0.001). While, mean ± standard deviation of other parameters, including cholesterol, HDL, LDL and VLDL, was higher in women with polycystic syndrome than in the control groupe. Conclusion: The more active fertile age group, 21 to 30 years old are more susceptible to the incidence of PCOS. Our data shows a significant correlation between DHEA and cholesterol, HDL, VLDL in the patient group. There is a positive statistical correlation between DHEA and LDL and between DHEA and LH, prolactin, and testosterone. The correlation between DHEA and FSH showed a passive association (statistically significant).","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervicovaginal Fetal Fibronectin Levels in Preterm Labor: Just Association or Reliable Screening Biomarker","authors":"Mazenah H.J Al-Hachami, Bushra J.U Alrubayae","doi":"10.25258/ijddt.13.3.52","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.52","url":null,"abstract":"Background: Preterm birth (PTB) is a chief reason for neonatal illness and death. Prediction of PTB can prevent complications. The cervico-vaginal fetal fibronectin (fFN) test is a good predictor for preterm labor (PTL) within 7 to 14 days from testing. The levels of fFN are high during the first 16 to 22 weeks of gestation in normal pregnancy before it drops to very low values and rises over again as the gestation reaches term. The current work aimed to assess the association and reliability of cervicovaginal fFN in predicting PTL. Patient and method: The study was cross-sectional that included hundred pregnant (aging from 20–34 years), gestational age ranging (from 24–34 weeks), and presented with abdominal pain. All applicants’ Detailed medical history regarding age, gravidity, and parity were taken from all applicants. Gestational age was calculated through general examination and abdominal and vaginal examination. During speculum vaginal examination, fFN samples were taken from the cervix and were examined for fFN using the quick check for assay. Statistical scrutiny was carried out by SPSS version 17. A p ≤ 0.05 was measured as significant. Result: The mean age was (27.53 ± 4.23), range (of 20–34). Positive fFN results were detected in only (22%) of patients. Around two-thirds of the women end their pregnancy by normal vaginal delivery. Less than half (45.5%) of the included women delivered within one week after presentation, around 1/3rd (31.8%) delivered after the second week, and only 22.2% delivered during the first day of presentation. There was a significant association between pregnancy outcome and fFN results. A majority (90.9%) of patients end with preterm labor during 2 weeks of follow-up were presented with positive fetal fibronectin. The majority (90.9%) of patients end with preterm labor during 2 weeks of follow-up were presented with positive fFN results. There were non-significant variations between means of gestational ages, parity, and gestational age/weeks between those with positive and negative fFN results. Conclusion: Among pregnant women with uterine contraction before advanced cervical dilatation, the presence of cervicovaginal fFN is an associated and reliable screening test in predicting the risk of PTL.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication, Optimization and Evaluation of Escin Enriched Emulgel System for Treatment of Varicose Veins","authors":"Chougule PN, Koumaravelou K, Chougule NB","doi":"10.25258/ijddt.13.3.10","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.10","url":null,"abstract":"Varicose veins, a widespread chronic venous ailment in lower limbs, impact many individuals, causing considerable physical, financial, and social burdens. While surgery is the most effective treatment, its cost hinders personalized care. In the quest for venous-specific therapies, herbal remedies, particularly horse chestnut extract containing escin, are being explored. Escin, a key component, offers anti-inflammatory, anti-edematous, and antioxidant effects. The saponin escin has two forms, α and β, with distinct actions via oral and topical routes. A gel system with permeability enhancers was developed to enhance topical escin’s effectiveness following meticulous pre-formulation and optimization studies. The physiochemical characteristics of emulsion and emulgel system, assay of escin, in-vitro permeation, emulgel studies such as pH, viscosity, spreadability and stability studies are all included in the evaluation part. The 2% escin in the light beige-colored emulgel system was significantly improved permeability when soy lecithin was added. The investigation on permeation enhancement shows that there is 1.5 times more activity than there would be with standard preparation. Escin’s concentration was measured using a UV spectrophotometer and was found to be between 98 and 102%. Studies such as pH, viscosity and spreadability are within the predefined limits. Overall, the developed escin-based emulgel system shows promising results for the management of varicose veins","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135866875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective Effect of Chlorogenic Acid against Pentylenetetrazol Induced Kindled Epilepsy in Mice","authors":"Akansha Singh, Lubhan Singh, Rupesh Pandey, Prabhat Singh, Moazzam Ali, Rahul Kaushik, Priyadarshini Soni","doi":"10.25258/ijddt.13.3.43","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.43","url":null,"abstract":"Background: Epilepsy is a group of chronic neurological disorders characterized by seizures. Kindling, a chronic epileptic mouse model that was used to explore the epileptogenic mechanism and seeking new anti-epileptics. In kindling, sub-convulsive (chemical/ electrical) stimuli are delivered repeatedly and erratically, eventually causes massive convulsions. The aim of this study was to investigate the neuroprotective effects of chlorogenic acid, a phenolic acid derived from coffee, on seizure severity and kindling progression. Memory impairment inflammation due to oxidative stress by pentylenetetrazol (PTZ). Objective: This study was used to investigate the neuroprotective effect of chlorogenic acid against pentylenetetrazol induced kindled epilepsy in mice. Methods: Kindling was provoked by subsequent (one-day-gap) injections of PTZ (subconvulsive; 35 mg/kg; s.c.) for 29 days in mice. The experimental protocol included six groups (n=6) receiving proconvulsant doses of PTZ (35 mg/kg i.p.) every other day for 31 days. Alternating subcutaneous injections of PTZ induced priming with 15 injections of PTZ. Compared with the PTZ group, pre-treatment with chlorogenic acid (5 and 10 mg/kg) 1 h before PTZ administration reduced seizure score, reduced metastasis latency due to increased normal maze, and decreased metastasis latency extension at FST. PTZ-induced biochemical changes were enhanced in chlorogenic acid-treated animals, as indicated by decreased lipid peroxidation (MDA), nitric oxide and AChE levels, and increased SOD, GSH, catalase level. Following PTZ injection, convulsive behaviours were noted for 30 minutes. Open-field-test (locomotor activity), force swimming test (depressive behaviors), elevated plus-maze and passive avoidance tests were employed to evaluate cognition. Brain homogenate was used to estimate oxidative stress (glutathione,superoxide-dismutase, lipid-peroxidation), and acetylcholinesterase activity. Results: This result suggest the neuroprotective potential of chlorogenic acid. This may be correlated with its ability to inhibit oxidative damage and reduce the occurrence of seizures and other related damage. It may be a promising candidate for mitigating the consequences of events. Conclusion: Our findings suggest effect of chlorogenic acid against pentylenetetrazol-induced kindled epilepsy in mice which were established by behavioral and biochemical paradigms","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135866877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Anti-aging Effects of Gemfibrozil on D-galactose induced Aging Mouse Model","authors":"Rana J. H. AL-Bairmani, Haitham M. Kadhim","doi":"10.25258/ijddt.13.3.40","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.40","url":null,"abstract":"Background: Aging is the sequential or progressive changes in the organisms that is associated with increasing susceptibility to disease and death. Advanced age is associated with increased incidence of a variety of chronic disease states that share oxidative stress and inflammation as causative role players. Accumulating evidence in published literature showed that the use of antioxidant and anti-inflammatory agents is an effective approach to alleviate or reverse aging-related changes with consequent reduction of the aging rate and related disease. Gemfibrozil, as a peroxisome proliferator-activated alpha receptor ligand (PPARα), is reported to have antioxidant and inflammatory activity. Aim of the study: Evaluate the anti-aging effect of gemfibrozil on many parameters associated with the aging process on the D-galactose induced aging mice model. Method: The current work was an experimental randomized controlled study in which 60 albino male mice weighing between 25 to 40 gm were randomly divided into 6 groups (10 mice each group). group1 apparently healthy group, receive normal saline orally. Group 2 (age induction group receive D-galactose 500 mg/kg) orally only for 6 weeks, group 3 (+D-galactose 500 mg/kg + vitc 100 mg/kg orally for 6 weeks) group 4 (D-galactose 500 mg/kg for 6 weeks then vitc 100 mg/kg for another 6 consecutive weeks group 5 (D-galactose 500 mg/kg + gemfibrozil 7.5 mg/kg concomitantly for 6 weeks) group 6 (D-galactose 500 mg/kg for 6 weeks then gemfibrozil 7.5 mg/kg for another 6 consecutive weeks. Then animals were sacrificed, liver and kidney were weighed for organ index measurement and tissue sections and heart homogenate were prepared for ELISA assay (measurement of TN alpha, IL1beta, SOD, GPX) and histopathological analysis of myocardial tissue. Results: results showed a significant rise in liver and kidney indices in animals that received gemfibrozil orally administered (during and after induction) compared to aged group, with a dramatic decrease in inflammatory and oxidative stress mediator level and a marked reversal effect on myocardial hypertrophy induced by D-galactose. Conclusion: Gemfibrozil oral administration alleviates aging-associated atrophic changes in liver and kidney, oxidative stress and inflammatory state in myocardial tissue and reverses aging-related myocardial hypertrophic changes.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation and Characterization of Phytoconstituents from the Plant Excoecaria agallocha Linn","authors":"Maruti K Shelar, Manohar J Patil, Santosh S Patil","doi":"10.25258/ijddt.13.3.16","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.16","url":null,"abstract":"Background: Marine resources are currently widely studied because academic and industrial researchers are striving to extract lead molecules from the interior of oceans. Marine resources are increasingly the subject of significant research. Excoecaria agallocha Linn., one of the plants with several pharmacological effects such as anti-inflammatory, analgesic, antiulcer, anticancer, etc., is one of the phytoconstituents in mangroves that have been widely used in folk medicine to treat disorders. Objective: The objective of present study to perform a comprehensive phytochemical investigation of milky mangrove. The plant E. agallocha were collected, extracted, isolated, and analyzed in an attempt to better comprehend the various phytochemical aspects of the plant. Material and method: The isolated product was analyzed by different spectroscopic method. Results: The isolated product is characterized as steroidal moiety containing two double bond at 6 and 22-position and alcoholic group at 3-position of cyclopentanoperhydrophenanthrene in to the isolation of (1,2,3,4,5,10,11,12,14,15,17-dodecahydro-3-hydroxy-4,4,10,13,14-pentamethyl17-(( E )- 5,6-dimethylhept-3-en- 2- yl-)9-H-cyclopenta[a]phenanthren-6,16-dione. Conclusion: The compound’s actual structure is made known using all of the UV, IR, NMR, and mass spectrometry evidence","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"128 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solid Lipid Nanoparticles: Drug Delivery Systems for Enhancing the Bioavailability of Antihypertensives","authors":"Neeraj K. Chauhan, Anuj Malik, Paramjeet K. Ratiyen","doi":"10.25258/ijddt.13.3.46","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.46","url":null,"abstract":"The pharmaceutical industry focuses the SLNs as promising drug deliverance methods for improving bioavailability. SLNs are a swiftly budding field of nanotechnology amid plentiful budding applications in medicine and research. Lipid-based nanoparticles possess unique properties due to their small size, allowing novel therapeutics to be developed. The encapsulation of drugs within nano-carriers presents a new paradigm in drug delivery, enabling enhanced targeting at secondary and tertiary levels. Consequently, SLNs have garnered significant attention from researchers for their site-specific drug delivery. This review enlightens on the responsibilities of SLN for improving the pharmacokinetics of poorly soluble antihypertensive drugs. Profound investigations confirmed SLNs have latent to transfigure antihypertensives through enhanced oral delivery.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}