International Journal of Drug Delivery Technology最新文献

{"title":"Solubility Enhancement of Itraconazole by Centrifugal Melt Spinning Technique","authors":"Rodge PJ, Shirolkar SV","doi":"10.25258/ijddt.13.3.06","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.06","url":null,"abstract":"Itraconazole is an antifungal drug with poor water solubility and limited bioavailability, presenting difficulties in achieving effective therapeutic applications. This study aimed to employ centrifugal melt spinning, an innovative method, to improve the solubility of itraconazole. In this process, itraconazole was subjected to centrifugal forces while melting, forming amorphous solid dispersions. Microfibers loaded with 10% w/w itraconazole were prepared through centrifugal melt spinning, employing sucrose as a carrier. ITZ-sucrose microfibers with uniform morphology and an average diameter of 14.27 ± 2.90 μm were successfully fabricated, as evidenced by the scanning electron microscopy results. XRD and DSC measurements confirmed the amorphous nature of the spun microfibers. The solubility of Itraconazole sucrose microfibers was significantly enhanced by 17-fold compared to plain itraconazole. The dissolution experiments demonstrated that sucrose microfibers loaded with ITZ achieved a significant release of 94.96 ± 1.47% within 10 minutes, representing a substantial enhancement compared to plain drugs. The study indicated that utilizing the centrifugal melt spinning technique successfully generated amorphous solid dispersions of itraconazole, leading to a considerable improvement in the drug’s solubility.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Extracelluar Matrix Protien 1 with Semen Parameters and Testosterone Concentration in Male Infertility","authors":"Mohammed A. Assi, Sajjad S. Hameed","doi":"10.25258/ijddt.13.3.03","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.03","url":null,"abstract":"Background: Extracellular matrix protein 1 (ECM1) is a glycoprotein that interacts with extracellular proteins into semen predominantly by epididymis, supports considering the role of the epididymis in sperm maturation. Testosterone is a steroid hormone from the androgen group is primarily secreted in the testes. Objectives: The aim of this study is to assess the concentration of ECM1 and serum by (ELISA) kit with semen parameters in fertile and infertile men in Najaf City, Iraq. Material and Methods: A total of 90 participants (45 infertile and 45 fertile men) were mean age (40.02) control fertility male, while the mean age as infertile (40.22) years included in the current study. The patients were sub-grouped into: 45 infertile with semen abnormal oligozoospermia, azoospermia, asthenozoospermia and teratozoospermia patients, it used for measuring the concentration and parameters ECM1and serum testosterone by Elisa kit. Results: Statistical analysis showed highly significant differences between the two groups show (p < 0.05). The level of ECM in the infertile group was lower in concentration than the control group with statistically significant differences (p < 0.0001*). The difference between the totals was highly significant by a criterion (p < 0.0001*) 45 in all group that studied a positive person correlation highly significant between serum testosterone (IU/mL) and seminal ECM1, (pg/mL) in all age groups of 45 male infertility at a (p < 0.001*). Conclusion: The decrease in serum testosterone levels with the decrease in the level of seminal plasma ECM1 in infertile men provide evidence that levels can be used as reliable markers in the diagnostic criteria of male infertility. This study’s results suggest that concentration ECM1.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation Development and Evaluation of Herbal Tablet of Diplocyclos palmatus (L.) Jeffry","authors":"Sumeet Dwivedi1, Devendra S. Lodhi, Deepak Kumawat, Pradeep Golani, Anup K. Chakraborty, Rekha Bisht","doi":"10.25258/ijddt.13.3.09","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.09","url":null,"abstract":"Diplocyclos palmatus (L.) Jeffry. (Shivlingi), is a plant in the Cucurbitaceae family that has been utilized extensively in indigenous medicine due to its purported biological properties. The goal of the current study was to formulate herbal tablets for the treatment of inflammation that contained a hydro-alcoholic extract of D. palmatus (L.) Jeffry. The formulated herbal tablet underwent IP evaluation, and all the results were found satisfactory.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Carvedilol on Organ Index, Inflammatory Mediators, Oxidative Stress Parameters and Skin Markers in D-Galactose-Induced Aging Mice","authors":"Elaf M Shihab, Haitham M Kadhim","doi":"10.25258/ijddt.13.3.41","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.41","url":null,"abstract":"Background: Aging processes are defined as those that increase the susceptibility of individuals, as they grow older, to the factors that eventually lead to death. It is a complex multi-factorial process where several factors may interact simultaneously and may operate at many levels of functional organization.. Accumulating evidence has suggested that active ingredients that possess antioxidative and anti-inflammatory proprties could decrease the incidence and development of aging-related diseases and promote longevity. Carvedilol is a non-selective third generation β-blocker/α1-blocker with antioxidant and inflammatory activity to evaluate its antiaging effect and to investigate if it is better to given carvedilol with aging induction or after aging induction is established. Aim: To evaluate the effect of carvedilol on organ index, inflammatory mediators, oxidative stress parameters and skin markers in d-galactose-induced aging mice. Method: Male (swiss albino mice) weighing 20 to 30 g and aged 3 to 6 months was randomly divided into six groups , each consisting of 10 animals (60 mice in total). Group I was given normal saline orally only for six weeks, group II was given d-galactose 500 mg/kg orally only for six weeks, group III was given d-galactose 500 mg/kg orally and vitamin C 100 mg/kg orally concomitantly for six weeks, group IV given d-galactose 500 mg/kg orally only for six weeks, then directly next day after ending of aging induction, vitamin c 100 mg/kg started for another six weeks, group V given d-galactose 500 mg/kg orally and carvedilol 10 mg/kg orally concomitantly for six weeks, group VI given d-galactose 500 mg/kg orally only for six weeks, then directly next day after ending of aging induction, carvedilol 10 mg/kg started for another six weeks. After that, animals were weighed, euthanized, and dissected, the heart was removed and the organ index was calculated. Also the heart tissue is divided in to two parts, one homogenated to measure interleukin-Iβ, tumor necrosis factor-alpha, glutathione peroxidase and malondialdehyde, while the other piece for histopathological analysis to determine the presence of hypertrophy. Skin tissue was taken and homogenated for ELISA assay (measurement of collagen I and III levels ). Results: Results showed a significant decrease in heart organ index in animals that received carvedilol orally administered compared to aged group, with a substantial decrease in inflammatory mediators, malondialdehyde level and a marked increase in glutathione peroxidase level, collagen I and collagen III levels. Furthermore, carvedilol reverses the myocardial hypertrophy induced by D-galactose. Conclusion: The present study suggests that carvedilol has a positive antiaging benefit in reducing oxidative stress, decreasing inflammatory and skin aging markers and improving hypertrophic cardiac cells. Regarding the timing of drug administration, although carvedilol shows a benficial continuing impact when given with a","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a Newly Formulated Anti-Inflammatory Ointment from Ficus religiosa Root Bark","authors":"Jyothisree G, S. Umadevi","doi":"10.25258/ijddt.13.3.05","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.05","url":null,"abstract":"The basis of the medical system is medicinal herbs. Herbal combinations for therapeutic alignment often include botanical components. This work aims to make an anti-inflammatory ointment from the Ficus religiosa root bark and test the medicine using a novel HPTLC technique. The flavonoid component from the hydroalcoholic extract was separated by column chromatography. The mobile phase used was a mixture of toluene, ethyl acetate, and methanol in the ratio 04:04:02. By using the fusion method to create a straightforward ointment from this separation, it was discovered that the formulation’s physicochemical properties were all within acceptable bounds. The mobile phase for the HPTLC study included toluene, ethyl acetate, formic acid, and methanol (3:3:0.8:0.2), and the wavelength was 280 nm. Using albino mice and the Carrageenan-induced paw edema method, the anti-inflammatory effect was assessed. Rf value is discovered to be 0.86, 0.88, and 0.89 for simple ointment, fractionate, and standard quercetin, respectively. According to ICH criteria, the HPTLC method was validated, and all parameters were within acceptable ranges. The created ointment can be used in a straightforward manner to alleviate inflammation. In comparison to NSAIDS, the topical formulation showed good anti-inflammatory action in carrageenan-induced paw edema.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Lipid Profile and Sexual Hormones in Women with Polycystic Ovarian Syndrome at Al-Najaf Province","authors":"Abdul-Samad U Hassan, Ameer N. K","doi":"10.25258/ijddt.13.3.27","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.27","url":null,"abstract":"Background: A multiple-factorial condition influencing females’ reproductive years is polycystic ovarian syndrome (PCOS). This study aims to investigate lipid profiles and sex hormones, and DHEA hormones related to patients suffering from PCOS. Method: In this investigation, the sex hormones, lipid profile and DHEA hormone of 45 females in their reproductive years who were suffering from PCOS were compared to those of 45 women who were healthy and of a similar age. Results: Our results showed that the mean ± standard deviation of triglyceride parameter is higher than others parameters in both women patients with polycystic syndrome (73.2 ± 147.3 mg/dl) and control (57.9 ± 123.7 mg/dl) groups with highly significant difference (p-value < 0.001). While, mean ± standard deviation of other parameters, including cholesterol, HDL, LDL and VLDL, was higher in women with polycystic syndrome than in the control groupe. Conclusion: The more active fertile age group, 21 to 30 years old are more susceptible to the incidence of PCOS. Our data shows a significant correlation between DHEA and cholesterol, HDL, VLDL in the patient group. There is a positive statistical correlation between DHEA and LDL and between DHEA and LH, prolactin, and testosterone. The correlation between DHEA and FSH showed a passive association (statistically significant).","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervicovaginal Fetal Fibronectin Levels in Preterm Labor: Just Association or Reliable Screening Biomarker","authors":"Mazenah H.J Al-Hachami, Bushra J.U Alrubayae","doi":"10.25258/ijddt.13.3.52","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.52","url":null,"abstract":"Background: Preterm birth (PTB) is a chief reason for neonatal illness and death. Prediction of PTB can prevent complications. The cervico-vaginal fetal fibronectin (fFN) test is a good predictor for preterm labor (PTL) within 7 to 14 days from testing. The levels of fFN are high during the first 16 to 22 weeks of gestation in normal pregnancy before it drops to very low values and rises over again as the gestation reaches term. The current work aimed to assess the association and reliability of cervicovaginal fFN in predicting PTL. Patient and method: The study was cross-sectional that included hundred pregnant (aging from 20–34 years), gestational age ranging (from 24–34 weeks), and presented with abdominal pain. All applicants’ Detailed medical history regarding age, gravidity, and parity were taken from all applicants. Gestational age was calculated through general examination and abdominal and vaginal examination. During speculum vaginal examination, fFN samples were taken from the cervix and were examined for fFN using the quick check for assay. Statistical scrutiny was carried out by SPSS version 17. A p ≤ 0.05 was measured as significant. Result: The mean age was (27.53 ± 4.23), range (of 20–34). Positive fFN results were detected in only (22%) of patients. Around two-thirds of the women end their pregnancy by normal vaginal delivery. Less than half (45.5%) of the included women delivered within one week after presentation, around 1/3rd (31.8%) delivered after the second week, and only 22.2% delivered during the first day of presentation. There was a significant association between pregnancy outcome and fFN results. A majority (90.9%) of patients end with preterm labor during 2 weeks of follow-up were presented with positive fetal fibronectin. The majority (90.9%) of patients end with preterm labor during 2 weeks of follow-up were presented with positive fFN results. There were non-significant variations between means of gestational ages, parity, and gestational age/weeks between those with positive and negative fFN results. Conclusion: Among pregnant women with uterine contraction before advanced cervical dilatation, the presence of cervicovaginal fFN is an associated and reliable screening test in predicting the risk of PTL.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication, Optimization and Evaluation of Escin Enriched Emulgel System for Treatment of Varicose Veins","authors":"Chougule PN, Koumaravelou K, Chougule NB","doi":"10.25258/ijddt.13.3.10","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.10","url":null,"abstract":"Varicose veins, a widespread chronic venous ailment in lower limbs, impact many individuals, causing considerable physical, financial, and social burdens. While surgery is the most effective treatment, its cost hinders personalized care. In the quest for venous-specific therapies, herbal remedies, particularly horse chestnut extract containing escin, are being explored. Escin, a key component, offers anti-inflammatory, anti-edematous, and antioxidant effects. The saponin escin has two forms, α and β, with distinct actions via oral and topical routes. A gel system with permeability enhancers was developed to enhance topical escin’s effectiveness following meticulous pre-formulation and optimization studies. The physiochemical characteristics of emulsion and emulgel system, assay of escin, in-vitro permeation, emulgel studies such as pH, viscosity, spreadability and stability studies are all included in the evaluation part. The 2% escin in the light beige-colored emulgel system was significantly improved permeability when soy lecithin was added. The investigation on permeation enhancement shows that there is 1.5 times more activity than there would be with standard preparation. Escin’s concentration was measured using a UV spectrophotometer and was found to be between 98 and 102%. Studies such as pH, viscosity and spreadability are within the predefined limits. Overall, the developed escin-based emulgel system shows promising results for the management of varicose veins","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135866875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective Effect of Chlorogenic Acid against Pentylenetetrazol Induced Kindled Epilepsy in Mice","authors":"Akansha Singh, Lubhan Singh, Rupesh Pandey, Prabhat Singh, Moazzam Ali, Rahul Kaushik, Priyadarshini Soni","doi":"10.25258/ijddt.13.3.43","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.43","url":null,"abstract":"Background: Epilepsy is a group of chronic neurological disorders characterized by seizures. Kindling, a chronic epileptic mouse model that was used to explore the epileptogenic mechanism and seeking new anti-epileptics. In kindling, sub-convulsive (chemical/ electrical) stimuli are delivered repeatedly and erratically, eventually causes massive convulsions. The aim of this study was to investigate the neuroprotective effects of chlorogenic acid, a phenolic acid derived from coffee, on seizure severity and kindling progression. Memory impairment inflammation due to oxidative stress by pentylenetetrazol (PTZ). Objective: This study was used to investigate the neuroprotective effect of chlorogenic acid against pentylenetetrazol induced kindled epilepsy in mice. Methods: Kindling was provoked by subsequent (one-day-gap) injections of PTZ (subconvulsive; 35 mg/kg; s.c.) for 29 days in mice. The experimental protocol included six groups (n=6) receiving proconvulsant doses of PTZ (35 mg/kg i.p.) every other day for 31 days. Alternating subcutaneous injections of PTZ induced priming with 15 injections of PTZ. Compared with the PTZ group, pre-treatment with chlorogenic acid (5 and 10 mg/kg) 1 h before PTZ administration reduced seizure score, reduced metastasis latency due to increased normal maze, and decreased metastasis latency extension at FST. PTZ-induced biochemical changes were enhanced in chlorogenic acid-treated animals, as indicated by decreased lipid peroxidation (MDA), nitric oxide and AChE levels, and increased SOD, GSH, catalase level. Following PTZ injection, convulsive behaviours were noted for 30 minutes. Open-field-test (locomotor activity), force swimming test (depressive behaviors), elevated plus-maze and passive avoidance tests were employed to evaluate cognition. Brain homogenate was used to estimate oxidative stress (glutathione,superoxide-dismutase, lipid-peroxidation), and acetylcholinesterase activity. Results: This result suggest the neuroprotective potential of chlorogenic acid. This may be correlated with its ability to inhibit oxidative damage and reduce the occurrence of seizures and other related damage. It may be a promising candidate for mitigating the consequences of events. Conclusion: Our findings suggest effect of chlorogenic acid against pentylenetetrazol-induced kindled epilepsy in mice which were established by behavioral and biochemical paradigms","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135866877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Anti-aging Effects of Gemfibrozil on D-galactose induced Aging Mouse Model","authors":"Rana J. H. AL-Bairmani, Haitham M. Kadhim","doi":"10.25258/ijddt.13.3.40","DOIUrl":"https://doi.org/10.25258/ijddt.13.3.40","url":null,"abstract":"Background: Aging is the sequential or progressive changes in the organisms that is associated with increasing susceptibility to disease and death. Advanced age is associated with increased incidence of a variety of chronic disease states that share oxidative stress and inflammation as causative role players. Accumulating evidence in published literature showed that the use of antioxidant and anti-inflammatory agents is an effective approach to alleviate or reverse aging-related changes with consequent reduction of the aging rate and related disease. Gemfibrozil, as a peroxisome proliferator-activated alpha receptor ligand (PPARα), is reported to have antioxidant and inflammatory activity. Aim of the study: Evaluate the anti-aging effect of gemfibrozil on many parameters associated with the aging process on the D-galactose induced aging mice model. Method: The current work was an experimental randomized controlled study in which 60 albino male mice weighing between 25 to 40 gm were randomly divided into 6 groups (10 mice each group). group1 apparently healthy group, receive normal saline orally. Group 2 (age induction group receive D-galactose 500 mg/kg) orally only for 6 weeks, group 3 (+D-galactose 500 mg/kg + vitc 100 mg/kg orally for 6 weeks) group 4 (D-galactose 500 mg/kg for 6 weeks then vitc 100 mg/kg for another 6 consecutive weeks group 5 (D-galactose 500 mg/kg + gemfibrozil 7.5 mg/kg concomitantly for 6 weeks) group 6 (D-galactose 500 mg/kg for 6 weeks then gemfibrozil 7.5 mg/kg for another 6 consecutive weeks. Then animals were sacrificed, liver and kidney were weighed for organ index measurement and tissue sections and heart homogenate were prepared for ELISA assay (measurement of TN alpha, IL1beta, SOD, GPX) and histopathological analysis of myocardial tissue. Results: results showed a significant rise in liver and kidney indices in animals that received gemfibrozil orally administered (during and after induction) compared to aged group, with a dramatic decrease in inflammatory and oxidative stress mediator level and a marked reversal effect on myocardial hypertrophy induced by D-galactose. Conclusion: Gemfibrozil oral administration alleviates aging-associated atrophic changes in liver and kidney, oxidative stress and inflammatory state in myocardial tissue and reverses aging-related myocardial hypertrophic changes.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135867551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}