固体脂质纳米颗粒:提高抗高血压药物生物利用度的药物输送系统

Q4 Pharmacology, Toxicology and Pharmaceutics

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI:10.25258/ijddt.13.3.46

Neeraj K. Chauhan, Anuj Malik, Paramjeet K. Ratiyen

{"title":"固体脂质纳米颗粒:提高抗高血压药物生物利用度的药物输送系统","authors":"Neeraj K. Chauhan, Anuj Malik, Paramjeet K. Ratiyen","doi":"10.25258/ijddt.13.3.46","DOIUrl":null,"url":null,"abstract":"The pharmaceutical industry focuses the SLNs as promising drug deliverance methods for improving bioavailability. SLNs are a swiftly budding field of nanotechnology amid plentiful budding applications in medicine and research. Lipid-based nanoparticles possess unique properties due to their small size, allowing novel therapeutics to be developed. The encapsulation of drugs within nano-carriers presents a new paradigm in drug delivery, enabling enhanced targeting at secondary and tertiary levels. Consequently, SLNs have garnered significant attention from researchers for their site-specific drug delivery. This review enlightens on the responsibilities of SLN for improving the pharmacokinetics of poorly soluble antihypertensive drugs. Profound investigations confirmed SLNs have latent to transfigure antihypertensives through enhanced oral delivery.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"18 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Solid Lipid Nanoparticles: Drug Delivery Systems for Enhancing the Bioavailability of Antihypertensives\",\"authors\":\"Neeraj K. Chauhan, Anuj Malik, Paramjeet K. Ratiyen\",\"doi\":\"10.25258/ijddt.13.3.46\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The pharmaceutical industry focuses the SLNs as promising drug deliverance methods for improving bioavailability. SLNs are a swiftly budding field of nanotechnology amid plentiful budding applications in medicine and research. Lipid-based nanoparticles possess unique properties due to their small size, allowing novel therapeutics to be developed. The encapsulation of drugs within nano-carriers presents a new paradigm in drug delivery, enabling enhanced targeting at secondary and tertiary levels. Consequently, SLNs have garnered significant attention from researchers for their site-specific drug delivery. This review enlightens on the responsibilities of SLN for improving the pharmacokinetics of poorly soluble antihypertensive drugs. Profound investigations confirmed SLNs have latent to transfigure antihypertensives through enhanced oral delivery.\",\"PeriodicalId\":13851,\"journal\":{\"name\":\"International Journal of Drug Delivery Technology\",\"volume\":\"18 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-09-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Drug Delivery Technology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.25258/ijddt.13.3.46\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Pharmacology, Toxicology and Pharmaceutics\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Drug Delivery Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.25258/ijddt.13.3.46","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}

引用次数: 0

摘要

制药行业将sln作为提高生物利用度的有前途的药物递送方法。sln是纳米技术的一个迅速发展的领域，在医学和研究中有许多新兴的应用。基于脂质的纳米颗粒由于其小尺寸而具有独特的性质，从而可以开发新的治疗方法。纳米载体内药物的包封为药物递送提供了一种新的范例，能够增强二级和三级靶向。因此，sln因其位点特异性给药而引起了研究人员的极大关注。本文综述了SLN在改善难溶性降压药的药代动力学中的作用。深入的调查证实，sln有潜在的变形抗高血压药物通过加强口服给药。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Solid Lipid Nanoparticles: Drug Delivery Systems for Enhancing the Bioavailability of Antihypertensives

The pharmaceutical industry focuses the SLNs as promising drug deliverance methods for improving bioavailability. SLNs are a swiftly budding field of nanotechnology amid plentiful budding applications in medicine and research. Lipid-based nanoparticles possess unique properties due to their small size, allowing novel therapeutics to be developed. The encapsulation of drugs within nano-carriers presents a new paradigm in drug delivery, enabling enhanced targeting at secondary and tertiary levels. Consequently, SLNs have garnered significant attention from researchers for their site-specific drug delivery. This review enlightens on the responsibilities of SLN for improving the pharmacokinetics of poorly soluble antihypertensive drugs. Profound investigations confirmed SLNs have latent to transfigure antihypertensives through enhanced oral delivery.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

International Journal of Drug Delivery Technology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.70

自引率

0.00%

发文量

期刊介绍： International Journal of Drug Delivery Technology (IJDDT) provides the forum for reporting innovations, production methods, technologies, initiatives and the application of scientific knowledge to the aspects of pharmaceutics, including controlled drug release systems, drug targeting etc. in the form of expert forums, reviews, full research papers, and short communications.