1-(苯基)- 1h吲哚的一锅合成及其生物学筛选和ADME研究

Q4 Pharmacology, Toxicology and Pharmaceutics

International Journal of Drug Delivery Technology Pub Date : 2023-09-25 DOI:10.25258/ijddt.13.3.30

Tirth Thaker, Dipen Panchani, Vaishal Bhuva

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引用次数: 0

摘要

本研究旨在开发一种合成吲哚衍生物的新方法。通过1-苯基-2-(苯基氨基)-乙烷-1- 1环化合成1-(苯基)- 1h -吲哚类似物。对标题化合物进行了生物学评价和吸收、分布、代谢和排泄(ADME)研究，标题化合物具有较高的亲和力，并与不同的蛋白质产生了充分的相互作用。

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One Pot Synthesis of 1-(phenyl)-1H Indoles, their Biological Screening and ADME Studies

This research aims to develop a novel way for synthesizing indole derivatives. 1-(phenyl)-1H-indole analogues were synthesized by cyclization of 1-phenyl-2-(phenyl amino)-ethane-1-one. Biological evaluation of title compounds and absorption, distribution, metabolism and excretion (ADME) studies were performed and title compounds had a higher affinity and created ample interactions with different proteins.

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来源期刊

International Journal of Drug Delivery Technology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.70

自引率

0.00%

发文量

期刊介绍： International Journal of Drug Delivery Technology (IJDDT) provides the forum for reporting innovations, production methods, technologies, initiatives and the application of scientific knowledge to the aspects of pharmaceutics, including controlled drug release systems, drug targeting etc. in the form of expert forums, reviews, full research papers, and short communications.