International Archives of Otorhinolaryngology最新文献

{"title":"Development of Clinical Practice Guidelines and Primary Care Referral Pathways for the Management of Otorhinolaryngological Conditions in Pakistan.","authors":"Alina Pervez, Russell Seth Martins, Huzaifa Moiz, Abbas Raza Syed, Muneeb Khan, Nashia Ali Rizvi, Mohsin Ali Mustafa, Muhammad Taha Nasim, Alina Abdul Rehman, Shayan Khalid, Saif Ur Rehman, Sarah Nadeem, Adil H Haider, Shabbir Akhtar","doi":"10.1055/s-0046-1818583","DOIUrl":"10.1055/s-0046-1818583","url":null,"abstract":"<p><strong>Introduction: </strong>Developing region-specific clinical practice guidelines (CPGs) for ear, nose, and throat (ENT) diseases is crucial in Pakistan's primary care, given their significant contribution to clinical cases, aiming to enhance healthcare standards through evidence-based practices with local adaptations.</p><p><strong>Objectives: </strong>To ensure the standardization of primary healthcare and reduce unnecessary specialist referrals by creating CPGs that are appropriate to our region.</p><p><strong>Methods: </strong>We selected eight guidelines regarding epistaxis, neck masses, hearing loss, Ménière's disease, dysphonia, allergic rhinitis, acute otitis externa, and rhinosinusitis from the American Academy of Otolaryngology-Head and Neck Surgery Foundation as the source guidelines, and employed the Grading of Recommendations, Assessment, Development, and Evaluation-Adoption, Adaptation, and De Novo Development (GRADE-ADOLOPMENT) approach to contextualize guidelines by adopting, adapting, or excluding recommendations from them. Clinical-referral algorithms were created using recommendations from the CPGs created, with additional recommendations sought through a best-evidence review process.</p><p><strong>Results: </strong>We developed local CPGs for eight ENT conditions using the GRADE-ADOLOPMENT approach. While most recommendations were adopted in the local CPGs, one recommendation for acute otitis externa, hearing loss, and epistaxis and two for allergic rhinitis were adopted with minor changes. Six recommendations were excluded due to service limitations in Pakistan. Additionally, we created 8 clinical-referral algorithms, incorporating 17 additional recommendations to address gaps in practice, distributed across various conditions.</p><p><strong>Conclusion: </strong>The newly-established CPGs are instrumental in delivering standardized, high-quality care at the primary care level. Simultaneously, the development of clinical referral pathways empowers general physicians to manage patients effectively and make timely, appropriate referrals to ENT specialists.</p>","PeriodicalId":13731,"journal":{"name":"International Archives of Otorhinolaryngology","volume":"30 1","pages":"1-9"},"PeriodicalIF":1.1,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13109012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Steroids for the Prevention of Sensorineural Hearing Loss Secondary to Acute Otitis Media: A Systematic Review.","authors":"André Filipi Brandão Santos Sampaio, Rafael da Costa Monsanto, José Jarjura Jorge, Godofredo Campos Borges","doi":"10.1055/s-0045-1811640","DOIUrl":"10.1055/s-0045-1811640","url":null,"abstract":"<p><strong>Introduction: </strong>Acute otitis media (AOM) is associated with the development of permanent sensorineural hearing loss (SNHL). The potential role of steroids in preventing cochlear damage secondary to AOM has been discussed.</p><p><strong>Objective: </strong>To critically analyze the current evidence on the use of steroids to prevent AOM-associated SNHL.</p><p><strong>Data synthesis: </strong>A total of 15 studies was categorized into 3 groups: 1) studies on histopathological changes in the inner ear secondary to AOM (n 5); 2) those on the relationship between AOM and hearing outcomes (n = 5); and 3) studies on the (hearing or histological) outcomes of AOM treatment using steroids (n = 5). Experimental studies in animals and human temporal bones revealed that AOM is associated with the upregulation of proinflammatory cytokines in the middle and inner ears, resulting in an inflammatory process. Inflammatory cytokines and bacterial toxins translocate from the middle to the inner ears through the semipermeable round window membrane, causing structural damage to the neuroepithelium, mainly in the cochlear basal turn. In experimental studies, the use of steroids has been shown to reduce the expression of inflammatory cells and cytokines and the structural damage affecting the stria vascularis and hair cells. One study clinically evaluated the effects of steroids on AOM patients with SNHL, and it demonstrated significant improvements in hearing thresholds.</p><p><strong>Conclusion: </strong>Experimental data demonstrate that steroids can reduce the expression of inflammatory cytokines and reduce structural damage to the cochlear neurosensory epithelium. However, these findings have yet to be translated to a clinical setting due to the lack of high-level evidence.</p>","PeriodicalId":13731,"journal":{"name":"International Archives of Otorhinolaryngology","volume":"30 2","pages":"1-13"},"PeriodicalIF":1.1,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13108986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between 8-OHdG Levels and Eosinophil Counts in Chronic Rhinosinusitis with Nasal Polyps.","authors":"Tamara Silva Vieira, Letícia Martins Guimarães, Elisa Carvalho Siqueira, Rafaela Magalhães Braga Amaral, Wilma Terezinha Anselmo-Lima, Edwin Tamashiro, Marina Gonçalves Diniz, Fabiana Cardoso Pereira Valera, Ricardo Santiago Gomez, Carolina Cavalieri Gomes","doi":"10.1055/s-0046-1819639","DOIUrl":"10.1055/s-0046-1819639","url":null,"abstract":"<p><strong>Introduction: </strong>Oxidative stress plays an important role in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). The 8-Hydroxydeoxyguanosine (8-OHdG) is a major oxidative DNA adduct, and its levels have been noted as a triggering factor for inflammation-related carcinogenesis, but have not been assessed in CRSwNP. The MAPK/ERK pathway importance in the pathogenesis of CRSwNP has previously been reported. Mutations in <i>RAS</i> family genes occur in neoplastic and non-neoplastic proliferative lesions, and it has been previously demonstrated that <i>KRAS</i> mutations do not occur in CRSwNP.</p><p><strong>Objective: </strong>To assess the levels of 8-OHdG in nasal polyps occurring in CRSwNP, to associate these levels with clinicopathological parameters, and to investigate <i>HRAS</i> and <i>NRAS</i> hotspot mutations in the same samples.</p><p><strong>Methods: </strong>Both the <i>HRAS</i> (codons 49 and 61) and <i>NRAS</i> (codon 61) mutations were investigated through Sanger sequencing, and the levels of 8-OHdG were determined using ELISA in 14 freshly collected snap-frozen samples of nasal polyps occurring in CRSwNP. The associations between the levels of 8-OHdG and patients' age, presence of asthma, and eosinophil counts in nasal polyps were tested.</p><p><strong>Results: </strong>No mutations were detected. The association between higher levels of 8-OHdG and higher eosinophil counts was observed, whereas there was no association between it and age or the presence of asthma.</p><p><strong>Conclusion: </strong>Based on the results in the present cohort, higher levels of 8-OHdG, indicative of oxidative stress, are associated with higher eosinophil counts in CRSwNP. Additionally, <i>HRAS</i> and <i>NRAS</i> mutations do not occur in nasal polyps or occur at a very low frequency.</p>","PeriodicalId":13731,"journal":{"name":"International Archives of Otorhinolaryngology","volume":"30 2","pages":"1-6"},"PeriodicalIF":1.1,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13108992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Efficiency of the Kannada Digit Triplet Test to Identify Older Adults with Mild-to-Moderate Sensorineural Hearing Loss.","authors":"Salman Safeer, Mohan Kumar Kalaiah","doi":"10.1055/s-0046-1818550","DOIUrl":"10.1055/s-0046-1818550","url":null,"abstract":"<p><strong>Introduction: </strong>Hearing loss, especially age-related, affects speech perception and quality of life. Despite its prevalence, many individuals remain undiagnosed due to low awareness and limited access to screening tools. The Digit Triplet Test (DTT) is a proven speech-in-noise screening tool adapted into many languages. In India, the Kannada DTT was developed to address the need for a regional screening method. The present study aims to evaluate the effectiveness of the Kannada DTT to identify older adults with hearing loss.</p><p><strong>Objective: </strong>To determine the sensitivity and specificity of the Kannada DTT in identifying older adults with mild-to-moderate sensorineural hearing loss (SNHL).</p><p><strong>Methods: </strong>A total of 125 native Kannada-speaking participants aged 50 to 84 years were divided into 2 groups: 57 with normal hearing and 68 with mild-to-moderate hearing loss. Pure tone audiometry and speech identification scores were recorded. Participants underwent the Kannada DTT monaurally in both ears using an adaptive protocol.</p><p><strong>Results: </strong>The DTT scores were significantly poorer in the hearing loss group. A moderate positive correlation (r ≈ 0.68) was observed between pure tone average and DTT score. The receiver operating characteristic (ROC) curve analysis revealed that a DTT cutoff score of -11.05 dB provided the best classification accuracy, with sensitivity and specificity of 79.4% and 82.5% for the right ear, and 83.8% and 86% for the left ear, respectively.</p><p><strong>Conclusion: </strong>The Kannada DTT demonstrates good sensitivity and specificity in identifying older adults with mild-to-moderate SNHL and can be considered a reliable screening tool for early detection.</p>","PeriodicalId":13731,"journal":{"name":"International Archives of Otorhinolaryngology","volume":"30 1","pages":"1-9"},"PeriodicalIF":1.1,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13109011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147770638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Headache Profile of Patients Attending Otorhinolaryngology Clinics: Navigating Diagnostic Challenges.","authors":"Thripthi Rai, Keshava K Pai, Meera Niranjan Khadilkar, Vijendra Shenoy","doi":"10.1055/s-0046-1818584","DOIUrl":"10.1055/s-0046-1818584","url":null,"abstract":"<p><strong>Introduction: </strong>Headache is a common complaint among otolaryngology patients, often presenting with an apparent diagnosis of <i>secondary headache</i> due to sinusitis. However, associated symptoms may also be linked to <i>primary headache</i> disorders such as migraines. The overlapping symptomatology of various headache causes poses a diagnostic challenge. The present study aims to evaluate the headache profiles of patients visiting the otolaryngology department.</p><p><strong>Objective: </strong>The present study aims to evaluate the headache profiles of patients visiting the otolaryngology department.</p><p><strong>Methods: </strong>A cross-sectional study was conducted on 128 otolaryngology patients presenting with headaches. The headaches were categorized according to the International Classification of Headache Disorders, third edition (ICHD-3), based on detailed history, examination, nasal endoscopy, and imaging studies.</p><p><strong>Results: </strong>Primary headaches were diagnosed in 45.31% of the cases, while 54.69% presented secondary headaches. Sinusitis was the most common diagnosis, found in 40.63% of the patients. Various causes of primary and secondary headaches were correlated and were found to be statistically significant ( <i>p</i>  < 0.001 each). Statistical significance was observed when correlating primary headache with laterality ( <i>p</i>  < 0.001). The correlation of secondary headache with laterality and age range also showed statistical significance ( <i>p</i>  < 0.001 and 0.035 respectively).</p><p><strong>Conclusion: </strong>Sinonasal symptoms may accompany headaches, with or without a direct causal link. The accurate diagnosis and treatment of headache disorders requires a thorough understanding of the latest guidelines and a multidisciplinary approach. This comprehensive strategy is essential to provide high-quality healthcare and significantly improve the quality of life of individuals suffering from this common and often debilitating condition.</p>","PeriodicalId":13731,"journal":{"name":"International Archives of Otorhinolaryngology","volume":"30 1","pages":"1-6"},"PeriodicalIF":1.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13043240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147608722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and Practices of Hearing Screening and Hearing Loss Management among Ear, Nose, and Throat Physicians in Saudi Arabia.","authors":"Fahad Wadi S Alanazi, Lujain Bandar Alotaibi, Yousef Aljathlany, Saleh Alabood","doi":"10.1055/s-0045-1811516","DOIUrl":"10.1055/s-0045-1811516","url":null,"abstract":"<p><strong>Introduction: </strong>One of the main factors that lead to increased hearing loss consequences and progression is inadequate knowledge and practice of hearing screening and hearing loss management modalities. In Saudi Arabia, ear, nose, and throat (ENT) physicians are the primary source of knowledge about hearing loss and its management. The aim of the present study is to assess the knowledge and practice of hearing screening and hearing loss management among ENT physicians in Saudi Arabia.</p><p><strong>Objective: </strong>The aim of the present study is to assess the knowledge and practice of hearing screening and hearing loss management among ENT physicians in Saudi Arabia.</p><p><strong>Methods: </strong>We conducted a cross-sectional descriptive study with 106 ENT physicians working at different hospitals in Saudi Arabia from January to May 2023. A questionnaire consisting of 2 sections with 20 questions was used to assess the knowledge and practice of hearing screening and hearing loss management for children.</p><p><strong>Results: </strong>The current study showed inadequate knowledge of hearing loss and its management. The mean knowledge score was of 12.4 ± 2.12. The knowledge scores of the different types of ENT professionals were compared, and no statistically significant differences were observed ( <i>p</i>  = 0.489).</p><p><strong>Conclusion: </strong>More research should be conducted to assess the practice of hearing screening in Saudi Arabia. Our recommendation is the provision of more educational sessions about the recent guidelines on hearing loss screening.</p>","PeriodicalId":13731,"journal":{"name":"International Archives of Otorhinolaryngology","volume":"30 1","pages":"1-9"},"PeriodicalIF":1.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13043241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147608756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hearing and Balance in Adult Patients with a History of Traumatic Brain Injury.","authors":"Maria Clara Martins Pace, Ana Karina Lima Buriti, Raquel Caroline Ferreira Lopes Fontanelli, Italo Capraro Suriano, Daniela Gil","doi":"10.1055/s-0046-1817135","DOIUrl":"10.1055/s-0046-1817135","url":null,"abstract":"<p><strong>Introduction: </strong>Traumatic brain injury (TBI) can result in peripheral or central injury, causing hearing loss.</p><p><strong>Objective: </strong>To identify possible hearing and balance disorders in adult patients with a history of TBI.</p><p><strong>Methods: </strong>Observational cross-sectional study conducted in a public hospital. The sample consisted of 34 individuals aged 18 to 60 years old who had suffered mild to severe TBI more than 6 months before. They underwent an otoscopy and a medical history survey, recording their clinical history, as well as their previous and current hearing and balance complaints. Next, their hearing was screened at 1,000, 2,000, and 4,000 Hz, and their balance was assessed using the Classic and Sharpened Romberg tests, as well as the Timed Up and Go test.</p><p><strong>Results: </strong>The present study assessed 34 patients, of whom 35.3% failed the right ear and 38.2% failed the left ear in the hearing screening, highlighting a statistically significant difference between the pre- and post-trauma results. Regarding balance, 3.1% had a positive result on the right and 3.1% positive on the left in the Classic Romberg test. The Sharpened test found a higher result of 9.4 positive on the left and front. The Timed Up and Go test results were normal for 75.0% and abnormal for 25% of the participants, revealing a risk of falling.</p><p><strong>Conclusion: </strong>The present study demonstrated that adults after TBI may have hearing and balance complaints and changes, highlighting the importance of referral to an otorhinolaryngologist and subsequent clinical diagnosis in this population.</p>","PeriodicalId":13731,"journal":{"name":"International Archives of Otorhinolaryngology","volume":"30 1","pages":"1-8"},"PeriodicalIF":1.1,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13016954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147521024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Curcuminoid in Preventing and Repairing Damage to the Organ of Corti in <i>Rattus norvegicus</i> Diabetes Mellitus Model as Assessed by DPOAE Examination with Plasma Levels of HIF-1α and VEGF-A.","authors":"Muhammad Edy Syahputra Nasution, Tengku Siti Hajar Haryuna, Juliandi Harahap, Syafruddin Ilyas, Dharma Lindarto","doi":"10.1055/s-0045-1811641","DOIUrl":"10.1055/s-0045-1811641","url":null,"abstract":"<p><strong>Introduction: </strong>Cells in diabetes mellitus (DM) respond to low oxygen by increasing hypoxia-inducible factor-1 (HIF-1), which impacts vascular endothelial growth factor (VEGF). Although curcuminoids show therapeutic promise, no validated options are available to repair organ of Corti damage caused by DM.</p><p><strong>Objective: </strong>The present study aims to evaluate the effects of curcuminoid administration on the signal-to-noise ratio (SNR) and plasma levels of HIF-1α and VEGF-A in a DM model using <i>Rattus norvegicus</i> .</p><p><strong>Methods: </strong>An in vivo experimental design was employed with a double-blind control set up. Twenty-five male Wistar rats were divided into 5 groups: group 1 (DM without curcuminoids), groups 2 and 3 (DM with curcuminoids at 200 and 400 mg/kg body weight for 10 days), and groups 4 and 5 (DM with curcuminoids at 200 and 400 mg/kg body weight for 13 days). Diabetes mellitus was induced through an intraperitoneal injection of alloxan (150 mg/kg body weight). Distortion product otoacoustic emission (DPOAE) tests were performed. Enzyme-linked immunosorbent assay (ELISA) was used to measure plasma levels of HIF-1α and VEGF-A.</p><p><strong>Results: </strong>Significant differences were observed in SNR values, HIF-1α, and VEGF-A ( <i>p</i>  < 0.05). A significant correlation was found between SNR and HIF-1α (r = - 0.553; <i>p</i>  = 0.004) and VEGF-A (r = - 0.564; <i>p</i>  = 0.003), indicating that lower levels of these factors were associated with higher SNR.</p><p><strong>Conclusion: </strong>Curcuminoids can prevent and treat outer hair cell damage in the organ of Corti due to DM, as shown by improvements in plasma HIF-1α, VEGF-A levels, and SNR values.</p>","PeriodicalId":13731,"journal":{"name":"International Archives of Otorhinolaryngology","volume":"30 1","pages":"1-10"},"PeriodicalIF":1.1,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13002300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147498669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Stapedotomy in Improving Audibility and Quality of Life in Patients with Unilateral Otosclerosis - A Retrospective Study.","authors":"Andrzej Pastuszak, Elżbieta Gos, Aleksandra Kolodziejak, Łukasz Plichta, Piotr Henryk Skarzynski","doi":"10.1055/s-0045-1811953","DOIUrl":"10.1055/s-0045-1811953","url":null,"abstract":"<p><strong>Objective: </strong>To assess the quality of life in patients with unilateral otosclerosis treated surgically with stapedotomy. Both objective indicators (hearing thresholds and air-bone gap) and subjective patient assessment of quality of life were considered.</p><p><strong>Methods: </strong>We included 84 patients with unilateral otosclerosis who underwent stapes surgery. There were 24 men and 60 women, aged between 22 and 73 (mean = 44.1 ± 10.5) years. Pure tone audiometry (frequency range: 0.125-8 kHz) was performed preoperatively and 6 and 12 months postoperatively. Quality of life was assessed with the Assessment of Quality of Life - 8 Dimensions (AQoL-8D) questionnaire.</p><p><strong>Results: </strong>The preoperative air-conduction hearing thresholds were on average 56.6 dB HL and improved significantly to 31.3 dB HL 6 months after stapes surgery. Air-bone gap before surgery was on average 29.8 dB HL and improved significantly to 9.9 dB 6 months after stapes surgery. Hearing thresholds were stable for 12 months after stapes surgery. Overall quality of life significantly increased after surgery, with improvements occurring in several domains: <i>independent living</i> , <i>senses</i> , <i>mental health</i> , <i>coping</i> , and <i>relationships</i> .</p><p><strong>Conclusion: </strong>Stapedotomy is an effective treatment for patients with unilateral otosclerosis. As well as improving hearing thresholds, it significantly enhances overall quality of life.</p>","PeriodicalId":13731,"journal":{"name":"International Archives of Otorhinolaryngology","volume":"30 1","pages":"1-7"},"PeriodicalIF":1.1,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Music Therapy and Tinnitus Treatment: Systematic Review and Meta-Analysis.","authors":"Ronaldo Kennedy de Paula Moreira, Maurício Freire Garcia, Patrícia Cotta Mancini, Anna Paula Batista de Ávila Pires, Luciana Macedo de Resende","doi":"10.1055/s-0045-1811695","DOIUrl":"10.1055/s-0045-1811695","url":null,"abstract":"<p><strong>Introduction: </strong>Tinnitus is the perception of sound without an external source. Various treatments and therapeutic strategies for tinnitus have been used. More recently, this includes music therapy (MT), which aims to mask tinnitus using specific musical elements such as rhythm, melody, harmony, and tempo.</p><p><strong>Objective: </strong>To identify evidence in the literature regarding the use of MT for the treatment of tinnitus, the techniques employed, and the outcomes achieved.</p><p><strong>Data synthesis: </strong>In the present systematic review, we searched for articles in the PubMed, Scopus, Web of Science, MEDLINE, LILACS, and SciELO databases, up until January 2024. The search included articles published in English, Portuguese, and German. Articles on the use of MT for the treatment of tinnitus were included. Duplicates, literature reviews, case reports, letters, and editorials were excluded. The descriptors used were \" <i>music therapy</i> \", \" <i>acoustic stimulation</i> \" and \" <i>tinnitus</i> \". Random effects models using the restricted maximum likelihood method were used to estimate the proportion of patients with favorable outcomes. The seardescriptions resulted in the initial selection of 552 articles containing one or more descriptors in the article title. We selected 211 for abstract review, and 48 were selected for full-text review. Finally, 23 articles published between 2005 and 2022 were selected for meta-analysis.</p><p><strong>Conclusion: </strong>As an effective method for the treatment of tinnitus, MT stimulates the peripheral and central auditory pathways as well as central para-auditory pathways (related to attention, concentration, memory, and emotions).</p>","PeriodicalId":13731,"journal":{"name":"International Archives of Otorhinolaryngology","volume":"30 1","pages":"1-13"},"PeriodicalIF":1.1,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}