Internal Medicine最新文献_第7页

Quantifying the Reversibility of Clofazimine-induced Pigmentation in a Patient with Mycobacterium abscessus Pulmonary Disease. 量化脓肿分枝杆菌肺病患者氯唑明诱发色素沉着的可逆性

IF 1 4区医学

Internal Medicine Pub Date : 2024-11-21 DOI: 10.2169/internalmedicine.4498-24

Masashi Ito, Fumiya Watanabe, Koji Furuuchi, Keiji Fujiwara, Tatsuya Kodama, Takashi Ohe, Yoshiaki Tanaka, Takashi Yoshiyama, Ken Ohta, Kozo Morimoto

引用次数: 0

Black Esophagus in Hyperosmolar Hyperglycemic Syndrome. 高渗性高血糖综合征的黑色食道

IF 1 4区医学

Internal Medicine Pub Date : 2024-11-21 DOI: 10.2169/internalmedicine.4663-24

Tomohide Kurahashi, Takuya Yamada, Atsushi Hosui, Naoki Hiramatsu

引用次数: 0

Serum TARC Level as a Predictive Marker of Severe Disease in COVID-19 During the Omicron Variant Period of the Pandemic. 血清 TARC 水平作为 COVID-19 在大流行 Omicron 变异期重症的预测标志物

IF 1 4区医学

Internal Medicine Pub Date : 2024-11-21 DOI: 10.2169/internalmedicine.4276-24

Taisuke Isono, Ayaka Kojima, Takashi Nishida, Yoichi Kobayashi, Takashi Ishiguro, Yotaro Takaku, Naho Kagiyama, Kazuyoshi Kurashima

{"title":"Serum TARC Level as a Predictive Marker of Severe Disease in COVID-19 During the Omicron Variant Period of the Pandemic.","authors":"Taisuke Isono, Ayaka Kojima, Takashi Nishida, Yoichi Kobayashi, Takashi Ishiguro, Yotaro Takaku, Naho Kagiyama, Kazuyoshi Kurashima","doi":"10.2169/internalmedicine.4276-24","DOIUrl":"https://doi.org/10.2169/internalmedicine.4276-24","url":null,"abstract":"Objectives Thymus and activation-regulated chemokine (TARC) can predict severe disease in patients with coronavirus disease 2019 (COVID-19). However, no reports have addressed the predictive value of TARC with the widespread use of vaccines and medications for COVID-19 during the Omicron variant period of the pandemic. Methods This single-center prospective cohort study enrolled COVID-19 patients admitted to our institution between December 1, 2021, and August 15, 2022. Patients with respiratory failure due to diseases other than COVID-19 were also excluded. We measured the serum TARC levels of patients at admission. Results We enrolled 157 patients, with 89 in the severe group and 68 in the non-severe group. The severe group was more likely than the non-severe group to include older patients, those with no or one dose of vaccine, and those with interstitial lung disease (ILD). The cutoff level of TARC derived from a receiver operator characteristic curve analysis to predict severe disease was 174.0 pg/mL. The sensitivity, specificity, positive predictive value, and negative predictive value were 72.1%, 69.7%, 64.5%, and 76.5%, respectively. The area under the curve was 0.722 (95% confidence interval: 0.635-0.809). A multivariate analysis showed that 2 vaccination doses were associated with non-severe disease, and TARC ≤174 pg/mL was associated with severe disease. Conclusion TARC was a predictive factor for severe disease, but its cutoff value was higher and its predictive accuracy lower than those in previous reports. We surmised that during the Omicron variant period of the pandemic, the widespread use of vaccines and medications for COVID-19 decreased the predictive accuracy of TARC.","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating Collection Time of Intragastric Fluid During Endoscopy for Point-of-care Test-based Helicobacter pylori Polymerase Chain Reaction. 评估内窥镜检查期间胃内液的收集时间，以用于基于幽门螺旋杆菌聚合酶链反应的床旁检测。

IF 1 4区医学

Internal Medicine Pub Date : 2024-11-21 DOI: 10.2169/internalmedicine.4320-24

Yoshiyuki Watanabe, Hiroyuki Yamamoto, Ichiro Oda, Kuniaki Torii, Seiji Futagami, Muhammad Miftahussurur, Kok-Ann Gwee, Momoko Tsuda, Mototsugu Kato, Keisuke Tateishi

{"title":"Evaluating Collection Time of Intragastric Fluid During Endoscopy for Point-of-care Test-based Helicobacter pylori Polymerase Chain Reaction.","authors":"Yoshiyuki Watanabe, Hiroyuki Yamamoto, Ichiro Oda, Kuniaki Torii, Seiji Futagami, Muhammad Miftahussurur, Kok-Ann Gwee, Momoko Tsuda, Mototsugu Kato, Keisuke Tateishi","doi":"10.2169/internalmedicine.4320-24","DOIUrl":"https://doi.org/10.2169/internalmedicine.4320-24","url":null,"abstract":"Objective To evaluate the influence of sample collection time during esophagogastroduodenoscopy (EGD) on the accuracy of a newly approved point-of-care test (POCT)-based polymerase chain reaction kit for detecting Helicobacter pylori and clarithromycin susceptibility in gastric wash fluid. Methods Intragastric fluid was collected at three time points: Collection Time 1 (start of EGD), Collection Time 2 (during EGD), and Collection Time 3 (after indigo carmine spraying). POCT-based quantitative PCR (qPCR) targeting 23S rRNA domain V (2142/2143) was used to quantify H. pylori DNA in the collected fluid at all three time points and compared with qPCR targeting 16S rRNA. Patients Fifty patients with suspected H. pylori infection were consecutively enrolled in this study over a three-month period and underwent EGD. Results In 9 out of 50 EGD cases that were H. pylori-positive, no significant differences in H. pylori DNA content, quantified using POCT-based qPCR targeting 23S rRNA, were observed between the three collection times: 1 vs. 2, p=0.81; 2 vs. 3, p=0.59; 1 vs. 3. Collection Time 2 had the strongest inverse correlation with the urea breath test (r=-0.80, p=0.01) and was the only time-point at which POCT-based qPCR could detect H. pylori in case 15. Conclusion This study suggests that the optimal collection timing for the H. pylori detection POCT kit (within 60 min) using intragastric fluid (with no biopsy) may be during EGD (Collection Time 2). However, our study had a limited sample size, so the findings must be verified through large-scale, multicenter collaboration studies.","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful Allogeneic Hematopoietic Stem Cell Transplantation for Nodal Epstein-Barr Virus-positive T/NK-cell Lymphoma. 成功进行异基因造血干细胞移植治疗结节性 Epstein-Barr 病毒阳性 T/NK 细胞淋巴瘤。

IF 1 4区医学

Internal Medicine Pub Date : 2024-11-21 DOI: 10.2169/internalmedicine.4672-24

Satoshi Ichikawa, Hiroaki Abe, Naoya Morota, Akihisa Kawajiri, Ryo Nakagawa, Kyoko Inokura, Shunsuke Hatta, Yuna Katsuoka, Koichi Onodera, Noriko Fukuhara, Yasushi Onishi, Hisayuki Yokoyama, Ryo Ichinohasama, Hideo Harigae

引用次数: 0

Pseudomonas otitidis Bacteremia in a Patient with Cancer During the Palliative-care Phase: A Case Report. 一名癌症患者在姑息治疗阶段出现耳形鼻疽假单胞菌菌血症：病例报告。

IF 1 4区医学

Internal Medicine Pub Date : 2024-11-21 DOI: 10.2169/internalmedicine.4591-24

Yoshiro Hadano, Koji Endo

引用次数: 0

Positive Antiganglioside Antibodies in a Patient with Primary Diffuse Large B-cell Lymphoma of the Central Nervous System. 中枢神经系统原发性弥漫大 B 细胞淋巴瘤患者的抗神经节苷脂抗体阳性。

IF 1 4区医学

Internal Medicine Pub Date : 2024-11-21 DOI: 10.2169/internalmedicine.2326-23

Ryoji Nishi, Haruki Koike, Tomoya Maekawa, Yoshitaka Nakamura, Yohei Kawade, Takashi Tsujiuchi, Masasuke Ohno, Yuki Fukami, Masahisa Katsuno, Takafumi Sagisaka

引用次数: 0

Effect of Empirical Antimicrobial Therapy of Piperacillin-tazobactam Versus Carbapenems on Mortality for Patients with Sepsis from Nursing Homes. 哌拉西林-他唑巴坦与碳青霉烯类的经验性抗菌疗法对养老院败血症患者死亡率的影响

IF 1 4区医学

Internal Medicine Pub Date : 2024-11-21 DOI: 10.2169/internalmedicine.4426-24

Yusuke Shimada, Hiroyuki Ohbe, Satoshi Kutsuna, Shintaro Kosaka, Hiroki Matsui, Hideo Yasunaga

{"title":"Effect of Empirical Antimicrobial Therapy of Piperacillin-tazobactam Versus Carbapenems on Mortality for Patients with Sepsis from Nursing Homes.","authors":"Yusuke Shimada, Hiroyuki Ohbe, Satoshi Kutsuna, Shintaro Kosaka, Hiroki Matsui, Hideo Yasunaga","doi":"10.2169/internalmedicine.4426-24","DOIUrl":"https://doi.org/10.2169/internalmedicine.4426-24","url":null,"abstract":"Background Nursing home residents with a high risk of multidrug-resistant organism infection pose a complex challenge to broad-spectrum empirical antimicrobial therapy, particularly those infected with extended-spectrum β-lactamase-producing Enterobacteriaceae. The present study compared the efficacy of piperacillin-tazobactam and carbapenems as empirical antimicrobial treatments for patients with sepsis from nursing homes. Patients and Methods Using a nationwide inpatient database in Japan, we identified patients diagnosed with sepsis within two days of admission from nursing homes between 2018 and 2021. We selected patients who received intravenous piperacillin-tazobactam or carbapenems within two days of admission. In-hospital mortality was compared between the piperacillin-tazobactam and carbapenem groups using inverse probability of treatment weighting. Result We identified 8,025 eligible patients. Of these, 3,391 (42%) received piperacillin-tazobactam, and 4,634 (58%) received carbapenems within 2 days of admission. The inverse probability of treatment weighting analysis showed no significant difference in in-hospital mortality between the groups (31.6% in the piperacillin-tazobactam group and 32.8% in the carbapenem group; risk difference, 1.2%; 95% confidence interval, -3.2% to 0.9%). Conclusions Carbapenems and piperacillin-tazobactam as empirical antimicrobial therapy in patients with sepsis from nursing homes were associated with comparable in-hospital mortality rates. These findings highlight the importance of making decisions regarding broad-spectrum empirical antimicrobial therapy.","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heart Regeneration for Clinical Application. 用于临床应用的心脏再生技术

IF 1 4区医学

Internal Medicine Pub Date : 2024-11-21 DOI: 10.2169/internalmedicine.4711-24

Hidenori Tani, Masaki Ieda

引用次数: 0

Changes in Hepatic Density Due to Oral Amiodarone-induced Liver injury Shown by Computed Tomography. 计算机断层扫描显示口服胺碘酮引起的肝损伤导致的肝密度变化

IF 1 4区医学

Internal Medicine Pub Date : 2024-11-21 DOI: 10.2169/internalmedicine.4436-24

Kenichi Kishimoto, Hiroshi Tobita, Masatoshi Kataoka, Tomotaka Yazaki, Akihiko Oka, Norihisa Ishimura, Kazuaki Tanabe, Shunji Ishihara

引用次数: 0