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Differences in Lung Cancer-related Clinical Practice and Basic Research Background between Japan and China: A Narrative Review. 日本与中国肺癌相关临床实践及基础研究背景的差异述评
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-09-01 Epub Date: 2025-03-01 DOI: 10.2169/internalmedicine.4808-24
Lan Wang, Yiyan Miao, Yihang Gu, Tomoya Kawaguchi, Megumi Mizutani, Toshiyuki Nakai, Tetsuya Watanabe, Kazuhisa Asai, Hui Zhang, Wenwen Cai, Yoko Tani, Hiroyasu Kaneda
{"title":"Differences in Lung Cancer-related Clinical Practice and Basic Research Background between Japan and China: A Narrative Review.","authors":"Lan Wang, Yiyan Miao, Yihang Gu, Tomoya Kawaguchi, Megumi Mizutani, Toshiyuki Nakai, Tetsuya Watanabe, Kazuhisa Asai, Hui Zhang, Wenwen Cai, Yoko Tani, Hiroyasu Kaneda","doi":"10.2169/internalmedicine.4808-24","DOIUrl":"10.2169/internalmedicine.4808-24","url":null,"abstract":"<p><p>With its increasing incidence, lung cancer has become one of the leading causes of cancer-related deaths worldwide, posing a great threat to the health and lives of patients. Due to varying economic and cultural backgrounds, there are significant differences in clinical treatment practices and related basic research on lung cancer between Japan and China. These differences are mainly reflected in many aspects, such as cancer prevention, cancer treatment, provision of medical insurance, patient compliance, medical education system, and sources of research funding. By understanding these differences, Japan and China can learn from each other, make progress together, and strengthen further exchanges and cooperation, which will help improve the long-term efficacy of lung cancer treatment and improve patients' clinical outcomes.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2524-2533"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12463414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sigmoid Septum: A Bystander or Contributor to a Left Ventricular Outflow Tract Obstruction in Takotsubo Syndrome - A Case Report with a Literature Review. 乙状结肠隔：Takotsubo综合征左心室流出道梗阻的旁观者或贡献者- 1例报告并文献复习。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-09-01 Epub Date: 2025-02-22 DOI: 10.2169/internalmedicine.4489-24
Marko Atanasković, Bojan Mihajlović, Maja Stefanović, Marija Bjelobrk, Branislav Crnomarković, Mila Kovačević
{"title":"Sigmoid Septum: A Bystander or Contributor to a Left Ventricular Outflow Tract Obstruction in Takotsubo Syndrome - A Case Report with a Literature Review.","authors":"Marko Atanasković, Bojan Mihajlović, Maja Stefanović, Marija Bjelobrk, Branislav Crnomarković, Mila Kovačević","doi":"10.2169/internalmedicine.4489-24","DOIUrl":"10.2169/internalmedicine.4489-24","url":null,"abstract":"<p><p>Approximately 20% of patients with Takotsubo syndrome (TTS) develop complications such as left ventricular outflow tract obstruction (LVOTO). The published data suggest that a significant proportion of these patients have predisposing septal hypertrophy or sigmoid septum. However, the pathophysiology regarding this connection has not yet been fully elucidated. We herein present the case of a 75-year-old female patient with TTS complicated by LVOTO, which was successfully managed. During the follow-up, mild basal septal hypertrophy was observed. Subsequent exercise and dobutamine stress echocardiography were performed to reveal the mechanism of LVOTO in TTS.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2557-2573"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12463423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dapagliflozin for the Treatment of Collagenofibrotic Glomerulopathy. 达格列净治疗胶原纤维性肾小球病。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-09-01 Epub Date: 2025-02-18 DOI: 10.2169/internalmedicine.4952-24
Enyu Imai, Atsuhiro Imai, Masaaki Izumi, Jun Nakazawa, Hideki Fujii, Shinichi Nishi
{"title":"Dapagliflozin for the Treatment of Collagenofibrotic Glomerulopathy.","authors":"Enyu Imai, Atsuhiro Imai, Masaaki Izumi, Jun Nakazawa, Hideki Fujii, Shinichi Nishi","doi":"10.2169/internalmedicine.4952-24","DOIUrl":"10.2169/internalmedicine.4952-24","url":null,"abstract":"<p><p>Collagenofibrotic glomerulopathy is a rare, incurable kidney disease characterized by severe proteinuria and extensive type III collagen deposition in mesangial and subendothelial spaces. To date, no effective treatment has yet been reported. A 45-year-old Japanese woman was treated daily with 10 mg dapagliflozin. Her eGFR slope improved from -3.61 mL/min/1.73 m<sup>2</sup>/year over 4 years before treatment to 0.11 mL/min/1.73 m<sup>2</sup>/year after 3 years of treatment. Additionally, her nephrotic-range proteinuria, initially exceeding 4 g/gCr, decreased to <2 g/gCr after dapagliflozin treatment. To our knowledge, this is the first documented case of effective treatment for collagenofibrotic glomerulopathy.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2615-2618"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12463412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of a Bioelectrical Impedance Analysis in Predicting Anemia among Cardiovascular Disease Patients. 生物电阻抗分析在预测心血管疾病患者贫血中的作用
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-09-01 Epub Date: 2025-03-15 DOI: 10.2169/internalmedicine.4824-24
Tomoaki Nishikawa, Akinori Higaki, Yutaro Okada, Rikako Horie, Yasuhisa Nakao, Tomoki Fujisawa, Shigehiro Miyazaki, Yusuke Akazawa, Toru Miyoshi, Hiroshi Kawakami, Haruhiko Higashi, Shunsuke Tamaki, Kazuhisa Nishimura, Katsuji Inoue, Shuntaro Ikeda, Osamu Yamaguchi
{"title":"Role of a Bioelectrical Impedance Analysis in Predicting Anemia among Cardiovascular Disease Patients.","authors":"Tomoaki Nishikawa, Akinori Higaki, Yutaro Okada, Rikako Horie, Yasuhisa Nakao, Tomoki Fujisawa, Shigehiro Miyazaki, Yusuke Akazawa, Toru Miyoshi, Hiroshi Kawakami, Haruhiko Higashi, Shunsuke Tamaki, Kazuhisa Nishimura, Katsuji Inoue, Shuntaro Ikeda, Osamu Yamaguchi","doi":"10.2169/internalmedicine.4824-24","DOIUrl":"10.2169/internalmedicine.4824-24","url":null,"abstract":"<p><p>Objective Anemia frequently complicates cardiovascular disease (CVD) and is associated with high mortality rates. A bioelectrical impedance analysis (BIA) is a noninvasive method for measuring human body composition. A direct association between serum hemoglobin (Hb) levels and the extracellular water-to-total body water (ECW/TBW) ratio, as measured by a BIA in patients with diabetes, has been reported. However, the predictive value of the ECW/TBW ratio for detecting anemia in patients with CVD has not been fully elucidated. Methods We conducted a study involving consecutive patients admitted to our cardiology department from January 1, 2021, to December 31, 2022. A BIA was performed once during hospitalization for all patients, whenever possible. The correlation between the Hb level and ECW/TBW ratio was assessed. The predictive accuracy for anemia was evaluated using a receiver operating characteristic (ROC) curve analysis. Results The ECW/TBW ratio was significantly higher in the anemia group than in the non-anemia group [0.41 (0.40, 0.41) vs. 0.39 (0.38, 0.40), p<0.001]. The ECW/TBW ratio exhibited a significant negative correlation with Hb, with an R value of 0.57 and a p value of <0.01. However, this correlation coefficient decreased to 0.45 among subjects with B-type natriuretic peptide (BNP) levels ≥200 pg/mL. The area under the ROC curve (AUC) for the ECW/TBW ratio for detecting anemia was 0.83. However, its predictive performance decreased in patients with BNP levels exceeding 200 pg/mL, with an AUC of 0.71. Conclusion The BIA-derived ECW/TBW ratio is a valuable predictor of anemia in patients with CVD, provided BNP levels are not elevated.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2534-2540"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12463406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anamorelin Induced Hyperglycemia in a Patient with Type 1 Diabetes by Stimulating Growth Hormone Secretion. 阿纳莫瑞林通过刺激生长激素分泌诱发1型糖尿病患者高血糖：1例报告。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-09-01 Epub Date: 2025-02-22 DOI: 10.2169/internalmedicine.4887-24
Kenta Okuro, Hiroki Hashimoto, Kanako Morita, Yu Noshi, Moe Kusushita, Susumu Ochiai, Yoshihiko Utsu, Soji Kasayama, Kunihiko Hashimoto
{"title":"Anamorelin Induced Hyperglycemia in a Patient with Type 1 Diabetes by Stimulating Growth Hormone Secretion.","authors":"Kenta Okuro, Hiroki Hashimoto, Kanako Morita, Yu Noshi, Moe Kusushita, Susumu Ochiai, Yoshihiko Utsu, Soji Kasayama, Kunihiko Hashimoto","doi":"10.2169/internalmedicine.4887-24","DOIUrl":"10.2169/internalmedicine.4887-24","url":null,"abstract":"<p><p>Anamorelin is a selective ghrelin receptor agonist that is used to treat cancer-related cachexia. Ghrelin stimulates growth hormone (GH) secretion. However, the association between anamorelin and hyperglycemia remains unclear. We herein report a case of anamorelin induced hyperglycemia in a patient with type 1 diabetes mellitus. A 67-year-old woman with a history of type 1 diabetes was hospitalized because of a pleural effusion. After hospitalization, the patient was administered anamorelin. Four days after starting anamorelin treatment, her blood glucose and GH levels increased. These results suggest that anamorelin stimulates GH secretion and induces hyperglycemia. Our findings suggest the need to take special care of hyperglycemia when anamorelin is prescribed to patients with type 1 diabetes.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2592-2596"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12463422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rituximab as an Effective Treatment for New-onset Evans Syndrome and Systemic Lupus Erythematosus with Lupus Nephritis. 利妥昔单抗对新发Evans综合征和系统性红斑狼疮合并狼疮肾炎的有效治疗。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-09-01 Epub Date: 2025-03-15 DOI: 10.2169/internalmedicine.4871-24
Koki Matsushita, Yu Nagayoshi, Ryuichi Yoshii, Tomohumi Nakamura, Kengo Kajiwara, Yutaka Kakizoe, Yuichiro Izumi, Masataka Adachi, Masao Tomita, Yukimasa Kohda, Masashi Mukoyama, Hideki Yokoi
{"title":"Rituximab as an Effective Treatment for New-onset Evans Syndrome and Systemic Lupus Erythematosus with Lupus Nephritis.","authors":"Koki Matsushita, Yu Nagayoshi, Ryuichi Yoshii, Tomohumi Nakamura, Kengo Kajiwara, Yutaka Kakizoe, Yuichiro Izumi, Masataka Adachi, Masao Tomita, Yukimasa Kohda, Masashi Mukoyama, Hideki Yokoi","doi":"10.2169/internalmedicine.4871-24","DOIUrl":"10.2169/internalmedicine.4871-24","url":null,"abstract":"<p><p>Evans syndrome (ES) is characterized by the development of autoimmune hemolytic anemia and immune thrombocytopenic purpura and is often linked to autoimmune diseases, such as systemic lupus erythematosus (SLE). Standard treatment includes prednisolone and intravenous immunoglobulin; however, relapse commonly occurs when prednisolone is tapered or stopped. Rituximab is increasingly used for refractory ES with SLE, although its efficacy in new-onset cases remains unclear. We herein report a 67-year-old woman with new-onset ES and SLE with lupus nephritis class IV-G whose condition improved with rituximab after prednisolone, hydroxychloroquine, and mycophenolate mofetil. The patient remained relapse-free for one year, suggesting that rituximab is a potentially viable first-line therapy.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2631-2636"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12463418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spontaneous Remission in a Patient with Anti-OJ Autoantibodies-positive Anti-synthetase Syndrome Following SARS-CoV-2 Infection and mRNA Vaccination. 一名感染 SARS-CoV-2 并接种 mRNA 疫苗后抗 OJ 自身抗体阳性的抗合成酶综合征患者病情自发缓解：病例报告。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-09-01 Epub Date: 2025-03-01 DOI: 10.2169/internalmedicine.4852-24
Yasuyuki Todoroki, Shingo Nakayamada, Ippei Miyagawa, Satoshi Kubo, Kiyotake Yoshioka, Minoru Satoh, Yoshiya Tanaka
{"title":"Spontaneous Remission in a Patient with Anti-OJ Autoantibodies-positive Anti-synthetase Syndrome Following SARS-CoV-2 Infection and mRNA Vaccination.","authors":"Yasuyuki Todoroki, Shingo Nakayamada, Ippei Miyagawa, Satoshi Kubo, Kiyotake Yoshioka, Minoru Satoh, Yoshiya Tanaka","doi":"10.2169/internalmedicine.4852-24","DOIUrl":"10.2169/internalmedicine.4852-24","url":null,"abstract":"<p><p>Anti-synthetase syndrome (ASyS) is a subset of idiopathic inflammatory myopathies characterized by a triad of myositis, interstitial lung disease, and arthritis. Patients with ASyS are generally treated with glucocorticoids, immunosuppressants, or both. We encountered a 53-year-old woman who developed anti-OJ autoantibodies-positive anti-synthetase syndrome following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and CoV-2 messenger RNA (mRNA) vaccination. Her dyspnea and rash resolved within 4 weeks of the initial examination, achieving spontaneous remission without treatment 52 weeks after the diagnosis. This case suggests a potential association between SARS-CoV-2 infection, mRNA vaccination, and the transient development of anti-OJ antibodies-positive ASyS.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2657-2662"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12463430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intestinal Endometriosis Mimicking Malignancy. 肠内膜异位症模拟恶性肿瘤。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-09-01 Epub Date: 2025-03-08 DOI: 10.2169/internalmedicine.4848-24
Nobutaka Takeda, Shinichi Morita, Takeshi Sakai, Kazuhiro Funakoshi
{"title":"Intestinal Endometriosis Mimicking Malignancy.","authors":"Nobutaka Takeda, Shinichi Morita, Takeshi Sakai, Kazuhiro Funakoshi","doi":"10.2169/internalmedicine.4848-24","DOIUrl":"10.2169/internalmedicine.4848-24","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2676-2677"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12463407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concurrent Large-vessel Vasculitis and Small-vessel Vasculitis Accompanied by Basal Cell Carcinoma. 并发大血管炎和小血管炎伴基底细胞癌1例。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-09-01 Epub Date: 2025-03-01 DOI: 10.2169/internalmedicine.4783-24
Takashi Nawata, Takayuki Okimura, Toru Ariyoshi, Natsumi Nishimura, Masafumi Fujinaka, Masaki Shibuya, Motoaki Sano, Masafumi Yano
{"title":"Concurrent Large-vessel Vasculitis and Small-vessel Vasculitis Accompanied by Basal Cell Carcinoma.","authors":"Takashi Nawata, Takayuki Okimura, Toru Ariyoshi, Natsumi Nishimura, Masafumi Fujinaka, Masaki Shibuya, Motoaki Sano, Masafumi Yano","doi":"10.2169/internalmedicine.4783-24","DOIUrl":"10.2169/internalmedicine.4783-24","url":null,"abstract":"<p><p>Variable-vessel vasculitis is a rare presentation of systemic vasculitis. We herein report a Japanese woman with large- and small-vessel vasculitis accompanied by basal cell carcinoma. The clinical course of our patient suggested paraneoplastic variable-vessel vasculitis. Our case suggests that there are two aspects that need to be considered. First, clinicians should consider cancer-related complications when treating variable-vessel vasculitis. Second, the evaluation of variable-vessels is needed when treating paraneoplastic vasculitis.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2663-2666"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12463433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunoglobulin A Nephropathy in a Kidney Transplant Recipient with Kabuki Syndrome. 免疫球蛋白A肾病在肾移植受者与歌舞伎综合征：1例报告。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-09-01 Epub Date: 2025-03-15 DOI: 10.2169/internalmedicine.4832-24
Takahiro Shinzato, Kojiro Nagai, Yuuki Hoshino, Yuuichi Fujiwara, Yoshihiro Yamamoto, Azusa Morishita, Takao Okawa, Kenta Ito, Masaaki Murakami, Ken Matsuo, Satoshi Tanaka, Kiyoshi Mori
{"title":"Immunoglobulin A Nephropathy in a Kidney Transplant Recipient with Kabuki Syndrome.","authors":"Takahiro Shinzato, Kojiro Nagai, Yuuki Hoshino, Yuuichi Fujiwara, Yoshihiro Yamamoto, Azusa Morishita, Takao Okawa, Kenta Ito, Masaaki Murakami, Ken Matsuo, Satoshi Tanaka, Kiyoshi Mori","doi":"10.2169/internalmedicine.4832-24","DOIUrl":"10.2169/internalmedicine.4832-24","url":null,"abstract":"<p><p>Kabuki syndrome is a rare genetic disorder that causes multiple congenital anomalies, including characteristic facial features reminiscent of Kabuki syndrome. It is often associated with congenital anomalies of the kidneys and urinary tract as well as immune abnormalities. While various autoimmune diseases have been reported in patients with this syndrome, only one case of membranoproliferative glomerulonephritis has been documented. We herein report a case of Kabuki syndrome in which immunoglobulin A nephropathy developed in a renal allograft, which subsequently improved with the administration of pulse steroids and an angiotensin II receptor blocker.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2619-2625"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12463411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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