Bucillamine-induced Yellow Nail Syndrome with Chylothorax.

IF 1.1 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL
Internal Medicine Pub Date : 2025-09-15 Epub Date: 2025-03-29 DOI:10.2169/internalmedicine.4935-24
Yukari Hisamoto, Yoriyuki Murata, Kazuki Matsuda, Koji Narikiyo, Taiga Kobayashi, Kosei Yonezawa, Keita Murakawa, Kazuki Hamada, Syuichiro Ohata, Toshiaki Utsunomiya, Yoshikazu Yamaji, Keiji Oishi, Maki Asami-Noyama, Nobutaka Edakuni, Tomoyuki Kakugawa, Tsunahiko Hirano, Kazuto Matsunaga
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引用次数: 0

Abstract

Yellow nail syndrome (YNS), a rare condition characterized by thickened yellow nails, lymphedema, and respiratory manifestations, is rarely caused by bucillamine, an anti-rheumatic agent. Respiratory manifestations of YNS include chylothorax in 18.8-22% of patients with pleural effusion. We herein report the first case of bucillamine-induced YNS with chylothorax. Lymphangiography revealed narrowing of the lymphatic vessels and stagnation of the lymphatic fluid, suggesting impaired lymphatic drainage. The chylothorax persisted despite the discontinuation of bucillamine. The present case illustrates that bucillamine can cause irreversible lymphatic impairment and chylothorax.

buillamine诱导的黄指甲综合征合并乳糜胸1例。
黄指甲综合征(YNS)是一种罕见的疾病,以黄指甲增厚、淋巴水肿和呼吸症状为特征,很少由抗风湿剂布西胺引起。18.8% ~ 22%的胸腔积液患者出现乳糜胸。我们在此报告首例buillamine诱导的YNS合并乳糜胸。淋巴管造影显示淋巴管变窄,淋巴液淤滞,提示淋巴管引流受损。乳糜胸持续存在,尽管停药buillamine。本病例说明布吉拉胺可引起不可逆的淋巴损伤和乳糜胸。
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来源期刊
Internal Medicine
Internal Medicine 医学-医学:内科
CiteScore
1.90
自引率
8.30%
发文量
0
审稿时长
2.2 months
期刊介绍: Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine. Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.
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