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Membranous Nephropathy Associated with Syphilis: Correlative Light and Electron Microscopy Revealing the Localization of Neuron-derived Neurotrophic Factor within Subepithelial Electron Dense Deposits. 膜性肾病伴梅毒1例：相关光镜和电镜显示上皮下电子致密沉积物中神经元源性神经营养因子的定位。
IF 1 4区 医学
Internal Medicine Pub Date : 2025-07-15 Epub Date: 2024-12-26 DOI: 10.2169/internalmedicine.4699-24
Chisato Minezaki, Tatsuhiko Azegami, Akinori Hashiguchi, Ayumi Yoshifuji, Norifumi Yoshimoto, Aika Hagiwara, Akihito Hishikawa, Kaori Hayashi
{"title":"Membranous Nephropathy Associated with Syphilis: Correlative Light and Electron Microscopy Revealing the Localization of Neuron-derived Neurotrophic Factor within Subepithelial Electron Dense Deposits.","authors":"Chisato Minezaki, Tatsuhiko Azegami, Akinori Hashiguchi, Ayumi Yoshifuji, Norifumi Yoshimoto, Aika Hagiwara, Akihito Hishikawa, Kaori Hayashi","doi":"10.2169/internalmedicine.4699-24","DOIUrl":"10.2169/internalmedicine.4699-24","url":null,"abstract":"<p><p>A 50-year-old man presented to our hospital with a fever, edema, and a rash. The clinical diagnosis was renal dysfunction, nephrotic syndrome, and syphilis. The patient was treated with benzylpenicillin, and his symptoms improved. A renal biopsy revealed membranous nephropathy (MN). Recently, neuron-derived neurotrophic factor (NDNF) was reported to be an antigen corresponding to syphilis-associated MN. In the present patient, immunofluorescence staining and immunoelectron microscopy revealed granular NDNF-positive findings within subepithelial deposits, suggesting the presence of NDNF-IgG immune complexes. Although the mechanism by which NDNF serves as a target antigen remains unclear, NDNF was found to colocalize within subepithelial immune complexes in syphilis-associated MN.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2202-2207"},"PeriodicalIF":1.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary Mycobacterium malmoense Infection in a Patient with Non-small Cell Lung Cancer, Systemic Sclerosis, and Interstitial Pneumonia: A Case Report and Brief Review of the Literature. 非小细胞肺癌、系统性硬化症、间质性肺炎合并肺马尔默氏分枝杆菌感染1例报告及文献综述
IF 1 4区 医学
Internal Medicine Pub Date : 2025-07-15 Epub Date: 2025-01-03 DOI: 10.2169/internalmedicine.4633-24
Ryo Torii, Kentaro Akata, Kei Yamasaki, Yudai Yamaguchi, Yusuke Nabe, Masaaki Inoue, Nobuyuki Hirose, Junichi Yoshida, Kazuhiro Yatera
{"title":"Pulmonary Mycobacterium malmoense Infection in a Patient with Non-small Cell Lung Cancer, Systemic Sclerosis, and Interstitial Pneumonia: A Case Report and Brief Review of the Literature.","authors":"Ryo Torii, Kentaro Akata, Kei Yamasaki, Yudai Yamaguchi, Yusuke Nabe, Masaaki Inoue, Nobuyuki Hirose, Junichi Yoshida, Kazuhiro Yatera","doi":"10.2169/internalmedicine.4633-24","DOIUrl":"10.2169/internalmedicine.4633-24","url":null,"abstract":"<p><p>A 69-year-old man with systemic sclerosis and interstitial pneumonia presented with an abnormal shadow in the right upper lung lobe. A thoracoscopic needle biopsy was performed on the right upper lobe lesion, and Mycobacterium malmoense was identified by 16S rRNA and rpoB gene sequencing. Surgical treatment was performed to obtain a radical cure, and lung squamous cell carcinoma and M. malmoense infection were detected in the resected specimen. We herein report the first case of the successful treatment of a patient with pulmonary M. malmoense infection and concomitant lung squamous cell carcinoma.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2223-2228"},"PeriodicalIF":1.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Twisted Appearance of Consolidation Located Proximally along Large Airway. 大气道近端实变扭曲。
IF 1 4区 医学
Internal Medicine Pub Date : 2025-07-15 Epub Date: 2024-12-26 DOI: 10.2169/internalmedicine.4582-24
Hideaki Yamakawa, Akiko Adachi, Tamiko Takemura, Hidekazu Matsushima
{"title":"Twisted Appearance of Consolidation Located Proximally along Large Airway.","authors":"Hideaki Yamakawa, Akiko Adachi, Tamiko Takemura, Hidekazu Matsushima","doi":"10.2169/internalmedicine.4582-24","DOIUrl":"10.2169/internalmedicine.4582-24","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2257-2258"},"PeriodicalIF":1.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myeloid Sarcoma in the Small Intestine. 小肠髓样肉瘤。
IF 1 4区 医学
Internal Medicine Pub Date : 2025-07-15 Epub Date: 2024-12-19 DOI: 10.2169/internalmedicine.4664-24
Masaya Iwamuro, Tomohiro Kamio, Shoichiro Hirata, Katsunori Matsueda, Daisuke Kametaka, Takehiro Tanaka, Seiji Kawano, Motoyuki Otsuka
{"title":"Myeloid Sarcoma in the Small Intestine.","authors":"Masaya Iwamuro, Tomohiro Kamio, Shoichiro Hirata, Katsunori Matsueda, Daisuke Kametaka, Takehiro Tanaka, Seiji Kawano, Motoyuki Otsuka","doi":"10.2169/internalmedicine.4664-24","DOIUrl":"10.2169/internalmedicine.4664-24","url":null,"abstract":"<p><p>Myeloid sarcoma is a rare extramedullary tumor of immature myeloid cells that is often associated with acute myeloid leukemia (AML). We herein report an 81-year-old man who presented with intestinal obstruction due to myeloid sarcoma of the small intestine. Diagnostic challenges were overcome using double-balloon enteroscopy and a biopsy, which confirmed the diagnosis of myeloid sarcoma. The patient subsequently developed AML but responded well to chemotherapy. This case underscores the importance of considering myeloid sarcoma in the differential diagnosis of small-bowel tumors. Highlighting the significance of a histological analysis, even in patients presenting with small bowel obstruction, the early diagnosis and treatment are crucial for improving outcomes, particularly in patients without a history of hematologic malignancies.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2155-2159"},"PeriodicalIF":1.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Granulomatous Appendicitis with Massive Hematochezia. 肉芽肿性阑尾炎伴大量便血。
IF 1 4区 医学
Internal Medicine Pub Date : 2025-07-15 Epub Date: 2024-12-19 DOI: 10.2169/internalmedicine.4797-24
Atsushi Ikehata, Itaru Sato, Manabu Nakayama, Sadahide Ono
{"title":"Granulomatous Appendicitis with Massive Hematochezia.","authors":"Atsushi Ikehata, Itaru Sato, Manabu Nakayama, Sadahide Ono","doi":"10.2169/internalmedicine.4797-24","DOIUrl":"10.2169/internalmedicine.4797-24","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2255-2256"},"PeriodicalIF":1.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ulcerative Colitis with Acute Pericarditis after Dose Escalation of Mesalazine. 溃疡性结肠炎伴急性心包炎一例美沙拉嗪剂量增加。
IF 1 4区 医学
Internal Medicine Pub Date : 2025-07-15 Epub Date: 2024-12-26 DOI: 10.2169/internalmedicine.4655-24
Jun Wada, Kazumasa Kawashima, Michio Onizawa, Naohiko Gunji, Yu Watahiki, Chiharu Sakuma, Mai Murakami, Tomoaki Mochimaru, Shunsuke Miura, Hiromasa Ohira
{"title":"Ulcerative Colitis with Acute Pericarditis after Dose Escalation of Mesalazine.","authors":"Jun Wada, Kazumasa Kawashima, Michio Onizawa, Naohiko Gunji, Yu Watahiki, Chiharu Sakuma, Mai Murakami, Tomoaki Mochimaru, Shunsuke Miura, Hiromasa Ohira","doi":"10.2169/internalmedicine.4655-24","DOIUrl":"10.2169/internalmedicine.4655-24","url":null,"abstract":"<p><p>Mesalazine-induced pericarditis is rare, and most cases occur at the time of treatment initiation. A 30-year-old man with ulcerative colitis who had experienced remission for 2 years with mesalazine 2,000 mg/day subsequently experienced relapse. Therefore, the mesalazine dose was increased to 4,000 mg. Thereafter, hematochezia improved, but anterior chest pain developed. Chest radiography revealed marked cardiac dilation (cardiothoracic ratio, 63%) and echocardiography revealed pericardial effusion. Adverse events associated with mesalazine should be carefully monitored, not only at the time of treatment initiation but also after dose escalation.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2165-2169"},"PeriodicalIF":1.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatocellular Carcinoma Presenting with Pseudoprogression in a Patient Receiving Atezolizumab Plus Bevacizumab Combination Therapy. 在接受阿特唑单抗加贝伐单抗联合治疗的患者中出现假进展的肝细胞癌
IF 1 4区 医学
Internal Medicine Pub Date : 2025-07-15 Epub Date: 2025-01-03 DOI: 10.2169/internalmedicine.4710-24
Takahiro Osuga, Tomohiro Kubo, Koji Miyanishi, Ryo Ito, Taro Sugawara, Hiroyuki Ohnuma, Kazuyuki Murase, Kohichi Takada
{"title":"Hepatocellular Carcinoma Presenting with Pseudoprogression in a Patient Receiving Atezolizumab Plus Bevacizumab Combination Therapy.","authors":"Takahiro Osuga, Tomohiro Kubo, Koji Miyanishi, Ryo Ito, Taro Sugawara, Hiroyuki Ohnuma, Kazuyuki Murase, Kohichi Takada","doi":"10.2169/internalmedicine.4710-24","DOIUrl":"10.2169/internalmedicine.4710-24","url":null,"abstract":"<p><p>A 65-year-old man with hepatocellular carcinoma and lung metastasis was treated with a combination of atezolizumab and bevacizumab. Subsequently, the patient developed fever and new liver lesions, which were considered to indicate a pseudoprogression. Despite this, the treatment was continued. Three months later, computed tomography scans demonstrated that the new lesions had disappeared and both the primary tumor and metastases had shrunk. A partial response was achieved and maintained for two years. A histological examination revealed a predominance of CD8-positive lymphocytes and programmed death-ligand 1-positive tumor-associated macrophages, which may predict a positive response to this therapy. Pseudoprogression may therefore be a favorable prognostic factor in hepatocellular carcinoma.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2148-2154"},"PeriodicalIF":1.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Occlusion of Dorsalis Pedis Artery in an Athlete. 运动员足背动脉闭塞。
IF 1 4区 医学
Internal Medicine Pub Date : 2025-07-15 Epub Date: 2025-01-15 DOI: 10.2169/internalmedicine.4584-24
Ryohei Akashi, Hiroaki Kawano, Satoshi Ikeda, Koji Maemura
{"title":"Occlusion of Dorsalis Pedis Artery in an Athlete.","authors":"Ryohei Akashi, Hiroaki Kawano, Satoshi Ikeda, Koji Maemura","doi":"10.2169/internalmedicine.4584-24","DOIUrl":"10.2169/internalmedicine.4584-24","url":null,"abstract":"<p><p>A 17-year-old Japanese boy was admitted to our hospital with intermittent claudication. He belonged to a weightlifting team at a high school. He had occasionally dropped lightweight lifting weights on his right foot. Arteriography of the right anterior and posterior tibial arteries revealed a 4-cm total occlusion in the right dorsalis pedis artery (DPA). Intravascular ultrasonography revealed intimal thickening and thrombus formation He was diagnosed with thrombus occlusion of the right DPA due to intimal artery damage caused by lightweight weightlifting. DPA thrombosis may occur in young athletes who do not have atherosclerosis or vasculitis.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2189-2191"},"PeriodicalIF":1.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating Collection Time of Intragastric Fluid During Endoscopy for Point-of-care Test-based Helicobacter pylori Polymerase Chain Reaction. 评估内窥镜检查期间胃内液的收集时间，以用于基于幽门螺旋杆菌聚合酶链反应的床旁检测。
IF 1 4区 医学
Internal Medicine Pub Date : 2025-07-15 Epub Date: 2024-11-21 DOI: 10.2169/internalmedicine.4320-24
Yoshiyuki Watanabe, Hiroyuki Yamamoto, Ichiro Oda, Kuniaki Torii, Seiji Futagami, Muhammad Miftahussurur, Kok-Ann Gwee, Momoko Tsuda, Mototsugu Kato, Keisuke Tateishi
{"title":"Evaluating Collection Time of Intragastric Fluid During Endoscopy for Point-of-care Test-based Helicobacter pylori Polymerase Chain Reaction.","authors":"Yoshiyuki Watanabe, Hiroyuki Yamamoto, Ichiro Oda, Kuniaki Torii, Seiji Futagami, Muhammad Miftahussurur, Kok-Ann Gwee, Momoko Tsuda, Mototsugu Kato, Keisuke Tateishi","doi":"10.2169/internalmedicine.4320-24","DOIUrl":"10.2169/internalmedicine.4320-24","url":null,"abstract":"<p><p>Objective To evaluate the influence of sample collection time during esophagogastroduodenoscopy (EGD) on the accuracy of a newly approved point-of-care test (POCT)-based polymerase chain reaction kit for detecting Helicobacter pylori and clarithromycin susceptibility in gastric wash fluid. Methods Intragastric fluid was collected at three time points: Collection Time 1 (start of EGD), Collection Time 2 (during EGD), and Collection Time 3 (after indigo carmine spraying). POCT-based quantitative polymerase chain reaction (qPCR) targeting 23S rRNA domain V (2142/2143) was used to quantify H. pylori DNA in the collected fluid at all three time points and compared with qPCR targeting 16S rRNA. Patients Fifty patients with suspected H. pylori infection were consecutively enrolled in this study over a three-month period and underwent EGD. Results In 9 out of 50 EGD cases that were H. pylori-positive, no significant differences in H. pylori DNA content, quantified using POCT-based qPCR targeting 23S rRNA, were observed between the three collection times: 1 vs. 2, p=0.81; 2 vs. 3, p=0.59; 1 vs. 3. Collection Time 2 had the strongest inverse correlation with the urea breath test (r=-0.80, p=0.01) and was the only time-point at which POCT-based qPCR could detect H. pylori in case 15. Conclusion This study suggests that the optimal collection timing for the H. pylori detection POCT kit (within 60 min) using intragastric fluid (with no biopsy) may be during EGD (Collection Time 2). However, our study had a limited sample size, so the findings must be verified through large-scale, multicenter collaboration studies.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2100-2107"},"PeriodicalIF":1.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hemodialysis-Related Portal-Systemic Encephalopathy Possibly Associated with Right Femoral Vein Thrombosis. 可能与右股静脉血栓形成相关的血液透析相关性门脉-全身性脑病1例报告。
IF 1 4区 医学
Internal Medicine Pub Date : 2025-07-15 Epub Date: 2024-12-19 DOI: 10.2169/internalmedicine.4621-24
Kiryu Yoshida, Yuki Mimura, Takumi Fukazawa, Mizuki Sano, Hirohito Sugawara, Hidetoshi Ito
{"title":"Hemodialysis-Related Portal-Systemic Encephalopathy Possibly Associated with Right Femoral Vein Thrombosis.","authors":"Kiryu Yoshida, Yuki Mimura, Takumi Fukazawa, Mizuki Sano, Hirohito Sugawara, Hidetoshi Ito","doi":"10.2169/internalmedicine.4621-24","DOIUrl":"10.2169/internalmedicine.4621-24","url":null,"abstract":"<p><p>In hemodialysis-related portal systemic encephalopathy (HRPSE), transient negative pressure in the inferior vena cava (IVC) during dialysis increases the blood flow through a portal-systemic shunt, leading to encephalopathy. We report the case of a 74-year-old man with a gastrorenal shunt who developed HRPSE for the first time following venous occlusion due to thrombosis around a right femoral tunneled-cuffed hemodialysis catheter. Before the thrombosis dissolved, ammonia levels increased after dialysis. Conversely, after the thrombosis was dissolved, the ammonia levels decreased after dialysis. We hypothesized that venous stasis in the right lower limb due to thrombosis intensified the negative pressure in the IVC during dialysis, triggering HRPSE.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2197-2201"},"PeriodicalIF":1.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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