Internal Medicine最新文献

IF 1.1 4区医学

Internal Medicine Pub Date : 2025-10-15 Epub Date: 2025-04-05 DOI: 10.2169/internalmedicine.5316-25

Yuki Chiko, Erika Makishi

引用次数: 0

Two Cases of Esophageal Mucosal Damage Observed after Peroral Endoscopic Myotomy for Esophageal Motility Disorders. 食管运动障碍经口内窥镜肌切开术后食管黏膜损伤2例观察。

IF 1.1 4区医学

Internal Medicine Pub Date : 2025-10-15 Epub Date: 2025-04-05 DOI: 10.2169/internalmedicine.4943-24

Shoichiro Hirata, Tomohiro Kamio, Takuya Satomi, Kenta Hamada, Hiroyuki Sakae, Masaya Iwamuro, Seiji Kawano, Yoshiro Kawahara, Noriaki Manabe, Motoyuki Otsuka

引用次数: 0

A Rare Case of Hughes-Stovin Syndrome Presenting with Ischemic Colitis Caused by an Arteriovenous Malformation. 一例罕见的休斯-斯托文综合征，表现为由动静脉畸形引起的缺血性结肠炎。

IF 1.1 4区医学

Internal Medicine Pub Date : 2025-10-15 Epub Date: 2025-04-12 DOI: 10.2169/internalmedicine.5185-24

Kazuya Maruo, Makoto Tanaka, Yutaka Inada, Akifumi Fukui, Naoya Tomatsuri, Hideki Sato, Osamu Inamori, Masanori Yamashita, Katsuhiko Oka, Yusuke Okuyama

引用次数: 0

Intravenous Verapamil for the Management of Atrial Fibrillation: The Gap Between the Guidelines and Clinical Practice. 静脉注射维拉帕米治疗房颤：指南与临床实践之间的差距。

IF 1.1 4区医学

Internal Medicine Pub Date : 2025-10-15 Epub Date: 2025-04-12 DOI: 10.2169/internalmedicine.5288-25

Yuichi Baba, Toru Kubo, Kei Kawada, Yuri Ochi, Takayoshi Hirota, Naohito Yamasaki, Hiroaki Kitaoka

{"title":"Intravenous Verapamil for the Management of Atrial Fibrillation: The Gap Between the Guidelines and Clinical Practice.","authors":"Yuichi Baba, Toru Kubo, Kei Kawada, Yuri Ochi, Takayoshi Hirota, Naohito Yamasaki, Hiroaki Kitaoka","doi":"10.2169/internalmedicine.5288-25","DOIUrl":"10.2169/internalmedicine.5288-25","url":null,"abstract":"Objective According to the current guidelines, the use of non-dihydropyridine calcium-channel blockers for the rate control of atrial fibrillation (AF) is contraindicated in patients with heart failure (HF), especially in those with a reduced ejection fraction (EF). However, there is little data supporting this recommendation. This study aimed to investigate the use of intravenous verapamil in patients with AF. Methods We retrospectively studied 223 consecutive patients with AF treated with intravenous verapamil. We evaluated the clinical data of these patients, including any adverse events that occurred within 7 days. Results The median age of the patients was 75.9 (67.8-80.7) years. Before administration, 71 patients (31.8%) had HF, 112 patients (62.6%) had a high B-type natriuretic peptide (BNP) level, and 28 patients (13.6%) had a left ventricular (LV) EF less than 50%. The mean administered dose of verapamil was 5.4±1.6 mg. The median heart rate (HR) was significantly reduced after verapamil administration [HR:145 (130-160) bpm to 95 (82-105) bpm, p<0.001]. Twenty-eight patients (12.6%) suffered from hypotension. Two patients had bradyarrhythmias. Within 7 days, cardiovascular death occurred in three patients (1.3%). A multivariate analysis revealed that pre sBP and hemoglobin, but not LVEF or BNP, were independently associated with adverse events. Conclusion The intravenous administration of verapamil appears to be effective and safe for controlling the heart rate in most patients with AF, except in critically ill patients. However, further research is required to assess the safety of verapamil in patients for whom its use is not currently recommended by the clinical guidelines.","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2944-2952"},"PeriodicalIF":1.1,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharyngeal Syphilis in the Elderly. 老年人咽部梅毒。

IF 1.1 4区医学

Internal Medicine Pub Date : 2025-10-15 Epub Date: 2025-04-12 DOI: 10.2169/internalmedicine.5307-25

Yu Arakawa, Daisuke Sakanashi, Hiroshige Mikamo, Yuka Yamagishi

引用次数: 0

Successful Salvage Therapy with Pomalidomide, Cyclophosphamide, and Dexamethasone for IgM Myeloma with t (11;14) and Dim CD38 Expression Refractory to Daratumumab, Lenalidomide, and Dexamethasone. 泊马度胺、环磷酰胺和地塞米松成功挽救对达拉单抗、来那度胺和地塞米松难治的t（11;14）和Dim CD38表达的IgM骨髓瘤。

IF 1.1 4区医学

Internal Medicine Pub Date : 2025-10-15 Epub Date: 2025-04-26 DOI: 10.2169/internalmedicine.4774-24

Takashi Fujishima, Takahiro Kobayashi, Isuzu Kobayashi, Akihiro Kitadate, Yoshihiro Kameoka, Naoto Takahashi

引用次数: 0

Bullous Pemphigoid in Patients with Non-small-cell Lung Cancer Complicated by Diabetes Mellitus Receiving Dipeptidyl Peptidase-4 Inhibitors and Immune Checkpoint Inhibitors: A Case Report of Two Patients and Review of Literature. 接受二肽基肽酶-4抑制剂和免疫检查点抑制剂治疗的非小细胞肺癌合并糖尿病患者的大疱性类天疱疮：2例病例报告及文献复习

IF 1.1 4区医学

Internal Medicine Pub Date : 2025-10-15 Epub Date: 2025-04-05 DOI: 10.2169/internalmedicine.5090-24

Koki Nakashima, Yoshiki Demura, Satomi Kimura, Koji Yamaoka, Masahiro Oi, Tomoaki Sonoda, Toshihiko Tada, Tamotsu Ishizuka

引用次数: 0

The Skewness of a Histogram of White Matter Hyperintensity Is Associated with Symptomatic Stroke in Patients with CADASIL. CADASIL患者白质高强度直方图的偏斜度与症状性卒中相关

IF 1.1 4区医学

Internal Medicine Pub Date : 2025-10-15 Epub Date: 2025-04-12 DOI: 10.2169/internalmedicine.5270-25

Hiraku Matsuura, Koji Sakai, Kei Fujikawa, Akiko Watanabe-Hosomi, Mao Mukai, Shinji Ashida, Daiki Fukunaga, Takashi Koizumi, Tomoyuki Ohara, Ikuko Mizuta, Satoshi Teramukai, Kei Yamada, Toshiki Mizuno

{"title":"The Skewness of a Histogram of White Matter Hyperintensity Is Associated with Symptomatic Stroke in Patients with CADASIL.","authors":"Hiraku Matsuura, Koji Sakai, Kei Fujikawa, Akiko Watanabe-Hosomi, Mao Mukai, Shinji Ashida, Daiki Fukunaga, Takashi Koizumi, Tomoyuki Ohara, Ikuko Mizuta, Satoshi Teramukai, Kei Yamada, Toshiki Mizuno","doi":"10.2169/internalmedicine.5270-25","DOIUrl":"10.2169/internalmedicine.5270-25","url":null,"abstract":"Objective White matter hyperintensity (WMH) is the most prominent magnetic resonance imaging (MRI) feature of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), clinically characterized by recurrent ischemic stroke. This study aimed to explore the association between WMH and symptomatic stroke in patients with CADASIL by quantifying the volume and features extracted from histogram-segmented WMH. Methods Twenty-eight patients with CADASIL were retrospectively recruited. WMH was extracted from fluid-attenuated inversion recovery (FLAIR) images. A histogram analysis of WMH was performed using radiomics extension on a 3D slicer. We compared the histogram parameters between patients with and without symptomatic stroke. Results Thirteen patients had no symptoms, while 15 had previous symptomatic stroke. Their characteristics were similar, except for a higher frequency of males among stroke patients (73.3 vs. 15.4%, respectively). Among the histogram features, the skewness of the FLAIR intensity histogram was significantly lower in patients with stroke than in those without stroke (-0.179 vs. 0.210, respectively, p=0.0287), but there was no significant difference regarding any other histogram features or the WMH volume. According to a multiple logistic regression analysis, sex and skewness remained significant (odds ratio: 40.870 and 0.0119, p=0.0136 and 0.0473, respectively). Conclusion The skewness of the FLAIR WMH intensity histogram was significantly correlated with stroke in patients with CADASIL.","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2960-2965"},"PeriodicalIF":1.1,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Salvage HLA-haploidentical Peripheral Blood Stem Cell Transplantation Using Post-transplant Cyclophosphamide for Recurrent Hemophagocytic Lymphohistiocytosis-associated Graft Failure after Cord Blood Transplantations. 补救性hla -单倍体外周血干细胞移植后使用环磷酰胺治疗脐带血移植后复发性噬淋巴组织细胞相关移植失败1例报告。

IF 1.1 4区医学

Internal Medicine Pub Date : 2025-10-15 Epub Date: 2025-04-12 DOI: 10.2169/internalmedicine.5159-24

Keijiro Sato, Wataru Komaba, Saika Oka, Shintaro Kazama, Ryuto Ishikawa, Takahiro Morikawa, Mari Kitahara, Hiroko Kazumoto, Hiroko Kaiume, Toshimitsu Ueki, Yuki Hiroshima, Masahiko Sumi, Hikaru Kobayashi

{"title":"Salvage HLA-haploidentical Peripheral Blood Stem Cell Transplantation Using Post-transplant Cyclophosphamide for Recurrent Hemophagocytic Lymphohistiocytosis-associated Graft Failure after Cord Blood Transplantations.","authors":"Keijiro Sato, Wataru Komaba, Saika Oka, Shintaro Kazama, Ryuto Ishikawa, Takahiro Morikawa, Mari Kitahara, Hiroko Kazumoto, Hiroko Kaiume, Toshimitsu Ueki, Yuki Hiroshima, Masahiko Sumi, Hikaru Kobayashi","doi":"10.2169/internalmedicine.5159-24","DOIUrl":"10.2169/internalmedicine.5159-24","url":null,"abstract":"We describe a case of immunological rejection occurring twice after cord blood transplantation (CBT) for mixed phenotype blast phase chronic myeloid leukemia that was successfully salvaged by haploidentical peripheral blood stem cell transplantation (haplo-PBSCT) with post-transplant cyclophosphamide (PT-Cy). Pre-engraftment immune reaction (PIR) and subsequent hemophagocytic lymphohistiocytosis (HLH), likely due to HLA mismatch in the graft-versus-host (GVH) direction, lead to poor graft function (PGF) and graft failure (GF). This case highlights the pathophysiology of PIR, HLH, PGF, and GF, collectively termed \"post-transplant cytokine syndrome.\" PT-Cy haplo-PBSCT, with wide donor availability and reduced infection risk leading to HLH via rapid engraftment, may be a suitable salvage option for post-CBT cytokine syndrome-related GF.","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"3012-3019"},"PeriodicalIF":1.1,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sjögren's Syndrome with Sensory Neuronopathy and Polyradiculoneuropathy. Sjögren综合征伴感觉神经病变及多神经根神经病变1例。

IF 1.1 4区医学

Internal Medicine Pub Date : 2025-10-15 Epub Date: 2025-03-29 DOI: 10.2169/internalmedicine.5188-24

Takumi Funakoshi, Minoru Yamada, Kazuna Ikeda, Kazuki Yokokawa, Tarou Saito, Reiko Tsuda, Naotoshi Iwahara, Syuuichirou Suzuki, Shin Hisahara

引用次数: 0