Internal Medicine最新文献

Pathogenic TNFRSF13B Variant in an Adult Japanese Patient with Common Variable Immunodeficiency. 一名常见变异性免疫缺陷症日本成人患者的致病基因 TNFRSF13B 变体

IF 1 4区医学

Internal Medicine Pub Date : 2025-03-01 Epub Date: 2024-07-11 DOI: 10.2169/internalmedicine.4057-24

Naokazu Nakamura, Ryo Ikunari, Yasuhiro Tanaka, Hiroko Tsunemine, June Takeda, Nobuyoshi Arima

引用次数: 0

Spinal Dural Arteriovenous Fistulas in a Patient with Cowden Syndrome and a Phosphatase and Tensin Homolog Mutation. 一名患有考登综合征和磷酸酶与Tensin同源物突变的患者的脊髓硬膜动静脉瘘

IF 1 4区医学

Internal Medicine Pub Date : 2025-03-01 Epub Date: 2024-07-25 DOI: 10.2169/internalmedicine.3809-24

Atsuhito Fuse, Jiro Fukae, Asuka Nakajima, Takashi Mitsuhashi, Ami Kurita, Kohsuke Teranishi, Masami Arai, Yasushi Shimo, Nobutaka Hattori

引用次数: 0

Eosinophilic Gastroenteritis with Ascites, Elevated Serum IgG4, and Hypereosinophilic Syndrome: A Manifestation of IgG4-related Disease? 嗜酸性粒细胞性肠胃炎伴腹水、血清 IgG4 升高和嗜酸性粒细胞过多综合征：IgG4 相关疾病的一种表现形式？

IF 1 4区医学

Internal Medicine Pub Date : 2025-03-01 Epub Date: 2024-08-01 DOI: 10.2169/internalmedicine.3769-24

Takao Nagashima, Hiroki Yabe, Naota Okabe, Tsuyoshi Kobashigawa

引用次数: 0

Prognostic Factors of In-hospital Mortality in Patients without Human Immunodeficiency Virus Infection with Pneumocystis Pneumonia: A Retrospective Cohort Study. 无人类免疫缺陷病毒感染的肺囊虫肺炎患者院内死亡率的预后因素：一项回顾性队列研究。

IF 1 4区医学

Internal Medicine Pub Date : 2025-03-01 Epub Date: 2024-08-01 DOI: 10.2169/internalmedicine.4090-24

Jumpei Taniguchi, Shotaro Aso, Taisuke Jo, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga

{"title":"Prognostic Factors of In-hospital Mortality in Patients without Human Immunodeficiency Virus Infection with Pneumocystis Pneumonia: A Retrospective Cohort Study.","authors":"Jumpei Taniguchi, Shotaro Aso, Taisuke Jo, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga","doi":"10.2169/internalmedicine.4090-24","DOIUrl":"10.2169/internalmedicine.4090-24","url":null,"abstract":"Objective This study explored the prognostic factors of in-hospital mortality in patients with Pneumocystis pneumonia (PCP) without human immunodeficiency virus (HIV) infection, using a Japanese nationwide inpatient database. Methods We extracted the data of patients with PCP without HIV infection between July 2010 and March 2022 from the Diagnosis Procedure Combination database. We performed multivariable logistic regression analyses to identify the prognostic factors of in-hospital mortality in with PCP without HIV infection. Results We identified 1,704 patients with PCP without HIV infection and 404 (23.7%) in-hospital deaths. Higher in-hospital mortality was associated with advanced age, male sex [odds ratio (OR), 1.45; 95% confidence interval (CI), 1.06-2.00], a low Barthel index score, non-hematological malignancy (OR, 1.81; 95% CI, 1.22-2.70), receipt of mechanical ventilation (OR, 2.49; 95% CI, 1.47-4.21), and administration of antibiotics (OR, 1.52; 95% CI, 1.12-2.06) and antifungal drugs (OR, 1.83; 95% CI, 1.26-2.67). Lower in-hospital mortality was associated with connective tissue disease and vasculitis (OR, 0.55; 95% CI, 0.37-0.81), hematological malignancy (OR, 0.59; 95% CI, 0.38-0.93), and early trimethoprim-sulfamethoxazole treatment (OR, 0.63; 95% CI, 0.44-0.90). Conclusion These findings will help physicians identify patients who may benefit from early aggressive therapeutic interventions.","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"651-657"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Requirement of Repeated Serum VEGF Measurements in POEMS Syndrome. POEMS 综合征需要重复测量血清血管内皮生长因子。

IF 1 4区医学

Internal Medicine Pub Date : 2025-03-01 Epub Date: 2024-08-01 DOI: 10.2169/internalmedicine.4086-24

Taichi Nomura, Ikuko Iwata, Katsuki Eguchi, Shintaro Fujii, Takashi Inoue, Monami Tarisawa, Takashi Ishio, Yuichiro Toyama, Hisashi Uwatoko, Shinichi Shirai, Masaaki Matsushima, Hiroaki Yaguchi, Ichiro Yabe

引用次数: 0

Circulating Angiopoietin-like Protein 6 Levels and Clinical Features in Patients with Type 2 Diabetes. 2 型糖尿病患者的循环血管生成素样蛋白 6 水平与临床特征

IF 1 4区医学

Internal Medicine Pub Date : 2025-03-01 Epub Date: 2024-08-08 DOI: 10.2169/internalmedicine.3609-24

Kohzo Takebayashi, Tatsuhiko Suzuki, Mototaka Yamauchi, Kenji Hara, Takafumi Tsuchiya, Toshihiko Inukai, Koshi Hashimoto

{"title":"Circulating Angiopoietin-like Protein 6 Levels and Clinical Features in Patients with Type 2 Diabetes.","authors":"Kohzo Takebayashi, Tatsuhiko Suzuki, Mototaka Yamauchi, Kenji Hara, Takafumi Tsuchiya, Toshihiko Inukai, Koshi Hashimoto","doi":"10.2169/internalmedicine.3609-24","DOIUrl":"10.2169/internalmedicine.3609-24","url":null,"abstract":"Objective The main purpose of this study was to evaluate the associations between circulating angiopoietin-like protein 6 (ANGPTL6) levels and various diabetes- and atherosclerosis-related variables in patients with type 2 diabetes. Methods Serum ANGPTL6 levels in patients with type 2 diabetes hospitalized for glycemic control and/or diabetic education were measured using a chemiluminescent immunoassay. Results Most patients had elevated hemoglobin (Hb) A1c levels; 85.7% and 71.4% of patients had HbA1c levels ≥8%, and ≥9%, respectively. ANGPTL6 levels were significantly higher in patients with type 2 diabetes than in non-diabetic controls. In patients with type 2 diabetes, ANGPTL6 was significantly and positively correlated with the duration of diabetes, systolic blood pressure, gamma-glutamyl transpeptidase, C-reactive protein (CRP), and the intimal medial complex thickness of the carotid artery (IMT), and inversely correlated with HbA1c. In the multiple regression analysis, ANGPTL6 had a significant positive association with triglyceride in one of the models in which it was included as a variable. Furthermore, ANGPTL6 also showed significant positive associations with CRP and IMT in models in which they were included as variables. Conclusion The current study suggests that circulating levels of ANGPTL6 may be negatively associated with poor glycemic control and positively associated with the degree of atherosclerosis, as reflected by IMT, in patients with type 2 diabetes, most of whom had elevated HbA1c levels.","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"643-649"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impaired Consciousness Due to Hyperammonemia During S-1 Administration for Unresectable Pancreatic Cancer. 治疗无法切除的胰腺癌的 S-1 用药期间高氨血症导致的意识障碍。

IF 1 4区医学

Internal Medicine Pub Date : 2025-03-01 Epub Date: 2024-07-25 DOI: 10.2169/internalmedicine.3771-24

Nagahiro Tokuyama, Sayaka Ikeda, Ryosuke Ishida, Ryoko Futai, Kazutoshi Tobimatsu, Yuzo Kodama

引用次数: 0

Congenital Pulmonary Airway Malformation with Suspected Nontuberculous Mycobacterium Infection. 疑似非结核分枝杆菌感染的先天性肺气道畸形

IF 1 4区医学

Internal Medicine Pub Date : 2025-03-01 Epub Date: 2024-07-18 DOI: 10.2169/internalmedicine.4065-24

Tamio Okimoto, Teruaki Iwahashi, Masaomi Yamane, Yukari Tsubata

引用次数: 0

Reliability and Validity of the Japanese Version of the Fatigue Assessment Scale. 日文版疲劳评估量表的可靠性和有效性

IF 1 4区医学

Internal Medicine Pub Date : 2025-03-01 Epub Date: 2024-07-18 DOI: 10.2169/internalmedicine.4101-24

Kazuki Tokumasu, Nobuyoshi Matsuki, Hirohisa Fujikawa, Yoko Sakamoto, Fumio Otsuka

{"title":"Reliability and Validity of the Japanese Version of the Fatigue Assessment Scale.","authors":"Kazuki Tokumasu, Nobuyoshi Matsuki, Hirohisa Fujikawa, Yoko Sakamoto, Fumio Otsuka","doi":"10.2169/internalmedicine.4101-24","DOIUrl":"10.2169/internalmedicine.4101-24","url":null,"abstract":"Objective General fatigue is one of the most frequent chief complaints in primary care, and an accurate assessment of fatigue has a direct impact on a patient's quality of life and treatment decisions. The Fatigue Assessment Scale (FAS), a measure of general fatigue, is useful for assessing fatigue in diverse cultures and diseases. However, there has been no study showing the reliability and validity of the scale in the Japanese context. The present study assessed the reliability and validity of the Japanese version of the FAS. Methods This study was conducted on 649 patients with long COVID who had a high frequency of general fatigue. To test the structural validity of the FAS, the patients were randomly divided into two groups: one in which an exploratory factor analysis (EFA) was conducted and one in which a confirmatory factor analysis (CFA) was conducted. Cronbach's alpha was calculated to assess internal consistency reliability. Results As 58 patients had missing values, we analyzed the data of 591 patients. The EFA led to an FAS comprising two factors. The CFA showed an acceptable fit for this two-factor model. The internal consistency was found to be good (Cronbach's alpha =0.89). Conclusion This study verified the structural validity and internal consistency and reliability of the Japanese version of the FAS. The results indicate that the Japanese version of the FAS is useful for assessing general fatigue in patients with long COVID in Japan.","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"658-663"},"PeriodicalIF":1.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141633440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Man with Primary Hyperchylomicronemia with Triglyceride Levels Exceeding 11,000 mg/dL Was Well Controlled by Pemafibrate Combined with Dietary Therapy. 一名甘油三酯水平超过 11,000 mg/dL 的原发性高胆固醇血症患者通过培马贝特联合饮食疗法得到了很好的控制：病例报告。

IF 1 4区医学

Internal Medicine Pub Date : 2025-03-01 Epub Date: 2024-07-25 DOI: 10.2169/internalmedicine.3946-24

Hiroyuki Ueda, Ryohei Mineo, Takuya Sugiyama, Masahiro Koseki, Yoshito Itoh, Ryuya Iwamoto, Sachiko Tamba, Koji Yamamoto, Yuya Yamada, Hisatoyo Hiraoka, Yuji Matsuzawa

引用次数: 0