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Functional Gallbladder Disorder: Characteristic Hepatobiliary Scintigraphy Findings. 功能性胆囊疾病:特征性肝胆闪烁扫描结果。
IF 1 4区 医学
Internal Medicine Pub Date : 2025-04-01 Epub Date: 2024-08-28 DOI: 10.2169/internalmedicine.4222-24
Eri Oshina, Masanori Kobayashi, Ryuichi Okamoto
{"title":"Functional Gallbladder Disorder: Characteristic Hepatobiliary Scintigraphy Findings.","authors":"Eri Oshina, Masanori Kobayashi, Ryuichi Okamoto","doi":"10.2169/internalmedicine.4222-24","DOIUrl":"10.2169/internalmedicine.4222-24","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"1119-1120"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142092843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Life-threatening Neuroleptic Malignant Syndrome and Its Mechanism. 危及生命的神经性恶性综合征及其机制。
IF 1 4区 医学
Internal Medicine Pub Date : 2025-04-01 Epub Date: 2024-09-04 DOI: 10.2169/internalmedicine.4410-24
Takahiko Nagamine
{"title":"Life-threatening Neuroleptic Malignant Syndrome and Its Mechanism.","authors":"Takahiko Nagamine","doi":"10.2169/internalmedicine.4410-24","DOIUrl":"10.2169/internalmedicine.4410-24","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"985-986"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shark Fin Sign in a Patient with Sepsis-induced Cardiomyopathy Associated with Retained Placenta: A Case Report and Review of the Literature. 一名胎盘滞留的败血症诱发心肌病患者的鱼翅征:病例报告和文献综述。
IF 1 4区 医学
Internal Medicine Pub Date : 2025-04-01 Epub Date: 2024-09-04 DOI: 10.2169/internalmedicine.3501-24
Yoshiyuki Ohnaga, Ryohei Ono, Kaoruko Aoki, Hirotoshi Kato, Togo Iwahana, Hiroyuki Takaoka, Akiko Omoto, Kaito Nakama, Takashi Kishimoto, Jun-Ichiro Ikeda, Yoshio Kobayashi
{"title":"Shark Fin Sign in a Patient with Sepsis-induced Cardiomyopathy Associated with Retained Placenta: A Case Report and Review of the Literature.","authors":"Yoshiyuki Ohnaga, Ryohei Ono, Kaoruko Aoki, Hirotoshi Kato, Togo Iwahana, Hiroyuki Takaoka, Akiko Omoto, Kaito Nakama, Takashi Kishimoto, Jun-Ichiro Ikeda, Yoshio Kobayashi","doi":"10.2169/internalmedicine.3501-24","DOIUrl":"10.2169/internalmedicine.3501-24","url":null,"abstract":"<p><p>Retained placenta can lead to septic shock; however, sepsis-induced cardiomyopathy (SICM) due to retained placenta has not been reported previously. This report presents a rare case of SICM following septic shock due to retained placenta after miscarriage in a 40-year-old woman, accompanied by the \"shark fin sign\" on an electrocardiogram, a pattern typically linked to myocardial ischemia. She experienced ventricular tachycardia and required venoarterial extracorporeal membrane oxygenation; however, she was successfully treated. We also reviewed previous cases of shark fin sign in patients without myocardial infarction. A review showed that half of the cases experienced lethal arrhythmias, even without myocardial infarction.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"1047-1052"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TAFRO-like Symptoms in a Sjögren's Syndrome Patient with HTLV-1 Infection. 一例伴有 HTLV-1 感染的 Sjögren's 综合征患者的 TAFRO 样症状。
IF 1 4区 医学
Internal Medicine Pub Date : 2025-04-01 Epub Date: 2024-08-28 DOI: 10.2169/internalmedicine.4124-24
Takuya Masuda, Takeshi Suzuki, Miho Ohshima, Akitake Suzuki, Nobuyoshi Minemura, Hiroyoshi Nakajima
{"title":"TAFRO-like Symptoms in a Sjögren's Syndrome Patient with HTLV-1 Infection.","authors":"Takuya Masuda, Takeshi Suzuki, Miho Ohshima, Akitake Suzuki, Nobuyoshi Minemura, Hiroyoshi Nakajima","doi":"10.2169/internalmedicine.4124-24","DOIUrl":"10.2169/internalmedicine.4124-24","url":null,"abstract":"<p><p>A 58-year-old woman was admitted to our hospital with anasarca and generalized lymphadenopathy. Laboratory data showed serum creatinine 1.48 mg/dL, C-Reactive Protein 2.38 mg/dL, platelet 102,000/μL, and anti-SS-A antibodies. A lymph node biopsy revealed a regressed germinal center and hypervascularization in the interfollicular area. The patient was diagnosed with TAFRO-like symptoms occurring with Sjögren's syndrome and human T-cell leukemia virus type 1 (HTLV-1) infection, and 80 mg of methylprednisolone and tocilizumab 8 mg/kg biweekly were initiated. Her body weight decreased from 59.4 to 41 kg, and pleural effusion disappeared 8 weeks later. This case suggests that TAFRO-like symptoms may occur in patients with Sjögren's syndrome with HTLV-1 infection.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"1107-1112"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142092837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Renal Impairment Caused by Tosufloxacin Crystals in an Adult. 成人托舒沙星结晶引起的肾功能损伤
IF 1 4区 医学
Internal Medicine Pub Date : 2025-04-01 Epub Date: 2024-08-28 DOI: 10.2169/internalmedicine.4145-24
Tomofumi Hayashi
{"title":"Renal Impairment Caused by Tosufloxacin Crystals in an Adult.","authors":"Tomofumi Hayashi","doi":"10.2169/internalmedicine.4145-24","DOIUrl":"10.2169/internalmedicine.4145-24","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"1121"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142092847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coexistence of Sjögren's Syndrome-associated Interstitial Nephritis and Hypokalemic Nephropathy in a Patient with Distal Renal Tubular Acidosis. 一名远端肾小管酸中毒患者同时患有斯约格伦综合征相关性间质性肾炎和低钾血症肾病:病例报告。
IF 1 4区 医学
Internal Medicine Pub Date : 2025-04-01 Epub Date: 2024-08-28 DOI: 10.2169/internalmedicine.4152-24
Rena Matsui, Maika Gojo, Kohei Odajima, Shinichiro Asakawa, Shigeyuki Arai, Osamu Yamazaki, Yoshifuru Tamura, Satoe Numakura, Yasutoshi Oshima, Ryuji Ohashi, Shigeru Shibata, Yoshihide Fujigaki
{"title":"Coexistence of Sjögren's Syndrome-associated Interstitial Nephritis and Hypokalemic Nephropathy in a Patient with Distal Renal Tubular Acidosis.","authors":"Rena Matsui, Maika Gojo, Kohei Odajima, Shinichiro Asakawa, Shigeyuki Arai, Osamu Yamazaki, Yoshifuru Tamura, Satoe Numakura, Yasutoshi Oshima, Ryuji Ohashi, Shigeru Shibata, Yoshihide Fujigaki","doi":"10.2169/internalmedicine.4152-24","DOIUrl":"10.2169/internalmedicine.4152-24","url":null,"abstract":"<p><p>A 42-year-old woman presented with muscle weakness and hypokalemic distal renal tubular acidosis (dRTA). Investigations revealed concurrent Sjögren's syndrome (SS) and Hashimoto's thyroiditis contributing to hypokalemic dRTA. A renal biopsy revealed focal tubulointerstitial nephritis (TIN) suggestive of SS-related renal involvement, along with distinctive ischemic glomerular changes and tubular alterations consistent with hypokalemic nephropathy. Rapid improvement in tubular injury markers and hypobicarbonemia followed potassium supplementation, suggesting that hypokalemia contributed to proximal tubular injury. This case underscores the diagnostic challenge posed by the simultaneous presence of TIN and hypokalemic nephropathy, potentially masking hypokalemic nephropathy in patients with hypokalemic dRTA secondary to SS-TIN.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"1067-1074"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142092841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ectopic Production of Parathyroid Hormone and Production of Parathyroid Hormone-related Protein in Dedifferentiated Endometrial Carcinoma Induced Severe Hypercalcemia. 甲状旁腺激素的异位生成和甲状旁腺激素相关蛋白的生成在诱发严重高钙血症的未分化子宫内膜癌中的应用
IF 1 4区 医学
Internal Medicine Pub Date : 2025-04-01 Epub Date: 2024-09-04 DOI: 10.2169/internalmedicine.3899-24
Takeru Ogino, Hirofumi Watanabe, Shoko Yamazaki, Megumi Kurosawa, Akiko Kobayashi, Naofumi Imai, Takahiro Taguchi, Hajime Umezu, Ryo Aida, Kazuki Watanabe, Tadashi Otsuka, Hideyuki Kabasawa, Ryohei Kaseda, Suguru Yamamoto, Kosuke Yoshihara, Shin Goto, Ichiei Narita
{"title":"Ectopic Production of Parathyroid Hormone and Production of Parathyroid Hormone-related Protein in Dedifferentiated Endometrial Carcinoma Induced Severe Hypercalcemia.","authors":"Takeru Ogino, Hirofumi Watanabe, Shoko Yamazaki, Megumi Kurosawa, Akiko Kobayashi, Naofumi Imai, Takahiro Taguchi, Hajime Umezu, Ryo Aida, Kazuki Watanabe, Tadashi Otsuka, Hideyuki Kabasawa, Ryohei Kaseda, Suguru Yamamoto, Kosuke Yoshihara, Shin Goto, Ichiei Narita","doi":"10.2169/internalmedicine.3899-24","DOIUrl":"10.2169/internalmedicine.3899-24","url":null,"abstract":"<p><p>Hypercalcemia is a significant complication in cancer patients, primarily caused by parathyroid hormone-related peptide (PTHrP) and, rarely, by parathyroid hormone (PTH) production from tumors. We report a case of severe hypercalcemia in a woman with uterine cancer who exhibited elevated PTH and PTHrP levels. Surgical intervention revealed dedifferentiated endometrial carcinoma. Postoperatively, PTH and PTHrP levels normalized but subsequently increased due to metastases. A molecular analysis confirmed the expression of the PTH gene and protein within the tumor, indicating ectopic PTH production. In diagnosing and treating cancers, it is necessary to consider not only PTHrP production but also ectopic PTH production.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"1053-1059"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hemoglobinopathy as a Rare Differential Disease for Low Oxygen Saturation by Pulse Oximetry: A Case Report and Literature Review. 血红蛋白病是脉搏血氧饱和度低的一种罕见鉴别疾病:病例报告和文献综述。
IF 1 4区 医学
Internal Medicine Pub Date : 2025-04-01 Epub Date: 2024-08-28 DOI: 10.2169/internalmedicine.4011-24
Kenichiro Takeda, Toshihiko Sugiura, Satoshi Isomatsu, Hidemi Ogawa, Yushi Murai, Shizu Miyata, Shun Imai, Tadasu Okaya, Akira Naito, Ayumi Sekine, Ayako Shigeta, Takuji Suzuki
{"title":"Hemoglobinopathy as a Rare Differential Disease for Low Oxygen Saturation by Pulse Oximetry: A Case Report and Literature Review.","authors":"Kenichiro Takeda, Toshihiko Sugiura, Satoshi Isomatsu, Hidemi Ogawa, Yushi Murai, Shizu Miyata, Shun Imai, Tadasu Okaya, Akira Naito, Ayumi Sekine, Ayako Shigeta, Takuji Suzuki","doi":"10.2169/internalmedicine.4011-24","DOIUrl":"10.2169/internalmedicine.4011-24","url":null,"abstract":"<p><p>Pulse oximetry is used to screen for respiratory failure in dyspnea patients. However, pulse oximetry can yield false-positive results in certain situations. Unstable hemoglobinopathy is a disease in which mutations in the globin-encoding gene result in abnormal globin chain production, causing low percutaneous oxygen saturation (SpO<sub>2</sub>) levels due to changes in hemoglobin absorbance and oxygen affinity. We identified a new family lineage of Hb Hirosaki in an adult patient with chronic obstructive pulmonary disease, dyspnea, and low SpO<sub>2</sub>. According to our literature review, only a few cases of unstable hemoglobinopathy have been reported in adults. Most patients with unstable hemoglobinopathy are asymptomatic, and those with dyspnea often have respiratory diseases or severe anemia. To differentiate unstable hemoglobinopathy, an appropriate assessment of the discrepancy between SpO<sub>2</sub> values and arterial blood gas analysis results is important.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"987-991"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142092844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progressive Severe Hemophagocytic Syndrome due to Disseminated Histoplasmosis in a Patient with HIV-1 Infection. 一名 HIV-1 感染者因播散性组织胞浆菌病引发的进行性严重嗜血细胞综合征。
IF 1 4区 医学
Internal Medicine Pub Date : 2025-04-01 Epub Date: 2024-09-04 DOI: 10.2169/internalmedicine.4079-24
Lisa Yamasaki, Yutaro Akiyama, Keigo Ueno, Yasutaka Hoshino, Minoru Nagi, Nobuko Nakayama, Masahiro Abe, Yoshitsugu Miyazaki, Hiroyuki Gatanaga, Koji Watanabe
{"title":"Progressive Severe Hemophagocytic Syndrome due to Disseminated Histoplasmosis in a Patient with HIV-1 Infection.","authors":"Lisa Yamasaki, Yutaro Akiyama, Keigo Ueno, Yasutaka Hoshino, Minoru Nagi, Nobuko Nakayama, Masahiro Abe, Yoshitsugu Miyazaki, Hiroyuki Gatanaga, Koji Watanabe","doi":"10.2169/internalmedicine.4079-24","DOIUrl":"10.2169/internalmedicine.4079-24","url":null,"abstract":"<p><p>Histoplasmosis is caused by Histoplasma capsulatum and is prevalent in areas of the world where H. capsulatum is endemic. We herein report a patient diagnosed with human immunodeficiency virus-1 (HIV-1) who developed histoplasmosis from a non-H. capsulatum endemic area who experienced severe hemophagocytic syndrome due to a delayed diagnosis. The patient's symptoms emerged four years after residing in regions with a high histoplasmosis prevalence. The unrestricted administration of antifungal medication for oral candidiasis delayed the diagnosis because it improved the patient's condition. This case underscores the importance of prudent antifungal drug use in undiagnosed disseminated conditions and evaluating the travel history going back several years to facilitate a diagnosis.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"1113-1118"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thoracic Angiosarcoma Arising from Chronic Tuberculous Pyothorax. 慢性结核性气胸引发的胸腔血管肉瘤:病例报告。
IF 1 4区 医学
Internal Medicine Pub Date : 2025-04-01 Epub Date: 2024-09-04 DOI: 10.2169/internalmedicine.4088-24
Takayuki Horii, Jun Sasaki, Hidenobu Ishii, Misa Sudou, Reiko Takaki, Takaaki Tokito, Koichi Azuma, Tomoaki Hoshino
{"title":"Thoracic Angiosarcoma Arising from Chronic Tuberculous Pyothorax.","authors":"Takayuki Horii, Jun Sasaki, Hidenobu Ishii, Misa Sudou, Reiko Takaki, Takaaki Tokito, Koichi Azuma, Tomoaki Hoshino","doi":"10.2169/internalmedicine.4088-24","DOIUrl":"10.2169/internalmedicine.4088-24","url":null,"abstract":"<p><p>Angiosarcoma is a rare malignancy that can arise from chronic pyothorax. We herein report a 75-year-old Japanese man with a history of tuberculosis who presented with left-sided chest pain that had persisted for 4 months. Chest computed tomography revealed an encapsulated left-sided pleural effusion with chest wall invasion, and histopathology confirmed angiosarcoma arising from a chronic tuberculous pyothorax. Chemotherapy with paclitaxel (80 mg/m<sup>2</sup> weekly) was ineffective and was discontinued after 3 months. Our findings emphasize that physicians should inform patients with chronic tuberculous pyothorax about malignant complications for which chest pain is the initial symptom, in addition to highlighting the need for careful follow-up.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"1085-1088"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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