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Anti-aging and metabolic intervention of Glabridin and Totarol combination 光甘草定与Totarol联合抗衰老及代谢干预作用
4区 医学
Internal Medicine Pub Date : 2026-07-31 DOI: 10.26599/fmh.2027.9420160
Zhi-Chao Zhang, Xiao-Yue Zhang, Lu-Qi Li, Qiang Zhang
{"title":"Anti-aging and metabolic intervention of Glabridin and Totarol combination","authors":"Zhi-Chao Zhang, Xiao-Yue Zhang, Lu-Qi Li, Qiang Zhang","doi":"10.26599/fmh.2027.9420160","DOIUrl":"https://doi.org/10.26599/fmh.2027.9420160","url":null,"abstract":"Abstract Inspired by the similar antioxidant effect functions of Glabridin and Totarol, we investigates their synergistic anti-aging effects and the underlying metabolic intervention in Caenorhabditis elegans (C. elegans). Various concentrations of Glabridin and Totarol, individually and in combination, were administered to C. elegans, and their impacts on lifespan, body development, motility, oxidative stress resistance, reactive oxygen species (ROS) levels, lipofuscin accumulation, antioxidant enzyme levels, and gene expression were evaluated. The combined treatment significantly extended the lifespan by 37.3% and showed enhanced effects over individual treatments on C. elegans. Metabolomic profiling using LC-MS revealed that the combination modulated aging-related metabolic pathways, particularly those involving NAD+/NADH balance and insulin signaling. The synergistic action elevated antioxidant enzyme activities, reduced ROS levels, improved oxidative stress tolerance, and upregulated key genes like daf-16. These findings suggest that the combined administration of Glabridin and Totarol exerts profound anti-aging effects through synergistic interactions, enhancing metabolic regulation and stress resistance. This study provides new insights into their mechanisms of action and highlights their potential as a novel strategy for developing products for anti-aging.","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/local/article_pdf/10.26599/FMH.2027.9420160.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148861306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The in vitro and in vivo antioxidant activities of Sargassum pallidum ethanol extract and its effect on gut microbiota modulation 马尾藻乙醇提取物体外和体内抗氧化活性及其对肠道菌群调节的影响
4区 医学
Internal Medicine Pub Date : 2026-07-02 DOI: 10.26599/fmh.2027.9420154
Zhong Yu-zhen, Yuan‐Ming Zhang, Tong Liu, Yafei Ji, Lulu Wang, Xiao‐Long Chen, Jiao-Jiao Han, Chen-Yang Lu
{"title":"The in vitro and in vivo antioxidant activities of Sargassum pallidum ethanol extract and its effect on gut microbiota modulation","authors":"Zhong Yu-zhen, Yuan‐Ming Zhang, Tong Liu, Yafei Ji, Lulu Wang, Xiao‐Long Chen, Jiao-Jiao Han, Chen-Yang Lu","doi":"10.26599/fmh.2027.9420154","DOIUrl":"https://doi.org/10.26599/fmh.2027.9420154","url":null,"abstract":"Abstract Sargassum pallidum (S. pallidum), a traditional Chinese herb, is a homology of medicine and food that is widely used daily. This study focused on the antioxidant activity and modulation of the gut microbiota by S. pallidum ethanol extract (SPEE). The results of component determination showed that SPEE contained flavonoids (0.398 g/100 g) and polyphenols (0.193 g/100 g). SPEE effectively eliminated 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonate) (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and hydroxyl and superoxide radicals in vitro; reduced the reactive oxygen species (ROS) and malondialdehyde (MDA) contents; and increased the glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase (CAT) enzymatic activities in UVB-irradiated HaCaT cells, which indicated its in vitro antioxidant activity. In addition, the healthy mice that received SPEE treatment presented a reduced spleen index and MDA content and increased GSH-Px enzymatic activity, which indicated its in vivo antioxidant activity. Furthermore, 16S rRNA gene sequencing of fecal samples revealed that SPEE modulated the gut microbiota in mice, decreasing the abundance of harmful bacteria such as Helicobacter while increasing the abundance of beneficial bacteria such as Bifidobacterium and Akkermansia. This study systematically confirmed the antioxidant activity of SPEE, clarified its ability to modulate the gut microbiota, and elucidated the relationship between its antioxidant activity and the gut microbiota, laying a foundation for in-depth research and wider application of S. pallidum in antioxidants.","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/local/article_pdf/10.26599/FMH.2027.9420154.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148861301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent Advances in Gastrointestinal Cancer Endoscopic Diagnosis and Treatment: Focusing on Older Adults. 胃肠道肿瘤内镜诊断和治疗的最新进展：以老年人为重点。
IF 1 4区 医学
Internal Medicine Pub Date : 2026-02-01 Epub Date: 2025-03-22 DOI: 10.2169/internalmedicine.4665-24
Taro Akashi, Naoyuki Yamaguchi, Hajime Isomoto
{"title":"Recent Advances in Gastrointestinal Cancer Endoscopic Diagnosis and Treatment: Focusing on Older Adults.","authors":"Taro Akashi, Naoyuki Yamaguchi, Hajime Isomoto","doi":"10.2169/internalmedicine.4665-24","DOIUrl":"10.2169/internalmedicine.4665-24","url":null,"abstract":"<p><p>Recent advances in endoscopic equipment have improved the diagnosis of gastrointestinal tumors. Image-enhanced endoscopy, including narrow-band imaging, blue light imaging, and linked color imaging, has unified magnifying observation classification methods and significantly improved the qualitative and quantitative diagnostic performance of gastrointestinal epithelial tumors. Endoscopic submucosal dissection (ESD), a minimally invasive treatment for early-stage gastrointestinal cancer, is widely used. The aging population in Japan has been gradually increasing. Despite this, ESD has shown good outcomes in older adults. However, long-term prognostic analyses should take into account the high mortality rate from other illnesses. Prognostic indicators such as the Charlson Comorbidity Index (CCI) and the Prognostic Nutrition Index (PNI) should be used to determine whether ESD should be performed. Even in cases of noncurative resection, follow-up without additional surgical resection is an option if there are other comorbidities that affect the prognosis.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"353-361"},"PeriodicalIF":1.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12945434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of New Molecularly Targeted Agents in Inflammatory Bowel Disease. 新型炎性肠病分子靶向药物的研究进展。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2026-01-15 Epub Date: 2025-05-08 DOI: 10.2169/internalmedicine.5410-25
Hiroshi Nakase
{"title":"Development of New Molecularly Targeted Agents in Inflammatory Bowel Disease.","authors":"Hiroshi Nakase","doi":"10.2169/internalmedicine.5410-25","DOIUrl":"10.2169/internalmedicine.5410-25","url":null,"abstract":"<p><p>Inflammatory bowel disease (IBD) is a multifactorial disorder resulting from a complex interplay among genetic predisposition, immune dysregulation, intestinal microbiota, and environmental factors. This dynamic interaction leads to aberrant immune activation within the gastrointestinal tract, ultimately leading to chronic inflammation. Recent advances in elucidating the pathophysiology of this disease have facilitated the development of molecularly targeted therapies. This review provides a critical appraisal of these emerging therapeutic strategies and emphasizes their potential impact on disease management.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"214-220"},"PeriodicalIF":1.1,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12900601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of Antiviral Drugs for Influenza. 流感抗病毒药物的发展。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2026-01-15 Epub Date: 2025-03-08 DOI: 10.2169/internalmedicine.5157-24
Tadashi Ishida
{"title":"Development of Antiviral Drugs for Influenza.","authors":"Tadashi Ishida","doi":"10.2169/internalmedicine.5157-24","DOIUrl":"10.2169/internalmedicine.5157-24","url":null,"abstract":"<p><p>The efficacy of the anti-influenza drugs was examined before and after the 2009 H1N1 pandemic. Anti-influenza drugs reduce the viral load, which leads to improvement of symptoms, a reduced illness period, suppression of complications, and protection from transmission. It is desirable to administer antiviral drugs within 48 hours of the onset of symptoms. The use of antiviral drugs is limited mainly to individuals who are hospitalized, those who have severe, complicated, or progressive illness, or those who are at high risk for influenza complications in Western countries. On the other hand, the rapid diagnosis of influenza and treatment with antiviral drugs have been effective in Japan, leading to the suppression of worsening symptoms. Baloxavir, the newest anti-influenza drug, and neuraminidase inhibitors are recommended for use in adult patients.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"245-251"},"PeriodicalIF":1.1,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12900603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent Advances in Molecular Targeted Therapy for Inflammatory Bowel Disease. 炎症性肠病分子靶向治疗研究进展
IF 1.1 4区 医学
Internal Medicine Pub Date : 2026-01-15 Epub Date: 2025-04-05 DOI: 10.2169/internalmedicine.5491-25
Tadakazu Hisamatsu, Jun Miyoshi, Minoru Matsuura
{"title":"Recent Advances in Molecular Targeted Therapy for Inflammatory Bowel Disease.","authors":"Tadakazu Hisamatsu, Jun Miyoshi, Minoru Matsuura","doi":"10.2169/internalmedicine.5491-25","DOIUrl":"10.2169/internalmedicine.5491-25","url":null,"abstract":"<p><p>Progress in the development of molecular-targeted therapies in the field of inflammatory bowel disease has been remarkable. With the advent of molecular-targeted agents, treatment strategies have changed, and higher-level treatment goals have been set. In terms of the long-term prognosis of inflammatory bowel disease, there has been a clear decline in the rate of surgery since 2000 when anti-tumor necrosis factor antibody preparations were introduced. However, a large number of molecular-targeted agents with diverse modes of action have appeared, and their positioning has become complicated and often confusing for clinicians. Furthermore, these agents are expensive and therefore present economic challenges. The selection of therapeutic agents for inflammatory bowel disease based on the mode of action and prediction of treatment effects continues to be a major issue, and it is hoped that artificial intelligence and machine learning will help resolve these problems.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"196-202"},"PeriodicalIF":1.1,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12900592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute Ischemic Stroke: Significance of Multimodal Pre-operative Prediction of Intracranial Atherosclerosis-related Large Vessel Occlusion. 急性缺血性中风：多模式术前预测颅内动脉粥样硬化相关大血管闭塞的意义。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2026-01-15 Epub Date: 2025-03-29 DOI: 10.2169/internalmedicine.5350-25
Kenichi Sakuta, Yasuyuki Iguchi
{"title":"Acute Ischemic Stroke: Significance of Multimodal Pre-operative Prediction of Intracranial Atherosclerosis-related Large Vessel Occlusion.","authors":"Kenichi Sakuta, Yasuyuki Iguchi","doi":"10.2169/internalmedicine.5350-25","DOIUrl":"10.2169/internalmedicine.5350-25","url":null,"abstract":"<p><p>When large-vessel occlusion (LVO) occurs in acute ischemic stroke, accurate differentiation of intracranial atherosclerosis-related occlusion (ICAD-O) from embolism-related occlusion (EMB-O) is critical for guiding treatment decisions. This review focuses on the preoperative prediction of ICAD-O and emphasizes the practical clinical and imaging factors. ICAD-O is often associated with younger age, male sex, and vascular risk factors, such as hypertension and diabetes, and the absence of atrial fibrillation is a key characteristic of its differentiation. Imaging findings, including truncal-type occlusion and non-culprit stenosis, further aid in the identification of ICAD-O. Predictive scales integrating clinical and imaging data, such as the ISAT, REMIT, ABC<sup>2</sup>D, and ATHE scores, provide structured approaches for distinguishing ICAD-O from EMB-O. By reviewing these predictive tools and findings, this review aims to enhance the accuracy and efficiency of the preoperative diagnosis, supporting better-informed clinical decision-making for stroke patients with LVO.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"221-225"},"PeriodicalIF":1.1,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12900589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-amyloid β Antibody Therapies for Alzheimer's Disease: Association between the Target of Amyloid β Aggregates and the Clinical Efficacy of Anti-amyloid β Antibody. 治疗阿尔茨海默病的抗淀粉样β抗体疗法：淀粉样蛋白β聚集靶点与抗淀粉样蛋白β抗体临床疗效之间的关联。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2026-01-01 Epub Date: 2024-10-11 DOI: 10.2169/internalmedicine.4604-24
Moeko Noguchi-Shinohara, Kenjiro Ono
{"title":"Anti-amyloid β Antibody Therapies for Alzheimer's Disease: Association between the Target of Amyloid β Aggregates and the Clinical Efficacy of Anti-amyloid β Antibody.","authors":"Moeko Noguchi-Shinohara, Kenjiro Ono","doi":"10.2169/internalmedicine.4604-24","DOIUrl":"10.2169/internalmedicine.4604-24","url":null,"abstract":"<p><p>Phase 3 clinical trials have validated the clinical efficacy of some anti-amyloid β (Aβ) antibody therapies, such as lecanemab and donanemab. To date, several clinical trials of anti-Aβ drugs have been conducted. However, most of these methods have been unsuccessful. Various Aβ aggregates are present during Aβ aggregation. The difference in the clinical efficacy of anti-Aβ antibody therapy may be attributed to variations in the Aβ aggregates targeted. Lecanemab primarily targets protofibrils, and donanemab targets plaques. Solanezumab and bapinezumab target Aβ aggregates of monomers alone or from monomers to low molecular weight oligomers. Anti-Aβ antibody therapies with clinical cognitive efficacy are thus characterized by targeting large-molecular-weight Aβ aggregates, such as protofibrils and plaques. In addition, a positive association was observed between the reduction in amyloid deposition and the inhibition of cognitive decline.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"67-70"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12854962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in Technology and Technique in Percutaneous Coronary Intervention: A Clinical Review. 经皮冠状动脉介入治疗的技术和工艺进展：临床回顾。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2026-01-01 Epub Date: 2024-09-27 DOI: 10.2169/internalmedicine.4505-24
Yuichi Saito, Yoshio Kobayashi
{"title":"Advances in Technology and Technique in Percutaneous Coronary Intervention: A Clinical Review.","authors":"Yuichi Saito, Yoshio Kobayashi","doi":"10.2169/internalmedicine.4505-24","DOIUrl":"10.2169/internalmedicine.4505-24","url":null,"abstract":"<p><p>Percutaneous coronary intervention (PCI) has become the standard procedure for patients with angina and acute coronary syndrome. From the perspective of technology and technique, PCI has advanced over the last four decades, resulting in considerably improved clinical outcomes in patients with coronary artery disease in the current era. In this review article, we summarize recent advances, promising technologies, and areas for research in the field of PCI.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"1-10"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12854948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Migraine Management in Japan: Current Approaches and Science Narrative Including an Evidence-based Review. 日本偏头痛的管理：当前的方法和科学叙述，包括基于证据的回顾。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2026-01-01 Epub Date: 2024-12-19 DOI: 10.2169/internalmedicine.4846-24
Takao Takeshima, Shoji Kikui, Daisuke Danno
{"title":"Migraine Management in Japan: Current Approaches and Science Narrative Including an Evidence-based Review.","authors":"Takao Takeshima, Shoji Kikui, Daisuke Danno","doi":"10.2169/internalmedicine.4846-24","DOIUrl":"10.2169/internalmedicine.4846-24","url":null,"abstract":"<p><p>Migraine is a prevalent and highly disabling neurological disorder. Recent progress in neuroscientific research has contributed to the development of new therapies for migraine, including triptans, ditans, calcitonin gene-related peptide (CGRP) antagonists, and CGRP-related monoclonal antibodies. Noninvasive neuromodulation devices have also been developed. We herein review the recent advances in research and the current standard of management for migraine patients.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"46-66"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12854955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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