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Monitoring Theophylline and Caffeine Levels in Suspected Toxicity Is a Good Tool for Physician. 监测疑似中毒者的茶碱和咖啡因水平是医生的好帮手。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-08-15 Epub Date: 2025-02-22 DOI: 10.2169/internalmedicine.3481-24
Alberto Farinetti, Anna Vittoria Mattioli
{"title":"Monitoring Theophylline and Caffeine Levels in Suspected Toxicity Is a Good Tool for Physician.","authors":"Alberto Farinetti, Anna Vittoria Mattioli","doi":"10.2169/internalmedicine.3481-24","DOIUrl":"10.2169/internalmedicine.3481-24","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2522"},"PeriodicalIF":1.1,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Variables That Predict Liver-related Events in Steatotic Liver Disease Diagnosed by a Liver Biopsy. 预测肝活检诊断的脂肪变性肝病肝脏相关事件的临床变量
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-08-15 Epub Date: 2025-02-08 DOI: 10.2169/internalmedicine.4770-24
Shinnosuke Okubo, Akinobu Takaki, Ikumi Sato, Takuya Adachi, Yasuto Takeuchi, Masahiko Sue, Nozomi Miyake, Hideki Onishi, Satoshi Hirohata, Motoyuki Otsuka
{"title":"Clinical Variables That Predict Liver-related Events in Steatotic Liver Disease Diagnosed by a Liver Biopsy.","authors":"Shinnosuke Okubo, Akinobu Takaki, Ikumi Sato, Takuya Adachi, Yasuto Takeuchi, Masahiko Sue, Nozomi Miyake, Hideki Onishi, Satoshi Hirohata, Motoyuki Otsuka","doi":"10.2169/internalmedicine.4770-24","DOIUrl":"10.2169/internalmedicine.4770-24","url":null,"abstract":"<p><p>Objective Identifying patients at high risk of steatotic liver disease (SLD) is crucial. The liver fibrosis stage is the most reliable marker of liver-related mortality. However, non-invasive risk stratification methods remain controversial. Therefore, we analyzed the risk of liver-related events in patients who underwent a liver biopsy for metabolic dysfunction-associated steatotic liver disease (MASLD) or cryptogenic SLD at our hospital. Methods We retrospectively reviewed the clinical course of the patients to identify the occurrence of liver-related events. Patients This study included 146 patients diagnosed with SLD through a liver biopsy. Results Liver-related events occurred in 20 patients and were more frequent in those with advanced fibrosis than in those without advanced fibrosis. However, patients with advanced steatosis exhibit reduced disease progression. Patients with obesity and/or diabetes complications had a lower stage of fibrosis and better prognosis than the others. The non-invasive fibrosis-4 (FIB-4) index and non-alcoholic fatty liver disease (NAFLD) prognosis-related \"NAFLD outcomes score (NOS)\" effectively differentiated patients with disease progression. Standard laboratory data analyses revealed that high total bilirubin and low albumin levels were risk factors. A multivariate analysis with significant factors other than NOS score revealed that the absence of obesity and/or diabetes complications, a high FIB-4 index, and a high total bilirubin level were independent factors for liver-related events. Conclusion A high NOS score, absence of obesity and/or diabetes complications, a high FIB-4 index, and high total bilirubin levels are risk factors for disease progression. Patients with lean phenotypes or non-diabetic SLD should also be assessed using non-invasive markers to determine their risks and potential outcomes.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2425-2432"},"PeriodicalIF":1.1,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Restricted Movement Associated with Unilateral Diffuse Fasciitis. 单侧弥漫性筋膜炎伴活动受限。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-08-15 Epub Date: 2025-02-08 DOI: 10.2169/internalmedicine.4892-24
Takuya Tomokawa, Yoshiro Horai, Kazusato Hara, Atsushi Kawakami
{"title":"Restricted Movement Associated with Unilateral Diffuse Fasciitis.","authors":"Takuya Tomokawa, Yoshiro Horai, Kazusato Hara, Atsushi Kawakami","doi":"10.2169/internalmedicine.4892-24","DOIUrl":"10.2169/internalmedicine.4892-24","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2518-2519"},"PeriodicalIF":1.1,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Afatinib Response to EGFR E709G-mutated Lung Cancer. 阿法替尼对EGFR e709g突变肺癌的应答
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-08-15 Epub Date: 2025-02-18 DOI: 10.2169/internalmedicine.4902-24
Tamio Okimoto, Tasuku Kato, Kojiro Hata, Yukari Tsubata
{"title":"The Afatinib Response to EGFR E709G-mutated Lung Cancer.","authors":"Tamio Okimoto, Tasuku Kato, Kojiro Hata, Yukari Tsubata","doi":"10.2169/internalmedicine.4902-24","DOIUrl":"10.2169/internalmedicine.4902-24","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2512-2513"},"PeriodicalIF":1.1,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Caffeine Intoxication in Which the Theophylline Level Served as an Indicator of the Treatment Course and the Caffeine Level Could Be Measured. 以茶碱水平作为治疗过程指标并可测定咖啡因水平的一例咖啡因中毒。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-08-15 Epub Date: 2025-02-22 DOI: 10.2169/internalmedicine.4997-24
Naoyuki Yoshimine, Nobuyuki Oba, Chika Hasegawa, Nanako Inoue, Hideki Nagumo, Makoto Arashiyama, Shinya Orihara, Shintaro Takahashi, Mitsuko Inuyama, Shuta Nishinakagawa
{"title":"Caffeine Intoxication in Which the Theophylline Level Served as an Indicator of the Treatment Course and the Caffeine Level Could Be Measured.","authors":"Naoyuki Yoshimine, Nobuyuki Oba, Chika Hasegawa, Nanako Inoue, Hideki Nagumo, Makoto Arashiyama, Shinya Orihara, Shintaro Takahashi, Mitsuko Inuyama, Shuta Nishinakagawa","doi":"10.2169/internalmedicine.4997-24","DOIUrl":"10.2169/internalmedicine.4997-24","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2523"},"PeriodicalIF":1.1,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pneumatosis Intestinalis Induced by Nintedanib. 尼达尼布致肠性肺肿。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-08-15 Epub Date: 2025-02-18 DOI: 10.2169/internalmedicine.4722-24
Satoshi Hamada, Naoya Tanabe, Toyohiro Hirai
{"title":"Pneumatosis Intestinalis Induced by Nintedanib.","authors":"Satoshi Hamada, Naoya Tanabe, Toyohiro Hirai","doi":"10.2169/internalmedicine.4722-24","DOIUrl":"10.2169/internalmedicine.4722-24","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2514-2515"},"PeriodicalIF":1.1,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Empyema Necessitatis with Pancreatic Involvement Caused by Actinomycosis. 放线菌病所致必要脓胸伴胰腺受累。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-08-15 Epub Date: 2025-02-01 DOI: 10.2169/internalmedicine.4893-24
Yasuyuki Hayashi, Akihiko Sokai, Toshiyuki Iwata, Takashi Nishimura
{"title":"Empyema Necessitatis with Pancreatic Involvement Caused by Actinomycosis.","authors":"Yasuyuki Hayashi, Akihiko Sokai, Toshiyuki Iwata, Takashi Nishimura","doi":"10.2169/internalmedicine.4893-24","DOIUrl":"10.2169/internalmedicine.4893-24","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2510-2511"},"PeriodicalIF":1.1,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rapid Development of a Hemorrhagic Hyperplastic Polyp in a Patient with Evolving Autoimmune Gastritis after Helicobacter pylori Eradication. 幽门螺杆菌根除后自身免疫性胃炎患者出血性增生性息肉的快速发展
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-08-15 Epub Date: 2025-02-08 DOI: 10.2169/internalmedicine.4701-24
Tohru Kotera, Takahiro Takemoto, Ryoji Kushima, Ken Haruma
{"title":"Rapid Development of a Hemorrhagic Hyperplastic Polyp in a Patient with Evolving Autoimmune Gastritis after Helicobacter pylori Eradication.","authors":"Tohru Kotera, Takahiro Takemoto, Ryoji Kushima, Ken Haruma","doi":"10.2169/internalmedicine.4701-24","DOIUrl":"10.2169/internalmedicine.4701-24","url":null,"abstract":"<p><p>In 2020, a 56-year-old woman with a history of Helicobacter pylori (H. pylori) eradication 9 years previously presented with a hemorrhagic hyperplastic polyp. Endoscopic and histological findings led to the diagnosis of advanced-stage autoimmune gastritis (AIG). A review of endoscopic findings from 2014 was available, and narrow-band imaging showed swelling of the gastric areas, characteristic of early-stage AIG. Together with the rapid growth of a hyperplastic polyp, these findings suggest a case of AIG that rapidly exacerbated after eradication. To our knowledge, this is the first case report of a rapidly developing hemorrhagic hyperplastic polyp associated with AIG after H. pylori eradication.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2446-2451"},"PeriodicalIF":1.1,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brachial Plexitis during Maintenance Atezolizumab after Palliative Radiotherapy for Cervical Spine Metastasis in Lung Cancer. 肺癌颈椎转移患者姑息放疗后阿特唑单抗维持期间的臂丛炎。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-08-15 Epub Date: 2025-02-18 DOI: 10.2169/internalmedicine.4623-24
Riko Kamada, Makoto Hibino, Saki Nakachi, Hikari Higa, Shigehiro Watanabe, Kazunari Maeda, Tetsuri Kondo
{"title":"Brachial Plexitis during Maintenance Atezolizumab after Palliative Radiotherapy for Cervical Spine Metastasis in Lung Cancer.","authors":"Riko Kamada, Makoto Hibino, Saki Nakachi, Hikari Higa, Shigehiro Watanabe, Kazunari Maeda, Tetsuri Kondo","doi":"10.2169/internalmedicine.4623-24","DOIUrl":"10.2169/internalmedicine.4623-24","url":null,"abstract":"<p><p>We present the case of a patient with lung cancer who developed brachial plexitis following treatment with immunochemotherapy, which included atezolizumab and palliative radiotherapy for a metastatic cervical spine tumor. This case highlights the importance of considering immune-related adverse events (irAEs) when initiating immune checkpoint inhibitor therapy, in addition to other recognized causes such as radiation, tumor compression and invasion, and paraneoplastic syndromes. While brachial plexitis has been reported as an irAE associated with programmed cell death 1 (PD-1) antibodies, this is the first report associated with the administration of programmed cell death ligand 1 (PD-L1) antibodies.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2484-2488"},"PeriodicalIF":1.1,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anemia-induced Claudication Mimicking Lumbar Spinal Stenosis. 贫血性跛行模拟腰椎管狭窄1例报告。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-08-15 Epub Date: 2025-02-08 DOI: 10.2169/internalmedicine.4955-24
Chihiro Sekine, Yasuhiro Kano, Kengo Murata
{"title":"Anemia-induced Claudication Mimicking Lumbar Spinal Stenosis.","authors":"Chihiro Sekine, Yasuhiro Kano, Kengo Murata","doi":"10.2169/internalmedicine.4955-24","DOIUrl":"10.2169/internalmedicine.4955-24","url":null,"abstract":"<p><p>Anemia is not known to cause intermittent claudication. We herein present the case of a 74-year-old male patient with intermittent claudication, in whom the primary symptom was severe iron-deficiency anemia. The characteristics of claudication mimicked a neurogenic disorder, but lumbar magnetic resonance imaging ruled out lumbar spinal stenosis, and the symptoms resolved after the anemia improved. This case highlights the need to consider anemia in the differential diagnosis of patients presenting with intermittent neurogenic claudication. A comprehensive evaluation, including tests to rule out anemia, is crucial for making an accurate diagnosis and carrying out the appropriate management of intermittent claudication.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2506-2509"},"PeriodicalIF":1.1,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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