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Obinutuzumab-induced Acute Thrombocytopenia Mimicking Immune Thrombocytopenia in a Patient with Follicular Lymphoma. 在滤泡性淋巴瘤患者中obinutuzumab诱导的急性血小板减少模拟免疫性血小板减少。
IF 1 4区 医学
Internal Medicine Pub Date : 2025-04-12 DOI: 10.2169/internalmedicine.5191-24
Misato Tane, Hiroki Hosoi, Takayuki Hiroi, Shogo Murata, Toshiki Mushino, Takashi Sonoki
{"title":"Obinutuzumab-induced Acute Thrombocytopenia Mimicking Immune Thrombocytopenia in a Patient with Follicular Lymphoma.","authors":"Misato Tane, Hiroki Hosoi, Takayuki Hiroi, Shogo Murata, Toshiki Mushino, Takashi Sonoki","doi":"10.2169/internalmedicine.5191-24","DOIUrl":"https://doi.org/10.2169/internalmedicine.5191-24","url":null,"abstract":"<p><p>Obinutuzumab-induced acute thrombocytopenia is characterized by a rapid decrease in the platelet count after administration. The underlying mechanisms remain unclear. However, we present novel laboratory findings related to its pathophysiology. A 65-year-old woman with follicular lymphoma developed acute thrombocytopenia within 24 hours after obinutuzumab administration. Laboratory results showed features resembling acute immune thrombocytopenic purpura, including an elevated immature platelet fraction, mildly increased thrombopoietin levels, elevated platelet-associated IgG, and refractory to platelet transfusion. Our case and her laboratory findings suggest that increased platelet consumption might be involved in the development of obinutuzumab-induced acute thrombocytopenia.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Delayed Hepatitis B Virus Reactivation at 33 Months after the Completion of Rituximab-based Chemotherapy. 完成利妥昔单抗化疗后33个月乙肝病毒延迟再激活
IF 1 4区 医学
Internal Medicine Pub Date : 2025-04-12 DOI: 10.2169/internalmedicine.5179-24
Banri Ogawa, Toshiro Kamoshida, Asaji Yamamoto, Yuji Yamaguchi, Yukako Hamano, Haruka Okawara, Atsushi Okawara, Nobushige Kakinoki, Shinji Hirai
{"title":"Delayed Hepatitis B Virus Reactivation at 33 Months after the Completion of Rituximab-based Chemotherapy.","authors":"Banri Ogawa, Toshiro Kamoshida, Asaji Yamamoto, Yuji Yamaguchi, Yukako Hamano, Haruka Okawara, Atsushi Okawara, Nobushige Kakinoki, Shinji Hirai","doi":"10.2169/internalmedicine.5179-24","DOIUrl":"https://doi.org/10.2169/internalmedicine.5179-24","url":null,"abstract":"<p><p>We herein report a case of hepatitis B virus (HBV) reactivation in a female patient in her 70s with isolated anti-hepatitis B core (IAHBc) antibodies (HB surface antigen (HBsAg)-negative, HB surface antibody (HBsAb)-negative, and HB core antibody (HBcAb)-positive), receiving rituximab-based chemotherapy for follicular lymphoma. Her serum HBV DNA was negative. The patient was treated with rituximab for 21 months, and 33 months after completion of treatment, her HBV DNA level increased to 5.1 Log IU/mL, and the patient developed hepatic failure. Tenofovir alafenamide fumarate treatment was initiated for HBV reactivation, and DNA was not detected 9 months later.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disseminated fusariosis successfully treated with empirical liposomal amphotericin B and voriconazole combination followed by ocular therapy in an allogenic hematopoietic stem cell transplant recipient. 经验性两性霉素B脂质体联合伏立康唑治疗弥散性镰状虫病成功一例同种异体造血干细胞移植受体眼部治疗。
IF 1 4区 医学
Internal Medicine Pub Date : 2025-04-12 DOI: 10.2169/internalmedicine.4657-24
Yuya Kishida, Masahiro Sakaguchi, Tomoyuki Kunishige, Atsushi Takeyoshi, Taichiro Tokura, Kazuki Inai, Ryosuke Kinoshita, Toshio Ibaraki, Satoshi Yamanaka, Toshio Asayama, Shunsuke Yui, Satoshi Wakita, Hiroki Yamaguchi
{"title":"Disseminated fusariosis successfully treated with empirical liposomal amphotericin B and voriconazole combination followed by ocular therapy in an allogenic hematopoietic stem cell transplant recipient.","authors":"Yuya Kishida, Masahiro Sakaguchi, Tomoyuki Kunishige, Atsushi Takeyoshi, Taichiro Tokura, Kazuki Inai, Ryosuke Kinoshita, Toshio Ibaraki, Satoshi Yamanaka, Toshio Asayama, Shunsuke Yui, Satoshi Wakita, Hiroki Yamaguchi","doi":"10.2169/internalmedicine.4657-24","DOIUrl":"https://doi.org/10.2169/internalmedicine.4657-24","url":null,"abstract":"<p><p>We report the case of a 61-year-old man with chronic myelomonocytic leukemia, who underwent unrelated peripheral blood stem cell transplantation. Fusariosis was suspected prior to identification of the fungal species, and voriconazole and liposomal amphotericin B combination therapy were administered. The patient developed fusarium-related endophthalmitis, accompanied by eye pain. Despite vitrectomy, the endophthalmitis was poorly controlled, and the left eye was enucleated. No recurrence of fusariosis was observed until death following multiple-organ failure due to steroid-resistant graft-versus-host disease.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of Diffuse Large B Cell Lymphoma in a Patient with Systemic Lupus Erythematosus within Two Years after the Initiation of Anifrolumab and Mycophenolate Mofetil Treatment. 一名系统性红斑狼疮患者在接受抗瘤单抗和霉酚酸酯治疗两年内发生弥漫性大B细胞淋巴瘤。
IF 1 4区 医学
Internal Medicine Pub Date : 2025-04-12 DOI: 10.2169/internalmedicine.5362-25
Takuya Matsubara, Masahiro Takita, Ikue Sekai, Naoya Omaru, Natsuki Okai, Masahiro Morita, Ken Kamata, Kosuke Minaga, Tomohiro Watanabe, Masatoshi Kudo
{"title":"Development of Diffuse Large B Cell Lymphoma in a Patient with Systemic Lupus Erythematosus within Two Years after the Initiation of Anifrolumab and Mycophenolate Mofetil Treatment.","authors":"Takuya Matsubara, Masahiro Takita, Ikue Sekai, Naoya Omaru, Natsuki Okai, Masahiro Morita, Ken Kamata, Kosuke Minaga, Tomohiro Watanabe, Masatoshi Kudo","doi":"10.2169/internalmedicine.5362-25","DOIUrl":"https://doi.org/10.2169/internalmedicine.5362-25","url":null,"abstract":"<p><p>Anifrolumab is a newly developed biological agent for patients with moderate-to-severe systemic lupus erythematosus (SLE). Anifrolumab neutralizes the signaling pathways mediated by type I interferons (IFNs), which are involved in viral clearance and anticancer immunity. Although susceptibility to viral infections has been reported in patients treated with anifrolumab, whether anifrolumab treatment increases the cancer risk in patients with SLE is unknown. We herin report a case of SLE that manifested as aggressive diffuse large B-cell lymphoma (DLBCL) after treatment with anifrolumab. The neutralization of type I IFNs by anifrolumab may promote the development of DLBCL owing to defective anticancer immunity.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of Pulmonary Artery Tumor Embolism. 肺动脉肿瘤栓塞1例。
IF 1 4区 医学
Internal Medicine Pub Date : 2025-04-12 DOI: 10.2169/internalmedicine.4818-24
Tomoka Kuroki, Haruka Sato, Tatsuhiro Ogami, Yoshiki Asayama
{"title":"A Case of Pulmonary Artery Tumor Embolism.","authors":"Tomoka Kuroki, Haruka Sato, Tatsuhiro Ogami, Yoshiki Asayama","doi":"10.2169/internalmedicine.4818-24","DOIUrl":"https://doi.org/10.2169/internalmedicine.4818-24","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early-onset Colorectal Cancer in a Patient with Li-Fraumeni Syndrome: A Case Series and Literature Review. Li-Fraumeni综合征患者的早发性结直肠癌：病例系列和文献综述。
IF 1 4区 医学
Internal Medicine Pub Date : 2025-04-12 DOI: 10.2169/internalmedicine.4945-24
Kazuki Sekiguchi, Iori Motoo, Takayuki Ando, Akira Noguchi, Rei Fukuda, Keiko Nomura, Yurika Nakayama, Shinya Kajiura, Yuko Ueda, Yuno Goto, Seitarou Shimada, Yusuke Takashima, Saeko Takahashi, Haruka Fujinami, Ichiro Yasuda
{"title":"Early-onset Colorectal Cancer in a Patient with Li-Fraumeni Syndrome: A Case Series and Literature Review.","authors":"Kazuki Sekiguchi, Iori Motoo, Takayuki Ando, Akira Noguchi, Rei Fukuda, Keiko Nomura, Yurika Nakayama, Shinya Kajiura, Yuko Ueda, Yuno Goto, Seitarou Shimada, Yusuke Takashima, Saeko Takahashi, Haruka Fujinami, Ichiro Yasuda","doi":"10.2169/internalmedicine.4945-24","DOIUrl":"https://doi.org/10.2169/internalmedicine.4945-24","url":null,"abstract":"<p><p>Screening for colorectal cancer (CRC) in individuals with Li-Fraumeni syndrome (LFS) typically recommends initiating colonoscopy at 25 years old. We herein report a case of LFS with dual CRC and liver metastasis diagnosed before the recommended screening age. A 17-year-old boy with a history of sarcoma underwent colonoscopy, revealing 2 advanced CRCs: neuroendocrine carcinoma in the descending colon and adenocarcinoma in the rectum, each displaying distinct histological features. In addition, a TP53 missense mutation (p.His193Arg) was detected by a detailed genetic examination. LFS is associated with a heightened risk of rapid progression to invasive carcinomas due to TP53 variants. Therefore, earlier initiation of colonoscopy screening may be necessary for patients with LFS.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intravenous Methylprednisolone for Acute Right Middle Cerebral Artery Occlusion in Granulomatosis Polyangiitis: A Case Report. 静脉注射甲基强的松龙治疗肉芽肿性多血管炎急性右大脑中动脉闭塞1例。
IF 1 4区 医学
Internal Medicine Pub Date : 2025-04-12 DOI: 10.2169/internalmedicine.4873-24
Tsubasa Watanabe, Nakako Tanaka-Mabuchi, Yuto Morishima, Takanori Hata, Ryosuke Ito, Sho Nakajima, Atsuhiko Shindo, Yuki Nakamura, Hideyuki Yoshioka, Koji Hashimoto, Kazumasa Shindo, Hiroyuki Kinouchi, Daiki Nakagomi, Yuji Ueno
{"title":"Intravenous Methylprednisolone for Acute Right Middle Cerebral Artery Occlusion in Granulomatosis Polyangiitis: A Case Report.","authors":"Tsubasa Watanabe, Nakako Tanaka-Mabuchi, Yuto Morishima, Takanori Hata, Ryosuke Ito, Sho Nakajima, Atsuhiko Shindo, Yuki Nakamura, Hideyuki Yoshioka, Koji Hashimoto, Kazumasa Shindo, Hiroyuki Kinouchi, Daiki Nakagomi, Yuji Ueno","doi":"10.2169/internalmedicine.4873-24","DOIUrl":"https://doi.org/10.2169/internalmedicine.4873-24","url":null,"abstract":"<p><p>A 17-year-old Japanese woman diagnosed with granulomatosis with polyangiitis (GPA) and was treated with immunotherapy suddenly developed an impaired consciousness, left hemiplegia, and conjugate eye deviation to the right. Magnetic resonance imaging showed an acute cerebral infarction in the right striatum and right middle cerebral artery (MCA) occlusion. As her GPA had worsened recently, intravenous methylprednisolone (IVMP) was started. Immediately after IVMP was started, recanalization of the MCA was detected on repeat cerebral angiography. Aspirin and argatroban dissolved the residual thrombi. A combination of IVMP and antithrombotic therapy may be effective for large-vessel occlusions associated with GPA.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiation-induced Osteosarcoma in the Thoracic Cavity 28 Years after Irradiation for a Benign Disease: An Autopsy Case. 良性疾病放疗后28年胸腔内放射诱发的骨肉瘤：一个尸检病例。
IF 1 4区 医学
Internal Medicine Pub Date : 2025-04-12 DOI: 10.2169/internalmedicine.5162-24
Shima Sunanaga, Yusuke Sunanaga, Hirotaka Uto, Jiro Nakashioya, Takafumi Hamada, Yusuke Fujino, Shuya Tanaka
{"title":"Radiation-induced Osteosarcoma in the Thoracic Cavity 28 Years after Irradiation for a Benign Disease: An Autopsy Case.","authors":"Shima Sunanaga, Yusuke Sunanaga, Hirotaka Uto, Jiro Nakashioya, Takafumi Hamada, Yusuke Fujino, Shuya Tanaka","doi":"10.2169/internalmedicine.5162-24","DOIUrl":"https://doi.org/10.2169/internalmedicine.5162-24","url":null,"abstract":"<p><p>A 60-year-old man with a history of radiation therapy 28 years ago for a benign disease (an aneurysmal bone cyst) was admitted with dyspnea and dysphagia. Computed tomography showed an 8-cm tumor invading the trachea and esophagus. His condition declined rapidly, and he died on day 27 of hospitalization. Autopsy revealed radiation-induced osteosarcoma. Radiation-induced sarcoma can develop even after radiotherapy for benign diseases, in which case the latency period might be longer. Furthermore, the prognosis depends on the location of the resectable tumor. Therefore, longer-term internal imaging follow-up should be performed after radiotherapy for benign diseases to detect early-stage sarcoma.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intravascular Large B-cell Lymphoma in a Nasal Polyp. 鼻息肉的血管内大b细胞淋巴瘤。
IF 1 4区 医学
Internal Medicine Pub Date : 2025-04-12 DOI: 10.2169/internalmedicine.4642-24
Ikuo Matsuda, Hiroshi Kono, Kyoko Yoshihara, Seiichi Hirota
{"title":"Intravascular Large B-cell Lymphoma in a Nasal Polyp.","authors":"Ikuo Matsuda, Hiroshi Kono, Kyoko Yoshihara, Seiichi Hirota","doi":"10.2169/internalmedicine.4642-24","DOIUrl":"https://doi.org/10.2169/internalmedicine.4642-24","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deep Vein Thrombosis Caused by Hip Ganglion. 髋关节神经节引起的深静脉血栓。
IF 1 4区 医学
Internal Medicine Pub Date : 2025-04-12 DOI: 10.2169/internalmedicine.4282-24
Yuhei Fujisawa, Shigeto Horita, Keiko Wakabayashi
{"title":"Deep Vein Thrombosis Caused by Hip Ganglion.","authors":"Yuhei Fujisawa, Shigeto Horita, Keiko Wakabayashi","doi":"10.2169/internalmedicine.4282-24","DOIUrl":"https://doi.org/10.2169/internalmedicine.4282-24","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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