Internal Medicine最新文献_第10页

Monitoring Theophylline and Caffeine Levels in Suspected Toxicity Is a Good Tool for Physician. 监测疑似中毒者的茶碱和咖啡因水平是医生的好帮手。

IF 1.1 4区医学

Internal Medicine Pub Date : 2025-08-15 Epub Date: 2025-02-22 DOI: 10.2169/internalmedicine.3481-24

Alberto Farinetti, Anna Vittoria Mattioli

引用次数: 0

Clinical Variables That Predict Liver-related Events in Steatotic Liver Disease Diagnosed by a Liver Biopsy. 预测肝活检诊断的脂肪变性肝病肝脏相关事件的临床变量

IF 1.1 4区医学

Internal Medicine Pub Date : 2025-08-15 Epub Date: 2025-02-08 DOI: 10.2169/internalmedicine.4770-24

Shinnosuke Okubo, Akinobu Takaki, Ikumi Sato, Takuya Adachi, Yasuto Takeuchi, Masahiko Sue, Nozomi Miyake, Hideki Onishi, Satoshi Hirohata, Motoyuki Otsuka

{"title":"Clinical Variables That Predict Liver-related Events in Steatotic Liver Disease Diagnosed by a Liver Biopsy.","authors":"Shinnosuke Okubo, Akinobu Takaki, Ikumi Sato, Takuya Adachi, Yasuto Takeuchi, Masahiko Sue, Nozomi Miyake, Hideki Onishi, Satoshi Hirohata, Motoyuki Otsuka","doi":"10.2169/internalmedicine.4770-24","DOIUrl":"10.2169/internalmedicine.4770-24","url":null,"abstract":"Objective Identifying patients at high risk of steatotic liver disease (SLD) is crucial. The liver fibrosis stage is the most reliable marker of liver-related mortality. However, non-invasive risk stratification methods remain controversial. Therefore, we analyzed the risk of liver-related events in patients who underwent a liver biopsy for metabolic dysfunction-associated steatotic liver disease (MASLD) or cryptogenic SLD at our hospital. Methods We retrospectively reviewed the clinical course of the patients to identify the occurrence of liver-related events. Patients This study included 146 patients diagnosed with SLD through a liver biopsy. Results Liver-related events occurred in 20 patients and were more frequent in those with advanced fibrosis than in those without advanced fibrosis. However, patients with advanced steatosis exhibit reduced disease progression. Patients with obesity and/or diabetes complications had a lower stage of fibrosis and better prognosis than the others. The non-invasive fibrosis-4 (FIB-4) index and non-alcoholic fatty liver disease (NAFLD) prognosis-related \"NAFLD outcomes score (NOS)\" effectively differentiated patients with disease progression. Standard laboratory data analyses revealed that high total bilirubin and low albumin levels were risk factors. A multivariate analysis with significant factors other than NOS score revealed that the absence of obesity and/or diabetes complications, a high FIB-4 index, and a high total bilirubin level were independent factors for liver-related events. Conclusion A high NOS score, absence of obesity and/or diabetes complications, a high FIB-4 index, and high total bilirubin levels are risk factors for disease progression. Patients with lean phenotypes or non-diabetic SLD should also be assessed using non-invasive markers to determine their risks and potential outcomes.","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2425-2432"},"PeriodicalIF":1.1,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Restricted Movement Associated with Unilateral Diffuse Fasciitis. 单侧弥漫性筋膜炎伴活动受限。

IF 1.1 4区医学

Internal Medicine Pub Date : 2025-08-15 Epub Date: 2025-02-08 DOI: 10.2169/internalmedicine.4892-24

Takuya Tomokawa, Yoshiro Horai, Kazusato Hara, Atsushi Kawakami

引用次数: 0

The Afatinib Response to EGFR E709G-mutated Lung Cancer. 阿法替尼对EGFR e709g突变肺癌的应答

IF 1.1 4区医学

Internal Medicine Pub Date : 2025-08-15 Epub Date: 2025-02-18 DOI: 10.2169/internalmedicine.4902-24

Tamio Okimoto, Tasuku Kato, Kojiro Hata, Yukari Tsubata

引用次数: 0

Caffeine Intoxication in Which the Theophylline Level Served as an Indicator of the Treatment Course and the Caffeine Level Could Be Measured. 以茶碱水平作为治疗过程指标并可测定咖啡因水平的一例咖啡因中毒。

IF 1.1 4区医学

Internal Medicine Pub Date : 2025-08-15 Epub Date: 2025-02-22 DOI: 10.2169/internalmedicine.4997-24

Naoyuki Yoshimine, Nobuyuki Oba, Chika Hasegawa, Nanako Inoue, Hideki Nagumo, Makoto Arashiyama, Shinya Orihara, Shintaro Takahashi, Mitsuko Inuyama, Shuta Nishinakagawa

引用次数: 0

Empyema Necessitatis with Pancreatic Involvement Caused by Actinomycosis. 放线菌病所致必要脓胸伴胰腺受累。

IF 1.1 4区医学

Internal Medicine Pub Date : 2025-08-15 Epub Date: 2025-02-01 DOI: 10.2169/internalmedicine.4893-24

Yasuyuki Hayashi, Akihiko Sokai, Toshiyuki Iwata, Takashi Nishimura

引用次数: 0

Rapid Development of a Hemorrhagic Hyperplastic Polyp in a Patient with Evolving Autoimmune Gastritis after Helicobacter pylori Eradication. 幽门螺杆菌根除后自身免疫性胃炎患者出血性增生性息肉的快速发展

IF 1.1 4区医学

Internal Medicine Pub Date : 2025-08-15 Epub Date: 2025-02-08 DOI: 10.2169/internalmedicine.4701-24

Tohru Kotera, Takahiro Takemoto, Ryoji Kushima, Ken Haruma

引用次数: 0

Brachial Plexitis during Maintenance Atezolizumab after Palliative Radiotherapy for Cervical Spine Metastasis in Lung Cancer. 肺癌颈椎转移患者姑息放疗后阿特唑单抗维持期间的臂丛炎。

IF 1.1 4区医学

Internal Medicine Pub Date : 2025-08-15 Epub Date: 2025-02-18 DOI: 10.2169/internalmedicine.4623-24

Riko Kamada, Makoto Hibino, Saki Nakachi, Hikari Higa, Shigehiro Watanabe, Kazunari Maeda, Tetsuri Kondo

引用次数: 0

Anemia-induced Claudication Mimicking Lumbar Spinal Stenosis. 贫血性跛行模拟腰椎管狭窄1例报告。

IF 1.1 4区医学

Internal Medicine Pub Date : 2025-08-15 Epub Date: 2025-02-08 DOI: 10.2169/internalmedicine.4955-24

Chihiro Sekine, Yasuhiro Kano, Kengo Murata

引用次数: 0

The Perception of Asthma, Chronic Obstructive Pulmonary Disease, Asthma and Chronic Obstructive Pulmonary Disease Overlap, and Cough Variant Asthma: A Retrospective Observational Study. 哮喘、慢性阻塞性肺疾病、哮喘和慢性阻塞性肺疾病重叠以及咳嗽变异性哮喘的认知：一项回顾性观察研究

IF 1.1 4区医学

Internal Medicine Pub Date : 2025-08-01 Epub Date: 2025-02-08 DOI: 10.2169/internalmedicine.4519-24

Yasushi Obase, Susumu Fukahori, Jun Iriki, Yusei Tsukamoto, Yuka Nagae, Shinnosuke Takemoto, Takahiro Takazono, Noriho Sakamoto, Takehiro Matsumoto, Chizu Fukushima, Tomoya Nishino, Hiroshi Mukae

{"title":"The Perception of Asthma, Chronic Obstructive Pulmonary Disease, Asthma and Chronic Obstructive Pulmonary Disease Overlap, and Cough Variant Asthma: A Retrospective Observational Study.","authors":"Yasushi Obase, Susumu Fukahori, Jun Iriki, Yusei Tsukamoto, Yuka Nagae, Shinnosuke Takemoto, Takahiro Takazono, Noriho Sakamoto, Takehiro Matsumoto, Chizu Fukushima, Tomoya Nishino, Hiroshi Mukae","doi":"10.2169/internalmedicine.4519-24","DOIUrl":"10.2169/internalmedicine.4519-24","url":null,"abstract":"Objective The prevalence rates of bronchial asthma (BA) and chronic obstructive pulmonary disease (COPD) are 3-11% and 8-16%, respectively, in the general Japanese adult population. Few reports on patients' perceptions of BA, cough variant asthma (CVA), COPD, and asthma and COPD overlap (ACO) are available in Japan, and we aimed to investigate the agreement between the perception and diagnosis of BA and COPD-related diseases. Methods The subjects were 229 datasets matched to the sex and age distribution of the Japanese population of 1,000 adult patients who underwent respiratory function tests and screening for each disease at Nagasaki University Hospital between July 2014 and July 2017. The patients' self-perceptions of diagnosed BA, CVA, COPD, emphysema, chronic bronchitis, and ACO were determined. Results In total, 229 datasets were included in this study. The prevalence of BA was 10.0% (23 cases, including 2 CVA and 6 ACO cases) and 11.8% (27 cases, including 6 ACO cases). The prevalence of ACO was 2.6% (28.6% of BA and 22.2% of COPD), and that of CVA was 0.9% (8.7% of BA). The perception of COPD-related diseases had a much lower sensitivity than that of asthma-related diseases (0.481 vs. 0.995, p<0.0001). Cohen's kappa for asthma-related disease was 0.976, and that for COPD-related disease was 0.621. Conclusion Self-perception of asthma-related disease was adequately high, whereas that of COPD-related disease was low. The prevalence rates of BA, COPD, ACO, and CVA in our study were 10.0%, 11.8%, 2.6%, and 0.9%, respectively. An increase in the perception of COPD may help improve community healthcare for respiratory diseases.","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2284-2289"},"PeriodicalIF":1.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0