发布求助
文献互助 智能选刊 最新文献

Internal Medicine最新文献

筛选
英文 中文
Associations between Immune-related Adverse Events and Prognosis in Cancer Patients Receiving Immune Checkpoint Inhibitor Therapy. 接受免疫检查点抑制剂治疗的癌症患者的免疫相关不良事件与预后之间的关系
IF 1.1 4区 医学
Internal Medicine Pub Date : 2026-01-01 Epub Date: 2024-11-21 DOI: 10.2169/internalmedicine.4654-24
Yusuke Inoue, Naoki Inui
{"title":"Associations between Immune-related Adverse Events and Prognosis in Cancer Patients Receiving Immune Checkpoint Inhibitor Therapy.","authors":"Yusuke Inoue, Naoki Inui","doi":"10.2169/internalmedicine.4654-24","DOIUrl":"10.2169/internalmedicine.4654-24","url":null,"abstract":"<p><p>The number of patients with cancer qualifying for treatment with immune checkpoint inhibitors (ICIs) continues to increase, and a clearer understanding of the mechanisms underlying their activity-driven side effects, or immune-related adverse events (irAEs), has become crucial. Patients receiving ICIs can develop irAEs in any organ, and numerous studies have suggested that irAE development may be associated with improved ICI efficacy. However, the robustness and magnitude of such associations are unclear, and little is known about the relationship between irAE development and ICI efficacy at the individual organ level. A precise understanding of these links could improve patient care and provide further insight into the immunological mechanisms underlying both irAE development and ICI efficacy. We herein review the prognostic implications of irAEs occurring in patients with cancer treated with ICIs and discuss outstanding issues that should be addressed in future studies.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"71-87"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12854964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Basis of Anti-Aβ Antibody Therapy: The Toxicity of Aβ Aggregates and the Mechanism of Action of Anti-Aβ Antibodies. 抗 Aβ 抗体疗法的基础：Aβ 聚集体的毒性和抗 Aβ 抗体的作用机制。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2026-01-01 Epub Date: 2024-10-04 DOI: 10.2169/internalmedicine.4569-24
Kenjiro Ono, Moeko Noguchi-Shinohara, Takahiro Watanabe-Nakayama
{"title":"The Basis of Anti-Aβ Antibody Therapy: The Toxicity of Aβ Aggregates and the Mechanism of Action of Anti-Aβ Antibodies.","authors":"Kenjiro Ono, Moeko Noguchi-Shinohara, Takahiro Watanabe-Nakayama","doi":"10.2169/internalmedicine.4569-24","DOIUrl":"10.2169/internalmedicine.4569-24","url":null,"abstract":"<p><p>In the pathophysiology of Alzheimer's disease (AD), the amyloid hypothesis, which posits that amyloid β-protein (Aβ) abnormally aggregates and damages neurons with tau, has been proposed. It was originally thought that the accumulation of insoluble amyloid fibrils in the brain leads to AD-inducing neurotoxicity; however, in recent years, the positioning of early and intermediate aggregates has also been emphasized. In particular, following the positive results of phase 3 clinical trials of lecanemab and its approval in Japan and the United States, the pathology of protofibrils, which are the target molecules of lecanemab, has attracted attention. Using high-speed atomic force microscopy, we have previously reported that lecanemab, which has a high affinity for protofibrils, binds to and surrounds them. Donanemab, a recombinant monoclonal antibody that primarily targets fibrils composed of N3pG Aβ, has also attracted attention because of its efficacy in phase 3 clinical trials in patients with early stage AD.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"41-45"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12854941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heart Regeneration for Clinical Application. 用于临床应用的心脏再生技术
IF 1.1 4区 医学
Internal Medicine Pub Date : 2026-01-01 Epub Date: 2024-11-21 DOI: 10.2169/internalmedicine.4711-24
Hidenori Tani, Masaki Ieda
{"title":"Heart Regeneration for Clinical Application.","authors":"Hidenori Tani, Masaki Ieda","doi":"10.2169/internalmedicine.4711-24","DOIUrl":"10.2169/internalmedicine.4711-24","url":null,"abstract":"<p><p>There are high expectations regarding heart regeneration for refractory heart failure (HF). Transplantation of human pluripotent stem cell (hPSC)-derived cardiomyocytes (CMs) is expected to replace CMs lost due to HF, and various studies have been conducted to apply this therapy clinically. Though issues such as arrhythmias and immune rejection remain, the mass production of purified hPSC-derived CMs, their efficient transplantation, and methods to improve their engraftment pushed up the transplantation of hPSC-derived CMs to the clinical stage. In contrast, a direct cardiac reprogramming method has been developed, where cardiac fibroblasts are directly converted into CM-like cells without undergoing PSCs by overexpressing reprogramming factors. Although many challenges still remain in the clinical application of direct cardiac reprogramming, this can be a novel treatment which overcomes issues of transplantation of hPSC-derived CMs.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"11-22"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12854963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent Advances and New Therapeutic Goals in the Management of Severe Asthma. 重症哮喘治疗的新进展和新目标。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2026-01-01 Epub Date: 2025-01-15 DOI: 10.2169/internalmedicine.5004-24
Tomoya Harada, Genki Inui, Miki Takata, Ryota Okazaki, Kosuke Yamaguchi, Akira Yamasaki
{"title":"Recent Advances and New Therapeutic Goals in the Management of Severe Asthma.","authors":"Tomoya Harada, Genki Inui, Miki Takata, Ryota Okazaki, Kosuke Yamaguchi, Akira Yamasaki","doi":"10.2169/internalmedicine.5004-24","DOIUrl":"10.2169/internalmedicine.5004-24","url":null,"abstract":"<p><p>Asthma is characterized by chronic airway inflammation as its primary pathological condition, which leads to various respiratory symptoms due to airway narrowing, with type 2 inflammation playing a central role. Asthma treatment, primarily centered on inhaled corticosteroids, aims to suppress type 2 inflammation and improve airway narrowing. However, severe asthma that cannot be controlled with high-dose inhaled corticosteroids or other asthma medications remains a clinical issue. The availability of multiple biological agents has recently improved the management of severe asthma. In addition, the concept of clinical remission has emerged as a treatment goal, further clarifying the objectives of asthma management. However, despite these advancements, the treatment of severe asthma driven primarily by non-type 2 inflammation remains a major challenge, and new biologics are currently being developed to address this issue.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"23-31"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12854958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CAR-T Therapy Can Be a Useful Treatment Modality for More Than Just Hematologic Malignancies. CAR-T 疗法不仅仅是治疗血液恶性肿瘤的有效方法。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2026-01-01 Epub Date: 2024-08-28 DOI: 10.2169/internalmedicine.4235-24
Kazuhiro Ikegame
{"title":"CAR-T Therapy Can Be a Useful Treatment Modality for More Than Just Hematologic Malignancies.","authors":"Kazuhiro Ikegame","doi":"10.2169/internalmedicine.4235-24","DOIUrl":"10.2169/internalmedicine.4235-24","url":null,"abstract":"<p><p>Chimeric antigen receptor-T-cell (CAR-T) therapy for hematologic malignancies has made significant advancements over the years, and it is now incorporated as a treatment algorithm. Early phase clinical trials are underway for various solid tumors, and the effectiveness of CAR-T cell therapy has been demonstrated for specific types of glioma and several solid tumors. However, its efficacy does not match that observed in hematological malignancies. Recently, a case series reported CAR-T cell therapy targeting CD19 for autoimmune diseases such as systemic lupus erythematosus, leading to a dramatic improvement in the clinical symptoms and the possibility of discontinuing immunosuppressive agents. Furthermore, CAR-T cell therapy is expected to be effective against various viruses and Aspergillus spp. Finally, attempts have been made to introduce CAR constructs into regulatory T cells to target their immunosuppressive effects. This article introduces the current progress in CAR-T cell therapy beyond the treatment of only hematologic malignancies and discusses future directions, considering the current medical situation in Japan.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"32-40"},"PeriodicalIF":1.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12854966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142092840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of Gastrointestinal Perforation in Guillain-Barré Syndrome. 格林-巴罗综合征并发胃肠道穿孔1例。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-11-15 Epub Date: 2025-05-15 DOI: 10.2169/internalmedicine.5190-24
Ryutaro Kimura, Toshiyuki Hayashi, Miki Fukazawa, Kazumi Kimura
{"title":"A Case of Gastrointestinal Perforation in Guillain-Barré Syndrome.","authors":"Ryutaro Kimura, Toshiyuki Hayashi, Miki Fukazawa, Kazumi Kimura","doi":"10.2169/internalmedicine.5190-24","DOIUrl":"10.2169/internalmedicine.5190-24","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"3322-3323"},"PeriodicalIF":1.1,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12702533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In-hospital Mortality after Bronchoscopy in Patients Receiving Direct Oral Anticoagulants and Those Who Were Not: A Matched-pair Cohort Study Using a Nationwide Japanese Inpatient Database. 接受直接口服抗凝剂和未接受直接口服抗凝剂的患者在支气管镜检查后的住院死亡率：一项使用日本全国住院患者数据库的配对队列研究
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-11-15 Epub Date: 2025-05-08 DOI: 10.2169/internalmedicine.5253-25
Nobuyasu Awano, Taisuke Jo, Takehiro Izumo, Hirokazu Urushiyama, Hiroki Matsui, Kiyohide Fushimi, Hideaki Watanabe, Hideo Yasunaga
{"title":"In-hospital Mortality after Bronchoscopy in Patients Receiving Direct Oral Anticoagulants and Those Who Were Not: A Matched-pair Cohort Study Using a Nationwide Japanese Inpatient Database.","authors":"Nobuyasu Awano, Taisuke Jo, Takehiro Izumo, Hirokazu Urushiyama, Hiroki Matsui, Kiyohide Fushimi, Hideaki Watanabe, Hideo Yasunaga","doi":"10.2169/internalmedicine.5253-25","DOIUrl":"10.2169/internalmedicine.5253-25","url":null,"abstract":"<p><p>Objective The number of patients using direct oral anticoagulants (DOACs) has recently increased. However, the association between DOAC use and bronchoscopy (BS) safety has not been elucidated. This study examined the association between BS and DOAC use and safety. Methods Using data from the Japanese Diagnosis Procedure Combination database from July 1, 2010, to March 31, 2022, patients taking DOACs who underwent BS (n=603, DOAC group) and those who did not (n=187,827, non-DOAC group) were identified. Then, 1:4 matched-pair cohort analyses were performed based on the institution, sex, age, and treatment year. The primary outcome was all-cause in-hospital mortality. The secondary outcomes were 28-day mortality, mechanical ventilation use, pneumothorax, bleeding, and thromboembolism after BS. Results A total of 603 and 2,320 patients taking and not taking DOAC, respectively, were identified via matching. The all-cause in-hospital mortality rates in the DOAC and non-DOAC groups were 12.1% and 5.8%, respectively. In a multivariable logistic regression analysis, the DOAC group had a significantly higher all-cause in-hospital mortality rate than the non-DOAC group (odds ratio = 2.84, 95% confidence interval = 1.77-4.55). Secondary and composite outcomes (mechanical ventilation, pneumothorax, bleeding, and thromboembolism after BS combined) were more frequent in the DOAC group than in the non-DOAC group. Conclusion DOACs were associated with mortality and complications in patients undergoing BS. Further studies comparing BS outcomes between patients with and without DOAC treatment are necessary.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"3197-3202"},"PeriodicalIF":1.1,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12702550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Autopsied Case of Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids for Over Four Years. 慢性淋巴细胞性炎症伴脑桥血管周围增强对类固醇反应超过4年的尸检病例。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-11-15 Epub Date: 2025-05-15 DOI: 10.2169/internalmedicine.4948-24
Yusuke Sonezaki, Wataru Shiraishi, Izumi Kinoshita, Hiroyuki Honda, Yusuke Nakazawa, Ayano Matsuyoshi, Yukiko Inamori, Haruka Sonezaki, Akihiro Masaki, Ryoma Tatsumoto, Hiroshi Suga, Masahiro Nakagaki, Yuji Hidaka, Fumiko Kuwahara, Kenji Harada, Hidetoshi Kanai
{"title":"An Autopsied Case of Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids for Over Four Years.","authors":"Yusuke Sonezaki, Wataru Shiraishi, Izumi Kinoshita, Hiroyuki Honda, Yusuke Nakazawa, Ayano Matsuyoshi, Yukiko Inamori, Haruka Sonezaki, Akihiro Masaki, Ryoma Tatsumoto, Hiroshi Suga, Masahiro Nakagaki, Yuji Hidaka, Fumiko Kuwahara, Kenji Harada, Hidetoshi Kanai","doi":"10.2169/internalmedicine.4948-24","DOIUrl":"10.2169/internalmedicine.4948-24","url":null,"abstract":"<p><p>Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a rare inflammatory disease of the central nervous system, and many details, including pathological findings, are still unclear. We herein report a man in his 70s who had been diagnosed with CLIPPERS 4.5 years ago. He was treated with corticosteroids, and his symptoms were managed; however, he eventually died of coronavirus disease 2019. A postmortem autopsy revealed perivascular lymphocyte aggregation and demyelination centered in the brainstem and cerebellum. This is the world's first autopsied case of CLIPPERS with more than four years of follow-up.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"3287-3293"},"PeriodicalIF":1.1,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12702542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary Chromomycosis Caused by Exophiala phaeomuriformis in a Patient with a Typical Pulmonary Carcinoid Tumor. 典型肺类癌患者由嗜霞光外孢子虫引起的肺色霉菌病1例。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-11-15 Epub Date: 2025-05-08 DOI: 10.2169/internalmedicine.5271-25
Saki Ito, Kiyonobu Takatsuki, Masahiro Katsurada, Naoyuki Kojima, Teruaki Hyakudo, Maho Morikawa, Shun Yamazaki, Yuki Yamamoto, Takuya Naito, Kazumi Kaneshiro, Yuko Kono, Masataka Matsumoto, Yoshihiro Nishimura
{"title":"Pulmonary Chromomycosis Caused by Exophiala phaeomuriformis in a Patient with a Typical Pulmonary Carcinoid Tumor.","authors":"Saki Ito, Kiyonobu Takatsuki, Masahiro Katsurada, Naoyuki Kojima, Teruaki Hyakudo, Maho Morikawa, Shun Yamazaki, Yuki Yamamoto, Takuya Naito, Kazumi Kaneshiro, Yuko Kono, Masataka Matsumoto, Yoshihiro Nishimura","doi":"10.2169/internalmedicine.5271-25","DOIUrl":"10.2169/internalmedicine.5271-25","url":null,"abstract":"<p><p>Exophiala spp. cause dematiaceous mycoses, but rarely infect human lungs. A 61-year-old man presented with bloody black sputum. Chest computed tomography showed consolidation in the truncus intermedius and peripheral bronchus, and a mass shadow in the S<sub>7</sub> region of the right lung. Bronchoscopy revealed a protruding black lesion in the bronchial orifice of the truncus intermedius, and Exophiala phaeomuriformis was isolated. The consolidation resolved spontaneously, and the residual tumor was diagnosed as a carcinoid tumor. This case highlights the fact that pulmonary chromomycosis may occur in immunocompetent individuals without any preexisting structural changes in the airways.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"3311-3315"},"PeriodicalIF":1.1,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12702546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
G-CSF-induced Aortitis Mimicking TIPIC Syndrome. g - csf诱导的模拟TIPIC综合征的主动脉炎。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-11-15 Epub Date: 2025-05-08 DOI: 10.2169/internalmedicine.5248-25
Takao Nagashima, Hiroki Yabe, Yasunobu Sekiguchi
{"title":"G-CSF-induced Aortitis Mimicking TIPIC Syndrome.","authors":"Takao Nagashima, Hiroki Yabe, Yasunobu Sekiguchi","doi":"10.2169/internalmedicine.5248-25","DOIUrl":"10.2169/internalmedicine.5248-25","url":null,"abstract":"<p><p>A 60-year-old woman with a history of malignant lymphoma was referred to us with fever, sore throat, right-sided neck pain, and swelling while she was currently undergoing chemotherapy. Imaging studies, including computed tomography and ultrasonography of the neck, revealed significant perivascular wall thickening of the right carotid artery, which was suggestive of giant cell arteritis. However, fever, neck pain, and swelling resolved spontaneously and rapidly. Transient perivascular inflammation of the carotid artery (TIPIC) syndrome was most likely. However, these symptoms developed shortly after the administration of granulocyte colony-stimulating factor (G-CSF). Accordingly, the patient was diagnosed with G-CSF-induced aortitis mimicking TIPIC syndrome.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"3302-3305"},"PeriodicalIF":1.1,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12702552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书