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A Serial Assessment of T1 and T2 Mapping Cardiac Magnetic Resonance before and after Heart Failure Onset in a Case of Cardiomyopathy in Anti-mitochondrial Antibody-positive Myositis. 1例抗线粒体抗体阳性肌炎心肌病心衰发病前后的T1和T2心脏磁共振成像序列评估
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-10-01 Epub Date: 2025-03-22 DOI: 10.2169/internalmedicine.5007-24
Mitsuru Ishizuka, Hideaki Suzuki, Satoshi Higuchi, Hidenobu Takagi, Naoki Suzuki, Rumiko Izumi, Hirofumi Watanabe, Haruka Sato, Taijyu Satoh, Saori Miyamichi-Yamamoto, Nobuhiro Yaoita, Kouki Takeuchi, Marina Arai, Hideka Hayashi, Kotaro Nochioka, Hiroyuki Takahama, Shunsuke Tatebe, Hiroshi Fujii, Masashi Aoki, Satoshi Yasuda
{"title":"A Serial Assessment of T1 and T2 Mapping Cardiac Magnetic Resonance before and after Heart Failure Onset in a Case of Cardiomyopathy in Anti-mitochondrial Antibody-positive Myositis.","authors":"Mitsuru Ishizuka, Hideaki Suzuki, Satoshi Higuchi, Hidenobu Takagi, Naoki Suzuki, Rumiko Izumi, Hirofumi Watanabe, Haruka Sato, Taijyu Satoh, Saori Miyamichi-Yamamoto, Nobuhiro Yaoita, Kouki Takeuchi, Marina Arai, Hideka Hayashi, Kotaro Nochioka, Hiroyuki Takahama, Shunsuke Tatebe, Hiroshi Fujii, Masashi Aoki, Satoshi Yasuda","doi":"10.2169/internalmedicine.5007-24","DOIUrl":"10.2169/internalmedicine.5007-24","url":null,"abstract":"<p><p>A 69-year-old woman presented with heart failure and progressive muscle weakness and was diagnosed as anti-mitochondrial antibody (AMA) myositis with cardiac involvement. Immunosuppressive therapy with prednisolone and intravenous cyclophosphamide significantly improved the symptoms, hemodynamics, and cardiac function. Cardiac magnetic resonance (CMR) T1 and T2 mapping showed elevated native T1, T2, and extracellular volume fractions during heart failure exacerbation (day 37) compared to pre-hospitalization values (10 months before admission) and follow-up conducted 6 and 12 months after admission. This case underscores the importance of comprehensive evaluation, such as serial CMR imaging and immunosuppressive therapy, in managing myocardial involvement in AMA-positive myositis.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2870-2875"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selective Intracoronary Injection of Nitrates Was Effective for Contrast Media-induced Type I Kounis Syndrome After Treatment with Steroids and Antihistamines. 选择性冠状动脉内注射硝酸盐对类固醇和抗组胺药物治疗后造影剂诱导的I型库尼斯综合征有效。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-10-01 Epub Date: 2025-03-29 DOI: 10.2169/internalmedicine.5094-24
Tasuku Kurokawa, Aoi Takahata, Tadateru Iwayama, Toshiki Sasaki, Takeshi Niizeki, Masafumi Watanabe
{"title":"Selective Intracoronary Injection of Nitrates Was Effective for Contrast Media-induced Type I Kounis Syndrome After Treatment with Steroids and Antihistamines.","authors":"Tasuku Kurokawa, Aoi Takahata, Tadateru Iwayama, Toshiki Sasaki, Takeshi Niizeki, Masafumi Watanabe","doi":"10.2169/internalmedicine.5094-24","DOIUrl":"10.2169/internalmedicine.5094-24","url":null,"abstract":"<p><p>A 77-year-old man presented for computed tomography (CT) with iodinated contrast for follow-up of gastric cancer. After contrast injection, the patient experienced cardiac arrest. A post-return spontaneous circulation electrocardiogram showed ST segment elevation in the inferior leads and V1-3. Since type I Kounis syndrome (KS) was suspected, corticosteroids and antihistamines were administered intravenously. Subsequently, coronary angiography (CAG) revealed coronary spasms, and selective intracoronary injection of nitrates successfully resolved each spasm. Strategic substitution of contrast media did not induce any additional allergic reactions. The optimal timing and preferred strategies for performing CAG in patients with KS were also discussed.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2887-2891"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disseminated Fusariosis Successfully Treated with Empirical Liposomal Amphotericin B and Voriconazole Combination Followed by Ocular Therapy in an Allogenic Hematopoietic Stem Cell Transplant Recipient. 经验性两性霉素B脂质体联合伏立康唑治疗弥散性镰状虫病成功一例同种异体造血干细胞移植受体眼部治疗。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-10-01 Epub Date: 2025-04-12 DOI: 10.2169/internalmedicine.4657-24
Yuya Kishida, Masahiro Sakaguchi, Tomoyuki Kunishige, Atsushi Takeyoshi, Taichiro Tokura, Kazuki Inai, Ryosuke Kinoshita, Toshio Ibaraki, Satoshi Yamanaka, Toshio Asayama, Shunsuke Yui, Satoshi Wakita, Hiroki Yamaguchi
{"title":"Disseminated Fusariosis Successfully Treated with Empirical Liposomal Amphotericin B and Voriconazole Combination Followed by Ocular Therapy in an Allogenic Hematopoietic Stem Cell Transplant Recipient.","authors":"Yuya Kishida, Masahiro Sakaguchi, Tomoyuki Kunishige, Atsushi Takeyoshi, Taichiro Tokura, Kazuki Inai, Ryosuke Kinoshita, Toshio Ibaraki, Satoshi Yamanaka, Toshio Asayama, Shunsuke Yui, Satoshi Wakita, Hiroki Yamaguchi","doi":"10.2169/internalmedicine.4657-24","DOIUrl":"10.2169/internalmedicine.4657-24","url":null,"abstract":"<p><p>We report the case of a 61-year-old man with chronic myelomonocytic leukemia, who underwent unrelated peripheral blood stem cell transplantation. Fusariosis was suspected prior to identification of the fungal species, and voriconazole and liposomal amphotericin B combination therapy were administered. The patient developed fusarium-related endophthalmitis, accompanied by eye pain. Despite vitrectomy, the endophthalmitis was poorly controlled, and the left eye was enucleated. No recurrence of fusariosis was observed until death following multiple-organ failure due to steroid-resistant graft-versus-host disease.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2907-2912"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Biologics against Interleukin-5 Administered to Patients with Eosinophilic Gastroenteritis. 抗白细胞介素-5生物制剂治疗嗜酸性胃肠炎的疗效
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-10-01 Epub Date: 2025-03-15 DOI: 10.2169/internalmedicine.5029-24
Kazuya Miyaguchi, Hisashi Matsumoto, Rie Shiomi, Hiroshi Yamaguchi, Yoshikazu Tsuzuki, Hiroyuki Imaeda
{"title":"Effect of Biologics against Interleukin-5 Administered to Patients with Eosinophilic Gastroenteritis.","authors":"Kazuya Miyaguchi, Hisashi Matsumoto, Rie Shiomi, Hiroshi Yamaguchi, Yoshikazu Tsuzuki, Hiroyuki Imaeda","doi":"10.2169/internalmedicine.5029-24","DOIUrl":"10.2169/internalmedicine.5029-24","url":null,"abstract":"<p><p>Biologics against interleukin-5 were administered to five patients with eosinophilic gastroenteritis (EGE) and bronchial asthma (BA). BA and abdominal symptoms as well as changes in steroid dose and the blood eosinophil count were examined. The man-to-woman ratio was 1:4. The average age of onset was 63 years old. The duration of the disease was three to nine years. Four patients showed improved BA symptoms with mepolizumab or benralizumab, and three successfully discontinued steroids. Regarding abdominal symptoms, mepolizumab was effective in one of three cases, while benralizumab improved symptoms in three of four cases. Biologics targeting interleukin-5 are effective in some patients with EGE accompanied by BA.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2846-2851"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Central-venous Catheter Insertion in Progressive-fibrosing Interstitial Lung Disease. 进行性纤维化间质性肺病中心静脉导管置入。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-10-01 Epub Date: 2025-03-22 DOI: 10.2169/internalmedicine.5203-24
Masaki Anzai, Ai Takeuchi, Miho Mitsui, Tamotsu Ishizuka
{"title":"Central-venous Catheter Insertion in Progressive-fibrosing Interstitial Lung Disease.","authors":"Masaki Anzai, Ai Takeuchi, Miho Mitsui, Tamotsu Ishizuka","doi":"10.2169/internalmedicine.5203-24","DOIUrl":"10.2169/internalmedicine.5203-24","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2915-2916"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunosuppressive Drug-associated Lymphoproliferative Disease with a Cardiac Mass. 伴心脏肿块的免疫抑制药物相关淋巴细胞增生性疾病
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-10-01 Epub Date: 2025-03-22 DOI: 10.2169/internalmedicine.5184-24
Wataru Sone, Kaho Hayashi, Taito Miyake, Katsunori Kyoda
{"title":"Immunosuppressive Drug-associated Lymphoproliferative Disease with a Cardiac Mass.","authors":"Wataru Sone, Kaho Hayashi, Taito Miyake, Katsunori Kyoda","doi":"10.2169/internalmedicine.5184-24","DOIUrl":"10.2169/internalmedicine.5184-24","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2922-2923"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of Pulmonary Artery Tumor Embolism. 肺动脉肿瘤栓塞1例。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-10-01 Epub Date: 2025-04-12 DOI: 10.2169/internalmedicine.4818-24
Tomoka Kuroki, Haruka Sato, Tatsuhiro Ogami, Yoshiki Asayama
{"title":"A Case of Pulmonary Artery Tumor Embolism.","authors":"Tomoka Kuroki, Haruka Sato, Tatsuhiro Ogami, Yoshiki Asayama","doi":"10.2169/internalmedicine.4818-24","DOIUrl":"10.2169/internalmedicine.4818-24","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2919-2920"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Difficulty in Identifying the Source of Hemorrhage in Duodenal Diverticula Bleeding. 十二指肠憩室出血难辨出血来源1例报告。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-10-01 Epub Date: 2025-03-29 DOI: 10.2169/internalmedicine.5222-24
Fumioki Toyoda, Tomoaki Matsumori, Atsushi Matsumoto, Hirotaka Kashima, Sho Matsuyama, Taro Ueo, Hiroshi Seno
{"title":"Difficulty in Identifying the Source of Hemorrhage in Duodenal Diverticula Bleeding.","authors":"Fumioki Toyoda, Tomoaki Matsumori, Atsushi Matsumoto, Hirotaka Kashima, Sho Matsuyama, Taro Ueo, Hiroshi Seno","doi":"10.2169/internalmedicine.5222-24","DOIUrl":"10.2169/internalmedicine.5222-24","url":null,"abstract":"<p><p>Duodenal diverticular bleeding is a rare cause of upper gastrointestinal bleeding. We herein report a case of life-threatening duodenal diverticular bleeding with hypovolemic shock. Identifying the source of the hemorrhaging was difficult, and repeated endoscopic examinations - one colonoscopy and three esophagogastroduodenoscopy sessions - were required before the source was finally detected inside the diverticulum located in the third part of the duodenum. Hemostasis was successfully achieved using the hemoclips. Our case highlights the need to consider duodenal diverticulum bleeding in cases of suspected upper gastrointestinal bleeding without a clear source of bleeding.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2858-2862"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship between Daily Physical Activity and Muscle Cramping in Elderly Liver Cirrhosis Patients: A Multicenter Study. 老年肝硬化患者日常体力活动与肌肉痉挛的关系——一项多中心研究
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-10-01 Epub Date: 2025-03-29 DOI: 10.2169/internalmedicine.5189-24
Atsushi Hiraoka, Tadashi Namisaki, Masato Nakai, Nagisa Hara, Hirokazu Takahashi, Yuichiro Eguchi, Hideko Ohama, Fujimasa Tada, Naoya Sakamoto, Hitoshi Yoshiji
{"title":"Relationship between Daily Physical Activity and Muscle Cramping in Elderly Liver Cirrhosis Patients: A Multicenter Study.","authors":"Atsushi Hiraoka, Tadashi Namisaki, Masato Nakai, Nagisa Hara, Hirokazu Takahashi, Yuichiro Eguchi, Hideko Ohama, Fujimasa Tada, Naoya Sakamoto, Hitoshi Yoshiji","doi":"10.2169/internalmedicine.5189-24","DOIUrl":"10.2169/internalmedicine.5189-24","url":null,"abstract":"<p><p>Objective Sarcopenia is a common secondary muscle-related complication observed in patients with chronic liver disease (CLD), along with muscle cramping. The present study aimed to assess the daily activity levels to explore the relationship between the number of steps taken and muscle cramping in patients with liver cirrhosis (LC) in Japan. Methods Fifty patients were enrolled (male 25, Child-Pugh A, B=42:8). Daily steps were recorded over six months using a pedometer, and seasonal sub-analyses were performed. Sarcopenia was diagnosed in accordance with the guidelines of the Japan Society of Hepatology. Results The median number of steps per day was 3,881, with no significant seasonal differences. Muscle cramping, reduced handgrip strength and sarcopenia were noted in 66.0%, 34.0% and 23.9% of the patients, respectively. However, no significant relationships were found between muscle cramping, handgrip strength, and the average number of steps per day. Although no significant differences in daily steps were noted in the comparisons of patients with varying degrees of hepatic function or the sarcopenia status, those with muscle cramping had a worse modified ALBI grade (≥2b) than those without (42.4% vs. 5.9%, p=0.009). The median average number of steps per day was not significantly different between the patients with and without muscle cramping (3,673 vs. 4,775, p=0.292). Conclusion The present study revealed that the average number of steps per day in LC patients is low. Although no significant relationship between daily activity and muscle cramping was observed, the establishment of appropriate intervention strategies to maintain daily activity and prevent sarcopenia progression is urgently required.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2817-2822"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deep Vein Thrombosis Caused by Hip Ganglion. 髋关节神经节引起的深静脉血栓。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-10-01 Epub Date: 2025-04-12 DOI: 10.2169/internalmedicine.4282-24
Yuhei Fujisawa, Shigeto Horita, Keiko Wakabayashi
{"title":"Deep Vein Thrombosis Caused by Hip Ganglion.","authors":"Yuhei Fujisawa, Shigeto Horita, Keiko Wakabayashi","doi":"10.2169/internalmedicine.4282-24","DOIUrl":"10.2169/internalmedicine.4282-24","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2924-2925"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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