Internal Medicine最新文献

筛选
英文 中文
Intraductal Papillary Neoplasm of the Bile Duct Occurring 37 Years after Surgery for Congenital Biliary Dilatation: A Case Report.
IF 1 4区 医学
Internal Medicine Pub Date : 2024-12-19 DOI: 10.2169/internalmedicine.4477-24
Hidehito Sumiya, Daiki Kuboki, Kyohei Ariake, Shinsuke Koshita, Yoshihide Kanno, Takahisa Ogawa, Hiroaki Kusunose, Toshitaka Sakai, Keisuke Yonamine, Kazuaki Miyamoto, Fumisato Kozakai, Haruka Okano, Yuto Matsuoka, Kento Hosokawa, Masaya Oikawa, Takashi Sawai, Yutaka Noda, Kei Ito
{"title":"Intraductal Papillary Neoplasm of the Bile Duct Occurring 37 Years after Surgery for Congenital Biliary Dilatation: A Case Report.","authors":"Hidehito Sumiya, Daiki Kuboki, Kyohei Ariake, Shinsuke Koshita, Yoshihide Kanno, Takahisa Ogawa, Hiroaki Kusunose, Toshitaka Sakai, Keisuke Yonamine, Kazuaki Miyamoto, Fumisato Kozakai, Haruka Okano, Yuto Matsuoka, Kento Hosokawa, Masaya Oikawa, Takashi Sawai, Yutaka Noda, Kei Ito","doi":"10.2169/internalmedicine.4477-24","DOIUrl":"https://doi.org/10.2169/internalmedicine.4477-24","url":null,"abstract":"<p><p>We present the case of a 54-year-old woman who was diagnosed with intraductal papillary neoplasm of the bile duct (IPNB) in the remnant intrapancreatic bile duct, 37 years after surgery for congenital biliary dilatation. Endoscopic ultrasonography revealed a papillary, low-echoic mass in the intrapancreatic bile duct, and peroral cholangioscopy revealed a papillary mucosa. A pancreaticoduodenectomy was performed, and the patient was pathologically diagnosed with type 1 pancreatobiliary-type IPNB with associated invasive carcinoma. As a similar atypical epithelium was identified in the pancreatic duct, it was suggested that the IPNB extended longitudinally to the pancreatic duct through the common channel.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Characteristics and Management Considerations of Late-onset Rheumatoid Arthritis. 晚发性类风湿关节炎的特点和管理注意事项。
IF 1 4区 医学
Internal Medicine Pub Date : 2024-12-15 Epub Date: 2024-05-02 DOI: 10.2169/internalmedicine.3786-24
Ryusuke Yoshimi, Hideaki Nakajima
{"title":"The Characteristics and Management Considerations of Late-onset Rheumatoid Arthritis.","authors":"Ryusuke Yoshimi, Hideaki Nakajima","doi":"10.2169/internalmedicine.3786-24","DOIUrl":"10.2169/internalmedicine.3786-24","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"3267-3269"},"PeriodicalIF":1.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140856311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hermansky-Pudlak Syndrome with an Improvement in the Respiratory Symptoms after the Administration of Pirfenidone. 服用吡非尼酮后呼吸道症状有所改善的赫尔曼斯基-普德拉克综合征:病例报告。
IF 1 4区 医学
Internal Medicine Pub Date : 2024-12-15 Epub Date: 2024-05-09 DOI: 10.2169/internalmedicine.3459-24
Yoshinao Ono, Naoki Tode, Yuri Yamamoto, Chikashi Iwasaki, Shuichi Konno, Hatsumi Sugiyama, Takuto Endo, Shunichi Takeda, Shuichiro Matsumoto, Tadahisa Numakura, Tomohiro Ichikawa, Tsutomu Tamada, Hisatoshi Sugiura
{"title":"Hermansky-Pudlak Syndrome with an Improvement in the Respiratory Symptoms after the Administration of Pirfenidone.","authors":"Yoshinao Ono, Naoki Tode, Yuri Yamamoto, Chikashi Iwasaki, Shuichi Konno, Hatsumi Sugiyama, Takuto Endo, Shunichi Takeda, Shuichiro Matsumoto, Tadahisa Numakura, Tomohiro Ichikawa, Tsutomu Tamada, Hisatoshi Sugiura","doi":"10.2169/internalmedicine.3459-24","DOIUrl":"10.2169/internalmedicine.3459-24","url":null,"abstract":"<p><p>Herein, we report a case of Hermansky-Pudlak syndrome (HPS) in which respiratory symptoms improved with pirfenidone treatment. A 43-year-old Japanese woman with oculocutaneous albinism presented with a cough and dyspnea. High-resolution computed tomography revealed areas of reticular and frosted lung opacities. The diagnosis of HPS was confirmed by a prolonged bleeding time and HPS1 gene mutation. Generally, there is no effective treatment for interstitial pneumonia associated with HPS except for lung transplantation. In the present case, the cough and dyspnea improved with pirfenidone administration. Therefore, clinicians should administer pirfenidone in challenging transplantation cases and during the waiting period for transplantation.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"3353-3358"},"PeriodicalIF":1.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140891744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Incidence and Influencing Factors of In-hospital Frailty Progression following Transcatheter Aortic Valve Implantation. 经导管主动脉瓣植入术后院内虚弱进展的发生率和影响因素。
IF 1 4区 医学
Internal Medicine Pub Date : 2024-12-15 Epub Date: 2024-05-09 DOI: 10.2169/internalmedicine.3146-23
Tatsuya Miyazaki, Akihito Tanaka, Yoshiyuki Tokuda, Yoshinori Shirai, Koji Mizutani, Kenji Furusawa, Sho Akita, Takahiro Ozeki, Kiyonori Kobayashi, Hideki Ishii, Masato Mutsuga, Toyoaki Murohara
{"title":"The Incidence and Influencing Factors of In-hospital Frailty Progression following Transcatheter Aortic Valve Implantation.","authors":"Tatsuya Miyazaki, Akihito Tanaka, Yoshiyuki Tokuda, Yoshinori Shirai, Koji Mizutani, Kenji Furusawa, Sho Akita, Takahiro Ozeki, Kiyonori Kobayashi, Hideki Ishii, Masato Mutsuga, Toyoaki Murohara","doi":"10.2169/internalmedicine.3146-23","DOIUrl":"10.2169/internalmedicine.3146-23","url":null,"abstract":"<p><p>Objective Patients undergoing transcatheter aortic valve implantation (TAVI) are generally older and frailty is therefore an important clinical issue. The baseline degree of frailty is associated with the prognosis in patients undergoing TAVI; however, the incidence of in-hospital frailty progression and its influencing factors have not yet been elucidated. Methods This observational, single-center study retrospectively evaluated 281 patients who underwent TAVI. The degree of frailty at baseline and discharge was evaluated using the Clinical Frailty Scale (CFS). In-hospital frailty progression was defined as an increase of at least one level in the CFS score at discharge from baseline, and predictors of frailty progression were assessed. Results The median baseline CFS score was 4.0 (interquartile range: 3.0-4.0). In-hospital frailty progression was observed in 49 patients (17.4%). No significant differences were observed in age, sex, comorbidities, or surgical risk scores between patients with and without frailty progression. Patients with frailty progression experienced stroke more frequently during hospitalization than those without (12.2% vs. 1.3%, p=0.001). A multivariable logistic analysis showed that in-hospital stroke was a significant predictor of frailty progression (odds ratio, 10.7; 95% confidence interval: 2.34-49.2, p=0.002). Patients with frailty progression had a longer hospital stay than those without frailty progression [7.0 (4.0-17.0) vs. 4.0 (4.0-8.0) days, p=0.001]. Conclusion In-hospital frailty progression was not uncommon in patients undergoing TAVI. Stroke incidence was a significant influencing factor in frailty progression, whereas baseline comorbidities and surgical risks were not.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"3283-3289"},"PeriodicalIF":1.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140891694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subarachnoid Hemorrhaging with Multiple Cerebral Artery Stenoses after Initiating Remission Induction Therapy for Eosinophilic Granulomatosis with Polyangiitis. 嗜酸性粒细胞增多症伴多发性洋炎症启动缓解诱导疗法后出现蛛网膜下腔出血并伴有多处脑动脉狭窄:病例报告。
IF 1 4区 医学
Internal Medicine Pub Date : 2024-12-15 Epub Date: 2024-05-09 DOI: 10.2169/internalmedicine.3583-24
Haruka Yasuba, Hirotaka Yamada, Masaya Togo, Kento Matoba, Eriko Yamamoto Kashihara, Keisuke Nishimura, Sho Sendo, Yo Ueda, Jun Saegusa
{"title":"Subarachnoid Hemorrhaging with Multiple Cerebral Artery Stenoses after Initiating Remission Induction Therapy for Eosinophilic Granulomatosis with Polyangiitis.","authors":"Haruka Yasuba, Hirotaka Yamada, Masaya Togo, Kento Matoba, Eriko Yamamoto Kashihara, Keisuke Nishimura, Sho Sendo, Yo Ueda, Jun Saegusa","doi":"10.2169/internalmedicine.3583-24","DOIUrl":"10.2169/internalmedicine.3583-24","url":null,"abstract":"<p><p>We encountered a 64-year-old Japanese woman who developed subarachnoid hemorrhaging (SAH) with multiple cerebral artery stenoses during remission induction therapy for eosinophilic granulomatosis and polyangiitis (EGPA). The treatment involved intensified steroid pulse therapy and continued intravenous cyclophosphamide pulse therapy, which led to beneficial effects. Given the rarity of multiple EGPA-associated cerebral artery stenoses and SAH, it is crucial to differentiate them from other diseases. The mortality rate of EGPA complicated by intracranial hemorrhagic lesions, including SAH, is high. When headache is present at the onset of EGPA, the possibility of SAH must be considered.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"3389-3394"},"PeriodicalIF":1.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140891691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cholesterol Crystal Embolism: Autopsy-proven Gastrointestinal Lesions, Pancreatitis, and End-stage Kidney Disease Which Developed after Undergoing Selective Abdominal Angiography. 胆固醇晶体栓塞:尸检证实接受选择性腹部血管造影术后出现胃肠道病变、胰腺炎和终末期肾病。
IF 1 4区 医学
Internal Medicine Pub Date : 2024-12-15 Epub Date: 2024-05-09 DOI: 10.2169/internalmedicine.3469-24
Naoki Yamamoto, Norihiko Sakai, Daichi Kaikoi, Daichi Yomogida, Sho Kajikawa, Takaaki Wada, Takahiro Yuasa, Hisayuki Ogura, Koichi Sato, Taro Miyagawa, Shinji Kitajima, Tadashi Toyama, Akinori Hara, Miho Shimizu, Takashi Wada, Yasunori Iwata
{"title":"Cholesterol Crystal Embolism: Autopsy-proven Gastrointestinal Lesions, Pancreatitis, and End-stage Kidney Disease Which Developed after Undergoing Selective Abdominal Angiography.","authors":"Naoki Yamamoto, Norihiko Sakai, Daichi Kaikoi, Daichi Yomogida, Sho Kajikawa, Takaaki Wada, Takahiro Yuasa, Hisayuki Ogura, Koichi Sato, Taro Miyagawa, Shinji Kitajima, Tadashi Toyama, Akinori Hara, Miho Shimizu, Takashi Wada, Yasunori Iwata","doi":"10.2169/internalmedicine.3469-24","DOIUrl":"10.2169/internalmedicine.3469-24","url":null,"abstract":"<p><p>A 78-year-old man with atherosclerosis was diagnosed with hepatocellular carcinoma by transfemoral angiography of the celiac and superior mesenteric arteries (SMA). After surgery, a serum examination revealed progressive renal failure with eosinophilia, leading to end-stage kidney disease, in addition to active gastric ulcers and pancreatitis. Cyanosis in the bilateral toes showed a cholesterol crystal embolism (CCE) in a skin biopsy. Autopsy revealed that CCE involved the arterioles of multiple organs, and its distribution was anatomically consistent with the vascular territories of the celiac artery and SMA. CCE should therefore be considered in patients presenting with multiple types of tissue damage in the vascular territories after angiography.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"3325-3331"},"PeriodicalIF":1.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140891740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Type 1 Diabetes Mellitus with Diabetic Ketoacidosis Presenting with Transient Severe Fatty Liver and Subsequent Liver Dysfunction. 一例 1 型糖尿病并发糖尿病酮症酸中毒,表现为一过性严重脂肪肝及随后的肝功能障碍。
IF 1 4区 医学
Internal Medicine Pub Date : 2024-12-15 Epub Date: 2024-05-09 DOI: 10.2169/internalmedicine.3488-24
Takayuki Suzuki, Kazuki Orime, Ryoichi Akamatsu, Tomoaki Akiyama, Tadashi Yamakawa, Yasuo Terauchi
{"title":"Type 1 Diabetes Mellitus with Diabetic Ketoacidosis Presenting with Transient Severe Fatty Liver and Subsequent Liver Dysfunction.","authors":"Takayuki Suzuki, Kazuki Orime, Ryoichi Akamatsu, Tomoaki Akiyama, Tadashi Yamakawa, Yasuo Terauchi","doi":"10.2169/internalmedicine.3488-24","DOIUrl":"10.2169/internalmedicine.3488-24","url":null,"abstract":"<p><p>Patients often present with severe fatty liver (FL) due to insulin deficiency at the onset of diabetic ketoacidosis (DKA). On the other hand, glycogenic hepatopathy (GH) is a possible cause of liver dysfunction in patients with DKA. We herein report a case of type 1 diabetes mellitus with severe FL at the onset of DKA, who demonstrated subsequent marked liver dysfunction after achieving an improvement of FL. As liver dysfunction persisted even after the FL improved, GH was suspected to be the cause of liver dysfunction. FL and GH have different prognoses and should therefore be differentiated using imaging studies and biopsies.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"3339-3344"},"PeriodicalIF":1.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140891678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myasthenic Crisis and Concomitant Takotsubo Syndrome Complicated by Shock. 肌无力危象和休克并发的塔克次氏综合征:病例报告。
IF 1 4区 医学
Internal Medicine Pub Date : 2024-12-15 Epub Date: 2024-05-09 DOI: 10.2169/internalmedicine.3306-23
Moeko Omiya, Yusuke Morii, Masako Mukai, Yuya Mitsuhashi, Ken Kato, Toshiaki Isogai
{"title":"Myasthenic Crisis and Concomitant Takotsubo Syndrome Complicated by Shock.","authors":"Moeko Omiya, Yusuke Morii, Masako Mukai, Yuya Mitsuhashi, Ken Kato, Toshiaki Isogai","doi":"10.2169/internalmedicine.3306-23","DOIUrl":"10.2169/internalmedicine.3306-23","url":null,"abstract":"<p><p>A man in his 80s with myasthenia gravis (MG) developed dysmobility and chest discomfort. An electrocardiogram revealed ST-segment elevation, and coronary angiography revealed Takotsubo syndrome (TTS). He experienced myasthenic crisis that required ventilation and shock that was refractory to vasopressors and required intra-aortic balloon pump (IABP) insertion. He was managed conservatively without MG-specific treatment until his hemodynamics improved. On hospital day 6, he was weaned from IABP. MG is a high-risk condition for TTS, and TTS with myasthenic crisis (MC) is associated with high mortality. We successfully managed this case of TTS with MC with intubation and IABP, without MG-specific treatment.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"3383-3387"},"PeriodicalIF":1.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140891688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Utility of Helicobacter pylori Stool Antigen Testing with a Bioluminescent Enzyme Immunoassay Using a Fecal Occult Blood Test Container. 使用粪便隐血试验容器的生物发光酶免疫测定法检测幽门螺旋杆菌粪便抗原的临床实用性。
IF 1 4区 医学
Internal Medicine Pub Date : 2024-12-15 Epub Date: 2024-05-09 DOI: 10.2169/internalmedicine.3480-24
Atsushi Imagawa, Sho Takahashi, Katsuhiro Mabe
{"title":"Clinical Utility of <i>Helicobacter pylori</i> Stool Antigen Testing with a Bioluminescent Enzyme Immunoassay Using a Fecal Occult Blood Test Container.","authors":"Atsushi Imagawa, Sho Takahashi, Katsuhiro Mabe","doi":"10.2169/internalmedicine.3480-24","DOIUrl":"10.2169/internalmedicine.3480-24","url":null,"abstract":"<p><p>Objective A dedicated stool container is required for Helicobacter pylori stool antigen testing. If H. pylori fecal antigen can be measured from a fecal occult blood test container (S fecal collection container or S container), which is widely used for colorectal cancer screening, screening of the upper and lower gastrointestinal tract can be performed with a single stool sample. We investigated the clinical usefulness of an H. pylori stool antigen assay using an S container. Materials A total of 347 patients who underwent esophagogastroduodenoscopy (EGD) were included. After the procedure, H. pylori stool antigen was measured using the S container and collection container recommended for H. pylori stool antigen (BL-stool collection container or BL container), and the qualitative outcomes of each were compared. A bioluminescent enzyme immunoassay (BLEIA) was used to measure H. pylori stool antigen. Results The overall agreement between S containers and BL containers was 100% (347/347), indicating that the qualitative outcomes were equivalent. As a secondary analysis, the results of the S container samples were evaluated according to the diagnosis made by physicians, and the overall agreement rate was 99.7% (345/346), indicating a high correlation. Conclusion The detection of H. pylori stool antigen using the S container is clinically useful because the results are equivalent to those obtained by the usual method. Screening of the upper and lower gastrointestinal tract is expected to be possible with a single stool sample in the future.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"3271-3275"},"PeriodicalIF":1.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140891710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Steroid Therapy for Patients with Septic Shock: A Multicenter Observational Study Conducted in Japan. 脓毒性休克患者的类固醇治疗:日本一项多中心观察研究。
IF 1 4区 医学
Internal Medicine Pub Date : 2024-12-15 Epub Date: 2024-05-09 DOI: 10.2169/internalmedicine.1511-22
Maki Murata, Sayaka Shimizu, Ryohei Yamamoto, Tsukasa Kamitani, Hajime Yamazaki, Yusuke Ogawa, Shunichi Fukuhara, Hideto Yasuda, Yosuke Yamamoto
{"title":"Steroid Therapy for Patients with Septic Shock: A Multicenter Observational Study Conducted in Japan.","authors":"Maki Murata, Sayaka Shimizu, Ryohei Yamamoto, Tsukasa Kamitani, Hajime Yamazaki, Yusuke Ogawa, Shunichi Fukuhara, Hideto Yasuda, Yosuke Yamamoto","doi":"10.2169/internalmedicine.1511-22","DOIUrl":"10.2169/internalmedicine.1511-22","url":null,"abstract":"<p><p>Objective The Clinical Practice Guidelines for the Management of Sepsis and Septic Shock weakly recommend steroids for septic shock resistant to fluid resuscitation and vasopressors. This study aimed to describe the clinical practices for septic shock in the real world and to compare the association between the intermittent or continuous infusion of steroids and the prognosis. Methods This was a retrospective cohort study based on the AMOR-VENUS, in which Japanese intensive care unit (ICU) inpatients were enrolled between January and March 2018. Adult patients with sepsis who received vasopressors within 72 h of ICU admission were included. The patients were divided into non-steroid and steroid groups, which were further divided into intermittent and continuous infusion groups. The patient characteristics and details of the steroids are described. To investigate the association between intermittent or continuous infusion, shock reversal, and mortality, logistic regression analyses were performed after adjusting for possible confounding factors. Results A total of 180 patients with septic shock from 18 ICUs were enrolled. The mean age was 69.6 (standard deviation, 14.3) years. Sixty-three patients (35.0%) received steroids (26 intermittently, 37 continuously). In the steroid group, hydrocortisone was used in 85.7%, the median daily dose was 192 mg, and the steroids were administered within 6 h of initiating vasopressor in 71.4%. The adjusted odds ratios of shock reversal on the 7th day and the ICU mortality for continuous versus intermittent infusion were 1.90 (95% confidence interval, 0.43-8.40) and 0.61 (0.10-3.85), respectively. Conclusion There was considerable variation in the criteria for the selection of patients and in the decision to use continuous or intermittent steroid infusion.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"3307-3315"},"PeriodicalIF":1.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140891690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信