皮质类固醇和免疫抑制剂治疗脱屑性间质性肺炎和系统性硬化症：1例报告。

IF 1.1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Internal Medicine Pub Date : 2025-10-15 Epub Date: 2025-04-05 DOI:10.2169/internalmedicine.5001-24

Eiki Omoto, Kazuhiro Sato, Daichi Takahashi, Kentaroh Kudoh, Kengo Shimada, Satoshi Goshima, Ruriko Asahi, Yuri Takita, Yuka Izumiya, Sho Sakamoto, Mariko Asano, Yuji Okuda, Masahide Takeda, Katsutoshi Nakayama

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引用次数: 0

摘要

66岁男性，前吸烟者，表现为疲劳和非生产性咳嗽，并有2年磨玻璃混浊史。胸片恶化和KL-6水平升高与高分辨率CT弥漫性磨玻璃影的进展一致。手术肺活检显示的特征与脱屑性间质性肺炎相符。并发皮肤硬化和抗scl -70抗体的存在支持系统性硬化症的诊断。口服皮质类固醇治疗证明是有效的，导致影像学改善。随后给予环磷酰胺和霉酚酸酯稳定疾病进展。

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Treatment of Desquamative Interstitial Pneumonia and Systemic Sclerosis with Corticosteroids and Immunosuppressants.

A 66-year-old male ex-smoker presented with fatigue and non-productive cough, as well as a 2-year history of ground-glass opacities. Deterioration on chest radiography and increased Krebs von den Lungen-6 levels coincided with the progression of diffuse ground-glass opacities on high-resolution computed tomography. Surgical lung biopsy revealed features consistent with desquamative interstitial pneumonia. Concurrent skin hardening and presence of anti-Scl-70 antibodies supported the diagnosis of systemic sclerosis. Treatment with oral corticosteroids proved to be effective, leading to radiographic improvement. The subsequent administration of cyclophosphamide and mycophenolate mofetil stabilized disease progression.

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来源期刊

Internal Medicine 医学-医学：内科

CiteScore

1.90

自引率

8.30%

发文量

审稿时长

2.2 months

期刊介绍： Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine. Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.