Treatment of Anti-myelin-associated Glycoprotein Neuropathy with Tirabrutinib and a 3-year Follow-up.

IF 1.1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Internal Medicine Pub Date : 2025-10-15 Epub Date: 2025-04-26 DOI:10.2169/internalmedicine.4785-24

Chinami Yuzawa, Masateru Tajiri, Maho Usuda, Akira Matsushima, Minori Kodaira, Nagaaki Katoh, Yoshiki Sekijima

引用次数: 0

Abstract

A 69-year-old man was admitted to our hospital because of progressive numbness in the lower legs and fingertips as well as a burning sensation in the soles of both feet. The patient was diagnosed with anti-myelin-associated glycoprotein (anti-MAG) neuropathy based on increased serum IgM levels and anti-MAG antibody titers. Atypical pulmonary mycobacteriosis was also suspected. Following treatment with tirabrutinib (a second-generation Bruton tyrosine kinase inhibitor), his symptoms improved and the anti-MAG antibody titer and IgM levels decreased. Tirabrutinib may therefore be an effective treatment option for anti-MAG neuropathy, particularly in patients at risk of infection.

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替拉替尼治疗抗髓鞘相关糖蛋白神经病及3年随访：1例报告。

一名69岁男性患者因下肢和指尖进行性麻木以及双脚底烧灼感入住我院。根据血清IgM水平升高和抗mag抗体滴度，患者被诊断为抗髓鞘相关糖蛋白（抗mag）神经病变。疑似非典型肺分枝杆菌病。在使用替拉替尼（一种第二代布鲁顿酪氨酸激酶抑制剂）治疗后，患者的症状得到改善，抗mag抗体滴度和IgM水平下降。因此，替拉替尼可能是抗mag神经病变的有效治疗选择，特别是在有感染风险的患者中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Internal Medicine 医学-医学：内科

CiteScore

1.90

自引率

8.30%

发文量

审稿时长

2.2 months

期刊介绍： Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine. Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.