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The Association between Sarcopenia and Constipation Onset in Community-dwelling Older Adults in Japan.
IF 1 4区 医学
Internal Medicine Pub Date : 2024-12-12 DOI: 10.2169/internalmedicine.4391-24
Hiroaki Nakagawa, Taro Takeshima, Akihiro Ozaka, Sho Sasaki, Sugihiro Hamaguchi, Shunichi Fukuhara
{"title":"The Association between Sarcopenia and Constipation Onset in Community-dwelling Older Adults in Japan.","authors":"Hiroaki Nakagawa, Taro Takeshima, Akihiro Ozaka, Sho Sasaki, Sugihiro Hamaguchi, Shunichi Fukuhara","doi":"10.2169/internalmedicine.4391-24","DOIUrl":"https://doi.org/10.2169/internalmedicine.4391-24","url":null,"abstract":"<p><p>Objective Constipation is an important symptom in older adults. Sarcopenia is associated with constipation, but its directionality remains unclear. The present study assessed the association between sarcopenia and new-onset constipation. Methods This prospective cohort study assessed sarcopenia at baseline in 2019 using the SARC-F questionnaire. Sarcopenia was defined as a SARC-F score of ≥4. Constipation was measured in 2019 and 2020 based on self-reported constipation or laxative use, using a self-administered questionnaire. Logistic regression was used to estimate the association between new-onset constipation in 2020 and sarcopenia status at the baseline. Patients Independent community-dwelling adults ≥75 years old in Sukagawa City, Fukushima, Japan. Results The analysis included 2,388 participants without constipation at baseline (mean age: 80.0±4.3 years old; 44.9% men), of whom 310 (13.0%) had sarcopenia at baseline. Overall, 262 participants (11.0%) developed constipation, including 57 of 310 (18.4%) with sarcopenia and 205 of 2,078 (9.9%) without sarcopenia. Participants with sarcopenia had a significantly higher risk of developing constipation than those without sarcopenia after adjusting for age, sex, lifestyle factors, and comorbidities (adjusted odds ratio, 1.98; 95% confidence interval, 1.40-2.81; P <0.001). The association between sarcopenia and new-onset constipation remained statistically significant at higher and lower SARC-F cutoff values. Conclusion Sarcopenia was associated with new-onset constipation. Sarcopenia is a risk factor for constipation in independent community-dwelling older adults ≥75 years old. Measures addressing sarcopenia may help prevent constipation in older adults.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pancreatitis Due to a Giant Simple Hepatic Cyst.
IF 1 4区 医学
Internal Medicine Pub Date : 2024-12-12 DOI: 10.2169/internalmedicine.4637-24
Tetsushi Azami, Eiichi Yamamura, Yuichi Takano, Masatsugu Nagahama
{"title":"Pancreatitis Due to a Giant Simple Hepatic Cyst.","authors":"Tetsushi Azami, Eiichi Yamamura, Yuichi Takano, Masatsugu Nagahama","doi":"10.2169/internalmedicine.4637-24","DOIUrl":"https://doi.org/10.2169/internalmedicine.4637-24","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of Pulmonary Arteriovenous Malformations Requiring Surgical Resection due to the Migration of Two Coils into A Single Lesion with Mycobacterium Avium Complex Infection after Coil Embolization.
IF 1 4区 医学
Internal Medicine Pub Date : 2024-12-12 DOI: 10.2169/internalmedicine.4227-24
Akinaga Iijima, Masayuki Nakayama, Toshimi Kawahata, Mizuho Saito, Tomohiro Kikuchi, Atsushi Kihara, Makoto Maemondo
{"title":"A Case of Pulmonary Arteriovenous Malformations Requiring Surgical Resection due to the Migration of Two Coils into A Single Lesion with Mycobacterium Avium Complex Infection after Coil Embolization.","authors":"Akinaga Iijima, Masayuki Nakayama, Toshimi Kawahata, Mizuho Saito, Tomohiro Kikuchi, Atsushi Kihara, Makoto Maemondo","doi":"10.2169/internalmedicine.4227-24","DOIUrl":"https://doi.org/10.2169/internalmedicine.4227-24","url":null,"abstract":"<p><p>A 21-year-old male with hereditary hemorrhagic telangiectasia underwent coil embolization for three pulmonary arteriovenous malformations (right S<sup>6</sup>c, right S<sup>10</sup>a, and left S<sup>6</sup>b). Three years after coil embolization, coil migration was observed in the right S<sup>6</sup>c and S<sup>10</sup>a, and a cavitary lesion developed between the two coils. Four years after embolization, the two coil lesions were found to have merged within the cavity. Right lower lobectomy was performed for severe recurrent hemoptysis. A histological examination revealed a granuloma with caseous necrosis related to Mycobacterium avium complex (MAC) infection around the cavity. The patient did not exhibit hemoptysis or MAC recurrence after resection.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of the Bridge Dry Swallowing Exercise for Refractory Gastroesophageal Reflux Disease.
IF 1 4区 医学
Internal Medicine Pub Date : 2024-12-12 DOI: 10.2169/internalmedicine.4054-24
Tomoko Nishimura, Kenjiro Kunieda, Kei Aoyama, Takahito Shimomura, Toshio Suzuki, Yoshikazu Inagaki, Naomi Ban, Hideki Nakamura, Kyoko Sakamoto, Kenji Itani, Takefumi Nishimura, Fumiya Nakamura, Kyoichi Kassai, Tomohisa Ohno, Ichiro Fujishima
{"title":"Efficacy of the Bridge Dry Swallowing Exercise for Refractory Gastroesophageal Reflux Disease.","authors":"Tomoko Nishimura, Kenjiro Kunieda, Kei Aoyama, Takahito Shimomura, Toshio Suzuki, Yoshikazu Inagaki, Naomi Ban, Hideki Nakamura, Kyoko Sakamoto, Kenji Itani, Takefumi Nishimura, Fumiya Nakamura, Kyoichi Kassai, Tomohisa Ohno, Ichiro Fujishima","doi":"10.2169/internalmedicine.4054-24","DOIUrl":"https://doi.org/10.2169/internalmedicine.4054-24","url":null,"abstract":"<p><p>Background Gastroesophageal reflux disease (GERD) is a condition characterized by reflux of gastric contents, leading to damage to the esophageal mucosa and/or unpleasant symptoms, with a global prevalence of 13%. Although acid-suppressive medications are currently the most effective treatments for GERD, they may be ineffective against its symptoms. We therefore investigated the efficacy of a physical exercise program for the treatment of intractable GERD symptoms. Methods Fifteen participants who underwent upper gastrointestinal endoscopy were included in this study. They received acid-suppressive drugs for more than eight weeks and had a score of ≥8 on the Frequency Scale for the Symptoms of GERD (FSSG). Participants were instructed to perform a 2-week interventional exercise program comprising drinking saliva 10 times in the bridge position (bridge dry swallowing exercise). This involved swallowing saliva without any food or drink while the hip was raised in the supine position. Changes in the FSSG scores after exercise were examined (UMIN000047829). Results Among the 15 participants, 7 were men, with a median age of 59 years old. Each participant had mild reflux esophagitis or no mucosal injuries. All participants completed the exercise program safely. Of the 15 participants, 13 demonstrated an improvement in the FSSG score after the intervention. The total FSSG score improved significantly from a median of 17 to 11 (p <0.001). Five participants discontinued acid-suppressive drugs after the intervention ended. Conclusions Bridge dry swallowing exercises can improve the intractable symptoms of GERD. However, further studies are required to verify its efficacy and safety.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of Wilson's Disease Preceded by Schizophrenia-like Symptoms with Frontal-dominant Leukoencephalopathy.
IF 1 4区 医学
Internal Medicine Pub Date : 2024-12-12 DOI: 10.2169/internalmedicine.4353-24
Ryoji Miyano, Akihiko Mitsutake, Takashi Matsukawa, Satomi Obata, Hiroaki Koyama, Yudai Nakai, Hiroyuki Ishiura, Akatsuki Kubota, Jun Shimizu, Kaori Sakuishi, Tatsushi Toda
{"title":"A Case of Wilson's Disease Preceded by Schizophrenia-like Symptoms with Frontal-dominant Leukoencephalopathy.","authors":"Ryoji Miyano, Akihiko Mitsutake, Takashi Matsukawa, Satomi Obata, Hiroaki Koyama, Yudai Nakai, Hiroyuki Ishiura, Akatsuki Kubota, Jun Shimizu, Kaori Sakuishi, Tatsushi Toda","doi":"10.2169/internalmedicine.4353-24","DOIUrl":"https://doi.org/10.2169/internalmedicine.4353-24","url":null,"abstract":"<p><p>We herein report a 26-year-old man diagnosed with Wilson's disease (WD), initially treated for schizophrenia for 11 years. At 26 years old, he was admitted because of status epilepticus. Brain magnetic resonance imaging revealed frontal-dominant leukoencephalopathy with cystic changes and basal ganglia atrophy. The diagnosis of WD was confirmed based on neuropsychiatric symptoms, Kayser-Fleischer rings, abnormal copper metabolism, and a genetic analysis of ATP7B. Psychotic symptoms in WD can precede neurological manifestations, and extrapyramidal signs may be mistaken for drug-induced Parkinsonism. WD should be considered in patients presenting with progressive Parkinsonism preceded by schizophrenia-like psychiatric symptoms.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advanced Gastric Cancer with Mediastinal Dissemination Mimicking Mediastinitis.
IF 1 4区 医学
Internal Medicine Pub Date : 2024-12-12 DOI: 10.2169/internalmedicine.4474-24
Kimitoshi Kubo, Issei Ashida, Kei Hiraoka, Noriko Kimura
{"title":"Advanced Gastric Cancer with Mediastinal Dissemination Mimicking Mediastinitis.","authors":"Kimitoshi Kubo, Issei Ashida, Kei Hiraoka, Noriko Kimura","doi":"10.2169/internalmedicine.4474-24","DOIUrl":"https://doi.org/10.2169/internalmedicine.4474-24","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-Tr/DNER Antibody-associated Paraneoplastic Neurological Syndrome Presenting Limbic Encephalitis with Anaplastic Large Cell Lymphoma: A Case Report.
IF 1 4区 医学
Internal Medicine Pub Date : 2024-12-12 DOI: 10.2169/internalmedicine.4530-24
Shintaro Fujii, Hiroaki Yaguchi, Ikuko Takahashi-Iwata, Takashi Inoue, Monami Tarisawa, Taichi Nomura, Akihiko Kudo, Hisashi Uwatoko, Shinichi Shirai, Masaaki Matsushima, Riku Miyaishi, Noriyuki Otsuka, Keiko Tanaka, Koji Taniguchi, Masato Takahashi, Shinya Tanaka, Ichiro Yabe
{"title":"Anti-Tr/DNER Antibody-associated Paraneoplastic Neurological Syndrome Presenting Limbic Encephalitis with Anaplastic Large Cell Lymphoma: A Case Report.","authors":"Shintaro Fujii, Hiroaki Yaguchi, Ikuko Takahashi-Iwata, Takashi Inoue, Monami Tarisawa, Taichi Nomura, Akihiko Kudo, Hisashi Uwatoko, Shinichi Shirai, Masaaki Matsushima, Riku Miyaishi, Noriyuki Otsuka, Keiko Tanaka, Koji Taniguchi, Masato Takahashi, Shinya Tanaka, Ichiro Yabe","doi":"10.2169/internalmedicine.4530-24","DOIUrl":"https://doi.org/10.2169/internalmedicine.4530-24","url":null,"abstract":"<p><p>An 82-year-old man presented with acute progressive disturbance of consciousness. We suspected autoimmune limbic encephalitis because of abnormal magnetic resonance imaging findings in the bilateral temporal lobes and cerebrospinal fluid pleocytosis. The patient tested positive for anti-Tr/Delta/Notch-like epidermal growth factor-related receptor (DNER) antibodies, and a tissue biopsy revealed complications of anaplastic large cell lymphoma. Typically, anti-Tr/DNER antibody-associated paraneoplastic neurological syndrome presents with cerebellar ataxia and is complicated by Hodgkin lymphoma (HL). However, there are rare cases that present only with LE and are complicated by tumors other than HL; therefore, aggressive antibody measurement and search for tumors are important.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Re-evaluation of Renal Biopsy-based Diagnoses Through a Genetic Analysis in Two Families with Alport Syndrome: Case Reports.
IF 1 4区 医学
Internal Medicine Pub Date : 2024-12-05 DOI: 10.2169/internalmedicine.4485-24
Yoshiaki Higashi, Kenichi Koga, Masako Hasebe, Chiho Fukushima, Chiaki Omiya, Keisuke Nishioka, Kandai Nozu, Kensei Yahata
{"title":"A Re-evaluation of Renal Biopsy-based Diagnoses Through a Genetic Analysis in Two Families with Alport Syndrome: Case Reports.","authors":"Yoshiaki Higashi, Kenichi Koga, Masako Hasebe, Chiho Fukushima, Chiaki Omiya, Keisuke Nishioka, Kandai Nozu, Kensei Yahata","doi":"10.2169/internalmedicine.4485-24","DOIUrl":"https://doi.org/10.2169/internalmedicine.4485-24","url":null,"abstract":"<p><p>Alport syndrome is an inherited disorder characterized by progressive renal failure, sensorineural hearing loss, and ocular involvement due to pathogenic variants of genes encoding type IV collagen. A renal biopsy does not reveal specific findings in the early stages; thus, Alport syndrome may be diagnosed as another glomerular disease. We herein report two families that were previously diagnosed with other glomerular diseases based on renal biopsies and were then accurately diagnosed by genetic testing. An early diagnosis may lead to the avoidance of unnecessary biopsies and treatments, and appropriate management may improve the renal prognosis.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of a Patient with Atezolizumab-induced Encephalitis and Hepatocellular Carcinoma.
IF 1 4区 医学
Internal Medicine Pub Date : 2024-12-05 DOI: 10.2169/internalmedicine.4865-24
Kakeru Otomo, Masashi Fujita
{"title":"A Case of a Patient with Atezolizumab-induced Encephalitis and Hepatocellular Carcinoma.","authors":"Kakeru Otomo, Masashi Fujita","doi":"10.2169/internalmedicine.4865-24","DOIUrl":"https://doi.org/10.2169/internalmedicine.4865-24","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cutaneous Squamous Cell Carcinoma Producing Granulocyte Colony-stimulating Factor and Parathyroid Hormone-related Protein: A Case Report and Literature Review.
IF 1 4区 医学
Internal Medicine Pub Date : 2024-12-05 DOI: 10.2169/internalmedicine.3992-24
Takuya Kumagai, Masaya Saito, Takahiko Sato, Junichi Inoue, Norihisa Ishikawa, Tsuyoshi Ono, Michihiro Kono, Naoto Takahashi
{"title":"Cutaneous Squamous Cell Carcinoma Producing Granulocyte Colony-stimulating Factor and Parathyroid Hormone-related Protein: A Case Report and Literature Review.","authors":"Takuya Kumagai, Masaya Saito, Takahiko Sato, Junichi Inoue, Norihisa Ishikawa, Tsuyoshi Ono, Michihiro Kono, Naoto Takahashi","doi":"10.2169/internalmedicine.3992-24","DOIUrl":"https://doi.org/10.2169/internalmedicine.3992-24","url":null,"abstract":"<p><p>We herein report a case of cutaneous squamous cell carcinoma (SCC) characterized by paraneoplastic hypercalcemia-leukocytosis syndrome. The patient presented with systemic symptoms, including anorexia, a fever, and a tumoral lesion on the upper arm. Laboratory test results revealed hypercalcemia and leukocytosis. A tissue biopsy confirmed SCC, and further investigation revealed elevated parathyroid hormone-related protein (PTHrP) and granulocyte-colony stimulating factor (G-CSF) levels. Immunostaining demonstrated G-CSF production by the tumor cells. Radiation therapy was administered, which improved leukocytosis and decreased G-CSF and PTHrP levels. Through a case report and literature review, we explored the clinical characteristics of tumors that produce G-CSF and PTHrP.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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