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Intravascular Large B-cell Lymphoma in a Nasal Polyp. 鼻息肉的血管内大b细胞淋巴瘤。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-10-01 Epub Date: 2025-04-12 DOI: 10.2169/internalmedicine.4642-24
Ikuo Matsuda, Hiroshi Kono, Kyoko Yoshihara, Seiichi Hirota
{"title":"Intravascular Large B-cell Lymphoma in a Nasal Polyp.","authors":"Ikuo Matsuda, Hiroshi Kono, Kyoko Yoshihara, Seiichi Hirota","doi":"10.2169/internalmedicine.4642-24","DOIUrl":"10.2169/internalmedicine.4642-24","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2921"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatocellular Carcinoma Arising Adjacent to Antiphospholipid Syndrome-associated Hepatic Infarction in a Non-cirrhotic Liver. 非肝硬化肝脏抗磷脂综合征相关性肝梗死附近发生的肝细胞癌。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-10-01 Epub Date: 2025-03-22 DOI: 10.2169/internalmedicine.5081-24
Yuriko Kusumi, Takumu Hasebe, Manami Hayashi, Yuki Kamikokura, Shin Otake, Hidemi Hayashi, Yu Ota, Shunsuke Nakajima, Kazunobu Aso, Koji Sawada, Mishie Tanino, Mikihiro Fujiya
{"title":"Hepatocellular Carcinoma Arising Adjacent to Antiphospholipid Syndrome-associated Hepatic Infarction in a Non-cirrhotic Liver.","authors":"Yuriko Kusumi, Takumu Hasebe, Manami Hayashi, Yuki Kamikokura, Shin Otake, Hidemi Hayashi, Yu Ota, Shunsuke Nakajima, Kazunobu Aso, Koji Sawada, Mishie Tanino, Mikihiro Fujiya","doi":"10.2169/internalmedicine.5081-24","DOIUrl":"10.2169/internalmedicine.5081-24","url":null,"abstract":"<p><p>A man in his 70s with antiphospholipid syndrome (APS) presented with a hepatic mass. Initial imaging suggested hepatic infarction, as the liver tumor markers were normal, and coagulation tests indicated a hypercoagulable state. Three years later, follow-up imaging revealed tumor enlargement, leading to a biopsy-confirmed hepatocellular carcinoma diagnosis. Transarterial embolization was performed followed by lenvatinib therapy. The patient achieved complete response with no recurrence for over eight months. This case highlights the potential of APS to contribute to liver carcinogenesis in non-cirrhotic patients and illustrates the need for individualized treatment strategies.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2839-2845"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oligogenic Familial Hypercholesterolemia Treated by Combination Therapy of Statin, Ezetimibe, PCSK9 Inhibitor, and Lomitapide. 他汀、依折替米贝、PCSK9抑制剂和洛米他胺联合治疗低原性家族性高胆固醇血症1例。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-10-01 Epub Date: 2025-03-22 DOI: 10.2169/internalmedicine.5025-24
Nobuko Kojima, Hayato Tada, Masayuki Takamura
{"title":"Oligogenic Familial Hypercholesterolemia Treated by Combination Therapy of Statin, Ezetimibe, PCSK9 Inhibitor, and Lomitapide.","authors":"Nobuko Kojima, Hayato Tada, Masayuki Takamura","doi":"10.2169/internalmedicine.5025-24","DOIUrl":"10.2169/internalmedicine.5025-24","url":null,"abstract":"<p><p>We encountered a 40-year-old man diagnosed with homozygous familial hypercholesterolemia (FH) based on clinical findings. The initial low-density lipoprotein (LDL)-cholesterol level was 393 mg/dL. He underwent coronary artery bypass graft (CABG) surgery for three-vessel disease. Genetic testing revealed a pathogenic variant in the LDL receptor (LDLR) and a missense variant in apolipoprotein E (APOE), known as APOE4, leading to the diagnosis of oligogenic FH. His LDL-cholesterol level was well controlled by the introduction of a proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor and lomitapide (approximately 30 mg/dL). Combination therapy is effective in reducing LDL levels.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2876-2880"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lateral Medullary Infarction Presenting as Opalski Syndrome Associated with Headache Attributed to Orthostatic Hypotension. 侧髓梗死表现为欧泊斯基综合征，伴有直立性低血压引起的头痛。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-10-01 Epub Date: 2025-04-12 DOI: 10.2169/internalmedicine.4674-24
Rie Tohge, Kazuki Utsumi, Mitsuaki Oki, Takayuki Kondo
{"title":"Lateral Medullary Infarction Presenting as Opalski Syndrome Associated with Headache Attributed to Orthostatic Hypotension.","authors":"Rie Tohge, Kazuki Utsumi, Mitsuaki Oki, Takayuki Kondo","doi":"10.2169/internalmedicine.4674-24","DOIUrl":"10.2169/internalmedicine.4674-24","url":null,"abstract":"<p><p>Lateral medullary infarction is rarely associated with Opalski syndrome and autonomic dysfunction. Herein, we present the first case involving a 66-year-old patient with cancer who developed mild dysarthria, left-sided Horner's syndrome and lower limb-dominant ataxic hemiparesis, reduction in right-sided painful thermal sensation, and severe truncal ataxia, followed by orthostatic headache. The Schellong test revealed severe orthostatic hypotension. The patient was diagnosed with Opalski syndrome associated with headache attributed to orthostatic hypotension caused by the cerebral infarction in the caudal part of the lateral medulla oblongata. The patient's headache had poor response to analgesics. However, it resolved with orthostatic hypotension improvement.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2901-2906"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Small Intestinal Bacterial Overgrowth in a Healthy Female Patient Caused by Long-term Oral Proton Pump Inhibitor Administration. 健康女性长期口服质子泵抑制剂致小肠细菌过度生长1例。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-10-01 Epub Date: 2025-04-05 DOI: 10.2169/internalmedicine.4376-24
Koichi Soga, Sotaro Yamada, Yuto Suzuki, Yumi Kusano, Ikuhiro Kobori, Yasumi Katayama, Masaya Tamano
{"title":"Small Intestinal Bacterial Overgrowth in a Healthy Female Patient Caused by Long-term Oral Proton Pump Inhibitor Administration.","authors":"Koichi Soga, Sotaro Yamada, Yuto Suzuki, Yumi Kusano, Ikuhiro Kobori, Yasumi Katayama, Masaya Tamano","doi":"10.2169/internalmedicine.4376-24","DOIUrl":"10.2169/internalmedicine.4376-24","url":null,"abstract":"<p><p>Small-intestinal bacterial overgrowth (SIBO) causes gastrointestinal symptoms. Proton pump inhibitors (PPIs) are commonly used for acid peptic diseases; however, their long-term use can alter the gut microbiota, resulting in adverse effects. We herein report the case of a 26-year-old Japanese woman with SIBO caused by prolonged PPI use. After switching to a H2 receptor antagonist, her symptoms and blood test results improved. This case highlights the need to understand the pathogenesis of SIBO and also the risks associated with prolonged PPI use.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2852-2857"},"PeriodicalIF":1.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Venous Thromboembolism with Double Left Common Iliac Veins. 静脉血栓栓塞伴双左髂总静脉。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-09-15 Epub Date: 2025-03-08 DOI: 10.2169/internalmedicine.5252-25
Takao Konishi, Sakae Takenaka, Toshiyuki Nagai, Toshihisa Anzai
{"title":"Venous Thromboembolism with Double Left Common Iliac Veins.","authors":"Takao Konishi, Sakae Takenaka, Toshiyuki Nagai, Toshihisa Anzai","doi":"10.2169/internalmedicine.5252-25","DOIUrl":"10.2169/internalmedicine.5252-25","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2809-2810"},"PeriodicalIF":1.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How to Prevent Left Atrial Thrombus Formation Following TEER in Patients with Prior Left Atrial Appendage Occlusion. 如何预防既往左房附件闭塞患者TEER后左房血栓形成。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-09-15 Epub Date: 2025-03-08 DOI: 10.2169/internalmedicine.5125-24
Nobuyuki Fukuda, Teruhiko Imamura
{"title":"How to Prevent Left Atrial Thrombus Formation Following TEER in Patients with Prior Left Atrial Appendage Occlusion.","authors":"Nobuyuki Fukuda, Teruhiko Imamura","doi":"10.2169/internalmedicine.5125-24","DOIUrl":"10.2169/internalmedicine.5125-24","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2815"},"PeriodicalIF":1.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Clinical Outcomes Between Early and Delayed Percutaneous Coronary Intervention for the Culprit Lesion in Patients with Non-ST-segment Elevation Myocardial Infarction. 非st段抬高型心肌梗死患者罪魁祸首病变早期与延迟经皮冠状动脉介入治疗的临床效果比较
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-09-15 Epub Date: 2025-03-29 DOI: 10.2169/internalmedicine.4805-24
Yae Ota, Kenichi Sakakura, Hiroyuki Jinnouchi, Yousuke Taniguchi, Kei Yamamoto, Takunori Tsukui, Masashi Hatori, Taku Kasahara, Yusuke Watanabe, Shun Ishibashi, Masaru Seguchi, Hideo Fujita
{"title":"Comparison of Clinical Outcomes Between Early and Delayed Percutaneous Coronary Intervention for the Culprit Lesion in Patients with Non-ST-segment Elevation Myocardial Infarction.","authors":"Yae Ota, Kenichi Sakakura, Hiroyuki Jinnouchi, Yousuke Taniguchi, Kei Yamamoto, Takunori Tsukui, Masashi Hatori, Taku Kasahara, Yusuke Watanabe, Shun Ishibashi, Masaru Seguchi, Hideo Fujita","doi":"10.2169/internalmedicine.4805-24","DOIUrl":"10.2169/internalmedicine.4805-24","url":null,"abstract":"<p><p>Objective Immediate primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction is closely associated with better clinical outcomes. However, the optimal timing of PCI for the culprit lesion in non-ST-elevation myocardial infarction (NSTEMI) is not fully understood. The aim of this study was to compare clinical outcomes between patients with early and delayed PCI and to investigate whether early PCI within 24 hours of admission can improve long-term clinical outcomes in patients with NSTEMI. Methods This was a single-center, retrospective study. The primary endpoint was major adverse cardiovascular events (MACE), which was defined as the composite of all-cause death, non-fatal MI, and re-admission for heart failure. Results We included 816 patients with NSTEMI and divided them into an early PCI group (n=446) and a delayed PCI group (n=370). The median follow-up period was 856 days. The median age was lower in the early PCI group [73 (65-79) years] than in the delayed PCI group [76 (69-81)] (p<0.001). Shock at admission was more frequently observed in the early PCI group (11.9%) than in the delayed PCI group (3.2%) (p=0.001). The incidence of MACE in the delayed PCI group (40.8%) was higher than that in the early PCI group (28.5%) (p<0.001). However, a multivariate Cox hazard analysis revealed that early PCI was not associated with MACE after controlling for multiple confounding factors (hazard ratio 1.005, 95% confidence interval 0.763-1.322, p=0.973). Conclusion The timing of PCI may not be important in hemodynamically stable patients with NSTEMI, as long as primary PCI is performed.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2699-2707"},"PeriodicalIF":1.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disseminated Nocardiosis in Idiopathic CD4 Lymphocytopenia: A Rare Case and Literature Review. 特发性CD4淋巴细胞减少伴播散性诺卡菌病：一例罕见病例及文献回顾。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-09-15 Epub Date: 2025-03-29 DOI: 10.2169/internalmedicine.4984-24
Nayuta Seto, Takayuki Suzuki, Takahiko Fukuchi, Momori Honjo, Shinya Watanabe, Longzhu Cui, Hitoshi Sugawara
{"title":"Disseminated Nocardiosis in Idiopathic CD4 Lymphocytopenia: A Rare Case and Literature Review.","authors":"Nayuta Seto, Takayuki Suzuki, Takahiko Fukuchi, Momori Honjo, Shinya Watanabe, Longzhu Cui, Hitoshi Sugawara","doi":"10.2169/internalmedicine.4984-24","DOIUrl":"10.2169/internalmedicine.4984-24","url":null,"abstract":"<p><p>Nocardiosis typically affects immunocompromised patients; however, the clinical characteristics of idiopathic CD4 lymphocytopenia (ICL) remain poorly understood. A 64-year-old patient was diagnosed with ICL following disseminated nocardiosis, including bacteremia, pneumonia, knee arthritis, and brain abscess. The patient underwent trimethoprim-sulfamethoxazole therapy with frequent dose adjustments based on the renal function, ranging from 2 to 12 single-strength tablets daily over 5 months of hospitalization. While he had a 1-year uneventful course of lifelong prophylaxis, he experienced prolonged recovery in physical activity. A literature review highlighted the life-threatening nature of nocardiosis in ICL, underscoring the importance of a timely diagnosis and tailored management strategies.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2797-2803"},"PeriodicalIF":1.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Status Epilepticus Caused by Tick-borne Encephalitis. 蜱传脑炎致癫痫持续状态1例报告。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-09-15 Epub Date: 2025-03-22 DOI: 10.2169/internalmedicine.4773-24
Kazuhiro Horiuchi, Shuntaro Nakamura, Kazuki Yamada, Kazuya Mitsuhashi, Kei Watari, Kazuma Tamiya, Hiroki Yamaguchi, Shintaro Kobayashi
{"title":"Status Epilepticus Caused by Tick-borne Encephalitis.","authors":"Kazuhiro Horiuchi, Shuntaro Nakamura, Kazuki Yamada, Kazuya Mitsuhashi, Kei Watari, Kazuma Tamiya, Hiroki Yamaguchi, Shintaro Kobayashi","doi":"10.2169/internalmedicine.4773-24","DOIUrl":"10.2169/internalmedicine.4773-24","url":null,"abstract":"<p><p>We herein report a rare case of a 78-year-old Japanese man who developed refractory status epilepticus due to tick-borne encephalitis (TBE). The patient initially presented with left-sided hemiplegia and loss of consciousness. Initial diagnostic tests could not identify the cause of the encephalomyelitis, leading to a preliminary diagnosis of autoimmune encephalomyelitis. Despite treatment with corticosteroids and plasma exchange, the patient experienced status epilepticus, which required multiple antiseizure medications. TBE viral antibodies were eventually detected, confirming the diagnosis. Despite the treatment, the patient remained critically ill. Clinicians should consider TBE in the differential diagnosis of encephalitis of unknown origin associated with status epilepticus.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2784-2789"},"PeriodicalIF":1.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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