Intravenous Methylprednisolone for Acute Right Middle Cerebral Artery Occlusion in Granulomatosis Polyangiitis: A Case Report.

IF 1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Internal Medicine Pub Date : 2025-04-12 DOI:10.2169/internalmedicine.4873-24

Tsubasa Watanabe, Nakako Tanaka-Mabuchi, Yuto Morishima, Takanori Hata, Ryosuke Ito, Sho Nakajima, Atsuhiko Shindo, Yuki Nakamura, Hideyuki Yoshioka, Koji Hashimoto, Kazumasa Shindo, Hiroyuki Kinouchi, Daiki Nakagomi, Yuji Ueno

引用次数: 0

Abstract

A 17-year-old Japanese woman diagnosed with granulomatosis with polyangiitis (GPA) and was treated with immunotherapy suddenly developed an impaired consciousness, left hemiplegia, and conjugate eye deviation to the right. Magnetic resonance imaging showed an acute cerebral infarction in the right striatum and right middle cerebral artery (MCA) occlusion. As her GPA had worsened recently, intravenous methylprednisolone (IVMP) was started. Immediately after IVMP was started, recanalization of the MCA was detected on repeat cerebral angiography. Aspirin and argatroban dissolved the residual thrombi. A combination of IVMP and antithrombotic therapy may be effective for large-vessel occlusions associated with GPA.

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静脉注射甲基强的松龙治疗肉芽肿性多血管炎急性右大脑中动脉闭塞1例。

一名17岁的日本女性被诊断为肉芽肿病合并多血管炎（GPA），并接受免疫治疗，突然出现意识受损、左半瘫痪和右眼斜视。磁共振成像显示右侧纹状体急性脑梗死，右侧大脑中动脉闭塞。由于她的GPA最近恶化，开始静脉注射甲基强的松龙（IVMP）。在IVMP开始后立即，重复脑血管造影检测到MCA再通。阿司匹林和阿加曲班溶解了残留的血栓。IVMP联合抗血栓治疗可能对与GPA相关的大血管闭塞有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Internal Medicine 医学-医学：内科

CiteScore

1.90

自引率

8.30%

发文量

审稿时长

2.2 months

期刊介绍： Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine. Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.