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Methylprednisolone-induced Anaphylaxis in Acute Hepatitis B: A Case Report and Literature Review. 甲强的松龙致急性乙型肝炎过敏反应1例报告并文献复习。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-11-15 Epub Date: 2025-05-15 DOI: 10.2169/internalmedicine.5405-25
Yuki Tamura, Daichi Takizawa, Kaho Honda, Yu Maruyama, Kenta Ito, Makiko Inoue, Takahiro Abe, Mitsuhiko Shibasaki, Masanori Sekiguchi, Yoko Sogabe, Hirotaka Arai, Toshio Uraoka
{"title":"Methylprednisolone-induced Anaphylaxis in Acute Hepatitis B: A Case Report and Literature Review.","authors":"Yuki Tamura, Daichi Takizawa, Kaho Honda, Yu Maruyama, Kenta Ito, Makiko Inoue, Takahiro Abe, Mitsuhiko Shibasaki, Masanori Sekiguchi, Yoko Sogabe, Hirotaka Arai, Toshio Uraoka","doi":"10.2169/internalmedicine.5405-25","DOIUrl":"10.2169/internalmedicine.5405-25","url":null,"abstract":"<p><p>Although glucocorticoids are commonly used to suppress allergic reactions, systemic glucocorticoid-induced anaphylaxis has also been reported. A man with acute hepatitis B was administered intravenous methylprednisolone to prevent the progression to liver failure. Shortly thereafter, the patient developed a rash and hoarseness, and methylprednisolone-induced anaphylaxis was diagnosed. The injection was stopped, an antihistamine was administered, and the symptoms resolved quickly. Subsequently, antiviral therapy and 9.9 mg/day of dexamethasone were initiated. The patient recovered completely without persistent hepatitis B virus infection. This case highlights the importance of recognizing glucocorticoid-induced anaphylaxis and provides insights into alternative treatment strategies for acute hepatitis B.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"3232-3237"},"PeriodicalIF":1.1,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12702549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to: Pneumatosis Intestinalis Induced by Nintedanib? 对尼达尼布诱导的肠性肺肿的反应？
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-11-15 Epub Date: 2025-05-15 DOI: 10.2169/internalmedicine.5664-25
Satoshi Hamada, Naoya Tanabe, Toyohiro Hirai
{"title":"Response to: Pneumatosis Intestinalis Induced by Nintedanib?","authors":"Satoshi Hamada, Naoya Tanabe, Toyohiro Hirai","doi":"10.2169/internalmedicine.5664-25","DOIUrl":"10.2169/internalmedicine.5664-25","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"3327"},"PeriodicalIF":1.1,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12702537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Utility of the HELT-E2S2 Score for Risk Stratification in Patients with Acute Decompensated Heart Failure: Insights from the CURE-HF Registry. 急性失代偿性心力衰竭患者的HELT-E2S2评分风险分层的临床应用：来自CURE-HF注册的见解
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-11-15 Epub Date: 2025-05-08 DOI: 10.2169/internalmedicine.4897-24
Kiu Tanaka, Masatoshi Minamisawa, Ayako Okada, Daisuke Sunohara, Yoshiteru Okina, Ken Nishikawa, Sho Suzuki, Yukari Okuma, Hideki Kobayashi, Kazuhiro Kimura, Yasushi Ueki, Koji Yoshie, Yasutaka Oguchi, Tamon Kato, Tatsuya Saigusa, Soichiro Ebisawa, Hirohiko Motoki, Koichiro Kuwahara
{"title":"Clinical Utility of the HELT-E<sub>2</sub>S<sub>2</sub> Score for Risk Stratification in Patients with Acute Decompensated Heart Failure: Insights from the CURE-HF Registry.","authors":"Kiu Tanaka, Masatoshi Minamisawa, Ayako Okada, Daisuke Sunohara, Yoshiteru Okina, Ken Nishikawa, Sho Suzuki, Yukari Okuma, Hideki Kobayashi, Kazuhiro Kimura, Yasushi Ueki, Koji Yoshie, Yasutaka Oguchi, Tamon Kato, Tatsuya Saigusa, Soichiro Ebisawa, Hirohiko Motoki, Koichiro Kuwahara","doi":"10.2169/internalmedicine.4897-24","DOIUrl":"10.2169/internalmedicine.4897-24","url":null,"abstract":"<p><p>Objective The HELT-E<sub>2</sub>S<sub>2</sub> score is a novel risk assessment tool for ischemic stroke in patients with atrial fibrillation. We explored the prognostic impact of the HELT-E<sub>2</sub>S<sub>2</sub> score on cardiovascular outcomes in patients with heart failure (HF), beyond its original scope. Methods We enrolled 997 patients hospitalized for acute decompensated HF (ADHF) (median age, 81 years; 44.3% female) from the Clue of Risk Stratification in the Elderly Patients with Heart Failure (CURE-HF) registry. We evaluated the relationship between the HELT-E<sub>2</sub>S<sub>2</sub> score and all-cause death over a median follow-up of 2.7 years. Results The patients were categorized into four quartiles based on the HELT-E<sub>2</sub>S<sub>2</sub> score: score 0 or 1 (group 1, n=234), score 2 (group 2, n=244), score 3 (group 3, n=255), and score ≥4 (group 4, n=264). Atrial fibrillation was present in 592 (59.4%) patients (paroxysmal, 15.0%; persistent, 44.3%). All-cause death was observed in 384 patients (14.7 per 100 patient-years). A Kaplan-Meier analysis showed that the higher score group was associated with an increased risk of all-cause death (log-rank p<0.001). After multivariable adjustment, the higher score groups had an elevated risk of all-cause death compared to group 1 [group 2; hazard ratio (HR): 1.56; 95% confidence interval (CI): 1.03-2.37; p=0.037, group 3; HR: 2.74; 95% CI: 1.85-4.07; p<0.001, group 4; HR: 3.32; 95% CI: 2.34-4.94; p<0.001]. Conclusion Higher HELT-E<sub>2</sub>S<sub>2</sub> scores were associated with a higher risk of all-cause death in patients with ADHF.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"3178-3187"},"PeriodicalIF":1.1,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12702539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cisplatin-induced Severe Renal Salt-wasting Syndrome Complicated with Hypovolemic Shock and Various Electrolyte Abnormalities in a Patient with Thymoma. 顺铂所致严重肾盐耗综合征合并低血容量性休克及各种电解质异常一例胸腺瘤患者
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-11-15 Epub Date: 2025-05-15 DOI: 10.2169/internalmedicine.5218-24
Takatsune Hosoya, Takeshi Masuda, Kiyofumi Shimoji, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Taku Nakashima, Hiroshi Iwamoto, Hironobu Hamada, Noboru Hattori
{"title":"Cisplatin-induced Severe Renal Salt-wasting Syndrome Complicated with Hypovolemic Shock and Various Electrolyte Abnormalities in a Patient with Thymoma.","authors":"Takatsune Hosoya, Takeshi Masuda, Kiyofumi Shimoji, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Taku Nakashima, Hiroshi Iwamoto, Hironobu Hamada, Noboru Hattori","doi":"10.2169/internalmedicine.5218-24","DOIUrl":"10.2169/internalmedicine.5218-24","url":null,"abstract":"<p><p>Renal salt-wasting syndrome (RSWS) induced by cisplatin causes hyponatremia and dehydration. A 75-year-old woman with thymoma underwent cisplatin chemotherapy. She presented with hypovolemic shock, seizures, and impaired consciousness (Japan Coma Scale II-30) with a decreased serum sodium level of 116 mmol/L on day 9. In addition, the patient had hypokalemia, hypomagnesemia, hypocalcemia, and hypophosphatemia. We herein describe the first reported case of RSWS complicated by hypovolemic shock. This is the second reported case with multiple electrolyte abnormalities. Thus, we should recognize that severe RSWS with hypovolemic shock and multiple electrolyte abnormalities can occur in patients undergoing cisplatin treatment.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"3272-3278"},"PeriodicalIF":1.1,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12702544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune Checkpoint Inhibitor-induced Mass-forming Pancreatitis and Lipodystrophy: A Case Report and Review of the Literature. 免疫检查点抑制剂诱导的肿块性胰腺炎和脂肪营养不良：1例报告和文献回顾。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-11-15 Epub Date: 2025-05-15 DOI: 10.2169/internalmedicine.5072-24
Yuka Oi, Takuya Takayanagi, Koki Kakuta, Hitoshi Arioka, Tatsuya Matsunaga
{"title":"Immune Checkpoint Inhibitor-induced Mass-forming Pancreatitis and Lipodystrophy: A Case Report and Review of the Literature.","authors":"Yuka Oi, Takuya Takayanagi, Koki Kakuta, Hitoshi Arioka, Tatsuya Matsunaga","doi":"10.2169/internalmedicine.5072-24","DOIUrl":"10.2169/internalmedicine.5072-24","url":null,"abstract":"<p><p>Mass-forming pancreatitis and lipodystrophy are rare immune-related adverse events (irAEs). A 71-year-old woman received 12 cycles of pembrolizumab for recurrent uterine endometrial cancer. The patient presented with mass-forming pancreatitis and lipodystrophy. A needle biopsy of the pancreatic tissue revealed lymphocytic infiltration and fibrosis. Simultaneously, the patient exhibited lipodystrophy. The recurrent tumors disappeared, so the patient discontinued immune checkpoint inhibitor treatment and was administered oral prednisolone. In addition, the pancreatic mass disappeared; however, the fat loss did not improve. Considering pancreatitis and lipodystrophy to be irAEs, prompt management is important.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"3238-3243"},"PeriodicalIF":1.1,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12702553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rare Case of Severe Pancreatitis Induced by Encorafenib and Cetuximab in BRAF V600E-Positive Colorectal Cancer. 恩科非尼联合西妥昔单抗治疗BRAF v600e阳性结直肠癌的罕见重症胰腺炎
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-11-15 Epub Date: 2025-04-26 DOI: 10.2169/internalmedicine.5389-25
Yu Miyakawa, Yuki Ishigaki, Nobumi Suzuki, Go Endo, Chisaki Suzumori, Takeshi Hayashi, Kenji Tamada, Takuma Iwata, Gota Fujisawa, Yoku Hayakawa, Narikazu Boku, Mitsuhiro Fujishiro
{"title":"Rare Case of Severe Pancreatitis Induced by Encorafenib and Cetuximab in BRAF V600E-Positive Colorectal Cancer.","authors":"Yu Miyakawa, Yuki Ishigaki, Nobumi Suzuki, Go Endo, Chisaki Suzumori, Takeshi Hayashi, Kenji Tamada, Takuma Iwata, Gota Fujisawa, Yoku Hayakawa, Narikazu Boku, Mitsuhiro Fujishiro","doi":"10.2169/internalmedicine.5389-25","DOIUrl":"10.2169/internalmedicine.5389-25","url":null,"abstract":"<p><p>Doublet chemotherapy with encorafenib and cetuximab has demonstrated a survival benefit for BRAF V600E mutation-positive advanced colorectal cancer, which generally has a poor prognosis, as shown in the BEACON CRC trial. We encountered a case of rectal cancer with this mutation, complicated by grade 3 pancreatitis, one month after starting this doublet therapy. Despite aggressive treatment efforts, the pancreatitis led to duodenal ulcer perforation and a fatal intra-abdominal abscess. This case highlights pancreatitis as a rare, but severe, side effect of combination chemotherapy.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"3252-3256"},"PeriodicalIF":1.1,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12702560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early-onset Colorectal Cancer in a Patient with Li-Fraumeni Syndrome: A Case Series and Literature Review. Li-Fraumeni综合征患者的早发性结直肠癌：病例系列和文献综述。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-11-15 Epub Date: 2025-04-12 DOI: 10.2169/internalmedicine.4945-24
Kazuki Sekiguchi, Iori Motoo, Takayuki Ando, Akira Noguchi, Rei Fukuda, Keiko Nomura, Yurika Nakayama, Shinya Kajiura, Yuko Ueda, Yuno Goto, Seitarou Shimada, Yusuke Takashima, Saeko Takahashi, Haruka Fujinami, Ichiro Yasuda
{"title":"Early-onset Colorectal Cancer in a Patient with Li-Fraumeni Syndrome: A Case Series and Literature Review.","authors":"Kazuki Sekiguchi, Iori Motoo, Takayuki Ando, Akira Noguchi, Rei Fukuda, Keiko Nomura, Yurika Nakayama, Shinya Kajiura, Yuko Ueda, Yuno Goto, Seitarou Shimada, Yusuke Takashima, Saeko Takahashi, Haruka Fujinami, Ichiro Yasuda","doi":"10.2169/internalmedicine.4945-24","DOIUrl":"10.2169/internalmedicine.4945-24","url":null,"abstract":"<p><p>Screening for colorectal cancer (CRC) in individuals with Li-Fraumeni syndrome (LFS) typically recommends initiating colonoscopy at 25 years old. We herein report a case of LFS with dual CRC and liver metastasis diagnosed before the recommended screening age. A 17-year-old boy with a history of sarcoma underwent colonoscopy, revealing 2 advanced CRCs: neuroendocrine carcinoma in the descending colon and adenocarcinoma in the rectum, each displaying distinct histological features. In addition, a TP53 missense mutation (p.His193Arg) was detected by a detailed genetic examination. LFS is associated with a heightened risk of rapid progression to invasive carcinomas due to TP53 variants. Therefore, earlier initiation of colonoscopy screening may be necessary for patients with LFS.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"3244-3251"},"PeriodicalIF":1.1,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12702535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Amyloidosis as an Atypical Cause of Biliary Stricture Diagnosed by Cholangioscopy. 淀粉样变是胆道狭窄的不典型病因。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-11-15 Epub Date: 2025-05-08 DOI: 10.2169/internalmedicine.5205-24
Jun Kubota, Sakue Masuda, Kazuya Koizumi, Makomo Makazu, Karen Kimura
{"title":"Amyloidosis as an Atypical Cause of Biliary Stricture Diagnosed by Cholangioscopy.","authors":"Jun Kubota, Sakue Masuda, Kazuya Koizumi, Makomo Makazu, Karen Kimura","doi":"10.2169/internalmedicine.5205-24","DOIUrl":"10.2169/internalmedicine.5205-24","url":null,"abstract":"<p><p>Amyloidosis is a rare cause of common bile duct (CBD) stricture that often presents with nonspecific symptoms. We herein report the case of a 61-year-old woman with CBD stricture caused by amyloidosis diagnosed through cholangioscopy and confirmed by a biopsy, with subsequent findings identifying it as AA-type amyloidosis. This condition poses diagnostic challenges owing to its rarity and non-specific manifestations. When common causes are excluded, amyloidosis should be considered in the differential diagnosis of CBD stricture. Advanced imaging and cholangioscopy with targeted biopsies are essential for making an accurate diagnosis. Documenting such cases and further research are vital to improve the understanding and management of amyloidosis-related biliary stricture.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"3226-3231"},"PeriodicalIF":1.1,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12702557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sporadic Creutzfeldt-Jakob Disease Complicated by Intracerebral Hemorrhaging in the Early Stage of Onset. 散发性克雅氏病早期并发脑出血1例
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-11-15 Epub Date: 2025-05-15 DOI: 10.2169/internalmedicine.5229-24
Masako Fujita, Haruo Nishijima, Youhei Mikami, Chieko Suzuki, Masahiko Tomiyama
{"title":"Sporadic Creutzfeldt-Jakob Disease Complicated by Intracerebral Hemorrhaging in the Early Stage of Onset.","authors":"Masako Fujita, Haruo Nishijima, Youhei Mikami, Chieko Suzuki, Masahiko Tomiyama","doi":"10.2169/internalmedicine.5229-24","DOIUrl":"10.2169/internalmedicine.5229-24","url":null,"abstract":"<p><p>The coexistence of sporadic Creutzfeldt-Jakob disease (sCJD) and intracerebral hemorrhaging (ICH) has rarely been reported, and the relationship between these conditions remains unclear. This report presents the case of a 49-year-old woman without any hemorrhagic risk factors who developed subcortical hemorrhaging in the early stages of sCJD. This case suggests that sCJD is associated with ICH, particularly in cases of subcortical hemorrhaging.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"3294-3297"},"PeriodicalIF":1.1,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12702545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rheumatoid Arthritis That Developed in a Patient with Ulcerative Colitis During Adalimumab Therapy: A Case Report and Literature Review. 阿达木单抗治疗期间溃疡性结肠炎患者发生类风湿关节炎：一例报告和文献综述
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-11-01 Epub Date: 2025-04-26 DOI: 10.2169/internalmedicine.5393-25
Takeshi Zoshima, Makoto Horita, Hiroyuki Kawahara
{"title":"Rheumatoid Arthritis That Developed in a Patient with Ulcerative Colitis During Adalimumab Therapy: A Case Report and Literature Review.","authors":"Takeshi Zoshima, Makoto Horita, Hiroyuki Kawahara","doi":"10.2169/internalmedicine.5393-25","DOIUrl":"10.2169/internalmedicine.5393-25","url":null,"abstract":"<p><p>Patients with ulcerative colitis (UC) treated with tumor necrosis factor (TNF) inhibitors can sometimes develop articular manifestations, but rarely rheumatoid arthritis (RA). We herein report the case of a 70-year-old woman who developed seropositive RA during adalimumab therapy for UC diagnosed 11 years previously. A literature review, including 30 patients with both UC and RA, identified three patients (10%) who developed RA after their diagnosis of UC. Notably, the present study is the only case in which RA developed during TNF inhibitor therapy for UC. This result demonstrates that arthritis in patients with UC can be caused by RA despite TNF inhibitor administration.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"3158-3162"},"PeriodicalIF":1.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12659946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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