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Cutaneous Arteritis Complicated by Crohn's Disease. 一例克罗恩病并发皮肤动脉炎病例
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-09-15 Epub Date: 2025-03-15 DOI: 10.2169/internalmedicine.5052-24
Takao Nagashima, Hiroki Yabe, Naoka Umemoto, Satohiro Matsumoto, Hisashi Oshiro
{"title":"Cutaneous Arteritis Complicated by Crohn's Disease.","authors":"Takao Nagashima, Hiroki Yabe, Naoka Umemoto, Satohiro Matsumoto, Hisashi Oshiro","doi":"10.2169/internalmedicine.5052-24","DOIUrl":"10.2169/internalmedicine.5052-24","url":null,"abstract":"<p><p>Cutaneous arteritis (CA) is a rare cutaneous manifestation of Crohn's disease. A 50-year-old woman with a 15-year history of CA was admitted to our hospital with a fever, abdominal pain, and hematochezia. Based on these symptoms and increased C-reactive protein levels, systemic vasculitis was considered. However, emergency colonoscopy revealed multiple longitudinal ulcers throughout the colon, thus suggesting Crohn's disease. Prednisolone (60 mg/day) was administered intravenously. A histopathological examination of the biopsied colonic mucosa revealed epithelioid granulomas, which confirmed the diagnosis of Crohn's disease. Because the systemic evolution of CA is rare, other comorbidities should be considered when patients with CA experience systemic manifestations.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2794-2796"},"PeriodicalIF":1.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of Adult T-Cell Leukemia/Lymphoma During Treatment with PD-L1 Inhibitor for Lung Cancer. PD-L1抑制剂治疗肺癌期间成人t细胞白血病/淋巴瘤的发展
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-09-15 Epub Date: 2025-03-08 DOI: 10.2169/internalmedicine.5114-24
Hikari Fujioka, Kentaro Kikuchi, Takumi Nakahara, Satoshi Yoshioka, Rina Kawai, Maki Kajitani, Mana Ishizuka, Masaya Akiyama, Yutaro Tanaka, Ayako Kobayashi, Ken Sato, Kennosuke Karube, Goh Tanaka, Tadashi Kohyama
{"title":"Development of Adult T-Cell Leukemia/Lymphoma During Treatment with PD-L1 Inhibitor for Lung Cancer.","authors":"Hikari Fujioka, Kentaro Kikuchi, Takumi Nakahara, Satoshi Yoshioka, Rina Kawai, Maki Kajitani, Mana Ishizuka, Masaya Akiyama, Yutaro Tanaka, Ayako Kobayashi, Ken Sato, Kennosuke Karube, Goh Tanaka, Tadashi Kohyama","doi":"10.2169/internalmedicine.5114-24","DOIUrl":"10.2169/internalmedicine.5114-24","url":null,"abstract":"<p><p>Advancements in immunotherapy, the phenomenon of hyperprogression in cancer patients, have garnered increasing attention. We herein report a case of acute adult T-cell leukemia/lymphoma (ATL) that developed after administration of the programmed death-ligand1 inhibitor durvalumab in a patient with lung cancer. Although the patient was a carrier of human T-cell leukemia virus type 1 (HTLV-1), this was unknown prior to durvalumab treatment. HTLV-1 bZIP factor was detected in formalin-fixed lymph node tissue, confirming the diagnosis of ATL. Our findings suggest a potential association between immune checkpoint inhibition and ATL development in HTLV-1 carriers.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2760-2763"},"PeriodicalIF":1.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful Transvaginal Endoscopic Ultrasound-guided Pelvic Abscess Drainage. 经阴道超声内镜引导下盆腔脓肿引流成功1例。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-09-15 Epub Date: 2025-03-08 DOI: 10.2169/internalmedicine.4448-24
Yoshitaka Ando, Makoto Motegi, Toshiyuki Sakurai, Masayuki Saruta
{"title":"Successful Transvaginal Endoscopic Ultrasound-guided Pelvic Abscess Drainage.","authors":"Yoshitaka Ando, Makoto Motegi, Toshiyuki Sakurai, Masayuki Saruta","doi":"10.2169/internalmedicine.4448-24","DOIUrl":"10.2169/internalmedicine.4448-24","url":null,"abstract":"<p><p>Endoscopic ultrasound-guided pelvic abscess drainage (EUS-PAD) has emerged as a viable alternative to percutaneous drainage. However, reports of this method are limited to procedures associated with transrectal access. We herein present the first case of successful transvaginal EUS-PAD in a 22-year-old female who developed a pelvic abscess after undergoing a cesarean section. An ultrasound endoscope was inserted transvaginally to visualize the abscess. Puncture and dilation were performed and a 7 Fr endoscopic nasobiliary drainage tube was put in place. The patient showed a rapid improvement after the procedure and was discharged without any complications. This case report highlights the efficacy and safety of transvaginal EUS-PAD as a viable option for performing pelvic abscess drainage.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2723-2727"},"PeriodicalIF":1.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply: How to Prevent Left Atrial Thrombus Formation Following TEER in Patients with Prior Left Atrial Appendage Occlusion. 回复：如何预防既往左房附件闭塞患者TEER后左房血栓形成。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-09-15 Epub Date: 2025-03-08 DOI: 10.2169/internalmedicine.5322-25
Kyoko Unno, Atsushi Sakamoto, Keisuke Iguchi, Makoto Sano, Kenichiro Suwa, Hayato Ohtani, Yuichiro Maekawa
{"title":"Reply: How to Prevent Left Atrial Thrombus Formation Following TEER in Patients with Prior Left Atrial Appendage Occlusion.","authors":"Kyoko Unno, Atsushi Sakamoto, Keisuke Iguchi, Makoto Sano, Kenichiro Suwa, Hayato Ohtani, Yuichiro Maekawa","doi":"10.2169/internalmedicine.5322-25","DOIUrl":"10.2169/internalmedicine.5322-25","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2816"},"PeriodicalIF":1.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recurrent Vomiting due to Severe Hyponatremic-Hypertensive Syndrome in an Elderly Patient. 老年患者重度低钠高血压综合征所致反复呕吐1例。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-09-15 Epub Date: 2025-03-15 DOI: 10.2169/internalmedicine.4725-24
Koki Morishita, Kaito Nakamura, Takafumi Kubota, Yusuke Ota, Mirei Nabuchi, Keita Hibako, Yoshimoto Serizawa, Tetsuya Hoshi
{"title":"Recurrent Vomiting due to Severe Hyponatremic-Hypertensive Syndrome in an Elderly Patient.","authors":"Koki Morishita, Kaito Nakamura, Takafumi Kubota, Yusuke Ota, Mirei Nabuchi, Keita Hibako, Yoshimoto Serizawa, Tetsuya Hoshi","doi":"10.2169/internalmedicine.4725-24","DOIUrl":"10.2169/internalmedicine.4725-24","url":null,"abstract":"<p><p>Hyponatremic-hypertensive syndrome (HHS) is a rare disorder, particularly in adults. A 76-year-old woman presented with vomiting and severe hyponatremia. The patient had been hospitalized four times over the past four years due to hyponatremia and recurrent vomiting. On admission, magnetic resonance angiography revealed left renal artery stenosis, which led to a diagnosis of HHS. Treatment with enalapril followed by tolvaptan improved the patient's condition, without the need for renal artery angioplasty. HHS should therefore be considered in patients with hyponatremia, hypertension, or recurrent vomiting. In addition to angiotensin-converting enzyme inhibitors and renal artery angioplasty, tolvaptan may also be a new effective treatment option for HHS.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2804-2808"},"PeriodicalIF":1.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bucillamine-induced Yellow Nail Syndrome with Chylothorax. buillamine诱导的黄指甲综合征合并乳糜胸1例。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-09-15 Epub Date: 2025-03-29 DOI: 10.2169/internalmedicine.4935-24
Yukari Hisamoto, Yoriyuki Murata, Kazuki Matsuda, Koji Narikiyo, Taiga Kobayashi, Kosei Yonezawa, Keita Murakawa, Kazuki Hamada, Syuichiro Ohata, Toshiaki Utsunomiya, Yoshikazu Yamaji, Keiji Oishi, Maki Asami-Noyama, Nobutaka Edakuni, Tomoyuki Kakugawa, Tsunahiko Hirano, Kazuto Matsunaga
{"title":"Bucillamine-induced Yellow Nail Syndrome with Chylothorax.","authors":"Yukari Hisamoto, Yoriyuki Murata, Kazuki Matsuda, Koji Narikiyo, Taiga Kobayashi, Kosei Yonezawa, Keita Murakawa, Kazuki Hamada, Syuichiro Ohata, Toshiaki Utsunomiya, Yoshikazu Yamaji, Keiji Oishi, Maki Asami-Noyama, Nobutaka Edakuni, Tomoyuki Kakugawa, Tsunahiko Hirano, Kazuto Matsunaga","doi":"10.2169/internalmedicine.4935-24","DOIUrl":"10.2169/internalmedicine.4935-24","url":null,"abstract":"<p><p>Yellow nail syndrome (YNS), a rare condition characterized by thickened yellow nails, lymphedema, and respiratory manifestations, is rarely caused by bucillamine, an anti-rheumatic agent. Respiratory manifestations of YNS include chylothorax in 18.8-22% of patients with pleural effusion. We herein report the first case of bucillamine-induced YNS with chylothorax. Lymphangiography revealed narrowing of the lymphatic vessels and stagnation of the lymphatic fluid, suggesting impaired lymphatic drainage. The chylothorax persisted despite the discontinuation of bucillamine. The present case illustrates that bucillamine can cause irreversible lymphatic impairment and chylothorax.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2755-2759"},"PeriodicalIF":1.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Atypical Cystic Renal Mass in a Patient with IgG4-Related Kidney Disease. igg4相关肾病患者的非典型囊性肾肿块1例报告
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-09-15 Epub Date: 2025-03-29 DOI: 10.2169/internalmedicine.4691-24
Chisato Minezaki, Hiroki Uchida, Kouhei Todaka, Nobuchika Koumatsu, Jun Okita, Akiko Kudo, Takeshi Nakata, Akihiro Fukuda, Naoya Fukunaga, Noriko Uesugi, Hirotaka Shibata
{"title":"An Atypical Cystic Renal Mass in a Patient with IgG4-Related Kidney Disease.","authors":"Chisato Minezaki, Hiroki Uchida, Kouhei Todaka, Nobuchika Koumatsu, Jun Okita, Akiko Kudo, Takeshi Nakata, Akihiro Fukuda, Naoya Fukunaga, Noriko Uesugi, Hirotaka Shibata","doi":"10.2169/internalmedicine.4691-24","DOIUrl":"10.2169/internalmedicine.4691-24","url":null,"abstract":"<p><p>We herein report a case of IgG4-related kidney disease (IgG4-RKD) with an atypical cystic renal mass in a 73-year-old man. Computed tomography revealed diffuse renal enlargement and a cystic mass in the left kidney. Blood tests revealed elevated IgG and IgG4 levels. A renal biopsy led to the IgG4-RKD diagnosis. The cystic mass was deemed to be benign based on the clinical, imaging, and ultrasonography findings. No malignancy or abscess formation was noted. Both the renal function and IgG4 levels improved after steroid treatment; moreover, the mass shrunk, suggesting an IgG4-RKD etiology. Cystic renal masses with capsule formation should be considered in patients presenting with IgG4-RKD.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2740-2746"},"PeriodicalIF":1.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of Graves' Disease after Resection of an Autonomously Functioning Thyroid Nodule. 自主功能甲状腺结节切除术后Graves病的发展。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-09-15 Epub Date: 2025-03-22 DOI: 10.2169/internalmedicine.4597-24
Shigenori Nakamura
{"title":"Development of Graves' Disease after Resection of an Autonomously Functioning Thyroid Nodule.","authors":"Shigenori Nakamura","doi":"10.2169/internalmedicine.4597-24","DOIUrl":"10.2169/internalmedicine.4597-24","url":null,"abstract":"<p><p>We herein report a 46-year-old woman with autonomously functioning thyroid nodules (AFTNs) who developed Graves' disease (GD) approximately one year after AFTN resection. Before surgery, the patient was positive for anti-thyroglobulin antibodies (TgAb) and anti-thyroid peroxidase antibodies (TPOAb), and negative for TSH-receptor antibodies (TRAb). An AFTN is a follicular adenoma surrounded by chronic thyroiditis. At the onset of GD, her TgAb and TPOAb titers increased, and TRAb became positive. This case suggests that surgery releases a large amount of thyroid tissue that contains thyroid-stimulating hormone receptors, leading to GD in susceptible individuals. Preoperative chronic thyroiditis can predict the postoperative development of GD.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2728-2732"},"PeriodicalIF":1.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scoping Review of the Health Benefits of Stretching Exercises in Patients with Type 2 Diabetes Mellitus. 伸展运动对2型糖尿病患者健康益处的范围综述
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-09-15 Epub Date: 2025-03-29 DOI: 10.2169/internalmedicine.4928-24
Tomoko Takamiya, Rokuro Ito, Junko Sasaki, Toshihiro Amagawa, Sawako Wakui, Yuko Odagiri, Ryo Suzuki
{"title":"Scoping Review of the Health Benefits of Stretching Exercises in Patients with Type 2 Diabetes Mellitus.","authors":"Tomoko Takamiya, Rokuro Ito, Junko Sasaki, Toshihiro Amagawa, Sawako Wakui, Yuko Odagiri, Ryo Suzuki","doi":"10.2169/internalmedicine.4928-24","DOIUrl":"10.2169/internalmedicine.4928-24","url":null,"abstract":"<p><p>This study aimed to clarify the current state of research on the effects of stretching exercises on the health of patients with type 2 diabetes mellitus (T2DM). A scoping review of the literature was conducted in December 2024, using four databases. Experimental and clinical studies were included if they compared stretching exercises with non-stretching exercises for T2DM-related health outcomes. The primary search terms used were \"diabetes mellitus, type 2,\" \"muscle stretching exercises,\" and \"range of motion, articular.\" Eleven studies met our inclusion criteria. Eight studies focused on blood glucose levels, one of which assessed the functional capacity. The remaining studies investigated plantar pressure, shoulder joint mobility/pain/disability, and fatigue, with one study addressing each outcome. This review indicates that stretching exercises may affect a variety of health parameters, including blood glucose regulation, in patients with T2DM but emphasizes the need for further high-quality research to determine their effectiveness.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2681-2691"},"PeriodicalIF":1.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe Systemic Lupus Erythematosus with Anti-centromere Antibody. 重度系统性红斑狼疮伴着丝粒抗体1例。
IF 1.1 4区 医学
Internal Medicine Pub Date : 2025-09-15 Epub Date: 2025-02-22 DOI: 10.2169/internalmedicine.4951-24
Wataru Fujii, Takahiro Seno, Masataka Kohno, Ikoi Omatsu, Eiichi Konishi, Yu Mihara, Yutaka Kawahito
{"title":"Severe Systemic Lupus Erythematosus with Anti-centromere Antibody.","authors":"Wataru Fujii, Takahiro Seno, Masataka Kohno, Ikoi Omatsu, Eiichi Konishi, Yu Mihara, Yutaka Kawahito","doi":"10.2169/internalmedicine.4951-24","DOIUrl":"10.2169/internalmedicine.4951-24","url":null,"abstract":"<p><p>Systemic lupus erythematosus (SLE) is a systemic disease that affects several organs. The diagnosis was performed using the international classification criteria updated in 2019. The significance of anti-nuclear antibodies (ANAs) with a centromere pattern has not been clearly documented in these criteria. We herein report a patient with ANAs with a centromere pattern and anti-centromere antibodies, without anti-Sm antibodies or anti-dsDNA antibodies, who developed severe lupus nephritis, neuropsychiatric SLE, and lupus pleuritis. The patient was successfully treated with prednisolone, hydroxychloroquine, mycophenolate mofetil, cyclophosphamide, and belimumab, despite several relapses. Anti-centromere antibodies are not regarded as characteristics of SLE but can be detected in SLE patients with severe organ involvement.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2790-2793"},"PeriodicalIF":1.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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