在滤泡性淋巴瘤患者中obinutuzumab诱导的急性血小板减少模拟免疫性血小板减少。

IF 1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Internal Medicine Pub Date : 2025-04-12 DOI:10.2169/internalmedicine.5191-24

Misato Tane, Hiroki Hosoi, Takayuki Hiroi, Shogo Murata, Toshiki Mushino, Takashi Sonoki

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引用次数: 0

摘要

obinutuzumab诱导的急性血小板减少症的特点是在给药后血小板计数迅速下降。其潜在机制尚不清楚。然而，我们提出了与其病理生理相关的新的实验室发现。一名65岁的滤泡性淋巴瘤女性患者在服用binutuzumab后24小时内出现急性血小板减少症。实验室结果显示类似急性免疫性血小板减少性紫癜的特征，包括未成熟血小板分数升高，血小板生成素水平轻度升高，血小板相关IgG升高，血小板输注难治。我们的病例和她的实验室结果表明，血小板消耗增加可能参与了本脲单抗诱导的急性血小板减少症的发展。

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Obinutuzumab-induced Acute Thrombocytopenia Mimicking Immune Thrombocytopenia in a Patient with Follicular Lymphoma.

Obinutuzumab-induced acute thrombocytopenia is characterized by a rapid decrease in the platelet count after administration. The underlying mechanisms remain unclear. However, we present novel laboratory findings related to its pathophysiology. A 65-year-old woman with follicular lymphoma developed acute thrombocytopenia within 24 hours after obinutuzumab administration. Laboratory results showed features resembling acute immune thrombocytopenic purpura, including an elevated immature platelet fraction, mildly increased thrombopoietin levels, elevated platelet-associated IgG, and refractory to platelet transfusion. Our case and her laboratory findings suggest that increased platelet consumption might be involved in the development of obinutuzumab-induced acute thrombocytopenia.

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来源期刊

Internal Medicine 医学-医学：内科

CiteScore

1.90

自引率

8.30%

发文量

审稿时长

2.2 months

期刊介绍： Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine. Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.