Development of Graves' Disease after Resection of an Autonomously Functioning Thyroid Nodule.

IF 1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Internal Medicine Pub Date : 2025-03-22 DOI:10.2169/internalmedicine.4597-24

Shigenori Nakamura

引用次数: 0

Abstract

We herein report a 46-year-old woman with autonomously functioning thyroid nodules (AFTNs) who developed Graves' disease (GD) approximately one year after AFTN resection. Before surgery, the patient was positive for TgAb and TPOAb, and negative for TRAb. An AFTN is a follicular adenoma surrounded by chronic thyroiditis. At the onset of GD, her TgAb and TPOAb titers increased, and TRAb became positive. This case suggests that surgery releases a large amount of thyroid tissue that contains thyroid-stimulating hormone receptors, leading to GD in susceptible individuals. Preoperative chronic thyroiditis can predict the postoperative development of GD.

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我们在此报告了一名患有自主功能甲状腺结节（AFTN）的46岁女性患者，她在切除AFTN约一年后患上了巴塞杜氏病（GD）。手术前，患者的TgAb和TPOAb呈阳性，TRAb呈阴性。AFTN是一种被慢性甲状腺炎包围的滤泡性腺瘤。在广东发病时，她的TgAb和TPOAb滴度升高，TRAb呈阳性。该病例表明，手术会释放出大量含有促甲状腺激素受体的甲状腺组织，从而导致易感人群出现 GD。术前慢性甲状腺炎可预测术后GD的发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Internal Medicine 医学-医学：内科

CiteScore

1.90

自引率

8.30%

发文量

审稿时长

2.2 months

期刊介绍： Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine. Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.