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A Serial Assessment of T1 and T2 Mapping Cardiac Magnetic Resonance Before and After Heart Failure Onset in a Case of Cardiomyopathy in Anti-mitochondrial Antibody-positive Myositis. 1例抗线粒体抗体阳性肌炎心肌病心衰发病前后的T1和T2心脏磁共振成像序列评估
IF 1 4区 医学
Internal Medicine Pub Date : 2025-03-22 DOI: 10.2169/internalmedicine.5007-24
Mitsuru Ishizuka, Hideaki Suzuki, Satoshi Higuchi, Hidenobu Takagi, Naoki Suzuki, Rumiko Izumi, Hirofumi Watanabe, Haruka Sato, Taijyu Satoh, Saori Miyamichi-Yamamoto, Nobuhiro Yaoita, Kouki Takeuchi, Marina Arai, Hideka Hayashi, Kotaro Nochioka, Hiroyuki Takahama, Shunsuke Tatebe, Hiroshi Fujii, Masashi Aoki, Satoshi Yasuda
{"title":"A Serial Assessment of T1 and T2 Mapping Cardiac Magnetic Resonance Before and After Heart Failure Onset in a Case of Cardiomyopathy in Anti-mitochondrial Antibody-positive Myositis.","authors":"Mitsuru Ishizuka, Hideaki Suzuki, Satoshi Higuchi, Hidenobu Takagi, Naoki Suzuki, Rumiko Izumi, Hirofumi Watanabe, Haruka Sato, Taijyu Satoh, Saori Miyamichi-Yamamoto, Nobuhiro Yaoita, Kouki Takeuchi, Marina Arai, Hideka Hayashi, Kotaro Nochioka, Hiroyuki Takahama, Shunsuke Tatebe, Hiroshi Fujii, Masashi Aoki, Satoshi Yasuda","doi":"10.2169/internalmedicine.5007-24","DOIUrl":"https://doi.org/10.2169/internalmedicine.5007-24","url":null,"abstract":"<p><p>A 69-year-old woman presented with heart failure and progressive muscle weakness and was diagnosed as anti-mitochondrial antibody (AMA) myositis with cardiac involvement. Immunosuppressive therapy with prednisolone and intravenous cyclophosphamide significantly improved the symptoms, hemodynamics, and cardiac function. Cardiac magnetic resonance (CMR) T1 and T2 mapping showed elevated native T1, T2, and extracellular volume fractions during heart failure exacerbation (day 37) compared to pre-hospitalization values (10 months before admission) and follow-up conducted 6 and 12 months after admission. This case underscores the importance of comprehensive evaluation, such as serial CMR imaging and immunosuppressive therapy, in managing myocardial involvement in AMA-positive myositis.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Central-venous Catheter Insertion in Progressive-fibrosing Interstitial Lung Disease. 进行性纤维化间质性肺病中心静脉导管置入。
IF 1 4区 医学
Internal Medicine Pub Date : 2025-03-22 DOI: 10.2169/internalmedicine.5203-24
Masaki Anzai, Ai Takeuchi, Miho Mitsui, Tamotsu Ishizuka
{"title":"Central-venous Catheter Insertion in Progressive-fibrosing Interstitial Lung Disease.","authors":"Masaki Anzai, Ai Takeuchi, Miho Mitsui, Tamotsu Ishizuka","doi":"10.2169/internalmedicine.5203-24","DOIUrl":"https://doi.org/10.2169/internalmedicine.5203-24","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunosuppressive Drug-associated Lymphoproliferative Disease with a Cardiac Mass. 伴心脏肿块的免疫抑制药物相关淋巴细胞增生性疾病
IF 1 4区 医学
Internal Medicine Pub Date : 2025-03-22 DOI: 10.2169/internalmedicine.5184-24
Wataru Sone, Kaho Hayashi, Taito Miyake, Katsunori Kyoda
{"title":"Immunosuppressive Drug-associated Lymphoproliferative Disease with a Cardiac Mass.","authors":"Wataru Sone, Kaho Hayashi, Taito Miyake, Katsunori Kyoda","doi":"10.2169/internalmedicine.5184-24","DOIUrl":"https://doi.org/10.2169/internalmedicine.5184-24","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasma Cell-rich Nephritis with a Systemic Polyclonal Lymphoproliferative Disorder, Mimicking Idiopathic Multicentric Castleman Disease, Systemic Lupus Erythematosus, and IgG4-related Disease. 富浆细胞肾炎伴全身性多克隆淋巴增生性疾病，模拟特发性多中心Castleman病、系统性红斑狼疮和igg4相关疾病
IF 1 4区 医学
Internal Medicine Pub Date : 2025-03-22 DOI: 10.2169/internalmedicine.4906-24
Yu Hebisawa, Akihito Ohta, Ryutaro Sekimoto, Natsuko Sakurai, Keigo Setoguchi
{"title":"Plasma Cell-rich Nephritis with a Systemic Polyclonal Lymphoproliferative Disorder, Mimicking Idiopathic Multicentric Castleman Disease, Systemic Lupus Erythematosus, and IgG4-related Disease.","authors":"Yu Hebisawa, Akihito Ohta, Ryutaro Sekimoto, Natsuko Sakurai, Keigo Setoguchi","doi":"10.2169/internalmedicine.4906-24","DOIUrl":"https://doi.org/10.2169/internalmedicine.4906-24","url":null,"abstract":"<p><p>Idiopathic multicentric Castleman disease (iMCD), systemic lupus erythematosus (SLE), and IgG4-related disease (IgG4-RD) can cause lymphadenopathy with renal involvement. As no gold standards have been set for diagnosing these conditions, diagnoses can be made by excluding other conditions. However, some cases are difficult to identify. A 60-year-old man presented with lymphadenopathy, renal dysfunction, and hypocomplementemia. Autoimmune pancreatitis and iMCD had been suspected. A renal biopsy revealed immune complex-mediated glomerulonephritis superimposed on endothelial injury and plasma cell-rich tubulointerstitial nephritis with storiform-like fibrosis. While the features of iMCD, SLE, and IgG4-RD were present, a clear classification could not be achieved.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of Thyrotoxicosis and Excess Iodine Due to Habitual Use of Polyvinylpyrrolidone Iodine while Gargling in an Iodine-sufficient Area. 足碘地区含碘时习惯性使用聚乙烯吡咯烷酮碘致甲状腺毒症和碘过量1例。
IF 1 4区 医学
Internal Medicine Pub Date : 2025-03-22 DOI: 10.2169/internalmedicine.4868-24
Kanako Sato, Hiroaki Asai, Saori Yoshioka, Keisuke Murakawa, Hiroyuki Sho, Ryoko Inui, Motohiro Kosugi, Yoji Hazama, Tetsuyuki Yasuda
{"title":"A Case of Thyrotoxicosis and Excess Iodine Due to Habitual Use of Polyvinylpyrrolidone Iodine while Gargling in an Iodine-sufficient Area.","authors":"Kanako Sato, Hiroaki Asai, Saori Yoshioka, Keisuke Murakawa, Hiroyuki Sho, Ryoko Inui, Motohiro Kosugi, Yoji Hazama, Tetsuyuki Yasuda","doi":"10.2169/internalmedicine.4868-24","DOIUrl":"https://doi.org/10.2169/internalmedicine.4868-24","url":null,"abstract":"<p><p>Excess iodine can influence the pathophysiology of the thyroid gland and results of various thyroid-related examinations. We herein report a 60-year-old Japanese man with thyrotoxicosis and excess iodine due to habitual use of polyvinylpyrrolidone iodine (PVP-I) to gargle for 20 years. Initial laboratory and imaging findings were suggestive of painless thyroiditis. However, after cessation of PVP-I use for gargling, these results changed to findings suggestive of Graves' disease, with worsening thyrotoxicosis. A detailed questionnaire regarding excess iodine is important for the accurate diagnosis of thyrotoxicosis, even in patients living in iodine-sufficient areas where iodine-induced thyrotoxicosis is rare.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case with Oligogenic Familial Hypercholesterolemia Treated by Combination Therapy of Statin, Ezetimibe, PCSK9 Inhibitor, and Lomitapide. 他汀、依折替米贝、PCSK9抑制剂和洛米他胺联合治疗低原性家族性高胆固醇血症1例。
IF 1 4区 医学
Internal Medicine Pub Date : 2025-03-22 DOI: 10.2169/internalmedicine.5025-24
Nobuko Kojima, Hayato Tada, Masayuki Takamura
{"title":"A Case with Oligogenic Familial Hypercholesterolemia Treated by Combination Therapy of Statin, Ezetimibe, PCSK9 Inhibitor, and Lomitapide.","authors":"Nobuko Kojima, Hayato Tada, Masayuki Takamura","doi":"10.2169/internalmedicine.5025-24","DOIUrl":"https://doi.org/10.2169/internalmedicine.5025-24","url":null,"abstract":"<p><p>We encountered a 40-year-old man diagnosed with homozygous familial hypercholesterolemia (FH) based on clinical findings. The initial low-density lipoprotein (LDL)-cholesterol level was 393 mg/dL. He underwent coronary artery bypass graft (CABG) surgery for three-vessel disease. Genetic testing revealed a pathogenic variant in the LDL receptor (LDLR) and a missense variant in apolipoprotein E (APOE), known as APOE4, leading to the diagnosis of oligogenic FH. His LDL-cholesterol level was well controlled by the introduction of a proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor and lomitapide (approximately 30 mg/dL). Combination therapy is effective in reducing LDL levels.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coexistence of Relapsing Polychondritis, Crohn's Disease, and Pyoderma Gangrenosum Treated Successfully with Adalimumab: A Case Report and Literature Review. 阿达木单抗成功治疗复发性多软骨炎、克罗恩病和坏疽性脓皮病的共存：一例报告和文献综述
IF 1 4区 医学
Internal Medicine Pub Date : 2025-03-22 DOI: 10.2169/internalmedicine.5024-24
Shun Yamazaki, Kentaro Tominaga, Kotaro Watanabe, Makoto Watanabe, Shuhei Kondo, Norihiro Sakai, Tomoaki Yoshida, Yuichi Kojima, Yusuke Watanabe, Yuzo Kawata, Naruhiro Kimura, Kazuya Takahashi, Hiroki Sato, Satoshi Ikarashi, Hiroteru Kamimura, Kazunao Hayashi, Shuji Terai
{"title":"Coexistence of Relapsing Polychondritis, Crohn's Disease, and Pyoderma Gangrenosum Treated Successfully with Adalimumab: A Case Report and Literature Review.","authors":"Shun Yamazaki, Kentaro Tominaga, Kotaro Watanabe, Makoto Watanabe, Shuhei Kondo, Norihiro Sakai, Tomoaki Yoshida, Yuichi Kojima, Yusuke Watanabe, Yuzo Kawata, Naruhiro Kimura, Kazuya Takahashi, Hiroki Sato, Satoshi Ikarashi, Hiroteru Kamimura, Kazunao Hayashi, Shuji Terai","doi":"10.2169/internalmedicine.5024-24","DOIUrl":"https://doi.org/10.2169/internalmedicine.5024-24","url":null,"abstract":"<p><p>Relapsing polychondritis (RP) is a rare, progressive, immune-mediated systemic inflammatory disease of unknown etiology characterized by recurrent inflammation of cartilaginous structures. Approximately 30% of RP cases are associated with autoimmune disease. However, co-occurrence of RP and Crohn's disease (CD) has rarely been reported. We herein report a case of coexisting RP, CD, and pyoderma gangrenosum that was successfully treated with adalimumab in combination with methotrexate. We believe that this case and literature review will facilitate the accurate and prompt diagnosis and treatment of RP combined with CD and various other complications.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatocellular Carcinoma Arising Adjacent to Antiphospholipid Syndrome-associated Hepatic Infarction in a Non-cirrhotic Liver. 非肝硬化肝脏抗磷脂综合征相关性肝梗死附近发生的肝细胞癌。
IF 1 4区 医学
Internal Medicine Pub Date : 2025-03-22 DOI: 10.2169/internalmedicine.5081-24
Yuriko Kusumi, Takumu Hasebe, Manami Hayashi, Yuki Kamikokura, Shin Otake, Hidemi Hayashi, Yu Ota, Shunsuke Nakajima, Kazunobu Aso, Koji Sawada, Mishie Tanino, Mikihiro Fujiya
{"title":"Hepatocellular Carcinoma Arising Adjacent to Antiphospholipid Syndrome-associated Hepatic Infarction in a Non-cirrhotic Liver.","authors":"Yuriko Kusumi, Takumu Hasebe, Manami Hayashi, Yuki Kamikokura, Shin Otake, Hidemi Hayashi, Yu Ota, Shunsuke Nakajima, Kazunobu Aso, Koji Sawada, Mishie Tanino, Mikihiro Fujiya","doi":"10.2169/internalmedicine.5081-24","DOIUrl":"https://doi.org/10.2169/internalmedicine.5081-24","url":null,"abstract":"<p><p>A man in his 70s with antiphospholipid syndrome (APS) presented with a hepatic mass. Initial imaging suggested hepatic infarction, as the liver tumor markers were normal, and coagulation tests indicated a hypercoagulable state. Three years later, follow-up imaging revealed tumor enlargement, leading to a biopsy-confirmed hepatocellular carcinoma diagnosis. Transarterial embolization was performed followed by lenvatinib therapy. The patient achieved complete response with no recurrence for over eight months. This case highlights the potential of APS to contribute to liver carcinogenesis in non-cirrhotic patients and illustrates the need for individualized treatment strategies.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IgG4-related Disease Concomitant with Diffuse Large B-cell Lymphoma. 伴发弥漫大 B 细胞淋巴瘤的 IgG4 相关疾病。
IF 1 4区 医学
Internal Medicine Pub Date : 2025-03-15 Epub Date: 2024-08-08 DOI: 10.2169/internalmedicine.4010-24
Hiroto Yanagisawa, Keita Mishima, Yaya Yamanouchi, Yusuke Ueda, Takahiro Yamano, Haruka Iwao-Kawanami, Tomoyuki Sakai, Takafumi Kawanami, Kazunori Yamada, Mitsuhiro Kawano, Shuichi Mizuta, Toshihiro Fukushima, Yasufumi Masaki
{"title":"IgG4-related Disease Concomitant with Diffuse Large B-cell Lymphoma.","authors":"Hiroto Yanagisawa, Keita Mishima, Yaya Yamanouchi, Yusuke Ueda, Takahiro Yamano, Haruka Iwao-Kawanami, Tomoyuki Sakai, Takafumi Kawanami, Kazunori Yamada, Mitsuhiro Kawano, Shuichi Mizuta, Toshihiro Fukushima, Yasufumi Masaki","doi":"10.2169/internalmedicine.4010-24","DOIUrl":"10.2169/internalmedicine.4010-24","url":null,"abstract":"<p><p>A 77-year-old man presented with right inguinal lymphadenopathy and swollen parotid and submandibular glands bilaterally. Histopathology revealed germinal center B-cell type diffuse large B-cell lymphoma (DLBCL) in the inguinal lymph node. Lymphocyte and plasma cell infiltration in the submandibular gland with elevated serum IgG4 levels (13 g/L) prompted a diagnosis of IgG4-related disease (IgG4-RD). Systemic chemotherapy for DLBCL led to shrinkage of the lymph nodes and disappearance of the submandibular gland swelling, as confirmed by fluorodeoxyglucose-positron emission tomography/computed tomography. Although concomitant IgG4-RD and lymphoma have been reported, their simultaneous diagnosis is rare; therefore, a biopsy of all involved organs is crucial in cases with unusual organ involvement.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"953-957"},"PeriodicalIF":1.0,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interleukin-6 Immunology in Macrophage Activation Syndrome Related to Neuroimmunological Diseases. 与神经免疫疾病相关的巨噬细胞活化综合征中的白细胞介素-6免疫学。
IF 1 4区 医学
Internal Medicine Pub Date : 2025-03-15 Epub Date: 2024-08-28 DOI: 10.2169/internalmedicine.3757-24
Taichi Nomura, Masaaki Niino, Toshio Odani, Ryoji Naganuma, Itaru Amino, Yusei Miyazaki, Sachiko Akimoto, Zen-Ichi Tanei, Taichi Kimura, Naoya Minami, Seiji Kikuchi
{"title":"Interleukin-6 Immunology in Macrophage Activation Syndrome Related to Neuroimmunological Diseases.","authors":"Taichi Nomura, Masaaki Niino, Toshio Odani, Ryoji Naganuma, Itaru Amino, Yusei Miyazaki, Sachiko Akimoto, Zen-Ichi Tanei, Taichi Kimura, Naoya Minami, Seiji Kikuchi","doi":"10.2169/internalmedicine.3757-24","DOIUrl":"10.2169/internalmedicine.3757-24","url":null,"abstract":"<p><p>Macrophage activation syndrome (MAS) involves an excessive amount of acute inflammatory responses to inflammatory cytokines, particularly interleukin-6 (IL-6). IL-6 is also strongly associated with the pathophysiology of certain neuroimmunological diseases. However, there have so far been few reports of MAS being accompanied by neuroimmunological diseases. We herein report two cases of MAS comorbid with myasthenia gravis or neuromyelitis optica spectrum disorders, IL-6 related neuroimmunological diseases. Standard immunosuppressive therapies could not stabilize the symptoms in our cases until antibodies against the IL-6 receptor were administered. This finding suggests that it is important to consider the underlying pathophysiology of MAS in relation to these neuroimmunological diseases when treating affected patients.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"941-945"},"PeriodicalIF":1.0,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142092845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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