{"title":"伴发弥漫大 B 细胞淋巴瘤的 IgG4 相关疾病。","authors":"Hiroto Yanagisawa, Keita Mishima, Yaya Yamanouchi, Yusuke Ueda, Takahiro Yamano, Haruka Iwao-Kawanami, Tomoyuki Sakai, Takafumi Kawanami, Kazunori Yamada, Mitsuhiro Kawano, Shuichi Mizuta, Toshihiro Fukushima, Yasufumi Masaki","doi":"10.2169/internalmedicine.4010-24","DOIUrl":null,"url":null,"abstract":"<p><p>A 77-year-old man presented with right inguinal lymphadenopathy and swollen parotid and submandibular glands bilaterally. Histopathology revealed germinal center B-cell type diffuse large B-cell lymphoma (DLBCL) in the inguinal lymph node. Lymphocyte and plasma cell infiltration in the submandibular gland with elevated serum IgG4 levels (13 g/L) prompted a diagnosis of IgG4-related disease (IgG4-RD). Systemic chemotherapy for DLBCL led to shrinkage of the lymph nodes and disappearance of the submandibular gland swelling, as confirmed by fluorodeoxyglucose-positron emission tomography/computed tomography. Although concomitant IgG4-RD and lymphoma have been reported, their simultaneous diagnosis is rare; therefore, a biopsy of all involved organs is crucial in cases with unusual organ involvement.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"953-957"},"PeriodicalIF":1.0000,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"IgG4-related Disease Concomitant with Diffuse Large B-cell Lymphoma.\",\"authors\":\"Hiroto Yanagisawa, Keita Mishima, Yaya Yamanouchi, Yusuke Ueda, Takahiro Yamano, Haruka Iwao-Kawanami, Tomoyuki Sakai, Takafumi Kawanami, Kazunori Yamada, Mitsuhiro Kawano, Shuichi Mizuta, Toshihiro Fukushima, Yasufumi Masaki\",\"doi\":\"10.2169/internalmedicine.4010-24\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A 77-year-old man presented with right inguinal lymphadenopathy and swollen parotid and submandibular glands bilaterally. Histopathology revealed germinal center B-cell type diffuse large B-cell lymphoma (DLBCL) in the inguinal lymph node. Lymphocyte and plasma cell infiltration in the submandibular gland with elevated serum IgG4 levels (13 g/L) prompted a diagnosis of IgG4-related disease (IgG4-RD). Systemic chemotherapy for DLBCL led to shrinkage of the lymph nodes and disappearance of the submandibular gland swelling, as confirmed by fluorodeoxyglucose-positron emission tomography/computed tomography. Although concomitant IgG4-RD and lymphoma have been reported, their simultaneous diagnosis is rare; therefore, a biopsy of all involved organs is crucial in cases with unusual organ involvement.</p>\",\"PeriodicalId\":13719,\"journal\":{\"name\":\"Internal Medicine\",\"volume\":\" \",\"pages\":\"953-957\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2025-03-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Internal Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2169/internalmedicine.4010-24\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/8/8 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Internal Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2169/internalmedicine.4010-24","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/8/8 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
摘要
一名 77 岁的男子出现右腹股沟淋巴结病变，双侧腮腺和颌下腺肿大。组织病理学检查显示，腹股沟淋巴结中存在生殖中心 B 细胞型弥漫大 B 细胞淋巴瘤（DLBCL）。颌下腺淋巴细胞和浆细胞浸润，血清IgG4水平升高（13克/升），诊断为IgG4相关疾病（IgG4-RD）。氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描证实，DLBCL 的全身化疗导致淋巴结缩小，颌下腺肿胀消失。尽管有报道称同时存在IgG4-RD和淋巴瘤，但它们同时被诊断出来的情况并不多见；因此，在有异常器官受累的病例中，对所有受累器官进行活检至关重要。
IgG4-related Disease Concomitant with Diffuse Large B-cell Lymphoma.
A 77-year-old man presented with right inguinal lymphadenopathy and swollen parotid and submandibular glands bilaterally. Histopathology revealed germinal center B-cell type diffuse large B-cell lymphoma (DLBCL) in the inguinal lymph node. Lymphocyte and plasma cell infiltration in the submandibular gland with elevated serum IgG4 levels (13 g/L) prompted a diagnosis of IgG4-related disease (IgG4-RD). Systemic chemotherapy for DLBCL led to shrinkage of the lymph nodes and disappearance of the submandibular gland swelling, as confirmed by fluorodeoxyglucose-positron emission tomography/computed tomography. Although concomitant IgG4-RD and lymphoma have been reported, their simultaneous diagnosis is rare; therefore, a biopsy of all involved organs is crucial in cases with unusual organ involvement.
期刊介绍：
Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine.
Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.
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