A Serial Assessment of T1 and T2 Mapping Cardiac Magnetic Resonance Before and After Heart Failure Onset in a Case of Cardiomyopathy in Anti-mitochondrial Antibody-positive Myositis.

IF 1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Internal Medicine Pub Date : 2025-03-22 DOI:10.2169/internalmedicine.5007-24

Mitsuru Ishizuka, Hideaki Suzuki, Satoshi Higuchi, Hidenobu Takagi, Naoki Suzuki, Rumiko Izumi, Hirofumi Watanabe, Haruka Sato, Taijyu Satoh, Saori Miyamichi-Yamamoto, Nobuhiro Yaoita, Kouki Takeuchi, Marina Arai, Hideka Hayashi, Kotaro Nochioka, Hiroyuki Takahama, Shunsuke Tatebe, Hiroshi Fujii, Masashi Aoki, Satoshi Yasuda

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引用次数: 0

Abstract

A 69-year-old woman presented with heart failure and progressive muscle weakness and was diagnosed as anti-mitochondrial antibody (AMA) myositis with cardiac involvement. Immunosuppressive therapy with prednisolone and intravenous cyclophosphamide significantly improved the symptoms, hemodynamics, and cardiac function. Cardiac magnetic resonance (CMR) T1 and T2 mapping showed elevated native T1, T2, and extracellular volume fractions during heart failure exacerbation (day 37) compared to pre-hospitalization values (10 months before admission) and follow-up conducted 6 and 12 months after admission. This case underscores the importance of comprehensive evaluation, such as serial CMR imaging and immunosuppressive therapy, in managing myocardial involvement in AMA-positive myositis.

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1例抗线粒体抗体阳性肌炎心肌病心衰发病前后的T1和T2心脏磁共振成像序列评估

一名 69 岁的妇女出现心力衰竭和进行性肌无力，被诊断为抗线粒体抗体（AMA）肌炎并累及心脏。使用泼尼松龙和静脉注射环磷酰胺进行免疫抑制治疗后，症状、血流动力学和心功能明显改善。心脏磁共振（CMR）T1和T2图显示，与入院前（入院前10个月）和入院后6个月和12个月的随访值相比，心衰加重期（第37天）的原生T1、T2和细胞外容积分数升高。该病例强调了综合评估的重要性，如连续的CMR成像和免疫抑制治疗，对于控制AMA阳性肌炎的心肌受累非常重要。

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来源期刊

Internal Medicine 医学-医学：内科

CiteScore

1.90

自引率

8.30%

发文量

审稿时长

2.2 months

期刊介绍： Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine. Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.