{"title":"Sarcoid Neuropathy Presenting with Two Novel Ultrasound Findings of Increased Intraneural Blood Flow and Small Saphenous Vein Wall Thickening.","authors":"Hiroki Yamazaki, Ryota Sato, Tomoyasu Matsubara, Naoko Takamatsu, Yusuke Osaki, Takashi Kanda, Yuishin Izumi","doi":"10.2169/internalmedicine.4964-24","DOIUrl":null,"url":null,"abstract":"<p><p>Diagnosing sarcoid neuropathy (SN) can be difficult because of its nonspecific symptoms and requirement for histological confirmation. We herein report a 71-year-old woman who presented with distal muscle weakness and paresthesia. Nerve conduction studies support the existence of polyneuropathy. Nerve ultrasonography revealed enlargement of the sural nerve and loss of the normal \"honeycomb\" appearance. In addition, increased intraneural blood flow within the nerve and small saphenous vein wall thickening were observed. These ultrasound findings led to a successful nerve biopsy confirming SN. Steroid therapy has resulted in clinical and ultrasonographic improvements. These results suggest the potential utility of ultrasound for diagnosing and monitoring SN.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"2779-2783"},"PeriodicalIF":1.1000,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12508612/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Internal Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2169/internalmedicine.4964-24","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/8 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Diagnosing sarcoid neuropathy (SN) can be difficult because of its nonspecific symptoms and requirement for histological confirmation. We herein report a 71-year-old woman who presented with distal muscle weakness and paresthesia. Nerve conduction studies support the existence of polyneuropathy. Nerve ultrasonography revealed enlargement of the sural nerve and loss of the normal "honeycomb" appearance. In addition, increased intraneural blood flow within the nerve and small saphenous vein wall thickening were observed. These ultrasound findings led to a successful nerve biopsy confirming SN. Steroid therapy has resulted in clinical and ultrasonographic improvements. These results suggest the potential utility of ultrasound for diagnosing and monitoring SN.
期刊介绍：
Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine.
Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.
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