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Left Atrial Anomalous Band in Left Atrial Appendage. 左房阑尾异常带
IF 1 4区 医学
Internal Medicine Pub Date : 2024-11-21 DOI: 10.2169/internalmedicine.4652-24
Yuki Nakajima, Yuki Saito, Takumi Hatta, Yasuo Okumura
{"title":"Left Atrial Anomalous Band in Left Atrial Appendage.","authors":"Yuki Nakajima, Yuki Saito, Takumi Hatta, Yasuo Okumura","doi":"10.2169/internalmedicine.4652-24","DOIUrl":"https://doi.org/10.2169/internalmedicine.4652-24","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Patient with Calpainopathy Carrying Compound Heterozygous Mutations of a De Novo Pathogenic Variant of c.1333G>A and a Novel Variant of c.1331C>T in CAPN3. 一例携带 CAPN3 中 c.1333G>A 基因突变和 c.1331C>T 基因突变的钙蛋白酶病患者。
IF 1 4区 医学
Internal Medicine Pub Date : 2024-11-15 Epub Date: 2024-03-18 DOI: 10.2169/internalmedicine.3435-23
Shogo Komaki, Akatsuki Kubota, Kazuto Katsuse, Asuka Kitamura, Meiko Maeda, Takashi Matsukawa, Nobuyuki Eura, Yoshihiko Saito, Ichizo Nishino, Tatsushi Toda
{"title":"A Patient with Calpainopathy Carrying Compound Heterozygous Mutations of a De Novo Pathogenic Variant of c.1333G>A and a Novel Variant of c.1331C>T in CAPN3.","authors":"Shogo Komaki, Akatsuki Kubota, Kazuto Katsuse, Asuka Kitamura, Meiko Maeda, Takashi Matsukawa, Nobuyuki Eura, Yoshihiko Saito, Ichizo Nishino, Tatsushi Toda","doi":"10.2169/internalmedicine.3435-23","DOIUrl":"10.2169/internalmedicine.3435-23","url":null,"abstract":"<p><p>Calpainopathy is primarily an autosomal recessive inherited myopathy; however, dominantly inherited cases with a pathogenic variant of c.1333G>A have been reported. A 13-year-old Japanese girl presented with toe walking and elevated serum creatine kinase levels. Genetic panel testing revealed compound heterozygosity for c.1333G>A and a novel variant of c.1331C>T in CAPN3, leading to a diagnosis of calpainopathy. A genetic analysis of her parents revealed the possibility that c.1333G>A was de novo. In this patient, the onset age was earlier than that of the reported autosomal dominant cases, suggesting the influence of the novel variant in the contralateral allele.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"3083-3086"},"PeriodicalIF":1.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11637793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140143355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Calcifying Fibrous Tumors Resembling Coral. 类似珊瑚的钙化纤维瘤
IF 1 4区 医学
Internal Medicine Pub Date : 2024-11-15 Epub Date: 2024-03-18 DOI: 10.2169/internalmedicine.3500-24
Fumihiro Kashizaki, Taiki Kano, Yohei Kameda, Hiroyuki Osawa
{"title":"Calcifying Fibrous Tumors Resembling Coral.","authors":"Fumihiro Kashizaki, Taiki Kano, Yohei Kameda, Hiroyuki Osawa","doi":"10.2169/internalmedicine.3500-24","DOIUrl":"10.2169/internalmedicine.3500-24","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"3111-3112"},"PeriodicalIF":1.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11637799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140143357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Syphilitic Hepatitis. 梅毒性肝炎
IF 1 4区 医学
Internal Medicine Pub Date : 2024-11-15 Epub Date: 2024-03-18 DOI: 10.2169/internalmedicine.3383-23
Norihiko Terada, Taku Sawafuji
{"title":"Syphilitic Hepatitis.","authors":"Norihiko Terada, Taku Sawafuji","doi":"10.2169/internalmedicine.3383-23","DOIUrl":"10.2169/internalmedicine.3383-23","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"3117-3118"},"PeriodicalIF":1.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11637788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140143361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Usefulness of Mepolizumab for Mucus Plugs. 美泊利珠单抗对粘液栓的作用
IF 1 4区 医学
Internal Medicine Pub Date : 2024-11-15 Epub Date: 2024-03-25 DOI: 10.2169/internalmedicine.3531-24
Masamitsu Hamakawa, Tadashi Ishida
{"title":"Usefulness of Mepolizumab for Mucus Plugs.","authors":"Masamitsu Hamakawa, Tadashi Ishida","doi":"10.2169/internalmedicine.3531-24","DOIUrl":"10.2169/internalmedicine.3531-24","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"3113-3114"},"PeriodicalIF":1.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11637785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140206812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe Adenovirus Infection with SARS-CoV-2 Co-infection. 一例严重腺病毒感染与 SARS-CoV-2 合并感染病例
IF 1 4区 医学
Internal Medicine Pub Date : 2024-11-15 Epub Date: 2024-09-04 DOI: 10.2169/internalmedicine.3799-24
Yumi Inukai Motokura, Akihiro Ito, Yuri Tao, Tadashi Ishida
{"title":"Severe Adenovirus Infection with SARS-CoV-2 Co-infection.","authors":"Yumi Inukai Motokura, Akihiro Ito, Yuri Tao, Tadashi Ishida","doi":"10.2169/internalmedicine.3799-24","DOIUrl":"10.2169/internalmedicine.3799-24","url":null,"abstract":"<p><p>A 34-year-old man with no medical history presented to our hospital with a sore throat and difficult oral intake for two days before admission. He had various symptoms, including red eyes, ocular discharge, a fever, and intraoral ulcers, and he was admitted immediately. The polymerase chain reaction test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was positive, as was the adenovirus antigen test of the pharyngeal swab fluid, suggesting overlapping adenovirus and SARS-CoV-2 infections. The patient's condition improved with conservative treatment. This case of severe and varied symptoms caused by co-infection with adenovirus and SARS-CoV-2 has been previously reported.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"3077-3081"},"PeriodicalIF":1.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11637795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detailed Lipid Profiles and Lipid-related Residual Risk after 12-week 10 mg Rosuvastatin Treatment for Acute Myocardial Infarction. 10 毫克瑞舒伐他汀治疗急性心肌梗死 12 周后的详细血脂概况和血脂相关残余风险。
IF 1 4区 医学
Internal Medicine Pub Date : 2024-11-15 Epub Date: 2024-03-18 DOI: 10.2169/internalmedicine.3476-24
Yuki Kondo, Masaru Ishida, Takenori Ishisone, Masanobu Niiyama, Takuya Osaki, Yuki Matsumoto, Yuko Maegawa, Kenta Sasaki, Ryo Ninomiya, Yuji Takahashi, Yu Ishikawa, Takumi Kimura, Yudai Shimoda, Munetaka Morikawa, Hidenori Saito, Tomonori Itoh, Yoshihiro Morino
{"title":"Detailed Lipid Profiles and Lipid-related Residual Risk after 12-week 10 mg Rosuvastatin Treatment for Acute Myocardial Infarction.","authors":"Yuki Kondo, Masaru Ishida, Takenori Ishisone, Masanobu Niiyama, Takuya Osaki, Yuki Matsumoto, Yuko Maegawa, Kenta Sasaki, Ryo Ninomiya, Yuji Takahashi, Yu Ishikawa, Takumi Kimura, Yudai Shimoda, Munetaka Morikawa, Hidenori Saito, Tomonori Itoh, Yoshihiro Morino","doi":"10.2169/internalmedicine.3476-24","DOIUrl":"10.2169/internalmedicine.3476-24","url":null,"abstract":"<p><p>Objective We aimed to reveal detailed on-treatment lipid profiles, lipid-related surrogate markers, and factors predicting failure to achieve the guideline-recommended lipid management goal following guideline-recommended statin treatment in Japanese patients with acute myocardial infarction (AMI). Methods Sixty AMI patients who underwent coronary intervention and had received rosuvastatin 10 mg/day since the start of their hospitalization were assessed for on-treatment lipid-related profiles, including high-sensitivity C-reactive protein, small dense low-density lipoprotein cholesterol (sd LDL-C), and lipoprotein (a), at the 12-week follow-up. Patients who failed to achieve the guideline-recommended lipid management at 12 weeks were defined as the \"unachieved group.\" Univariate and multivariate logistic regression analyses were performed to evaluate the predictors of inclusion in the unachieved group after high-dose statin treatment. Results Despite the use of high-dose rosuvastatin, 61.7% of the enrolled AMI patients were included in the unachieved group. In addition, the unachieved group had higher sd LDL-C and lipoprotein (a) levels than the achieved group. Logistic regression analyses demonstrated that low baseline high-density lipoprotein cholesterol (HDL-C) levels and the absence of diabetes were predictors of inclusion in the unachieved group. Conclusion More than half of the Japanese AMI patients treated with rosuvastatin 10 mg/day did not achieve the guideline-recommended goal of lipid management and still had lipid-related residual risk at 12 weeks. Particular attention should be paid to patients with low baseline HDL-C levels and those without diabetes with regard to their on-treatment lipid profiles.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"3031-3038"},"PeriodicalIF":1.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11637786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140143358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safety and Effectiveness of Elotuzumab in Japanese Patients with Relapsed/Refractory Multiple Myeloma: A Post-marketing Surveillance Study. 埃洛珠单抗对日本复发性/难治性多发性骨髓瘤患者的安全性和有效性：上市后监测研究
IF 1 4区 医学
Internal Medicine Pub Date : 2024-11-15 Epub Date: 2024-03-18 DOI: 10.2169/internalmedicine.2487-23
Fumiya Kaneko, Hiroshi Suzuka, Tomoaki Yoshino, Ryosuke Hinosugi
{"title":"Safety and Effectiveness of Elotuzumab in Japanese Patients with Relapsed/Refractory Multiple Myeloma: A Post-marketing Surveillance Study.","authors":"Fumiya Kaneko, Hiroshi Suzuka, Tomoaki Yoshino, Ryosuke Hinosugi","doi":"10.2169/internalmedicine.2487-23","DOIUrl":"10.2169/internalmedicine.2487-23","url":null,"abstract":"<p><p>Objective Elotuzumab plus lenalidomide and dexamethasone (ELd) was approved in Japan in 2016 for the treatment of relapsed/refractory multiple myeloma (RRMM). This post-marketing surveillance study evaluated the safety and effectiveness of ELd in RRMM patients during routine clinical practice in Japan. Methods Elotuzumab safety was assessed by evaluating adverse drug reactions (ADRs), and effectiveness was assessed primarily by the best overall response. Patients The study enrolled patients with RRMM who received ELd therapy between November 18, 2016, and June 18, 2017. The safety and effectiveness analysis sets included 831 and 755 patients, respectively. Results In the safety analysis set, patients received a median (range) of 12 (1-40) elotuzumab administrations over 108 (1-728) days of treatment. The relative dose intensity of elotuzumab was ≥90% in 74.1% of patients. ADRs and serious ADRs were reported in 41.2% and 15.2% of the patients, respectively. The most common ADR was infection (12.0%), followed by lymphocytopenia (10.1%), infusion reactions (7.5%), secondary malignancies (e.g., gastric cancer and pancreatic carcinoma), cataracts, and interstitial lung disease (0.2% each). While most patients with ADRs recovered, 71 discontinued treatment, and 14 deaths were reported. The presence of comorbidities, particularly cardiovascular disorders, significantly affected the safety. The overall response rate was 41.1%. Conclusion This all-case post-marketing surveillance study showed that ELd had an acceptable tolerability profile and promising clinical activity in Japanese patients with RRMM.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"3039-3048"},"PeriodicalIF":1.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11637807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140143360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrasound-assisted Trigger Point Injection for Cutaneous Nerve Entrapment Syndrome. 超声辅助触发点注射治疗皮肤神经卡压综合征。
IF 1 4区 医学
Internal Medicine Pub Date : 2024-11-15 Epub Date: 2024-03-18 DOI: 10.2169/internalmedicine.3612-24
Shogo Shirota, Hiroaki Nishioka
{"title":"Ultrasound-assisted Trigger Point Injection for Cutaneous Nerve Entrapment Syndrome.","authors":"Shogo Shirota, Hiroaki Nishioka","doi":"10.2169/internalmedicine.3612-24","DOIUrl":"10.2169/internalmedicine.3612-24","url":null,"abstract":"","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"3125"},"PeriodicalIF":1.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11637787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140143364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endoscopic Findings of 'Salmon Roe-like Nodular Lesions' in a Case of Severe Disseminated Strongyloidiasis in a Foreign Resident in Japan. 一名旅日外国人的严重播散性斯龙线虫病病例中的 "鲑鱼籽样结节病变 "内窥镜检查结果。
IF 1 4区 医学
Internal Medicine Pub Date : 2024-11-15 Epub Date: 2024-03-04 DOI: 10.2169/internalmedicine.3389-23
Keigo Kobayashi, Yasuhiro Umekawa
{"title":"Endoscopic Findings of 'Salmon Roe-like Nodular Lesions' in a Case of Severe Disseminated Strongyloidiasis in a Foreign Resident in Japan.","authors":"Keigo Kobayashi, Yasuhiro Umekawa","doi":"10.2169/internalmedicine.3389-23","DOIUrl":"10.2169/internalmedicine.3389-23","url":null,"abstract":"<p><p>A Southeast Asian man in his 30s residing in Japan developed severe disseminated strongyloidiasis during long-term steroid therapy. Initially misdiagnosed as gastroenteritis, his condition was later identified as strongyloidiasis by fecal smears and endoscopy. An endoscopic examination revealed salmon roe-like nodular lesions, indicating an advanced stage. Despite treatment, the patient died of the illness. This case underscores the importance of considering the patient's geographical background and immunosuppressive history in medical assessments. It further highlights the need for early and proactive diagnostic approaches, such as stool testing and gastrointestinal endoscopy, to effectively detect and treat imported infectious diseases.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"3055-3058"},"PeriodicalIF":1.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11637804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140021631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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