Integrative Medicine Research最新文献

{"title":"Curcumin, inflammation, and neurological disorders: How are they linked?","authors":"Prachi Garodia ,&nbsp;Mangala Hegde ,&nbsp;Ajaikumar B. Kunnumakkara ,&nbsp;Bharat B. Aggarwal","doi":"10.1016/j.imr.2023.100968","DOIUrl":"10.1016/j.imr.2023.100968","url":null,"abstract":"<div><h3>Background</h3><p>Despite the extensive research in recent years, the current treatment modalities for neurological disorders are suboptimal. Curcumin, a polyphenol found in <em>Curcuma</em> genus, has been shown to mitigate the pathophysiology and clinical sequalae involved in neuroinflammation and neurodegenerative diseases.</p></div><div><h3>Methods</h3><p>We searched PubMed database for relevant publications on curcumin and its uses in treating neurological diseases. We also reviewed relevant clinical trials which appeared on searching PubMed database using ‘Curcumin and clinical trials’.</p></div><div><h3>Results</h3><p>This review details the pleiotropic immunomodulatory functions and neuroprotective properties of curcumin, its derivatives and formulations in various preclinical and clinical investigations. The effects of curcumin on neurodegenerative diseases such as Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), brain tumors, epilepsy, Huntington's disorder (HD), ischemia, Parkinson's disease (PD), multiple sclerosis (MS), and traumatic brain injury (TBI) with a major focus on associated signalling pathways have been thoroughly discussed.</p></div><div><h3>Conclusion</h3><p>This review demonstrates curcumin can suppress spinal neuroinflammation by modulating diverse astroglia mediated cascades, ensuring the treatment of neurological disorders.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/83/fd/main.PMC10469086.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10152438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient preferences and shared decision making for the traditional Chinese medicine treatment of lung cancer: A discrete choice experiment study","authors":"Yue Teng ,&nbsp;Yan Wei ,&nbsp;Yingyao Chen ,&nbsp;Juntao Yan ,&nbsp;Shimeng Liu ,&nbsp;Fuming Li ,&nbsp;Shiyi Bao ,&nbsp;Yanfeng Ren ,&nbsp;Liu Liu ,&nbsp;Yi Yang","doi":"10.1016/j.imr.2023.100969","DOIUrl":"10.1016/j.imr.2023.100969","url":null,"abstract":"<div><h3>Background</h3><p>Traditional Chinese Medicine (TCM), integrating patient preferences into decision-making process, has been widely used in the multimodality therapy of lung cancer. This study aimed to estimate patient preferences for treatment and shared decision-making (SDM) modes concerning inpatient TCM treatment of lung cancer in Shanghai in order to provide a basis for clinical decision-making process on TCM therapy for lung cancer.</p></div><div><h3>Methods</h3><p>This study was conducted among patients (<em>n</em> = 347) from nine tertiary hospitals in Shanghai by discrete-choice experiment (DCE) survey and Shared Decision-Making Questionnaire-patient version (SDM-Q-9) survey. The DCE was developed with the inclusion of the most relevant attributes at appropriate levels for the TCM treatment of lung cancer. The empirical data analyses of patients were performed using mixed logit models. Additionally, subgroup analysis was conducted.</p></div><div><h3>Results</h3><p>In total, 347 respondents completed the questionnaire. All attributes’ coefficients were statistically significant for patients’ preferences. Patients showed strong preferences for increasing disease control rate, relieving nausea and vomiting, reducing the risk of side effects, and were concerned about monthly out-of-pocket costs. Subgroup analysis indicated that patients with a lower SDM-Q-9 score and those who were satisfied with medical services emphasized more importance of higher disease control rate. Furthermore, most of the patients (90.20%) self-reported a high willingness to use SDM during the decision-making process.</p></div><div><h3>Conclusion</h3><p>In Shanghai, patients mainly preferred SDM and considered disease control rate as the most essential attribute in the TCM treatment of lung cancer. The study findings could underscore the importance of considering patients’ preferences and promote SDM.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5f/f2/main.PMC10400851.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10308768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture as an alternative or in addition to conventional treatment for chronic non-specific low back pain: A systematic review and meta-analysis","authors":"Carlo Maria Giovanardi ,&nbsp;Marien Gonzalez-Lorenzo ,&nbsp;Alessandra Poini ,&nbsp;Eleonora Marchi ,&nbsp;Antonio Culcasi ,&nbsp;Francesco Ursini ,&nbsp;Cesare Faldini ,&nbsp;Alberto Di Martino ,&nbsp;Umberto Mazzanti ,&nbsp;Emanuela Campesato ,&nbsp;Annunzio Matrà ,&nbsp;Sabina Cevoli ,&nbsp;Maria Grazia Benedetti","doi":"10.1016/j.imr.2023.100972","DOIUrl":"10.1016/j.imr.2023.100972","url":null,"abstract":"<div><h3>Background</h3><p>Conventional therapies (CTs), pharmacological (PH) and non–pharmacological (NPH), do not always achieve benefits in the treatment of chronic low back pain (CLBP). We assessed efficacy and safety of acupuncture for CLBP as alternative or addition to CT.</p></div><div><h3>Methods</h3><p>We included randomised controlled trials (RCTs) comparing acupuncture alone or in combination with CT to CT. We searched Medline, Cochrane Library, Embase up to May 2022. We assessed risk of bias with the original Cochrane tool and GRADE certainty of evidence. Results were pooled through meta-analysis.</p></div><div><h3>Results</h3><p>Ten RCTs (2122 participants) were included comparing acupuncture versus CT and 4 RCTs (374 participants) were comparing acupuncture plus CT to CT alone. In terms of comparing acupuncture with NPH or PH, no differences were found for pain and disability. Comparing acupuncture with PH and NPH combined, pain and disability were reduced (SMD=-0.50, 95% CI -0.62 to -0.37; SMD=-0.71, 95% CI -1.17 to -0.24). Comparing acupuncture plus NPH with NPH alone, pain and disability were reduced (SMD=-0.70, 95% CI -0.94 to -0.46; SMD=-0.95, 95% CI -1.36 to -0.54). Comparing acupuncture plus PH with PH alone, pain and disability were reduced (MD=-0.21, 95% CI -433.28 to -10.42; MD=-3.1, 95% CI -4.87 to -1.83). Comparing acupuncture plus combined treatment versus combined treatment alone, no differences were found in pain, while disability was reduced (MD=-3.40 95% CI -5.17 to -1.63). No studies assessed adverse event. Certainty of evidence ranged from moderate to very low.</p></div><div><h3>Conclusions</h3><p>We are uncertain whether acupuncture is more effective and safer than CT. In the comparisons without estimates’ imprecision, acupuncture showed promising results. Acupuncture could be an option based on patients’ preferences.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/13/d0/main.PMC10448023.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10482866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture-related therapies for protracted opioid abstinence syndrome: A systematic review and meta-analysis","authors":"Lu Ding ,&nbsp;Cui Li ,&nbsp;Peiming Zhang ,&nbsp;Chen Chen ,&nbsp;Jie Zhan ,&nbsp;Jinchun Zeng ,&nbsp;Liming Lu","doi":"10.1016/j.imr.2023.100976","DOIUrl":"10.1016/j.imr.2023.100976","url":null,"abstract":"<div><h3>Background</h3><p>An increasing amount of clinical evidence of acupuncture's effect on protracted opioid abstinence syndrome (POAS) has emerged in recent years. The aim of this study was to evaluating the evidence of efficacy of acupuncture for POAS. clinical and scientific research work.</p></div><div><h3>Methods</h3><p>Four English-language databases (PubMed, Medline, Embase, Cochrane Libraries) and three Chinese-language databases (CNKI, WanFang and VIP Libraries) were searched, with coverage from database inception to March 31, 2022. Randomized clinical trials (RCTs) evaluating the effects of acupuncture and acupuncture-related therapies for prophylaxis or treatment of POAS were included. Data were screened and extracted independently according to pre-set tabular formats. RCT quality was assessed using risk of bias tool in the Cochrane Collaboration. The primary outcome was opiate withdrawal scale. The secondary outcomes are depression, anxiety for assessing protracted symptoms. The scores on the above scales are proportional to the severity of the symptoms.</p></div><div><h3>Results</h3><p>Twenty-eight trials met the inclusion criteria and provided data for the meta-analysis. A total of only 3 studies (11%) were judged to be low-risk overall due to various biases in them. Acupuncture-related therapy showed statistical differences in improving protracted withdrawal symptom scores compared with sham acupuncture (5 studies, Standard mean difference (SMD), -1.85, 95% CI [-3.21, -0.50], <em>P</em> = 0.007), western medicine (7 studies, SMD, -0.72, 95% CI [-1.22, -0.21], <em>P</em> = 0.005) and no treatment (3 studies, SMD,-2.26, 95% CI [-3.82, -0.69], <em>P</em> = 0.005) with high heterogeneity.</p></div><div><h3>Conclusions</h3><p>Acupuncture maybe safe and effective in relieving POAS individuals’ protracted withdrawal symptoms. However, the results of our review should be interpreted with caution because of the high risk of bias of the included trials.</p></div><div><h3>Study registration</h3><p>The protocol of this review has been registered at PROSPERO (CRD42022335505).</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/80/20/main.PMC10448024.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10465126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of herbal medicine (Binafuxi granules) for the common cold with fever: A multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial","authors":"Xuemei Liu ,&nbsp;Jie Min ,&nbsp;Bin She ,&nbsp;Yan Chen ,&nbsp;Jun Li ,&nbsp;Lei Huang ,&nbsp;Ju Chen ,&nbsp;Ai Luo ,&nbsp;Mei Yang ,&nbsp;Ting Li ,&nbsp;Yanqing Wu ,&nbsp;Daohong Chen ,&nbsp;Hongli Zhong ,&nbsp;Wei Liu ,&nbsp;Bing Mao ,&nbsp;Hongli Jiang","doi":"10.1016/j.imr.2023.100956","DOIUrl":"10.1016/j.imr.2023.100956","url":null,"abstract":"<div><h3>Background</h3><p>Binafuxi granules are a traditional Uighur medicine (TUM) for treating the common cold with fever. However, high-quality clinical studies supporting its efficacy and safety are lacking.</p></div><div><h3>Methods</h3><p>In this multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial, patients with common cold and fever were randomly assigned to a high-dose group, low-dose group, and placebo group in a 1:1:1 ratio. Outcomes were time to fever relief, time to fever clearance, proportion of afebrile patients, time to symptom disappearance, rate of symptom disappearance, effective rate, emergency drug usage and safety assessment.</p></div><div><h3>Results</h3><p>A total of 235 patients were recruited. Of these, 234 were included in the full analysis set (FAS), and 217 were included in the per-protocol set (PPS). In the FAS analysis, the median time to fever relief was 6.00 h, 5.54 h and 10.65 h (<em>P</em> = 0.31) in the high-dose group, low-dose group and placebo group, respectively. The median time to fever clearance was 18.29 h, 20.08 h and 25.00 h (<em>P</em> = 0.0018), respectively, and the proportion of afebrile patients was 92.4%, 89.7% and 71.4% (<em>P</em> = 0.0002), respectively. There was a significant difference in the disappearance time and disappearance rate of all symptoms and of individual symptoms. No serious adverse events were found.</p></div><div><h3>Conclusions</h3><p>Binafuxi granules can dose-dependently shorten the fever course and improve clinical symptoms in patients suffering from the common cold with fever.</p></div><div><h3>Trial Registration</h3><p>This trial was registered at Chinese Clinical Trial Registry (ChiCTR-IIR-17013379).</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f3/4f/main.PMC10285547.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9714664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI Chat bot - ChatGPT-4: A new opportunity and challenges in complementary and alternative medicine","authors":"Tae-Hun Kim ,&nbsp;Jung Won Kang ,&nbsp;Myeong Soo Lee","doi":"10.1016/j.imr.2023.100977","DOIUrl":"https://doi.org/10.1016/j.imr.2023.100977","url":null,"abstract":"","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49813478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thread-embedding acupuncture may improve symptom resolution in patients with gastroesophageal reflux disease: A randomized controlled trial","authors":"Dieu-Thuong Thi Trinh ,&nbsp;An Hoa Tran ,&nbsp;Minh-Man Pham Bui ,&nbsp;Nguyen Lam Vuong","doi":"10.1016/j.imr.2023.100971","DOIUrl":"10.1016/j.imr.2023.100971","url":null,"abstract":"<div><h3>Background</h3><p>Various traditional medicine treatments have been investigated to treat GERD. Among those, thread-embedding acupuncture (TEA) has the advantage that patients need to undergo the procedure infrequently; however, its efficacy is unclear. This study evaluated the efficacy of TEA in treating GERD.</p></div><div><h3>Methods</h3><p>A randomized controlled trial was conducted with 66 participants with GERD: 33 received two sessions of TEA + standard therapy (proton-pump inhibitor [PPI]) (TEA+PPI group) and 33 received PPI alone (PPI group). Primary outcomes included GerdQ score and heartburn and regurgitation resolution. Secondary outcomes were antacids requirement, the Frequency Scale for Symptoms of GERD (FSSG) score, and Gastroesophageal Reflux Disease-Health Related Quality of Life (GERD-HRQL) score. The safety outcome was adverse events (AEs).</p></div><div><h3>Results</h3><p>After four weeks of treatment, the TEA+PPI group significantly reduced the GerdQ score (mean difference [MD] and 95% confidence interval [CI]: -1.8 [-2.4, -1.1]) and increased the rate of heartburn and regurgitation resolution compared to PPI (54.5% versus 9.1%, respectively) compared to PPI. The TEA+PPI group also significantly reduced the number of antacid packs used (MD [95%-CI]: -9.4 [-12.1, -6.7]), FSSG score (MD [95%-CI]: -9.4 [-11.0, -7.8]), and GERD-HRQL score (MD [95%-CI]: -5.6 [-7.7, -3.5]) compared to PPI. Five patients experienced AEs, which were mild local complications at the acupoints.</p></div><div><h3>Conclusion</h3><p>TEA combined with PPI is more effective than PPI alone in treating GERD. Further studies with longer follow-ups are required to confirm these findings.</p></div><div><h3>Clinical trials registration information</h3><p>This study was registered at ClinicalTrials.gov, <span>NCT05353933</span><svg><path></path></svg>.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e7/6f/main.PMC10448015.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10164499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical effectiveness of decoction form of herbal medicine in primary care treatment of allergic rhinitis: A retrospective cohort study","authors":"Mi Ju Son ,&nbsp;Sungha Kim ,&nbsp;Young-Eun Kim ,&nbsp;Bo-Young Kim ,&nbsp;Chang-Sub Yeum ,&nbsp;Jong Cheol Lee ,&nbsp;Jae Hoon Cha ,&nbsp;Soonsik Kang ,&nbsp;Ching Hao Chang ,&nbsp;Seokho Son","doi":"10.1016/j.imr.2023.100973","DOIUrl":"10.1016/j.imr.2023.100973","url":null,"abstract":"<div><h3>Background</h3><p>The decoction form of herbal medicine (D-HM) is mainly prescribed to patients with allergic rhinitis (AR) in Korean Medicine (KM) clinics in the Republic of Korea; however, it is difficult to conduct clinical trials of D-HM due to regulatory issues. This study investigated the clinical safety and effectiveness of D-HM combination therapy for the treatment of AR by analyzing the AR outpatient data from 17 KM clinics.</p></div><div><h3>Methods</h3><p>This retrospective cohort study included patients who visited KM clinics for AR treatment from January 1, 2021, to March 31, 2022. Cases were collated using structured case report forms and divided into the D-HM with KM usual care group (D-HM group) and the KM usual care group (UC group). Since D-HM therapy could not be randomly assigned to the study population, we used optimal propensity score (PS) matching to investigate the effectiveness and safety of D-HM combination therapy in the treatment of AR.</p></div><div><h3>Results</h3><p>Data from 228 patients were collected. After PS matching, 144 patients were finally analyzed. The total nasal symptom score (TNSS) and mini-rhinoconjunctivitis quality of life questionnaire (mini-RQLQ) were significantly improved in the D-HM group compared with those in the UC group (TNSS: p=0.02; mini-RQLQ: p=0.04). Four patients in the D-HM group experienced minor adverse events that were mild and resolved within 15 days.</p></div><div><h3>Conclusions</h3><p>D-HM combination therapy may be beneficial in the management of symptoms and rhinitis-associated quality of life and potentially useful in clinical practice. However, randomized placebo-controlled clinical trials are required to confirm their effectiveness.</p></div><div><h3>Study registration</h3><p>This study has been registered at Clinical Research Information Service (KCT0007242).</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/87/51/main.PMC10448014.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10464643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Economic evaluation of acupuncture as an adjunctive treatment with usual care for mild-to-moderate knee osteoarthritis: A Markov model-based analysis","authors":"Eunhye Hyun ,&nbsp;Byung-Cheul Shin ,&nbsp;NamKwen Kim ,&nbsp;Byungmook Lim","doi":"10.1016/j.imr.2023.100982","DOIUrl":"10.1016/j.imr.2023.100982","url":null,"abstract":"<div><h3>Background</h3><p>Collaborative care (CC), in which acupuncture is combined with usual care (UC), improves clinical outcomes and increases costs in knee osteoarthritis (KOA). We evaluated the economic feasibility of CC for Korean female patients with mild-to-moderate KOA by using a cost-effectiveness approach.</p></div><div><h3>Methods</h3><p>Two alternatives for KOA (1. UC as a comparator; and 2. CC as an intervention) were defined based on clinical guidelines, official Korean statistics, and expert validation. Each alternative was simulated in a Markov model every 6 months for 10 years. Estimates of costs, utilities, and transition probabilities were obtained from official statistics and previous studies. The effectiveness of CC was synthesized from randomized controlled trials. A base-case analysis of a limited societal perspective, univariate sensitivity analysis, and probability sensitivity analysis were performed. An annual discount rate of 4.5% and threshold of 20,000 United States dollar per Quality-adjusted life year (USD/QALY) were applied.</p></div><div><h3>Results</h3><p>Every incremental cost-effectiveness ratio (ICER) of CC calculated from the analyses was sub-threshold. In the base-case analysis, with a limited societal perspective, the ICER was 11,085 USD/QALY. The ICERs from the univariate sensitivity analyses were -2,577–16,748 USD/QALY. The average ICER in the probability sensitivity analysis was 12,412 USD/QALY. When the threshold surpassed 8,000 USD/QALY, the cost-effectiveness of CC exceeded 50%. The probability was 70.27% when the threshold was 20,000 USD/QALY.</p></div><div><h3>Conclusions</h3><p>CC for Korean female patients with mild-to-moderate KOA was generally cost-effective. Considering the limitations of the evidence, we propose a re-evaluation using further clinical studies in the future.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8c/06/main.PMC10470223.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10143952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of yoga on stress, metabolic parameters, and cognition of Indian adolescents: A cluster randomized controlled trial","authors":"Harish Ranjani ,&nbsp;Narayanaswamy Jagannathan ,&nbsp;Tina Rawal ,&nbsp;Radhakrishnan Vinothkumar ,&nbsp;Nikhil Tandon ,&nbsp;Jayaram Vidyulatha ,&nbsp;Viswanathan Mohan ,&nbsp;Yashdeep Gupta ,&nbsp;Ranjit Mohan Anjana","doi":"10.1016/j.imr.2023.100979","DOIUrl":"https://doi.org/10.1016/j.imr.2023.100979","url":null,"abstract":"<div><h3>Background</h3><p>This project aimed to assess the impact of yoga on stress, metabolic parameters and cognition (attention &amp; concentration) in adolescents, aged 13–15 years from public and private schools in two cities (Chennai and New Delhi) in India.</p></div><div><h3>Methods</h3><p>The study recruited 2000 adolescents from 24 schools in a cluster randomized controlled trial design. The yoga group participants underwent 17 yoga sessions, which included: pranayama, basic asanas, meditation and relaxation exercises. Yoga sessions, were held in the school premises once a week. A total of five awareness talks on healthy lifestyle were delivered once a month to the education group. ADOlescence Stress Scale (ADOSS), salivary cortisol, metabolic and clinical parameters and Letter Cancellation Test (LCT) score were measured at baseline and post-intervention (5–6 months).</p></div><div><h3>Results</h3><p>The yoga group showed statistically significant differences in the mean ADOSS score, metabolic parameters, salivary cortisol, and LCT scores compared to the education group. In the intention- to- treat analysis, a significant reduction [5.11, 95% CI (4.78, 5.36), <em>p</em> = 0.001] in ADOSS score was seen in the yoga group compared to education.</p></div><div><h3>Conclusion</h3><p>Implementation of a 17-week standardized yoga program at the school level significantly decreased stress, improved attention and concentration, metabolic and clinical parameters in Indian adolescents.</p></div><div><h3>Trial registration</h3><p>This trial was registered at Clinical Trials Registry, India (CTRI/2017/08/009203).</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49772555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}