Reducing Parkinson's disease incidence in patients with insomnia through acupuncture: A cohort study

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research Pub Date : 2024-09-02 DOI:10.1016/j.imr.2024.101083

Cheng-Hao Huang , Shun-Ku Lin , Mei-Chen Lin , Shih-Ya Hung

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引用次数: 0

Abstract

Background

Parkinson's disease (PD) is a prevalent neurodegenerative condition characterized primarily by motor symptoms, often accompanied by non-motor manifestations such as insomnia. Acupuncture, an increasingly popular alternative therapy, has shown promise in the prevention and alleviation of PD motor symptoms. However, the specific impact of acupuncture on the risk of developing PD in insomnia patients remains uncertain.

Methods

In this retrospective study, we identified and matched 152,585 newly diagnosed insomnia patients from Taiwan's National Health Insurance Research Database (NHIRD) from 2000 to 2010. Using a 1:1 propensity score matching method, we ensured the comparability of two groups: patients who received acupuncture treatment and those who did not. It resulted in a final cohort of 20,112 patients in both the acupuncture and non-acupuncture groups.

Results

Our analysis revealed that insomnia patients who underwent acupuncture treatment exhibited a significantly reduced risk of developing PD. The adjusted hazard ratio (aHR) was 0.44 (95 % confidence interval = 0.39–0.50) compared to those who did not receive acupuncture. Furthermore, the cumulative incidence of PD in the acupuncture group was significantly lower, as evidenced by the log-rank test (p < 0.001).

Conclusion

In conclusion, our study provides evidence suggesting that acupuncture treatment is associated with a decreased risk of PD in patients with insomnia. However, further research is warranted to strengthen the evidence supporting these findings.

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通过针灸降低失眠患者的帕金森病发病率：一项队列研究

背景帕金森病（PD）是一种以运动症状为主要特征的神经退行性疾病，通常伴有失眠等非运动症状。针灸作为一种日益流行的替代疗法，在预防和缓解帕金森病运动症状方面显示出良好的前景。方法在这项回顾性研究中，我们从台湾的国民健康保险研究数据库（NHIRD）中识别并匹配了152585名2000年至2010年间新诊断的失眠患者。通过 1:1 的倾向得分匹配法，我们确保了两组患者的可比性：接受针灸治疗的患者和未接受针灸治疗的患者。结果我们的分析表明，接受针灸治疗的失眠患者罹患帕金森病的风险显著降低。与未接受针灸治疗的患者相比，调整后的危险比（aHR）为 0.44（95 % 置信区间 = 0.39-0.50）。总之，我们的研究提供的证据表明，针灸治疗与失眠患者罹患帕金森病的风险降低有关。然而，还需要进一步的研究来加强支持这些发现的证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Integrative Medicine Research Medicine-Complementary and Alternative Medicine

CiteScore

6.50

自引率

2.90%

发文量

审稿时长

12 weeks

期刊介绍： Integrative Medicine Research (IMR) is a quarterly, peer-reviewed journal focused on scientific research for integrative medicine including traditional medicine (emphasis on acupuncture and herbal medicine), complementary and alternative medicine, and systems medicine. The journal includes papers on basic research, clinical research, methodology, theory, computational analysis and modelling, topical reviews, medical history, education and policy based on physiology, pathology, diagnosis and the systems approach in the field of integrative medicine.