Integrative Medicine Research最新文献

{"title":"Acupuncture for acute ischemic stroke: A systematic review and meta-analysis of randomized controlled trials","authors":"Shanshan Huang ,&nbsp;Yuting Wang ,&nbsp;Yifan Wu ,&nbsp;Puchen Huang ,&nbsp;Yu Dong ,&nbsp;Qiao Zhang ,&nbsp;Mengjiao Zhao ,&nbsp;Jingchun Zeng ,&nbsp;Liming Lu ,&nbsp;Xinxia Liu","doi":"10.1016/j.imr.2024.101092","DOIUrl":"10.1016/j.imr.2024.101092","url":null,"abstract":"<div><h3>Objective</h3><div>Assess the safety and effectiveness of acupuncture for acute ischemic stroke (AIS).</div></div><div><h3>Methods</h3><div>We conducted a comprehensive search across the PubMed, Cochrane Library, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), Wanfang, and SinoMed databases from their inception until October 3, 2023. Two reviewers screened eligible randomized controlled trials (RCTs) according to criteria and extracted data using a pre-established form. Cochrane tool was used for risk of bias assessment, and Revman 5.3 was used for subsequent meta-analysis. The GRADE tool will be used to assess the quality of evidence.</div></div><div><h3>Results</h3><div>Thirty-one RCTs were included, involving 3604 patients. Meta-analysis showed that compared with conventional treatments (CTs), acupuncture combined with CTs could improve in National Institutes of Health Stroke Scale (NIHSS) and Efficiency (MD:1.70, 95 %CI [-2.27, -1.14], <em>P</em> &lt; 0.00001;RR: 1.21, 95 %CI [1.12, 1.31], <em>P</em> &lt; 0.00001,);On the Chinese Stroke Scale (CSS) and effectiveness based on CSS, acupuncture showed positive effects (MD:4.33, 95 %CI [-5.67, -2.98], <em>P</em> &lt; 0.00001; RR: 1.26, 95 %CI [1.13, 1.41], <em>P</em> &lt; 0.0001). Furthermore, ADL, Fugl-Meyer Assessment Scale (FMA), prognosis analyses also showed the effectiveness of acupuncture. (SMD: 0.98, 95 % CI [0.64, 1.31], <em>P</em> &lt; 0.00001; MD: 16.46, 95 %CI [12.56, 20.35], <em>P</em> &lt; 0.00001; RR: 0.38, 95 %CI [0.16, 0.89], <em>P</em> = 0.03). However, the certainty of evidence was low.</div></div><div><h3>Conclusion</h3><div>According to current evidence, Acupuncture may be effective and safe for AIS. The future still needs high-quality evidence to support this conclusion.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 4","pages":"Article 101092"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of electroacupuncture on internal carotid artery blood flow in patients undergoing laparoscopic gallbladder surgery: A randomized clinical trial","authors":"Lili Hu ,&nbsp;Yongyan Zhang ,&nbsp;Ying Li ,&nbsp;Ruiping Wang ,&nbsp;Hua Xu","doi":"10.1016/j.imr.2024.101097","DOIUrl":"10.1016/j.imr.2024.101097","url":null,"abstract":"<div><h3>Background</h3><div>Little is known about the effect of electroacupuncture (EA) on cerebral blood flow. We investigated this question in patients undergoing laparoscopic cholecystectomy, hypothesizing that EA would increase cerebral blood flow during surgery.</div></div><div><h3>Methods</h3><div>Eighty-two patients undergoing laparoscopic cholecystectomy were randomly divided into receiving electroacupuncture and intravenous anesthesia (EA+IA) and receving intravenous anesthesia alone (IA). The patients in EA+IA were treated with EA at Baihui (GV 20), Shuigou (GV 26), unilateral Neiguan (PC 6) and unilateral Zusanli (ST 36) points 20 min before anesthesia until the end of the operation. The patients in IA received intravenous anesthesia alone. The internal carotid artery blood flow (Q), mean arterial pressure (MAP), end-tidal carbon dioxide pressure (P_ETCO₂) and heart rate (HR) were recorded respectively before anesthesia induction (T₁), 2 min after anesthesia induction (T₂), 1 min after pneumoperitoneum (T₃), 1 min after head-up tilt (T₄) and after anesthesia resuscitation (T₅).</div></div><div><h3>Results</h3><div>The internal carotid artery blood flow was significantly higher in EA+IA (mean [SD], T₃, 294.0 [89.6] ml min^-1; T₄, 303.8 [90.6] ml min^-1) than in IA (mean [SD], T₃, 246.4 [80.9] ml min^-1; T4, 253.5 [78.4] ml min^-1) at T₃ and T₄ (<em>P</em> &lt; 0.05). There was no difference in blood flow between the two groups at T₂ and T₅. As compared with baseline (T₁), the internal carotid artery blood flow decreased at T₂-T₄ in two groups (<em>P</em> &lt; 0.05). There were no differences in MAP, P_ETCO₂, and HR between the two groups.</div></div><div><h3>Conclusion</h3><div>Electroacupuncture intervention could reduce the decline of internal carotid artery blood flow in patients undergoing laparoscopic cholecystectomy.</div></div><div><h3>Trial registration</h3><div>ChiCTR: 2,100,041,761.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 4","pages":"Article 101097"},"PeriodicalIF":2.8,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142705670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of and factors associated with trauma surgeons' referral and patients' willingness to acupuncture treatment after traumatic rib fractures: A single-center cross-sectional study","authors":"Min Ha Kim ,&nbsp;Hyun Min Cho ,&nbsp;Seon Hee Kim ,&nbsp;Youngwoong Kim ,&nbsp;Yu Kyung Shin ,&nbsp;Kun Hyung Kim","doi":"10.1016/j.imr.2024.101096","DOIUrl":"10.1016/j.imr.2024.101096","url":null,"abstract":"<div><h3>Background</h3><div>Pain after traumatic rib fractures (TRF) detrimentally affects the injured. Multidisciplinary pain management is crucial for patient care. There is little empirical evidence on acupuncture as a multidisciplinary treatment for patients with TRF. This study aimed to illustrate the characteristics of the patients referred for or received acupuncture and explore the associated factors.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional study of Korean Trauma Data Bank and electronic medical records of patients aged 19 or older with TRF from August 2016 to October 2021 in the regional trauma center of Pusan National University Hospital. The sociodemographic and clinical characteristics of patients referred for acupuncture by trauma surgeons and those who received acupuncture were analysed descriptively. In multivariable logistic regression analyses, associations between covariates and either surgeon referrals for or patient willingness to receive acupuncture were quantitatively estimated.</div></div><div><h3>Results</h3><div>Among 2,937 injured patients, trauma surgeons referred 178 (6.1 %) to acupuncture. Among the referred patients, 111 (72.1 %) underwent acupuncture. Patients with polytrauma (aOR 0.46; 0.30 to 0.68) were less likely to be referred to acupuncture, whereas female patients (aOR 3.92, 1.31 to 11.77) were most likely to receive acupuncture.</div></div><div><h3>Conclusions</h3><div>A small proportion of patients with TRF were referred for acupuncture, but the referred patients were more likely to receive acupuncture. Polytrauma may be an important criterion for referral to acupuncture services from the perspective of trauma surgeons, while the willingness to receive acupuncture may be associated with gender-related factors. Further studies are warranted to investigate the role of acupuncture in the postinjury care of patients with TRF.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 4","pages":"Article 101096"},"PeriodicalIF":2.8,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142705669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-pharmacological interventions of traditional Chinese medicine in treating polycystic ovary syndrome: a group consensus","authors":"Tianyi Zhou ,&nbsp;Fangfang Wang ,&nbsp;Xinfen Xu ,&nbsp;Yuhang Zhu ,&nbsp;Rong Zhang ,&nbsp;Hye Won Lee ,&nbsp;Xiao-Yang Mio Hu ,&nbsp;Fan Qu ,&nbsp;Minchen Dai ,&nbsp;Yijing He ,&nbsp;Xinyue Li ,&nbsp;Zhichun Jin ,&nbsp;Yan Yin ,&nbsp;Ziming Huang ,&nbsp;Kaiqing Lin ,&nbsp;Bianba Zhuoma ,&nbsp;Xiaoyong Chen ,&nbsp;Mali Chen ,&nbsp;Longlong Fan ,&nbsp;Lanzhong Guo ,&nbsp;Dan Pan","doi":"10.1016/j.imr.2024.101093","DOIUrl":"10.1016/j.imr.2024.101093","url":null,"abstract":"<div><h3>Background</h3><div>To make a group consensus about non-pharmacological interventions of traditional Chinese medicine in treating polycystic ovary syndrome based on the previous guidelines, literature, and expert viewpoints.</div></div><div><h3>Methods</h3><div>Organized by Chinese Integrative Medicine &amp; Traditional Chinese Medicine Academy, Chinese Maternal and Child Health Association, China, 29 experts from 18 Chinese provinces and 2 international experts, who specialize in gynecology, obstetrics, pediatrics, endocrinology, cardiovascular, psychology, reproductive genetics, nursing, acupuncture and tuina, traditional Chinese medicine, integrative medicine, and other disciplines, discussed and revised the recommendations one by one through in-person or online communication. Each recommendation was approved by ≥90% of the experts before it could be established. The main outcome measure is an optimal clinical regimen for addressing the requirements of women with PCOS and improving their quality of life.</div></div><div><h3>Result(s)</h3><div>The writing panel drafted the initial report, following a consensus process via adequate communication, which was then reviewed and revised by the consensus panel. This consensus provides 12 non-pharmacological interventions (including acupuncture, thumbtack needle, thread-embedding therapy, TEAS, AA, acupoint hot compress, cupping, acupressure, moxibustion, five elements music, aromatherapy, traditional Chinese exercises) for 8 phenotypes of PCOS, resulting in 34 items of clinical practice recommendations.</div></div><div><h3>Conclusion(s)</h3><div>The consensus provides 12 non-pharmacological interventions of traditional Chinese medicine for 8 phenotypes of PCOS, resulting in 34 items of clinical practice recommendations, which may be improved by more high-quality multicenter clinical trials.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 4","pages":"Article 101093"},"PeriodicalIF":2.8,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142705668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture in the emergency department (ACUITY): Results from a BraveNet multi-center feasibility randomized controlled trial","authors":"Jeffery A. Dusek ,&nbsp;Gene A. Kallenberg ,&nbsp;Alan B. Storrow ,&nbsp;Robert M. Hughes ,&nbsp;Christopher J. Coyne ,&nbsp;David R. Vago ,&nbsp;Arya Nielsen ,&nbsp;Alison Karasz ,&nbsp;Ryung S. Kim ,&nbsp;Jessica Surdam ,&nbsp;Tracy Segall ,&nbsp;Kiran A. Faryar ,&nbsp;Natalie L. Dyer ,&nbsp;Bruce A. Barton ,&nbsp;M. Diane McKee","doi":"10.1016/j.imr.2024.101095","DOIUrl":"10.1016/j.imr.2024.101095","url":null,"abstract":"<div><h3>Background</h3><div>Pain plays a significant role in emergency department (ED) visits, however safe and effective nonpharmacologic options are needed. Prior studies of acupuncture in the ED reported pain reduction with minimal side effects, but most were small and single site.</div></div><div><h3>Methods</h3><div>We conducted ACUITY, a prospectively designed multi-center feasibility RCT. Our goal was to recruit 165 adults with acute non-emergent pain ≥4 on a 0–10-point scale at three EDs affiliated with BraveNet Practice Based Research Network. At baseline and 45–60 min later (post), participants self-assessed their pain and anxiety using a 0–10 rating scale. The primary feasibility outcome was recruitment of participants, whereas secondary outcomes were retention, and participant/provider acceptability.</div></div><div><h3>Results</h3><div>From May 3, 2021, to September 24, 2022, 632 eligible individuals were approached and 165 enrolled (165/632: 26.1 %), meeting our recruitment goal. Notably, 42.4 % of enrollees were Black/African American, 42.4 % were White/Caucasian, and 13.9 % were Hispanic/Latino. Participants were randomized to Acupuncture (<em>n</em> = 83) or Usual care (<em>n</em> = 82), of which 151 (91.5 %) and 128 (77.6 %) provided pain and anxiety scores at post-treatment and 1-week respectively. Acupuncture was rated acceptable to participants and providers. Mean pain ratings (pre-to-post) were 7.4 (2.2) to 4.8 (2.8) for acupuncture and 7.1 (2.3) to 6.4 (2.5) for usual care. Mean anxiety ratings (pre-to-post) were 4.5 (3.4) to 2.5 (2.6) for acupuncture and 4.1 (3.4) to 3.5 (3.2) for usual care.</div></div><div><h3>Conclusion</h3><div>Successful completion of ACUITY indicates we have the expertise and preliminary data to conduct a future definitive, multi-center RCT.</div></div><div><h3>Trial registration: Clinical trials.gov</h3><div>NCT04880733.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 4","pages":"Article 101095"},"PeriodicalIF":2.8,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142705667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical cannabis: From research breakthroughs to shifting public perceptions and ensuring safe use","authors":"Muhammad Kamal Hossain ,&nbsp;Han Jung Chae","doi":"10.1016/j.imr.2024.101094","DOIUrl":"10.1016/j.imr.2024.101094","url":null,"abstract":"<div><div>The landscape of medical cannabis has evolved dramatically over the past few decades. Once stigmatized and illegal in most parts of the world, cannabis is now recognized for its potential therapeutic benefits, supported by an expanding body of scientific research. However, the transition from prohibition to medical recognition is shaped by complex interactions among scientific advancements, public perception and regulatory frameworks for its legalization. This review examines the recent breakthroughs in medical cannabis research, explores the shifting public perceptions and the stigma associated with its use and discusses strategies for enhancing the safety of medical cannabis. We also synthesize the connections between scientific research, public perception and safety considerations in the uses of medical cannabis, providing a comprehensive understanding of how these elements influence each other and shape the future of medical cannabis use for patient adherence.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 4","pages":"Article 101094"},"PeriodicalIF":2.8,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142705665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptom improvements and adverse effects with Reishi mushroom use: A Cross-Sectional survey of cancer patients","authors":"Xiaotong Li ,&nbsp;Lingyun Sun ,&nbsp;Susan Chimonas ,&nbsp;Susan Q. Li ,&nbsp;Peng Feng ,&nbsp;Yufei Yang ,&nbsp;Jun J. Mao","doi":"10.1016/j.imr.2024.101089","DOIUrl":"10.1016/j.imr.2024.101089","url":null,"abstract":"<div><h3>Background</h3><div>Reishi, a medicinal mushroom, is increasingly used for symptom control by cancer patients worldwide. However, data around patients' experiences with Reishi in oncology are lacking, limiting safe, effective clinical applications. We thus sought to evaluate patient reported benefits and harms of using Reishi.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional survey among Chinese cancer patients using Reishi products, probing for symptom improvements and/or adverse events (AEs) after taking Reishi. Multivariable logistic regression models assessed whether socio-demographic or clinical factors, as well as duration of Reishi use or combination with other TCM herbs, were associated with being a “responder” – reporting “quite a bit” or “very much” symptom improvement.</div></div><div><h3>Results</h3><div>Among 1374 participants, more than half of participants reported that nausea (55 %), fatigue (52 %), poor appetite (51 %), and depression (50 %) improved quite a bit or very much after taking Reishi. In multivariate analyses, age &lt;65 years (adjusted odds ratios [AOR] = 1.76, <em>p</em> = 0.001), diagnosis ≥ 10 years (AOR = 1.78, <em>p</em> = 0.018), and duration of Reishi use ≥ 1 year (1–3 years: AOR = 1.53, <em>p</em> = 0.045; 3–5 years: AOR = 2.04, <em>p</em> = 0.001; &gt;5 years: AOR = 2.07, <em>p</em> &lt; 0.001) were significantly associated with higher responder rates for symptom improvement. However, 125 (9.1 %) also reported a range of AEs, including dry mouth (5 %), constipation (4 %), insomnia (3 %), pruritus (3 %) and vertigo (3 %).</div></div><div><h3>Conclusion</h3><div>While majority of cancer patients using Reishi reported symptom improvements, some reported adverse effects. This information can assist clinicians in advising cancer patients on safe and effective use of Reishi and help identify specific outcomes for assessment in future prospective clinical trials.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 4","pages":"Article 101089"},"PeriodicalIF":2.8,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142663393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical research on the effectiveness and safety of Uchasingihwan for low back pain with radiculopathy caused by herniated intervertebral disc of the lumbar spine: A multicenter, randomized, controlled equivalence trial","authors":"Bonhyuk Goo ,&nbsp;Jung-Hyun Kim ,&nbsp;Eun-Jung Kim ,&nbsp;Dongwoo Nam ,&nbsp;Hyun-Jong Lee ,&nbsp;Jae-Soo Kim ,&nbsp;Yeon-Cheol Park ,&nbsp;Yong-Hyeon Baek ,&nbsp;Sang-Soo Nam ,&nbsp;Byung-Kwan Seo","doi":"10.1016/j.imr.2024.101090","DOIUrl":"10.1016/j.imr.2024.101090","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to establish the clinical evidence regarding the effectiveness and safety of Uchasingihwan (UCSGH) in improving pain, function, and quality of life in patients with lumbar herniated intervertebral disc (LHIVD).</div></div><div><h3>Methods</h3><div>This was a multicenter, randomized, controlled, equivalence trial with two parallel arms. Seventy-four participants with LHIVD were recruited and randomly allocated to the experimental and control groups. The participants in each group took 2.5 g of UCSGH granule or loxoprofen 60 mg tablet three times a day for six weeks. Additionally, both groups received the same acupuncture treatment once a week for six weeks. Outcomes about effectiveness and safety were assessed at baseline and 3, 6, and 10 weeks after screening.</div></div><div><h3>Results</h3><div>As the primary outcome, the mean differences with a 95 % confidence interval (CI) of changes in low back pain between the two groups at weeks 6 (95 % CI:9.26, 8.37) and 10 (95 % CI:9.03, 9.62) from baseline were within the equivalence limit. Also, changes in radiating pain at weeks 6 (95 % CI:1.70, 15.69) and 10 (95 % CI:4.72, 13.75) were within the equivalence limit. Outcome measures for function and quality of life also showed no statistical difference. Regarding safety, the frequency of adverse events related to intervention was lower in UCSGH.</div></div><div><h3>Conclusion</h3><div>UCSGH showed the equivalent level of effectiveness as loxoprofen in reducing low back and radiating pain in LHIVD patients and showed sufficient safety to be used as a complementary treatment option.</div></div><div><h3>Trial registration</h3><div>ClinicalTrials.gov (NCT03386149), CRIS (KCT0002848).</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 4","pages":"Article 101090"},"PeriodicalIF":2.8,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142705666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A deeper understanding of acupoints: Are superficial landmarks enough?","authors":"In-Seon Lee ,&nbsp;Seunghoon Lee ,&nbsp;Heeyoung Moon ,&nbsp;Da-Eun Yoon ,&nbsp;Younbyoung Chae","doi":"10.1016/j.imr.2024.101091","DOIUrl":"10.1016/j.imr.2024.101091","url":null,"abstract":"","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 4","pages":"Article 101091"},"PeriodicalIF":2.8,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142705671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy and safety of acupuncture in the treatment of sudden sensorineural hearing loss: A systematic review and meta-analysis","authors":"Wenqi Ren ,&nbsp;Bo Tao ,&nbsp;Haixia Deng","doi":"10.1016/j.imr.2024.101087","DOIUrl":"10.1016/j.imr.2024.101087","url":null,"abstract":"<div><h3>Background</h3><div>Despite numerous pharmacological and therapeutic options for sudden sensorineural hearing loss(SSNHL), treatment remains challenging due to various side effects and suboptimal efficacy. Acupuncture, as a complementary and alternative therapy, has achieved some success in this field. The objective of this study was to systematically evaluate the efficacy and safety of acupuncture for SSNHL, and to seek robust evidence-based medical evidence for the therapeutic effect of acupuncture.</div></div><div><h3>Methods</h3><div>The following databases were searched: PubMed, EMbase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang Data Knowledge Service Platform, VIP Information Database, and China Biomedical Literature Database (SinoMed) up to September 1, 2024. The quality of the RCTs was evaluated utilizing the risk of bias assessment tool from the Cochrane Collaboration. Risk ratio (RR), risk difference (RD), mean differences (MD), and 95% confidence interval (CI) were used to estimate the effect. Data analysis was used RevMan 5.3.</div></div><div><h3>Results</h3><div>A total of 28 randomized controlled trials involving 2,456 patients were included in this systematic review and meta-analysis. The meta-analysis results indicate that the integration of acupuncture with WMCT for SSNHL may enhance the total effective rate (RR=1.18, 95% CI: 1.14–1.23, <em>P</em>&lt;0.00001), change in hearing threshold (MD=-10.71, 95% CI: -12.52 to -8.89, <em>P</em>&lt;0.00001), and cure rate (RD=0.15, 95% CI: 0.11–0.19, <em>P</em>&lt;0.00001) compared to WMCT alone. Acupuncture as a monotherapy seems to be superior to WMCT in terms of total effective rate (RR=1.19, 95% CI: 1.07–1.32, <em>P</em>=0.001) and cure rate (RD=0.11, 95% CI: 0.02–0.19, <em>P</em>=0.01). There was no significant difference observed between acupuncture alone and WMCT in improving pure tone hearing thresholds (MD=-5.45, 95%CI: -20.75 to 9.85, <em>P</em>=0.48). While the combination of acupuncture with WMCT may offer greater efficacy in reducing tinnitus symptoms (RR=1.12, 95% CI:1.01 to 1.24, <em>P</em>=0.03), but the reliability of this outcome is contested upon sensitivity analysis (RR=1.07, 95% CI:0.87–1.31, <em>P</em>=0.51).</div></div><div><h3>Conclusions</h3><div>The findings of the meta-analysis indicate that acupuncture, either as a standalone intervention or in conjunction with WMCT, may offer supplementary therapeutic advantages in certain respects. However, the results should be interpreted with caution due to the quality and potential bias of the included studies.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 4","pages":"Article 101087"},"PeriodicalIF":2.8,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142721470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}