Integrative Medicine Research最新文献

{"title":"Integrating artificial intelligence into Korean medicine: Insights from neural and pulse signal analysis","authors":"In-Seon Lee","doi":"10.1016/j.imr.2025.101257","DOIUrl":"10.1016/j.imr.2025.101257","url":null,"abstract":"","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 4","pages":"Article 101257"},"PeriodicalIF":3.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145216527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of herbal medicine Xiao-Feng-San combined with auricular acupuncture for atopic dermatitis: A randomized controlled trial","authors":"Nga Thu Tran ,&nbsp;An Hoa Tran ,&nbsp;Dieu-Thuong Thi Trinh","doi":"10.1016/j.imr.2025.101256","DOIUrl":"10.1016/j.imr.2025.101256","url":null,"abstract":"<div><h3>Background</h3><div>Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a considerable burden. Xiao-Feng-San (XFS) has been widely used in traditional medicine for the wind-dampness-heat pattern. Auricular acupuncture (AA) may relieve AD symptoms, but its added benefit with XFS is unclear.</div></div><div><h3>Methods</h3><div>In this randomized, sham-controlled clinical trial, 156 adults with non-severe AD and wind-dampness-heat pattern, all of whom were prescribed XFS decoction, were additionally assigned to receive either AA (XFS plus AA group, n=78) or sham AA (XFS plus Sham AA group, n=78) for four weeks. The primary outcome was the change in the SCORAD index from baseline to week 4. Secondary outcomes included fexofenadine use, Dermatology Life Quality Index (DLQI), serum total IgE, and adverse events.</div></div><div><h3>Results</h3><div>Compared with the XFS plus sham AA, the XFS plus AA group showed a significantly greater reduction in SCORAD at week 4 (mean difference [MD] −9.1; <em>p</em> &lt; 0.0001), exceeding the minimal clinically important difference. DLQI also improved more in the XFS plus AA group (MD −1.8; <em>p</em> = 0.0362). Fexofenadine use was lower in this group, though not significantly; no significant differences in serum total IgE were found. Adverse events were mild and transient.</div></div><div><h3>Conclusions</h3><div>Adding AA to XFS enhanced clinical outcomes and quality of life in patients with non-severe AD, with a favorable safety profile. These findings support AA as a promising adjunctive therapy in integrative approaches for AD. Further studies should validate these results across broader populations, with post-intervention follow-up, and diverse traditional medicine regimens.</div></div><div><h3>Trial registration information</h3><div>ClinicalTrials.gov (NCT06492902).</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"15 2","pages":"Article 101256"},"PeriodicalIF":3.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145195762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of electroacupuncture versus prucalopride for ultra-severe chronic constipation: Secondary analysis of a randomized controlled trial","authors":"Shuai Gao ,&nbsp;Lili Zhu ,&nbsp;Hao Yao ,&nbsp;Jiufei Fang ,&nbsp;Zhishun Liu","doi":"10.1016/j.imr.2025.101253","DOIUrl":"10.1016/j.imr.2025.101253","url":null,"abstract":"<div><h3>Background</h3><div>To explore the effect and safety of electroacupuncture (EA) compared to prucalopride in patients with ultra-severe chronic constipation (USCC), a condition defined by the absence of weekly complete spontaneous bowel movements (CSBMs).</div></div><div><h3>Methods</h3><div>This study was a secondary analysis using data from a multicenter, non-inferiority randomized controlled trial, involving patients with USCC. Participants received either EA or prucalopride treatment. The primary outcome was the mean weekly CSBMs from weeks 1 to 8. Secondary outcomes included the mean weekly CSBMs, the proportion of overall and weekly responders, changes in straining and stool consistency scores, Patient Assessment of Constipation Quality of Life (PAC-QOL) scores, and the proportion of patients using rescue medication.</div></div><div><h3>Results</h3><div>A total of 317 participants with USCC were included (151 in the EA group and 166 in the prucalopride group). From weeks 1 to 8, both groups showed similar increases in the CSBMs (difference: -0.02; 95% confidence interval [CI], -0.34 to 0.30, <em>P</em> &lt; 0.001 for noninferiority). However, during weeks 1 to 2, the prucalopride group showed greater effects than the EA group in increasing CSBMs, alleviating defecation difficulties, and improving stool consistency. The EA group experienced fewer adverse events (AEs) than the prucalopride group.</div></div><div><h3>Conclusions</h3><div>In participants with USCC, EA showed improvements in CSBMs, defecation-related symptoms, and quality of life that were comparable to those observed with prucalopride. The effects of EA might persist for 24 weeks, and EA exhibited a superior safety profile.</div></div><div><h3>Trial registration number</h3><div>NCT02047045 (ClinicalTrials.gov).</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"15 1","pages":"Article 101253"},"PeriodicalIF":3.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145216942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early acupuncture exposure and mortality in older adults with ischemic heart disease: A nationwide cohort study in Korea","authors":"Hyungsun Jun ,&nbsp;Dasol Park ,&nbsp;Haerim Kim ,&nbsp;Ye-Seul Lee ,&nbsp;Jungtae Leem","doi":"10.1016/j.imr.2025.101252","DOIUrl":"10.1016/j.imr.2025.101252","url":null,"abstract":"<div><h3>Background</h3><div>Cardiovascular disease is a leading cause of morbidity and mortality in older adults. However, older adults with ischemic heart disease (IHD) are often exposed to risks associated with polypharmacy, and standard treatments may not fully address their complex clinical needs. Therefore, integrative approaches, such as acupuncture, may play a complementary role. This study assessed the association between early acupuncture exposure and mortality among older adults with newly diagnosed IHD.</div></div><div><h3>Methods</h3><div>Using the Korean National Health Insurance Service database, we identified patients aged ≥65 years with newly diagnosed IHD. Those receiving ≥6 acupuncture sessions within six months post-diagnosis formed the acupuncture group; those without any acupuncture formed the conventional group. Primary outcomes were five-year all-cause and circulatory system disease-specific mortality. Exploratory analyses compared regular and irregular acupuncture exposure.</div></div><div><h3>Results</h3><div>Of 9865 patients, 667 received acupuncture. They were younger, included more females, and had more severe disabilities than the conventional group. After adjustment for confounders, the acupuncture group showed lower all-cause mortality (adjusted hazard ratio [aHR] 0.71, 95 % confidence interval [CI] 0.58–0.88) and circulatory system disease-specific mortality (aHR 0.54, 95 % CI 0.34–0.89). Regular acupuncture use conferred further survival benefits over irregular use and no acupuncture.</div></div><div><h3>Conclusions</h3><div>These findings suggest that early-phase acupuncture intervention may play a meaningful role in improving survival outcomes in this population. Prospective studies are needed to confirm these findings and determine causality.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"15 2","pages":"Article 101252"},"PeriodicalIF":3.0,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacopuncture for patients with psychological stress caused by traffic accidents: A pragmatic randomized controlled pilot trial","authors":"Ja-Yean Son ,&nbsp;Seol Jung ,&nbsp;Young-Hoon Lee ,&nbsp;Dong-Gyu Kim ,&nbsp;Joon-Woo Kim ,&nbsp;Tae-Jun Lee ,&nbsp;Sung-Hwan Cho ,&nbsp;Jeong-Hyo Ji ,&nbsp;Hyun-Woo Cho ,&nbsp;Sang-Don Kim ,&nbsp;Yoon Jae Lee ,&nbsp;In-Hyuk Ha ,&nbsp;Doori Kim ,&nbsp;Byung-Cheul Shin","doi":"10.1016/j.imr.2025.101251","DOIUrl":"10.1016/j.imr.2025.101251","url":null,"abstract":"<div><h3>Background</h3><div>The effectiveness and safety of stress-focused pharmacopuncture in patients experiencing psychological stress following a traffic accident remain unclear. We aimed to conduct a randomized controlled trial to determine the effectiveness and safety of pharmacopuncture for these patients.</div></div><div><h3>Methods</h3><div>A total of 50 patients were included in this randomized controlled pilot trial. Inpatients who scored ≥8 on the Hospital Anxiety and Depression Scale-Anxiety (HADS-A) or Depression (HADS-D) subscales following a traffic accident were randomized to receive either integrative Korean medicine (IKM) treatment alone (comparison group) or IKM treatment combined with stress-focused pharmacopuncture (pharmacopuncture group). The primary outcomes were the changes in the Hospital Anxiety and Depression Scale (HADS) scores, HADS total score (HADS-T), HADS-A, and HADS-D, from baseline to discharge. Secondary outcomes included the Numeric Rating Scale (NRS) for anxiety, depression, and physical pain; the Korean version of the Impact of Event Scale-Revised (IES-R-K); the Korean version of the Insomnia Severity Index (ISI-K); the EuroQol 5-Dimension (EQ-5D); and the Patient Global Impression of Change (PGIC) score.</div></div><div><h3>Results</h3><div>Compared to the comparison group, the pharmacopuncture group showed statistically significant improvements in the HADS-T (difference: 2.30, 95 % CI 0.53 to 4.07), HADS-A (difference: 1.09, 95 % CI 0.17 to 2.02), HADS-D (difference: 1.25, 95 % CI 0.25 to 2.25), NRS of anxiety (difference: 0.85, 95 % CI 0.10 to 1.59), and PGIC (difference: 0.52, 95 % CI 0.07 to 0.97) at the primary endpoint. No serious adverse events were reported.</div></div><div><h3>Conclusion</h3><div>Stress-focused pharmacopuncture may alleviate anxiety and depression symptoms and potentially accelerate recovery after traffic accidents.</div></div><div><h3>Trial registration</h3><div>ClinicalTrials.gov, NCT06107777.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"15 1","pages":"Article 101251"},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145019368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain functional changes in chronic partial sleep-deprivation population by electroacupuncture at shenmen(HT7) and neiguan (PC6) acupoints: A BOLD-fMRI study","authors":"Hui Zeng ,&nbsp;Ganbin Qiu ,&nbsp;Chunyan Wang ,&nbsp;Peifan Liu ,&nbsp;Chunxing Liu ,&nbsp;Mouyuan Liu ,&nbsp;Xiaotong Xie ,&nbsp;Liheng Ma","doi":"10.1016/j.imr.2025.101250","DOIUrl":"10.1016/j.imr.2025.101250","url":null,"abstract":"<div><h3>Background</h3><div>The aim of this study is to explore how electroacupuncture at the Shenmen (HT7) and Neiguan (PC6) acupoints can improve chronic partial sleep deprivation(CPSD) by regulating brain function, and to elucidate its potential neural mechanisms using resting state Blood Oxygen Level-Dependent functional magnetic resonance imaging (BOLD-fMRI).</div></div><div><h3>Methods</h3><div>43 CPSD participants and 48 healthy controls (HC) were recruited and underwent neuropsychological assessments before electroacupuncture. 3.0T BOLD-fMRI scans were conducted before and after receiving bilateral electroacupuncture at HT7 and PC6. Amplitude of low-frequency fluctuation (ALFF) regional homogeneity (ReHo) values and functional connectivity were analyzed between two groups before and after electroacupuncture.</div></div><div><h3>Results</h3><div>CPSD participants showed prolonged reaction time (RT), increased omission rate (OR), and decreased accuracy (ACC) compared to HC. Significant differences (P &lt; 0.05) in ALFF, ReHo, and functional connectivity were observed between groups before and after electroacupuncture, particularly in the default mode network (DMN) and limbic system. ALFF in the right parahippocampal gyrus positively correlated with ACC (r = 0.637, P = 0.001) and negatively with OR (r = -0.427, P = 0.047). ReHo in the left superior frontal gyrus negatively correlated with RT (r = -0.514, P = 0.014).</div></div><div><h3>Conclusion</h3><div>CPSD disrupts functional brain activity, while electroacupuncture at HT7 and PC6 modulates resting-state brain function, offering neuroimaging insights into its potential mechanisms for treating emotional and cognitive impairments in CPSD.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"15 1","pages":"Article 101250"},"PeriodicalIF":3.0,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145045632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating uncertainty in evidence-informed decision-making for traditional, complementary and integrative medicine: An updated critical interpretive review","authors":"Jennifer Hunter ,&nbsp;Matthew Leach ,&nbsp;Dennis Chang ,&nbsp;Myeong Soo Lee ,&nbsp;Yutong Fei ,&nbsp;Jianping Liu","doi":"10.1016/j.imr.2025.101231","DOIUrl":"10.1016/j.imr.2025.101231","url":null,"abstract":"<div><h3>Background</h3><div>Evidence-informed decision-making (EIDM) presents unique challenges for traditional, complementary and integrative medicine (TCIM). To aid decision-making, a critical interpretive review was updated to examine how internationally and nationally endorsed consensus statements on guideline development and policy briefs, along with TCIM-specific recommendations may address these challenges.</div></div><div><h3>Methods</h3><div>The review drew on critical interpretive synthesis and rapid review methods. PubMed, CINAHL and AIMED were searched on 19 January 2024. Single reviewers conducted the screening and extracted descriptive data. Analysis began deductively from the original review themes and developed iteratively.</div></div><div><h3>Results</h3><div>Included were 167 publications. Over the past decade, evidence-to-decision (EtD) frameworks have considered a broader range of modifying factors (e.g., importance of the problem, stakeholder preferences, feasibility, costs, health equity, human rights, social impacts) that may warrant making a stronger recommendation despite lower certainty evidence, and vice versa. Additional strategies proposed by TCIM guideline developers included systematically incorporating multiple evidence sources and developing TCIM extensions for reporting guidelines. Four interrelated themes affirmed the importance of 1) transparent and inclusive decision-making, 2) ensuring the scope and framing of the problem are sensitive to TCIM contexts, 3) using diverse types of evidence in EtD frameworks and when there is evidence uncertainty, and 4) centering equity, including epistemic equity, throughout the EIDM process.</div></div><div><h3>Conclusion</h3><div>Advancing EIDM methodologies specifically for TCIM guideline development and policy can help decision-makers navigate evidence uncertainty to support the appropriate integration of TCIM into global health systems.</div></div><div><h3>Protocol registration</h3><div>International Platform of Registered Systematic Review and Meta-analysis Protocols: INPLASY202510066.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"15 1","pages":"Article 101231"},"PeriodicalIF":3.0,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145045631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI in medicine and traditional medicine - opportunities for healthcare transformation","authors":"Benjamin Becker","doi":"10.1016/j.imr.2025.101233","DOIUrl":"10.1016/j.imr.2025.101233","url":null,"abstract":"","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 4","pages":"Article 101233"},"PeriodicalIF":3.0,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145010022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A catalyst for traditional medicine: AI as a scientific, standardized, and regulated bridge","authors":"Ji-Sheng Han ,&nbsp;Haiting Jiang","doi":"10.1016/j.imr.2025.101232","DOIUrl":"10.1016/j.imr.2025.101232","url":null,"abstract":"","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 4","pages":"Article 101232"},"PeriodicalIF":3.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145044887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guided and motor imagery for pain management and functional recovery after arthroplasty of the hip or knee: A pragmatic prospective mixed-methods study","authors":"Herman A. van Wietmarschen ,&nbsp;Martine Busch ,&nbsp;Miek C. Jong","doi":"10.1016/j.imr.2025.101230","DOIUrl":"10.1016/j.imr.2025.101230","url":null,"abstract":"<div><h3>Background</h3><div>Athroplastic surgery often results in acute post-operative pain, hindering rehabilitation compliance. To improve pain management and functional recovery, guided and motor imagery (GMI) exercises were introduced in hip and knee arthroplasty.</div></div><div><h3>Methods</h3><div>A pragmatic prospective mixed-methods implementation evaluation was conducted at the orthopaedic department of Schakelring, the Netherlands. 80 subjects underwent a 4-week rehabilitation program including GMI after knee or hip arthroplasty. Outcomes included self-reported pain, Timed Up &amp; Go test, 10-meter walk test, and medication use compared with a historical control group. A process evaluation was based on 6 meeting reports, a focus group and 8 interviews.</div></div><div><h3>Results</h3><div>Last measured pain scores were significantly lower in the GMI group compared to control (<em>p</em> = 0,030, Standard Mean Difference (SMD) = 0,87). Pain scores reduced over time in the GMI knee group compared to control (<em>p</em> = 0,015, SMD = 1,15), not in the hip group (<em>p</em> = 0,39, SMD = 0,43). Better Timed Up &amp; Go and 10-meter walk test in GMI knee group versus control at the end of the 4 week rehabilitation period (<em>p</em> = 0,006 and <em>p</em> = 0,027). Thematic analysis of meetings, focus group and interviews resulted in the following critical themes for implementation were: individual adaptation, embedding in the rehabilitation program, motivation and attitudes of staff, perceived support, monitoring of outcome and creating a learning history, perceived effects.</div></div><div><h3>Conclusions</h3><div>Monitoring and evaluating the implementation process and positive clinical results facilitated the implementation of GMI in the rehabilitation setting in the Netherlands.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"15 1","pages":"Article 101230"},"PeriodicalIF":3.0,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}