Integrative Medicine Research最新文献

{"title":"Thread-embedding acupuncture may improve symptom resolution in patients with gastroesophageal reflux disease: A randomized controlled trial","authors":"Dieu-Thuong Thi Trinh ,&nbsp;An Hoa Tran ,&nbsp;Minh-Man Pham Bui ,&nbsp;Nguyen Lam Vuong","doi":"10.1016/j.imr.2023.100971","DOIUrl":"10.1016/j.imr.2023.100971","url":null,"abstract":"<div><h3>Background</h3><p>Various traditional medicine treatments have been investigated to treat GERD. Among those, thread-embedding acupuncture (TEA) has the advantage that patients need to undergo the procedure infrequently; however, its efficacy is unclear. This study evaluated the efficacy of TEA in treating GERD.</p></div><div><h3>Methods</h3><p>A randomized controlled trial was conducted with 66 participants with GERD: 33 received two sessions of TEA + standard therapy (proton-pump inhibitor [PPI]) (TEA+PPI group) and 33 received PPI alone (PPI group). Primary outcomes included GerdQ score and heartburn and regurgitation resolution. Secondary outcomes were antacids requirement, the Frequency Scale for Symptoms of GERD (FSSG) score, and Gastroesophageal Reflux Disease-Health Related Quality of Life (GERD-HRQL) score. The safety outcome was adverse events (AEs).</p></div><div><h3>Results</h3><p>After four weeks of treatment, the TEA+PPI group significantly reduced the GerdQ score (mean difference [MD] and 95% confidence interval [CI]: -1.8 [-2.4, -1.1]) and increased the rate of heartburn and regurgitation resolution compared to PPI (54.5% versus 9.1%, respectively) compared to PPI. The TEA+PPI group also significantly reduced the number of antacid packs used (MD [95%-CI]: -9.4 [-12.1, -6.7]), FSSG score (MD [95%-CI]: -9.4 [-11.0, -7.8]), and GERD-HRQL score (MD [95%-CI]: -5.6 [-7.7, -3.5]) compared to PPI. Five patients experienced AEs, which were mild local complications at the acupoints.</p></div><div><h3>Conclusion</h3><p>TEA combined with PPI is more effective than PPI alone in treating GERD. Further studies with longer follow-ups are required to confirm these findings.</p></div><div><h3>Clinical trials registration information</h3><p>This study was registered at ClinicalTrials.gov, <span>NCT05353933</span><svg><path></path></svg>.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 3","pages":"Article 100971"},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e7/6f/main.PMC10448015.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10164499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical effectiveness of decoction form of herbal medicine in primary care treatment of allergic rhinitis: A retrospective cohort study","authors":"Mi Ju Son ,&nbsp;Sungha Kim ,&nbsp;Young-Eun Kim ,&nbsp;Bo-Young Kim ,&nbsp;Chang-Sub Yeum ,&nbsp;Jong Cheol Lee ,&nbsp;Jae Hoon Cha ,&nbsp;Soonsik Kang ,&nbsp;Ching Hao Chang ,&nbsp;Seokho Son","doi":"10.1016/j.imr.2023.100973","DOIUrl":"10.1016/j.imr.2023.100973","url":null,"abstract":"<div><h3>Background</h3><p>The decoction form of herbal medicine (D-HM) is mainly prescribed to patients with allergic rhinitis (AR) in Korean Medicine (KM) clinics in the Republic of Korea; however, it is difficult to conduct clinical trials of D-HM due to regulatory issues. This study investigated the clinical safety and effectiveness of D-HM combination therapy for the treatment of AR by analyzing the AR outpatient data from 17 KM clinics.</p></div><div><h3>Methods</h3><p>This retrospective cohort study included patients who visited KM clinics for AR treatment from January 1, 2021, to March 31, 2022. Cases were collated using structured case report forms and divided into the D-HM with KM usual care group (D-HM group) and the KM usual care group (UC group). Since D-HM therapy could not be randomly assigned to the study population, we used optimal propensity score (PS) matching to investigate the effectiveness and safety of D-HM combination therapy in the treatment of AR.</p></div><div><h3>Results</h3><p>Data from 228 patients were collected. After PS matching, 144 patients were finally analyzed. The total nasal symptom score (TNSS) and mini-rhinoconjunctivitis quality of life questionnaire (mini-RQLQ) were significantly improved in the D-HM group compared with those in the UC group (TNSS: p=0.02; mini-RQLQ: p=0.04). Four patients in the D-HM group experienced minor adverse events that were mild and resolved within 15 days.</p></div><div><h3>Conclusions</h3><p>D-HM combination therapy may be beneficial in the management of symptoms and rhinitis-associated quality of life and potentially useful in clinical practice. However, randomized placebo-controlled clinical trials are required to confirm their effectiveness.</p></div><div><h3>Study registration</h3><p>This study has been registered at Clinical Research Information Service (KCT0007242).</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 3","pages":"Article 100973"},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/87/51/main.PMC10448014.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10464643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Economic evaluation of acupuncture as an adjunctive treatment with usual care for mild-to-moderate knee osteoarthritis: A Markov model-based analysis","authors":"Eunhye Hyun ,&nbsp;Byung-Cheul Shin ,&nbsp;NamKwen Kim ,&nbsp;Byungmook Lim","doi":"10.1016/j.imr.2023.100982","DOIUrl":"10.1016/j.imr.2023.100982","url":null,"abstract":"<div><h3>Background</h3><p>Collaborative care (CC), in which acupuncture is combined with usual care (UC), improves clinical outcomes and increases costs in knee osteoarthritis (KOA). We evaluated the economic feasibility of CC for Korean female patients with mild-to-moderate KOA by using a cost-effectiveness approach.</p></div><div><h3>Methods</h3><p>Two alternatives for KOA (1. UC as a comparator; and 2. CC as an intervention) were defined based on clinical guidelines, official Korean statistics, and expert validation. Each alternative was simulated in a Markov model every 6 months for 10 years. Estimates of costs, utilities, and transition probabilities were obtained from official statistics and previous studies. The effectiveness of CC was synthesized from randomized controlled trials. A base-case analysis of a limited societal perspective, univariate sensitivity analysis, and probability sensitivity analysis were performed. An annual discount rate of 4.5% and threshold of 20,000 United States dollar per Quality-adjusted life year (USD/QALY) were applied.</p></div><div><h3>Results</h3><p>Every incremental cost-effectiveness ratio (ICER) of CC calculated from the analyses was sub-threshold. In the base-case analysis, with a limited societal perspective, the ICER was 11,085 USD/QALY. The ICERs from the univariate sensitivity analyses were -2,577–16,748 USD/QALY. The average ICER in the probability sensitivity analysis was 12,412 USD/QALY. When the threshold surpassed 8,000 USD/QALY, the cost-effectiveness of CC exceeded 50%. The probability was 70.27% when the threshold was 20,000 USD/QALY.</p></div><div><h3>Conclusions</h3><p>CC for Korean female patients with mild-to-moderate KOA was generally cost-effective. Considering the limitations of the evidence, we propose a re-evaluation using further clinical studies in the future.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 3","pages":"Article 100982"},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8c/06/main.PMC10470223.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10143952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of yoga on stress, metabolic parameters, and cognition of Indian adolescents: A cluster randomized controlled trial","authors":"Harish Ranjani ,&nbsp;Narayanaswamy Jagannathan ,&nbsp;Tina Rawal ,&nbsp;Radhakrishnan Vinothkumar ,&nbsp;Nikhil Tandon ,&nbsp;Jayaram Vidyulatha ,&nbsp;Viswanathan Mohan ,&nbsp;Yashdeep Gupta ,&nbsp;Ranjit Mohan Anjana","doi":"10.1016/j.imr.2023.100979","DOIUrl":"https://doi.org/10.1016/j.imr.2023.100979","url":null,"abstract":"<div><h3>Background</h3><p>This project aimed to assess the impact of yoga on stress, metabolic parameters and cognition (attention &amp; concentration) in adolescents, aged 13–15 years from public and private schools in two cities (Chennai and New Delhi) in India.</p></div><div><h3>Methods</h3><p>The study recruited 2000 adolescents from 24 schools in a cluster randomized controlled trial design. The yoga group participants underwent 17 yoga sessions, which included: pranayama, basic asanas, meditation and relaxation exercises. Yoga sessions, were held in the school premises once a week. A total of five awareness talks on healthy lifestyle were delivered once a month to the education group. ADOlescence Stress Scale (ADOSS), salivary cortisol, metabolic and clinical parameters and Letter Cancellation Test (LCT) score were measured at baseline and post-intervention (5–6 months).</p></div><div><h3>Results</h3><p>The yoga group showed statistically significant differences in the mean ADOSS score, metabolic parameters, salivary cortisol, and LCT scores compared to the education group. In the intention- to- treat analysis, a significant reduction [5.11, 95% CI (4.78, 5.36), <em>p</em> = 0.001] in ADOSS score was seen in the yoga group compared to education.</p></div><div><h3>Conclusion</h3><p>Implementation of a 17-week standardized yoga program at the school level significantly decreased stress, improved attention and concentration, metabolic and clinical parameters in Indian adolescents.</p></div><div><h3>Trial registration</h3><p>This trial was registered at Clinical Trials Registry, India (CTRI/2017/08/009203).</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 3","pages":"Article 100979"},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49772555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three aspects of acupuncture-related adverse events: Issues around the reporting of acupuncture-related adverse events","authors":"Tae-Hun Kim ,&nbsp;Stephen Birch ,&nbsp;Terje Alraek ,&nbsp;Myeong Soo Lee","doi":"10.1016/j.imr.2023.100980","DOIUrl":"10.1016/j.imr.2023.100980","url":null,"abstract":"","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 3","pages":"Article 100980"},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/16/d7/main.PMC10468376.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10152433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between acupuncture therapy and the risk of reduced pressure ulcers in dementia patients: A retrospective matched cohort study","authors":"Chia-Yu Huang ,&nbsp;Mei-Yao Wu ,&nbsp;Ming-Cheng Huang ,&nbsp;Teng-Shun Yu ,&nbsp;Hung-Rong Yen","doi":"10.1016/j.imr.2023.100981","DOIUrl":"10.1016/j.imr.2023.100981","url":null,"abstract":"<div><h3>Background</h3><p>The pressure ulcer is a complication developed from dementia. The aim of this study is to study the association between the development of pressure ulcers and the use of acupuncture therapy in patients with dementia.</p></div><div><h3>Methods</h3><p>We performed a retrospective 1:1 propensity score-matched cohort study to investigate the association between acupuncture therapy and the risk of pressure ulcers in patients with dementia.</p></div><div><h3>Results</h3><p>A total of 8,994 patients were identified, 237 patients in the acupuncture cohort and 362 patients in the no-acupuncture cohort developed pressure ulcers. A reduced cumulative incidence of pressure ulcers was observed in the acupuncture cohort (<em>P</em>&lt;0.001). The association between acupuncture and reducing the incidence of pressure ulcers was not affected by sex, age, residence, income, or comorbidities. The variables of etiologies to cause dementia did not change the final result. In the subgroups analyses, the patients without medication for dementia control had a significantly lower rate of pressure ulcers development when they had accepted acupuncture therapy (log-rank test, <em>P</em>&lt;0.001).</p></div><div><h3>Conclusion</h3><p>Our results revealed the association between acupuncture therapy and a reduced incidence of pressure ulcer development in patients with dementia. This finding offers important ideas for further research.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 3","pages":"Article 100981"},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e0/0e/main.PMC10468362.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10143951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complementary, alternative, and integrative medicine-specific COVID-19 misinformation on social media: A scoping review","authors":"Jeremy Y. Ng ,&nbsp;Shawn Liu ,&nbsp;Ishana Maini ,&nbsp;Will Pereira ,&nbsp;Holger Cramer ,&nbsp;David Moher","doi":"10.1016/j.imr.2023.100975","DOIUrl":"10.1016/j.imr.2023.100975","url":null,"abstract":"<div><h3>Background</h3><p>The sharing of health-related information has become increasingly popular on social media. Unregulated information sharing has led to the spread of misinformation, especially regarding complementary, alternative, and integrative medicine (CAIM). This scoping review synthesized evidence surrounding the spread of CAIM-related misinformation on social media during the COVID-19 pandemic.</p></div><div><h3>Methods</h3><p>This review was informed by a modified version of the Arksey and O'Malley scoping review framework. AMED, EMBASE, PsycINFO and MEDLINE databases were searched systematically from inception to January 2022. Eligible articles explored COVID-19 misinformation on social media and contained sufficient information on CAIM therapies. Common themes were identified using an inductive thematic analysis approach.</p></div><div><h3>Results</h3><p>Twenty-eight articles were included. The following themes were synthesized: 1) misinformation prompts unsafe and harmful behaviours, 2) misinformation can be separated into different categories, 3) individuals are capable of identifying and refuting CAIM misinformation, and 4) studies argue governments and social media companies have a responsibility to resolve the spread of COVID-19 misinformation.</p></div><div><h3>Conclusions</h3><p>Misinformation can spread more easily when shared on social media. Our review suggests that misinformation about COVID-19 related to CAIM that is disseminated online contributes to unsafe health behaviours, however, this may be remedied via public education initiatives and stricter media guidelines. The results of this scoping review are crucial to understanding the behavioural impacts of the spread of COVID-19 misinformation about CAIM therapies, and can inform the development of public health policies to mitigate these issues.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 3","pages":"Article 100975"},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5a/22/main.PMC10460953.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10176422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical effectiveness of mindfulness-based music therapy on improving emotional regulation in blind older women: A randomized controlled trial","authors":"Sunny H.W. Chan ,&nbsp;Meryl Y.C. Cheung ,&nbsp;Armstrong T.S. Chiu ,&nbsp;Mimi H.T. Leung ,&nbsp;Michael C.C. Kuo ,&nbsp;Donald Y.C. Yip ,&nbsp;Carole C.Y. Hui ,&nbsp;Sally W.I. Kam ,&nbsp;King Yeung ,&nbsp;Doreen S.P. Mui ,&nbsp;Shu-Mei Wang ,&nbsp;Calvin C.K. Yip","doi":"10.1016/j.imr.2023.100993","DOIUrl":"10.1016/j.imr.2023.100993","url":null,"abstract":"<div><h3>Background</h3><p>This study aimed to investigate clinical effectiveness of a structured eight-week mindfulness-based music therapy (MBMT) program on improving mood regulation in older women with blindness. This investigation compared a MBMT group with a mindfulness intervention (MI) group and a control group.</p></div><div><h3>Methods</h3><p>Ninety-two older females with blindness from a residential setting in Hong Kong were recruited and randomly allocated to a MBMT (<em>n</em> = 31), MI (<em>n</em> = 30), or control (<em>n</em> = 31) group. Psychological measurements regarding mood regulation and general mood states (namely, Difficulties in Emotion Regulation Scale [DERS], Geriatric Depression Scale [GDS], and Depression Anxiety Stress Scales-21), were taken at pretest and posttest. Outcome assessors were blinded to group assignment.</p></div><div><h3>Results</h3><p>Data was analyzed based on intention-to-treat basis. At posttest, DERS scores in the MBMT group (mean differences and 95% confidence interval: 12.1, 5.5 to 18.8) and the MI group (7.2, 0.5 to 13.8) were lower than that in the control group. GDS scores in the MBMT group (2.9, 1.7 to 4.0) and the MI group (1.7, 0.6 to 2.9) were lower than those in the control group. Compared with the MI group, the MBMT group improved emotional awareness sub-scores in DERS (2.1, 0.2 to 4.1) and appeared to lower depression in GDS scores (1.1, -0.0 to 2.3; <em>p</em> = 0.053).</p></div><div><h3>Conclusion</h3><p>MBMT seems more beneficial than MI alone for improving emotional regulation in older women with blindness. The combination of mindfulness and music can generate a synergetic effect by enhancing both attention and appraisal components within the emotional-regulation process.</p></div><div><h3>Trial registration</h3><p>ClinicalTrials.gov, NCT05583695.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 4","pages":"Article 100993"},"PeriodicalIF":3.4,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42836280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Brief History of Complementary, Alternative, and Integrative Medicine Terminology and the Development and Creation of an Operational Definition","authors":"Jeremy Y. Ng ,&nbsp;Tushar Dhawan ,&nbsp;Renee-Gabrielle Fajardo ,&nbsp;Hooriya A. Masood ,&nbsp;Samira Sunderji ,&nbsp;L. Susan Wieland ,&nbsp;David Moher","doi":"10.1016/j.imr.2023.100978","DOIUrl":"10.1016/j.imr.2023.100978","url":null,"abstract":"<div><p>The definition of complementary, alternative, and integrative medicine (CAIM) remains dynamic and complex despite a steady increase in the popularity/usage of CAIM therapies across the globe. A lack of consistency in how these terms are defined remains a challenge for researchers, clinicians, and national and international organizations (e.g., World Health Organization, National Center for Complementary and Integrative Health) alike. In the present article, we provide a brief history of the use of these terminologies, and then outline the process we took to develop and create an operational definition of complementary, alternative, and integrative medicine. Our operational definition is the first to be informed by a systematic search of four quality-assessed information resource types, ultimately yielding 604 unique CAIM therapies. We then developed a single search string for the most common bibliographic databases using the finalized operational definition list of CAIM therapies. These CAIM therapies were searched against the Therapeutic Research Center's “Natural Medicines” database for all 604 therapies, whereby each item's scientific name and/or synonym was included as a keyword or phrase in the search string. While the current definition is not without limitations and ongoing debates still surround the field, this work is arguably a steppingstone towards enabling increased collaboration and communication amongst healthcare clinicians, researchers, and the public. This operational definition provides a foundation for developing well-coordinated research efforts that will assist in the acceptance and understanding of this field, while also focusing on adopting knowledge translation techniques and efforts for further research advancement and use.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 4","pages":"Article 100978"},"PeriodicalIF":3.4,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44230703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Chinese medicine formula Huashibaidu granule on mild COVID-19 patients: A prospective, non-randomized, controlled trial","authors":"Bowu Chen ,&nbsp;Yan Xue ,&nbsp;Hua Jing ,&nbsp;Xiaodong Wang ,&nbsp;Peimin Zhu ,&nbsp;Weiwei Hao ,&nbsp;Man Li ,&nbsp;Yueqiu Gao","doi":"10.1016/j.imr.2023.100950","DOIUrl":"10.1016/j.imr.2023.100950","url":null,"abstract":"<div><h3>Background</h3><p>The effectiveness and safety of herbal medicine Huashibaidu granule (HSBD) in treating mild Coronavirus Disease 2019 (COVID-19) patients infected with SARS-CoV-2 remain to be identified. We aimed to evaluate the effectiveness of HSBD in mild COVID-19 patients.</p></div><div><h3>Methods</h3><p>A prospective, non-randomized, controlled study in mild COVID-19 patients was conducted in Shanghai, China, from April 8 to May 6, 2022. Finally, 360 mild COVID-19 patients received HSBD (orally 20 g twice daily for 7 days), and 368 patients received herbal medicine placebo (orally 20 g twice daily for 7 days). The primary endpoints were the negative conversion rate of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and the negative conversion time. Secondary endpoints included the hospitalized days and the improvement in the clinical condition.</p></div><div><h3>Results</h3><p>The negative conversion rate of SARS-CoV-2 at 7 days posttreatment in the HSBD group was higher than that in the control group (95.28% vs. 82.61%, <em>P</em> &lt; 0.001). The median negative conversion time in the HSBD group was markedly decreased by 2 days compared with the control group (3 [3–6] vs. 5 [4–7], <em>P</em> &lt; 0.001). In addition, the median hospitalized day was shortened in the HSBD group by 1 day compared with the control group (6 [4–7] vs. 7 [5–9], <em>P</em> &lt; 0.001). The clinical improvement rate (275/360 [76.39%]) in the HSBD group within 7 days was significantly higher than that (203/368 [55.16%]) in the control group (<em>P</em> &lt; 0.001). The improvement of symptom scores in the HSBD group was higher than that in the control group (2 [1–4] vs. 1 [1–2], <em>P</em> &lt; 0.001). No severe adverse events occurred.</p></div><div><h3>Conclusions</h3><p>Our study suggested that HSBD effectively increased the negative conversion rate of SARS-CoV-2 and shortened the negative conversion time and hospitalized days in mild COVID-19 patients.</p></div><div><h3>Clinical trial registration</h3><p>The trial was registered at Chinese Clinical Trial Registry, ChiCTR2200058668.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 2","pages":"Article 100950"},"PeriodicalIF":3.4,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e9/93/main.PMC10121152.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10299679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}