Integrative Medicine Research最新文献

{"title":"Complementary and alternative medicine mention and recommendations in pancreatic cancer clinical practice guidelines: A systematic review and quality assessment","authors":"Jeremy Y Ng,&nbsp;Hardil Anup Bhatt,&nbsp;Maheen Raja","doi":"10.1016/j.imr.2023.100921","DOIUrl":"10.1016/j.imr.2023.100921","url":null,"abstract":"<div><h3>Background</h3><p>Pancreatic cancer is the third leading cause of cancer death in the United States, which is attributed to limited treatment options. Complementary and alternative medicine (CAM) therapies have been proposed to provide benefits in treating pancreatic cancer. Despite its importance in treatment, clinicians are not generally well equipped to counsel their patients about CAM therapies. This review identified the quantity and assessed the quality of clinical practice guidelines (CPGs) providing CAM recommendations for the treatment and/or management of pancreatic cancer.</p></div><div><h3>Methods</h3><p>A systematic review was conducted to identify pancreatic cancer CPGs. MEDLINE, EMBASE and CINAHL were searched from 2011 to 2022. The Guidelines International Network (GIN) and the National Center for Complementary and Integrative Health (NCCIH) websites were also searched. Eligible CPGs published by non-profit agencies on treatment and/or management of pancreatic cancer for adults were assessed using the Appraisal of Guidelines, Research and Evaluation II (AGREE II) instrument.</p></div><div><h3>Results</h3><p>From 31 eligible search results, 7 CPGs mentioned CAM and 3 CPGs made CAM recommendations. The mean scaled domain percentages of the CPGs in this study (overall, CAM-specific) were as follows: scope and purpose (81.3%, 77.8%), stakeholder involvement (63.9%, 42.6%), rigor-of-development (51.0%, 40.3%), clarity-of-presentation (83.3%, 54.6%), applicability (42.3%, 30.5%), and editorial independence (58.3%, 58.3%).</p></div><div><h3>Conclusions</h3><p>Evaluation of the CPGs demonstrated that quality varied both within and between CPGs. CPGs that scored well could be used by patients and clinicians as the basis for discussion for the use of CAM therapies. Future research should identify other appropriate CAM therapies for further development of CPGs for pancreatic cancer.</p></div><div><h3>Registration</h3><p>The protocol was registered on PROSPERO (registration number: CRD42022334025).</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 1","pages":"Article 100921"},"PeriodicalIF":3.4,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a6/c1/main.PMC9852932.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10579016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of antibiotics and other treatments in Chinese adults with acute cough: An online survey","authors":"Xiao-Yang Hu ,&nbsp;Ru-Yu Xia ,&nbsp;Michael Moore ,&nbsp;Beth Stuart ,&nbsp;Ling-Zi Wen ,&nbsp;Bertrand Graz ,&nbsp;Lily Lai ,&nbsp;Jian-Ping Liu ,&nbsp;Yu-Tong Fei ,&nbsp;Merlin Willcox","doi":"10.1016/j.imr.2022.100920","DOIUrl":"10.1016/j.imr.2022.100920","url":null,"abstract":"<div><h3>Background</h3><p>Acute respiratory tract infections are common worldwide and there has been a rapid increase in antibiotic consumption. This study aimed to identify use of various treatments and their association with the use of antibiotics and patient reported clinical recovery in Chinese adults with acute cough.</p></div><div><h3>Methods</h3><p>An online survey recruiting people who had recently experienced cough was conducted. Their sociodemographic, clinical characteristics, treatments received and their perceived changes in symptoms were collected. Factors influencing avoidance of antibiotics and improvement in symptoms were explored.</p></div><div><h3>Results</h3><p>A total of 22,787 adults with recent acute cough completed the questionnaire, covering all 34 province-level administrative units in China. Most respondents were male (68.0%), young (89.4%, aged 18–45), educated to university/degree or postgraduate level (44.6%), with a median cough severity of 6/10 on a numerical rating scale. Nearly half of the participants (46.4%) reported using antibiotics, among which 93.1% were for presumed upper respiratory tract infections (URTIs). Pharmacies (48.8%) were the most common source of antibiotics. Fewer patients took antibiotics after taking CHM (14.9%), compared to those who started with home remedies (18.0%), or allopathic non-antibiotic medication (25.0%). Antibiotics, allopathic non-antibiotic medications, CHM and home remedies were all perceived beneficial in relieving cough.</p></div><div><h3>Conclusions</h3><p>Chinese adult responders report use of a considerable variety of treatments alone or in combination for acute cough. Patient-reported clinical recovery was similar regardless of treatment. There is likely a high proportion of inappropriate use of antibiotics for treatment of simple acute cough. As the majority of respondents did not use antibiotics as a first-line, and use of CHM was associated with relief of cough symptoms and reduction in the use of antibiotics, this presents an important opportunity for prudent antibiotic stewardship in China.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 1","pages":"Article 100920"},"PeriodicalIF":3.4,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/80/7a/main.PMC9850188.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10579009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chinese herbal medicine for drug-induced liver injury in patients with HIV/AIDS: A systematic review of randomized controlled trials","authors":"Xiao-wen Zhang ,&nbsp;Jing Li ,&nbsp;Wen-bin Hou ,&nbsp;Yue Jiang ,&nbsp;Ruo-xiang Zheng ,&nbsp;De-hao Xu ,&nbsp;Chen Shen ,&nbsp;Nicola Robinson ,&nbsp;Jian-ping Liu","doi":"10.1016/j.imr.2022.100918","DOIUrl":"10.1016/j.imr.2022.100918","url":null,"abstract":"<div><h3>Background</h3><p>To explore the effectiveness and safety of Chinese herbal medicine (CHM) for drug-induced liver injury (DILI) in patients with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS).</p></div><div><h3>Methods</h3><p>A systematic search was made of eight databases (Pubmed, Cochrane Library, Web of Science, Embase, CNKI, Wanfang, VIP, Sinomed) and two trial registries (WHO ICTRP, ClinicalTrials.gov) from inception to September 2022. The effect size was presented as risk ratio (RR) or mean difference (MD) with their 95% confidence interval (CI). The Cochrane Risk of Bias and Grading of Recommendations, Assessment, Development and Evaluations (GRADE) tools were used for quality appraisal.</p></div><div><h3>Results</h3><p>Ten randomized controlled trials (RCTs) involving 732 participants were included. Comparing CHM alone with routine treatment, the CHM group showed lower aspartate aminotransferase (MD=-11.47 U/L, 95%CI[-13.05, -9.89], low certainty), lower alanine aminotransferase (MD=-2.68 U/L, 95%CI[-4.27, -1.08], low certainty), lower total bilirubin (MD=-4.31 mmol/L, 95%CI[-5.66, -2.96], low certainty), lower bilirubin direct (MD=-3.19 mmol/L, 95%CI[-3.87, -2.51], low certainty), and higher effective rate (assessed by symptoms and liver indicators) (RR=1.13, 95%CI[1.06, 1.20], low certainty). A significant difference was also found in CHM plus routine treatment versus routine treatment in the previous outcomes. No significant difference was found on helper T cells among these comparisons. Only one RCT reported safety of CHM and found no adverse reaction during the trial.</p></div><div><h3>Conclusions</h3><p>CHM may improve the liver function indices and effective rate for HIV/AIDS patients with DILI. However, the sample size was small and quality was low. Larger-samples of high-quality trials are needed.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 1","pages":"Article 100918"},"PeriodicalIF":3.4,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/12/98/main.PMC9826828.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9088701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reporting quality of economic evaluations of the negotiated Traditional Chinese Medicines in national reimbursement drug list of China: A systematic review","authors":"Juntao Yan ,&nbsp;Shiyi Bao ,&nbsp;Liu Liu ,&nbsp;Yu-Qing Zhang ,&nbsp;Jian Ming ,&nbsp;Yan Wei ,&nbsp;Yingyao Chen","doi":"10.1016/j.imr.2022.100915","DOIUrl":"10.1016/j.imr.2022.100915","url":null,"abstract":"<div><h3>Background</h3><p>Traditional Medicine (TM) has a wide uptake in most countries. In China, Traditional Chinese Medicine (TCM) is a common kind of primary health because of its beneficial effects. This review aimed to appraise the publication reporting quality of economic evaluations for selective TCM in the National Reimbursement Drug List (NRDL), Version 2020, based on the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement.</p></div><div><h3>Methods</h3><p>Electronic databases were searched for economic evaluation that supported the TCM negotiations in NRDL (2020 version) published from 2001 to 2021, including PubMed, Web of Science, Embase, CNKI, WanFang, and SinoMed. The CHEERS statement was used to appraise the reporting quality of included TCM economic evaluations.</p></div><div><h3>Results</h3><p>A total of 360 articles were retrieved, but only 38 economic evaluations met the inclusion criteria. None of the articles reported all items in the CHEERS checklist. The mean score of included articles is low at 10.93±2.62, with an average scoring rate of 51.31±10.53%. The least reported items included: “Characterizing heterogeneity,” “Conflicts of interest”, “Discount rate,” and “Study perspective,” with a reporting rate of 0.00%, 5.26%, 7.89%, and 15.79%, respectively.</p></div><div><h3>Conclusion</h3><p>An upward trend occurred in the quantity and quality of the economic evaluation publications of TCM in China. TCM economic evaluations are still at an early stage, with an urgent need for improving reporting quality. It may result from research experiences or different ideas between TCM and Western Medicine. Adhering to reporting guidelines like CHEERS and educating economic evaluation investigators can improve TCM economic evaluations’ reporting quality.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 1","pages":"Article 100915"},"PeriodicalIF":3.4,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5f/96/main.PMC9826834.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9088702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomical features of the GV20 acupoint","authors":"Sang Hyun Kim ,&nbsp;Ji-Yeun Park ,&nbsp;Young Ho Lee","doi":"10.1016/j.imr.2022.100919","DOIUrl":"10.1016/j.imr.2022.100919","url":null,"abstract":"","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 1","pages":"Article 100919"},"PeriodicalIF":3.4,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/58/fd/main.PMC9826820.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9088703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of clinical practice guidelines for Korean medicine: Towards evidence-based complementary and alternative medicine","authors":"Seungwon Shin ,&nbsp;Wonkyung Moon ,&nbsp;Suran Kim ,&nbsp;Seok Hee Chung ,&nbsp;Jongwoo Kim ,&nbsp;Namkwen Kim ,&nbsp;Yoon Jae Lee ,&nbsp;Minjung Park","doi":"10.1016/j.imr.2023.100924","DOIUrl":"10.1016/j.imr.2023.100924","url":null,"abstract":"<div><h3>Background</h3><p>Since evidence-based medicine has been pursued in complementary and alternative medicine, the clinical practice guideline (CPG) has become a key factor in providing standardized and validated practices in Korean Medicine (KM). We aimed to review the current status and characteristics of the development, dissemination, and implementation of KM-CPGs.</p></div><div><h3>Methods</h3><p>We searched KM-CPGs and relevant publication <em>via</em> web-based databases. We organized the searching results focused on the year of publications and the development programs to show which and how KM-CPGs have been development. We also reviewed the manuals for KM-CPG development to introduce concise characteristics of the KM-CPGs published in Korea.</p></div><div><h3>Results</h3><p>The KM-CPGs have been developed according to manuals and standard templates for developing evidence-based KM-CPGs. First, CPG developers reviews the previously published CPGs for a clinical condition of interest and plans the CPG development. After finalizing the key clinical questions, the evidence is searched, selected, appraised, and analyzed following the internationally standardized methods. The quality of the KM-CPGs is controlled by a tri-step appraisal process. Second, the CPGs were submitted for the appraisal of the KM-CPG Review and Evaluation Committee. The committee evaluates the CPGs according to the AGREE II tool. Finally, the Steering Committee of the KoMIT project reviews the entire process of developing the CPGs and confirms it for public disclosure and dissemination.</p></div><div><h3>Conclusion</h3><p>Evidence-based KM from research to practice can be achieved with the attention and effort of multidisciplinary entities such as clinicians, practitioners, researchers, and policymakers for the CPGs.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 1","pages":"Article 100924"},"PeriodicalIF":3.4,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8c/76/main.PMC9971282.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9388111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The digital metaverse: Applications in artificial intelligence, medical education, and integrative health","authors":"Abhimanyu S. Ahuja ,&nbsp;Bryce W. Polascik ,&nbsp;Divyesh Doddapaneni ,&nbsp;Eamonn S. Byrnes ,&nbsp;Jayanth Sridhar","doi":"10.1016/j.imr.2022.100917","DOIUrl":"10.1016/j.imr.2022.100917","url":null,"abstract":"","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 1","pages":"Article 100917"},"PeriodicalIF":3.4,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a4/22/main.PMC9860100.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10615634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing cancer-related fatigue through sleep: A secondary analysis of a randomized trial comparing acupuncture and cognitive behavioral therapy for insomnia","authors":"Xiaotong Li ,&nbsp;Kevin T. Liou ,&nbsp;Susan Chimonas ,&nbsp;Karolina Bryl ,&nbsp;Greta Wong ,&nbsp;Eugenie Spiguel ,&nbsp;Susan Q. Li ,&nbsp;Sheila N. Garland ,&nbsp;Ting Bao ,&nbsp;Jun J. Mao","doi":"10.1016/j.imr.2023.100922","DOIUrl":"10.1016/j.imr.2023.100922","url":null,"abstract":"<div><h3>Background</h3><p>Fatigue is a troublesome symptom in cancer survivors that often results from disrupted sleep. We sought to assess whether two insomnia-focused non-pharmacological interventions are also effective for improving fatigue.</p></div><div><h3>Methods</h3><p>We analyzed data from a randomized clinical trial comparing cognitive behavioral therapy for insomnia (CBT-I) versus acupuncture for insomnia among cancer survivors. Participants were 109 patients who reported insomnia and moderate or worse fatigue. Interventions were delivered over eight weeks. Fatigue was evaluated at baseline, week 8, and week 20 using the Multidimensional Fatigue Symptom Inventory-Short Form (MFSI-SF). We used both mediation analysis and t-tests to explore the extent to which fatigue reduction was attributable to insomnia response.</p></div><div><h3>Results</h3><p>Compared to baseline, both CBT-I and acupuncture produced significant reductions in total MFSI-SF scores at week 8 (−17.1 points; 95% confidence interval [CI]: −21.1 to −13.1, and −13.2 points; 95% CI: -17.2 to -9.2, respectively, all <em>p</em>&lt;0.001) and week 20 (-14.6 points; 95% CI: -18.6 to -10.6, and −14.2 points; 95% CI: -18.1 to -10.3. respectively, all <em>p</em>&lt;0.001), with no significant between-group differences. MFSI-SF total scores at week 8 were significantly associated with sleep improvements in both CBT-I and acupuncture groups (<em>p</em>&lt;0.001 and <em>p</em>=0.011, respectively). Insomnia responders demonstrated significantly greater improvements in mean MFSI-SF total scores compared with non-responders in the CBT-I group (<em>p</em>=0.016) but not in the acupuncture group.</p></div><div><h3>Conclusion</h3><p>CBT-I and acupuncture produced similar, clinically meaningful, and durable fatigue reductions in cancer survivors with insomnia, primarily through improvements in sleep. Acupuncture may also reduce fatigue through additional pathways.</p></div><div><h3>Trial registration</h3><p>ClinicalTrials.gov, identifier: NCT02356575</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 1","pages":"Article 100922"},"PeriodicalIF":3.4,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0d/cf/main.PMC9944506.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9585366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rg3-enriched Korean red ginseng alleviates chloroquine-induced itch and dry skin pruritus in an MrgprA3-dependent manner in mice","authors":"Wook-Joo Lee ,&nbsp;Won-Sik Shim","doi":"10.1016/j.imr.2022.100916","DOIUrl":"10.1016/j.imr.2022.100916","url":null,"abstract":"<div><h3>Background</h3><p>Previous studies have found that Korean red ginseng extract (KRG) has antipruritic effects, which can be attributed to the presence of Rg3, one of the most potent ginsenosides. Therefore, Rg3-enriched KRG extract (Rg3EKRG) is anticipated to have enhanced antipruritic effects. The present study was conducted to examine the effects of Rg3EKRG in acute chloroquine (CQ)-induced and chronic dry skin pruritus.</p></div><div><h3>Methods</h3><p>Calcium imaging technique was used in HE293T cells expressing MrgprA3 and TRPA1 (“MrgprA3/TRPA1”) and in primary cultures of mouse dorsal root ganglia (DRG) neurons. Mouse scratching behavior tests were performed on dry skin models. To verify the altered expression of itch-related genes, real-time RNA sequencing analysis and PCR were performed on DRG sections obtained from dry skin models.</p></div><div><h3>Results</h3><p>Rg3EKRG suppressed CQ-induced intracellular calcium changes to a greater degree than KRG. Rg3EKRG dose-dependently inhibited CQ-induced responses in MrgprA3/TRPA1 cells. Rg3EKRG likely targeted MrgprA3 rather than TRPA1 to exert its inhibitory effect. Further, Rg3EKRG strongly inhibited the scratching behavior in mice induced by acute CQ injection. Importantly, DRG neurons obtained from dry skin mice models showed increased mRNA levels of <em>MrgprA3</em>, and treatment with Rg3EKRG alleviated chronic dry skin conditions and suppressed spontaneous scratching behaviors.</p></div><div><h3>Conclusion</h3><p>The results of the present study imply that Rg3EKRG has a stronger antipruritic effect than KRG, inhibiting both acute CQ-induced and chronic dry skin pruritus in an MrgprA3-dependent manner. Therefore, Rg3EKRG is a potential antipruritic agent that can suppress acute and chronic itching at the peripheral sensory neuronal level.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 1","pages":"Article 100916"},"PeriodicalIF":3.4,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/72/9e/main.PMC9826840.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9088700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of acupuncture for cardiopulmonary cerebral resuscitation: A systematic review and meta-analysis","authors":"Yunlan Liu ,&nbsp;Mengjuan Ren ,&nbsp;Zhuoran Kuang ,&nbsp;Xufei Luo ,&nbsp;Huishan Li ,&nbsp;Yikai Zhang ,&nbsp;Wanxin Wen ,&nbsp;Yefeng Cai ,&nbsp;Xiaojia Ni ,&nbsp;Yaolong Chen","doi":"10.1016/j.imr.2023.100925","DOIUrl":"10.1016/j.imr.2023.100925","url":null,"abstract":"<div><h3>Background</h3><p>Cerebral resuscitation is one of the main therapeutic aims in the treatment of cardiac arrest (CA) patients who experience a return of spontaneous circulation (ROSC). However, the therapeutic effects of current treatments are not ideal. The purpose of this study was to evaluate the efficacy of neurological function of acupuncture combined with conventional cardiopulmonary cerebral resuscitationthe (CPCR) for patients after ROSC.</p></div><div><h3>Methods</h3><p>Seven electronic databases and other related websites were searched to identify studies on acupuncture combined with conventional CPCR for patients after ROSC. R software was used to conduct a meta-analysis, and the outcomes that could not be pooled were analyzed using a descriptive analysis.</p></div><div><h3>Results</h3><p>Seven RCTs involving 411 participants who had experienced ROSC were eligible for inclusion. The main acupoints were <em>Neiguan</em> (PC6), <em>Shuigou</em> (DU26), <em>Baihui</em> (DU20), <em>Yongquan</em> (KI1), and <em>Sanyinjiao</em> (SP6). Compared to conventional CPCR, acupuncture combined with conventional CPCR led to significantly higher Glasgow Coma Scale (GCS) scores on day 3 (mean difference (MD)=0.89, 95% CI: 0.43, 1.35, I² = 0%), day 5 (MD = 1.21, 95% CI: 0.27, 2.15; I² = 0%), and day 7 (MD = 1.92, 95% CI: 1.35, 2.50; I² = 0%).</p></div><div><h3>Conclusion</h3><p>Acupuncture-assisted conventional CPCR may have a potential role in improving neurological function in CA patients after ROSC, but the certainty of evidence is very low and more high-quality studies are required.</p></div><div><h3>Protocol registration</h3><p>This review was registered at the International Prospective Registry of Systematic Reviews (PROSPERO): CRD42021262262.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 1","pages":"Article 100925"},"PeriodicalIF":3.4,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e0/56/main.PMC9971281.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9372150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}