Integrative Medicine Research最新文献

{"title":"Effectiveness of Chinese medicine formula Huashibaidu granule on mild COVID-19 patients: A prospective, non-randomized, controlled trial","authors":"Bowu Chen ,&nbsp;Yan Xue ,&nbsp;Hua Jing ,&nbsp;Xiaodong Wang ,&nbsp;Peimin Zhu ,&nbsp;Weiwei Hao ,&nbsp;Man Li ,&nbsp;Yueqiu Gao","doi":"10.1016/j.imr.2023.100950","DOIUrl":"10.1016/j.imr.2023.100950","url":null,"abstract":"<div><h3>Background</h3><p>The effectiveness and safety of herbal medicine Huashibaidu granule (HSBD) in treating mild Coronavirus Disease 2019 (COVID-19) patients infected with SARS-CoV-2 remain to be identified. We aimed to evaluate the effectiveness of HSBD in mild COVID-19 patients.</p></div><div><h3>Methods</h3><p>A prospective, non-randomized, controlled study in mild COVID-19 patients was conducted in Shanghai, China, from April 8 to May 6, 2022. Finally, 360 mild COVID-19 patients received HSBD (orally 20 g twice daily for 7 days), and 368 patients received herbal medicine placebo (orally 20 g twice daily for 7 days). The primary endpoints were the negative conversion rate of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and the negative conversion time. Secondary endpoints included the hospitalized days and the improvement in the clinical condition.</p></div><div><h3>Results</h3><p>The negative conversion rate of SARS-CoV-2 at 7 days posttreatment in the HSBD group was higher than that in the control group (95.28% vs. 82.61%, <em>P</em> &lt; 0.001). The median negative conversion time in the HSBD group was markedly decreased by 2 days compared with the control group (3 [3–6] vs. 5 [4–7], <em>P</em> &lt; 0.001). In addition, the median hospitalized day was shortened in the HSBD group by 1 day compared with the control group (6 [4–7] vs. 7 [5–9], <em>P</em> &lt; 0.001). The clinical improvement rate (275/360 [76.39%]) in the HSBD group within 7 days was significantly higher than that (203/368 [55.16%]) in the control group (<em>P</em> &lt; 0.001). The improvement of symptom scores in the HSBD group was higher than that in the control group (2 [1–4] vs. 1 [1–2], <em>P</em> &lt; 0.001). No severe adverse events occurred.</p></div><div><h3>Conclusions</h3><p>Our study suggested that HSBD effectively increased the negative conversion rate of SARS-CoV-2 and shortened the negative conversion time and hospitalized days in mild COVID-19 patients.</p></div><div><h3>Clinical trial registration</h3><p>The trial was registered at Chinese Clinical Trial Registry, ChiCTR2200058668.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 2","pages":"Article 100950"},"PeriodicalIF":3.4,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e9/93/main.PMC10121152.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10299679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential role of acupuncture in the treatment of Parkinson's disease: A narrative review","authors":"Jaeyoung Park ,&nbsp;Ju-Young Oh ,&nbsp;Hi-Joon Park","doi":"10.1016/j.imr.2023.100954","DOIUrl":"10.1016/j.imr.2023.100954","url":null,"abstract":"<div><h3>Background</h3><p>The prevalence of Parkinson’s disease (PD) has grown rapidly compared to that of other neurological disorders. Acupuncture has been used to address the complex symptoms of PD. Recently, similarities in the mechanisms of action between acupuncture and neuromodulation have received considerable attention. This review aims to summarize the evidence regarding these similarities to suggest potential role of acupuncture in the treatment of PD.</p></div><div><h3>Methods</h3><p>The literature from two electronic databases, PubMed and Google Scholar, was searched using the search terms 'Acupuncture', 'Parkinson's disease', 'Vagus nerve stimulation', and 'Brain functional connectivity'. We then explored the evidence for the effectiveness of acupuncture in PD and evaluated the evidence for similarities in the mechanisms of action between acupuncture and neuromodulation.</p></div><div><h3>Results</h3><p>Data suggests that acupuncture treatment is effective for PD symptoms by modulating inflammation and brain functional connectivity (BFC). These acupuncture effects have been shown to be similar to neuromodulation in controlling inflammation and BFC. Based on the shared mechanisms of action, potential acupuncture mechanisms that may ameliorate a wide range of PD symptoms include but are not limited to (1) vagal activation of the anti-inflammatory pathway and (2) BFC enhancement.</p></div><div><h3>Conclusion</h3><p>The development of acupuncture strategies based on shared mechanisms with neuromodulation will provide new treatment options for patients with PD as personalized neuromodulating therapies. Further studies are needed to gather scientific evidence for optimizing parameters in PD patients.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 2","pages":"Article 100954"},"PeriodicalIF":3.4,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cc/80/main.PMC10238843.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9585454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-oxidative-initiated cognitive impairment amelioration in Alzheimer's disease model rats through preventive transcutaneous electrical acupoint stimulation","authors":"Heng Weng ,&nbsp;Qing Wang ,&nbsp;Ran Ye,&nbsp;Yamei Bai,&nbsp;Hui Yang,&nbsp;Guihua Xu,&nbsp;Qiuqin Wang","doi":"10.1016/j.imr.2023.100946","DOIUrl":"10.1016/j.imr.2023.100946","url":null,"abstract":"<div><h3>Background</h3><p>Alzheimer's disease (AD) is a chronic and irreversible neurodegenerative disease. Oxidative stress emerges at the early AD stage. As a non-invasive therapy with few adverse reactions, transcutaneous electrical acupoint stimulation (TEAS) combines acupuncture points of traditional Chinese medicine (TCM) and electrical stimulation. This study aimed to investigate the amelioration effects of preventive TEAS treatment (P-TEAS) on cognitive impairment and oxidative stress in AD model rats.</p></div><div><h3>Methods</h3><p>The AD model was established via subcutaneous injections of D-galactose (D-gal, 120 mg/kg/d) into the back of neck for 9 weeks in Sprague Dawley (SD) rats to simulate the oxidative stress in the early AD stage. On the first day of the 10th week, Aβ_1–42 (1 μg/μl) was injected into the CA1 regions of the bilateral hippocampus. P-TEAS was synchronized from the first day of subcutaneous D-gal injections for 9 weeks.</p></div><div><h3>Results</h3><p>Empirical measurements showed that P-TEAS can improve the spatial memory ability of AD model rats in the Morris water maze. Superoxide dismutase (SOD) was upregulated in the P-TEAS group. Through the detection of the anti-oxidative stress signaling pathway, namely, Kelch-like ECH-associated protein 1 (Keap1)/ NFE2-related factor 2 (Nrf2), it was found that P-TEAS could promote Nrf2 entering into the nucleus and upregulating the production of protective factors heme oxygenase 1 (HO-1) and NADPH quinone oxidoreductase 1 (NQO1). It was also found that P-TEAS could downregulate the expressions of BCL2-associated X-protein (Bax), caspase 3, and caspase 9 to inhibit neuronal apoptosis.</p></div><div><h3>Conclusions</h3><p>P-TEAS has similar efficacy to electroacupuncture in preventing AD occurrence and development. P-TEAS is a new non-invasive intervention therapy for the prevention of AD.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 2","pages":"Article 100946"},"PeriodicalIF":3.4,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/84/6e/main.PMC10176170.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9475857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frankincense ameliorates endometriosis via inducing apoptosis and reducing adhesion","authors":"Min Kyoung Cho ,&nbsp;Jung-Sook Jin ,&nbsp;Yunju Jo ,&nbsp;Jung Ho Han ,&nbsp;Su Shin ,&nbsp;Sung-Jin Bae ,&nbsp;Dongryeol Ryu ,&nbsp;Jongkil Joo ,&nbsp;Jang-Kyung Park ,&nbsp;Ki-Tae Ha","doi":"10.1016/j.imr.2023.100947","DOIUrl":"10.1016/j.imr.2023.100947","url":null,"abstract":"<div><h3>Background</h3><p>Frankincense, a resin derived from trees of the Boswellia genus, has been used as an incense and a type of herbal medicine for treating inflammatory diseases such arthritis, chronic bowel illness, and asthma. While endometriosis is a well-known inflammatory gynecological illness caused by the ectopic attachment and development of uterine tissue over the menstrual cycle, the impact of frankincense on this illness is poorly understood. The purpose of this study was to explore the effects of frankincense on endometriosis.</p></div><div><h3>Methods</h3><p>We used a network pharmacological assessment, <em>in vitro</em> and <em>in vivo</em> investigations with a human endometriotic cell line as well as a syngeneic uterine transfer mouse model. High-performance liquid chromatographic analysis was used to compare water-extracted frankincense (Fr) to its reference compounds and validate the sample.</p></div><div><h3>Results</h3><p>A network pharmacological analysis suggested a positive effect of Fr on endometriosis. Fr relieved endometriosis by reducing ectopic endometrial adherence and development, according to both <em>in vivo</em> and <em>in vitro</em> models. We suggested that the ER stress/p53-apoptosis and chemokine-migration/adhesion pathways underlie Fr's anti-endometriotic action using RNA sequencing and bioinformatic analysis.</p></div><div><h3>Conclusion</h3><p>This study revealed the potential effect of Fr on endometriosis using an experimental investigation. Fr may have the potential to be an effective and safe treatment for endometriosis.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 2","pages":"Article 100947"},"PeriodicalIF":3.4,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/35/d3/main.PMC10165193.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9452941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beneficial effect of Gyejibokryeong-hwan on climacteric syndrome with blood stasis pattern: A randomized, double-blinded, placebo-controlled clinical pilot trial","authors":"Kyungsun Han ,&nbsp;Jeong-Eun Yoo ,&nbsp;Jung-Eun Kim ,&nbsp;Ojin Kwon ,&nbsp;Ae-Ran Kim ,&nbsp;Hyo-Ju Park ,&nbsp;So-Young Jung ,&nbsp;Mikyung Kim ,&nbsp;Changsop Yang ,&nbsp;Jung-Hyo Cho ,&nbsp;Jun-Hwan Lee","doi":"10.1016/j.imr.2023.100951","DOIUrl":"10.1016/j.imr.2023.100951","url":null,"abstract":"<div><h3>Background</h3><p>Gyejibokryeong-hwan (GBH), a herbal mixture that is widely used for climacteric syndrome, is studied for its efficacy; however, no study evaluated the GBH indication, which is a blood-stasis pattern based on traditional Chinese medicine theory.</p></div><div><h3>Methods</h3><p>This was a randomized, double-blinded, placebo-controlled clinical pilot trial. Fifty subjects with climacteric syndrome were recruited and randomly assigned to GBH group or placebo group. Subjects were administered GBH or placebo granules for 4 weeks followed by 4 weeks of observation period. For the primary outcome, the Menopause Rating Scale (MRS) was evaluated. For the secondary outcomes, quality of life, degrees of abdominal resistance and tenderness, blood-stasis pattern questionnaire and degree of upward movement of <em>Qi</em> were evaluated.</p></div><div><h3>Results</h3><p>After 4-week intervention, the mean change of total MRS score significantly decreased in the GBH group compared to the placebo group (<em>p</em> = 0.037). The quality of life related to physical health (<em>p</em> = 0.008) and blood-stasis pattern (<em>p</em> = 0.018) significantly improved in the GBH group but not in the placebo group.</p></div><div><h3>Conclusion</h3><p>Our findings provide evidence of the feasibility of recruiting subjects with GBH indications and show that GBH may have clinical efficacy for the treatment of menopausal symptoms, especially urogenital symptoms, without any significant adverse events.</p></div><div><h3>Trial registration</h3><p>This trial was registered at Clinical Research Information Service (CRIS identifier: KCT0002040).</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 2","pages":"Article 100951"},"PeriodicalIF":3.4,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/93/7d/main.PMC10176163.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9475853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing TCM clinical practice guidelines: A comparison between traditional Chinese medicine and western medicine","authors":"Xuan Yu ,&nbsp;Shouyuan Wu ,&nbsp;Juanjuan Zhang ,&nbsp;Yue Hu ,&nbsp;Meng Luo ,&nbsp;Hongmei Zhao ,&nbsp;Xuping Song ,&nbsp;Yaolong Chen ,&nbsp;Xiaohui Wang","doi":"10.1016/j.imr.2023.100952","DOIUrl":"10.1016/j.imr.2023.100952","url":null,"abstract":"<div><p>Clinical practice guidelines in Traditional Chinese Medicine (CPG-TCM) is the recommendation that aims to provide the best service to users by identifying and summarizing the rules of prevention, diagnosis, treatment, rehabilitation, and regression of diseases based on systematic reviews of evidence and balancing the advantages and disadvantages of different interventions for clinical questions of Traditional Chinese Medicine. Over the past 30 years, the concept and methods of evidence-based medicine have had a significant impact on the development of clinical practice guidelines in Western Medicine (CPG-WM), and their standardized guideline development methods are being adapted and used in the development of CPG-TCM. However, the quality of CPG-TCM is far from CPG-WM, and the methodological system for developing CPG-TCM is not yet fully established. Therefore, this study aims to explore the methodological differences between CPG-TCM and CPG-WM and to inform the development of high-quality CPGTCM.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 2","pages":"Article 100952"},"PeriodicalIF":3.4,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8f/f4/main.PMC10176161.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9475854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of ejaculation upon effect of acupuncture on chronic prostatitis/chronic pelvic pain syndrome: Secondary analysis of a randomized controlled trial","authors":"Lili Zhu ,&nbsp;Jiufei Fang ,&nbsp;Yuanjie Sun ,&nbsp;Min Yang ,&nbsp;Hao Yao ,&nbsp;Zhishun Liu","doi":"10.1016/j.imr.2023.100943","DOIUrl":"10.1016/j.imr.2023.100943","url":null,"abstract":"<div><h3>Background</h3><p>Acupuncture can improve chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Ejaculation frequencies might impact the conditions of CP/CPPS. The present study aimed to explore the impact of different ejaculation frequencies on the effect of acupuncture among men with CP/CPPS.</p></div><div><h3>Methods</h3><p>This was a secondary analysis of the data from a multicenter, randomized, clinical trial. Eligible participants were patients with moderate to severe CP/CPPS, who had taken 8-week acupuncture treatment, and followed until week 32. Participants fell into the category of 0–3, 4–7, or at least 8 according to their monthly ejaculation frequencies reported at baseline. The primary outcome was the proportion of responders, defined as men who reported at least 6 points reduction from baseline in the National Institute of Health-Chronic Prostatitis Symptom Index (NIH<img>CPSI) total score at weeks 8 and 32.</p></div><div><h3>Results</h3><p>214 participants were included in this secondary analysis, of whom 42 reported a monthly ejaculation frequency of 0–3, 89 reported a frequency of 4–7, and 83 reported a frequency of at least 8. At week 8, 52.20% participants with an ejaculation frequency of 0–3 responded to the acupuncture treatment, 65.38% participants with a frequency of 4–7 responded, and 63.09% participants with a frequency of at least 8 responded. At week 32, 56.14%, 59.57%, and 68.36% participants responded in the three groups, respectively. No significant differences were observed between three groups (all <em>P</em>&gt;0.05).</p></div><div><h3>Conclusion</h3><p>Acupuncture can improve symptoms of CP/CPPS, regardless of ejaculation frequencies. Ejaculation frequencies may not affect the efficacy of acupuncture on CP/CPPS among Chinese men.</p></div><div><h3>Trial registration</h3><p>ClinicalTrials.gov, NCT03213938</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 2","pages":"Article 100943"},"PeriodicalIF":3.4,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ca/8b/main.PMC10134442.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9392580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ACURATE: A guide for reporting sham controls in trials using acupuncture","authors":"Ye-Seul Lee ,&nbsp;Song-Yi Kim ,&nbsp;Hyangsook Lee ,&nbsp;Younbyoung Chae ,&nbsp;Myeong Soo Lee","doi":"10.1016/j.imr.2023.100955","DOIUrl":"10.1016/j.imr.2023.100955","url":null,"abstract":"<div><p>This paper presents the Acupuncture Controls gUideline for Reporting humAn Trials and Experiments (ACURATE) checklist, an extension of The Consolidated Standards for Reporting of Trials (CONSORT) and to be used along with STandards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA) when both real and sham acupuncture needles are used in the study. This checklist focuses on a clear depiction of sham needling procedures to enhance replicability and enable a precise appraisal. We encourage researchers to use ACURATE in trials and reviews involving sham acupuncture to assist reporting of sham acupuncture procedures and the related components.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 2","pages":"Article 100955"},"PeriodicalIF":3.4,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5d/2c/main.PMC10220258.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9546987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Misreport of burns as a result of ‘coining’, Gua sha; inherent harms from publication and ongoing citation of false facts","authors":"Arya Nielsen ,&nbsp;Marsha Handel ,&nbsp;Jennifer  A.  M. Stone ,&nbsp;Myeong  Soo Lee","doi":"10.1016/j.imr.2023.100953","DOIUrl":"10.1016/j.imr.2023.100953","url":null,"abstract":"","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 2","pages":"Article 100953"},"PeriodicalIF":3.4,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/81/c8/main.PMC10186471.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9845463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effectiveness of Chinese herbal injections treating for rotavirus enteritis in children: A systematic review and Bayesian network meta-analysis","authors":"Li-Qing Niu ,&nbsp;Lu Xiao ,&nbsp;Qiu-Han Cai ,&nbsp;Yu-Yi Wu ,&nbsp;Si-Yuan Hu ,&nbsp;Sheng-Xuan Guo ,&nbsp;Yu-Ling Tian ,&nbsp;Qiu-Rong Wang","doi":"10.1016/j.imr.2023.100944","DOIUrl":"10.1016/j.imr.2023.100944","url":null,"abstract":"<div><h3>Background</h3><p>Rotavirus enteritis (RVE) accounts for 37% of all death in children (&lt;5 years) with diarrhea. Chinese herbal injections (CHIs) have drawn more attention from practitioners because of the valid effects for RVE. However, the most beneficial one has not yet been determined.</p></div><div><h3>Methods</h3><p>Eight databases were searched from their inception up to September 3, 2022. The primary outcome was clinical effective rate and the secondary outcomes were time for disappearance of diarrhea, time of defervescence, time for disappearance of vomiting, and adverse drug reactions or adverse drug events. OpenBUGS 3.2.3 and STATA 14.0 software were employed to carry out the NMA.</p></div><div><h3>Results</h3><p>58 randomized controlled trials (RCTs) with 6436 child patients were included in this Bayesian NMA. Four CHIs were investigated including Yanhuning injection (YHN), Xiyanping injection (XYP), Reduning injection (RDN), and Zedoary Turmeric Oil injection (ZTO). The results showed that YHN [OR=6.16, 95% CI (4.39, 8.77)] had a superior effect in improving clinical effective rate compared to Ribavirin based on Western medicine (WM). According to SUCRA values, YHN (84.1%) ranked highest. As for the secondary outcomes, XYP was the better intervention in shortening the time for disappearance of diarrhea. Regarding time for defervescence, RDN had obvious advantages and also performed well in time for disappearance of vomiting.</p></div><div><h3>Conclusions</h3><p>CHIs combined with WM could be beneficial than Ribavirin in improving clinical effective rate, and YHN was the optimum treatment. From the comprehensive evaluations of both the clinical effective rate and other outcomes, YHN also indicated a favorable therapeutic effect in RVE.</p></div><div><h3>Study registration</h3><p>This study was registered on PROSPERO (CRD42022357149).</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 2","pages":"Article 100944"},"PeriodicalIF":3.4,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e5/91/main.PMC10134445.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9392579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}