Integrative Medicine Research最新文献

{"title":"What is integrative medicine? Establishing the decision criteria for an operational definition of integrative medicine for general practice health services research in Australia","authors":"Jennifer Hunter ,&nbsp;Joanna E. Harnett ,&nbsp;Wai-Jo Jocelin Chan ,&nbsp;Marie Pirotta","doi":"10.1016/j.imr.2023.100995","DOIUrl":"https://doi.org/10.1016/j.imr.2023.100995","url":null,"abstract":"<div><h3>Background</h3><p>Operational definitions outline how a conceptual definition will be measured for consistent, reproducible data collection and analysis. This article reports the decision criteria that will be used for an operational definition of integrative medicine (IM) in a secondary analysis of an Australian national survey of general practitioner activity.</p></div><div><h3>Methods</h3><p>A multidisciplinary team applied an iterative approach, informed by expert knowledge and literature reviews to establish decision criteria for categorizing the terms in the Australian clinical interface terminology of the International Classification of Primary Care, second edition (ICPC-2 PLUS) and the Coding Atlas for Pharmaceutical Substances, according to whether they reflected IM, conventional/mainstream medicine (MM), or both IM and MM (IM/MM).</p></div><div><h3>Results</h3><p>The final decision criteria categorized all terms for examinations, investigations, advice/counselling, and drugs with synthetic ingredients, and terms for referrals to secondary care services and healthcare practitioners that are not a traditional or complementary medicine practitioner as MM. Terms that could apply to both styles of clinical practice (e.g., preventive health, lifestyle medicine, psychosocial and some drugs with natural ingredients) were categorised as IM/MM. The remaining terms, that mostly reflected the World Health Organization's theoretical definitions of traditional and complementary medicine, were categorized as IM.</p></div><div><h3>Conclusion</h3><p>Differentiating between integrative and conventional/mainstream medicine in general practice is context specific and not always possible. The category IM/MM proposes integrative medicine as an extension, rather than an alternative. The rationale for the integrative medicine operational definition has relevance for researchers and health services in Australia, and internationally.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 4","pages":"Article 100995"},"PeriodicalIF":3.4,"publicationDate":"2023-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49729391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curcumin, inflammation, and neurological disorders: How are they linked?","authors":"Prachi Garodia ,&nbsp;Mangala Hegde ,&nbsp;Ajaikumar B. Kunnumakkara ,&nbsp;Bharat B. Aggarwal","doi":"10.1016/j.imr.2023.100968","DOIUrl":"10.1016/j.imr.2023.100968","url":null,"abstract":"<div><h3>Background</h3><p>Despite the extensive research in recent years, the current treatment modalities for neurological disorders are suboptimal. Curcumin, a polyphenol found in <em>Curcuma</em> genus, has been shown to mitigate the pathophysiology and clinical sequalae involved in neuroinflammation and neurodegenerative diseases.</p></div><div><h3>Methods</h3><p>We searched PubMed database for relevant publications on curcumin and its uses in treating neurological diseases. We also reviewed relevant clinical trials which appeared on searching PubMed database using ‘Curcumin and clinical trials’.</p></div><div><h3>Results</h3><p>This review details the pleiotropic immunomodulatory functions and neuroprotective properties of curcumin, its derivatives and formulations in various preclinical and clinical investigations. The effects of curcumin on neurodegenerative diseases such as Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), brain tumors, epilepsy, Huntington's disorder (HD), ischemia, Parkinson's disease (PD), multiple sclerosis (MS), and traumatic brain injury (TBI) with a major focus on associated signalling pathways have been thoroughly discussed.</p></div><div><h3>Conclusion</h3><p>This review demonstrates curcumin can suppress spinal neuroinflammation by modulating diverse astroglia mediated cascades, ensuring the treatment of neurological disorders.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 3","pages":"Article 100968"},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/83/fd/main.PMC10469086.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10152438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moxibustion for medical personnel with negative emotion and insomnia during COVID-19 pandemic: A randomized, controlled trial","authors":"Xiying Li ,&nbsp;Xiaojuan Li ,&nbsp;Xian Wang ,&nbsp;Xuan Yin ,&nbsp;Shanshan Li ,&nbsp;Junyi Wu ,&nbsp;Xiumei Ren ,&nbsp;Wei Zhang ,&nbsp;Yiqun Mi ,&nbsp;Shifen Xu","doi":"10.1016/j.imr.2023.100974","DOIUrl":"10.1016/j.imr.2023.100974","url":null,"abstract":"<div><h3>Background</h3><p>We conducted this randomized controlled trial (RCT) to evaluate the effectiveness and safety of moxibustion at Sanyinjiao (SP6) acupoint for treatment of negative mood and sleep quality in healthcare workers during the 2019 coronavirus disease (COVID-19).</p></div><div><h3>Methods</h3><p>A total of 180 participants were divided in a 1:1 ratio into two groups, the treatment group (for moxibustion) and the control group (for no treatment). The treatment group had a 30-minute moxibustion therapy once a day for two weeks, followed by a two-week follow-up. The Hamilton Anxiety Scale (HAMA) was used to assess the degree of the participants' anxiety, and the Patient Health Questionnaire-9 (PHQ-9) was utilized to examine their depressed condition. The Maslach Burnout Inventory-General Survey (MBI-GS) was used to measure the level of burnout among healthcare workers. To determine the severity of insomnia, the Sleep Dysfunction Rating Scale (SDRS) was utilized. At baseline, week 2, and week 4, all scales were evaluated.</p></div><div><h3>Results</h3><p>Compared to the control group, the treatment group improved more significantly in the HAMA at week 2 (MD = -19.01, 95% CI: -21.89 to -16.14; <em>P</em>&lt;0.001) and at week 4 follow-up visits (MD = -8.96, 95% CI: -11.19 to -6.73; <em>P</em>&lt;0.001). A subgroup study of HAMA scores revealed that position and education had significant impact on treatment effectiveness. During the 2-week intervention period, the treatment group showed more significant improvements in depressive symptoms measured by PHQ-9 (13.00±2.41 vs. 15.60±3.65; <em>P</em>&lt;0.001), work burnout symptoms measured by MBI-GS (MD = -11.88, 95% CI, -15.73 to -8.03; <em>P</em>&lt;0.001), and insomnia symptoms measured by SDRS (MD = -2.45, 95% CI, -4.24 to -0.66; <em>P</em>&lt;0.01). There were no significant adverse effects reported.</p></div><div><h3>Conclusion</h3><p>Moxibustion at SP6 may be an effective treatment to improve anxiety, depression, sleep quality, and quality of life for healthcare workers during COVID-19.</p></div><div><h3>Trial registration</h3><p>This trial was registered at Chinese Clinical Trial Registry (ChiCTR): ChiCTR-2200059327.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 3","pages":"Article 100974"},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/44/9a/main.PMC10448013.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10464641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture treatment for functional gastrointestinal disorders: Identification of major acupoints using network analysis","authors":"Heeyoung Moon ,&nbsp;Yeonhee Ryu ,&nbsp;In-Seon Lee ,&nbsp;Younbyoung Chae","doi":"10.1016/j.imr.2023.100970","DOIUrl":"10.1016/j.imr.2023.100970","url":null,"abstract":"<div><h3>Background</h3><p>Using network analysis, we sought to determine the acupoints most commonly used to treat functional gastrointestinal disorders (FGIDs), particularly functional dyspepsia (FD) and irritable bowel syndrome (IBS).</p></div><div><h3>Methods</h3><p>To explore the acupoint patterns used for FGID, data on acupoint combinations for FD and IBS were gathered from systematic reviews. Network analysis was used to determine the degree, closeness centrality, betweenness centrality, and eigenvector centrality of each acupoint. The most common acupoint combinations for FD and IBS were examined based on the eigenvector centrality.</p></div><div><h3>Results</h3><p>Network analysis revealed that CV12, ST25, ST36, CV10, and LR3, which had the highest eigenvector centrality values, were the main acupoints for treating FGID. CV12 was the main acupoint for treating FD, while ST25 was the hub acupoint for treating IBS in the abdomen. ST36, LR3, and PC6 were the key peripheral acupoints for FD and IBS.</p></div><div><h3>Conclusions</h3><p>Using network analysis, we provided data that will aid the selection of both general and specific acupoints for FD and IBS, along with spatial information (i.e., the positions of acupoints on a body map). These findings could be applied in future acupuncture research on therapy for gastrointestinal system dysfunction. They may also help bridge the gap between the traditional meridian theory, which assumes that there is a link between diseases/symptoms and the specific body region being treated, and real-world clinical evidence.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 3","pages":"Article 100970"},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/18/a1/main.PMC10407428.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10026930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture as an alternative or in addition to conventional treatment for chronic non-specific low back pain: A systematic review and meta-analysis","authors":"Carlo Maria Giovanardi ,&nbsp;Marien Gonzalez-Lorenzo ,&nbsp;Alessandra Poini ,&nbsp;Eleonora Marchi ,&nbsp;Antonio Culcasi ,&nbsp;Francesco Ursini ,&nbsp;Cesare Faldini ,&nbsp;Alberto Di Martino ,&nbsp;Umberto Mazzanti ,&nbsp;Emanuela Campesato ,&nbsp;Annunzio Matrà ,&nbsp;Sabina Cevoli ,&nbsp;Maria Grazia Benedetti","doi":"10.1016/j.imr.2023.100972","DOIUrl":"10.1016/j.imr.2023.100972","url":null,"abstract":"<div><h3>Background</h3><p>Conventional therapies (CTs), pharmacological (PH) and non–pharmacological (NPH), do not always achieve benefits in the treatment of chronic low back pain (CLBP). We assessed efficacy and safety of acupuncture for CLBP as alternative or addition to CT.</p></div><div><h3>Methods</h3><p>We included randomised controlled trials (RCTs) comparing acupuncture alone or in combination with CT to CT. We searched Medline, Cochrane Library, Embase up to May 2022. We assessed risk of bias with the original Cochrane tool and GRADE certainty of evidence. Results were pooled through meta-analysis.</p></div><div><h3>Results</h3><p>Ten RCTs (2122 participants) were included comparing acupuncture versus CT and 4 RCTs (374 participants) were comparing acupuncture plus CT to CT alone. In terms of comparing acupuncture with NPH or PH, no differences were found for pain and disability. Comparing acupuncture with PH and NPH combined, pain and disability were reduced (SMD=-0.50, 95% CI -0.62 to -0.37; SMD=-0.71, 95% CI -1.17 to -0.24). Comparing acupuncture plus NPH with NPH alone, pain and disability were reduced (SMD=-0.70, 95% CI -0.94 to -0.46; SMD=-0.95, 95% CI -1.36 to -0.54). Comparing acupuncture plus PH with PH alone, pain and disability were reduced (MD=-0.21, 95% CI -433.28 to -10.42; MD=-3.1, 95% CI -4.87 to -1.83). Comparing acupuncture plus combined treatment versus combined treatment alone, no differences were found in pain, while disability was reduced (MD=-3.40 95% CI -5.17 to -1.63). No studies assessed adverse event. Certainty of evidence ranged from moderate to very low.</p></div><div><h3>Conclusions</h3><p>We are uncertain whether acupuncture is more effective and safer than CT. In the comparisons without estimates’ imprecision, acupuncture showed promising results. Acupuncture could be an option based on patients’ preferences.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 3","pages":"Article 100972"},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/13/d0/main.PMC10448023.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10482866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient preferences and shared decision making for the traditional Chinese medicine treatment of lung cancer: A discrete choice experiment study","authors":"Yue Teng ,&nbsp;Yan Wei ,&nbsp;Yingyao Chen ,&nbsp;Juntao Yan ,&nbsp;Shimeng Liu ,&nbsp;Fuming Li ,&nbsp;Shiyi Bao ,&nbsp;Yanfeng Ren ,&nbsp;Liu Liu ,&nbsp;Yi Yang","doi":"10.1016/j.imr.2023.100969","DOIUrl":"10.1016/j.imr.2023.100969","url":null,"abstract":"<div><h3>Background</h3><p>Traditional Chinese Medicine (TCM), integrating patient preferences into decision-making process, has been widely used in the multimodality therapy of lung cancer. This study aimed to estimate patient preferences for treatment and shared decision-making (SDM) modes concerning inpatient TCM treatment of lung cancer in Shanghai in order to provide a basis for clinical decision-making process on TCM therapy for lung cancer.</p></div><div><h3>Methods</h3><p>This study was conducted among patients (<em>n</em> = 347) from nine tertiary hospitals in Shanghai by discrete-choice experiment (DCE) survey and Shared Decision-Making Questionnaire-patient version (SDM-Q-9) survey. The DCE was developed with the inclusion of the most relevant attributes at appropriate levels for the TCM treatment of lung cancer. The empirical data analyses of patients were performed using mixed logit models. Additionally, subgroup analysis was conducted.</p></div><div><h3>Results</h3><p>In total, 347 respondents completed the questionnaire. All attributes’ coefficients were statistically significant for patients’ preferences. Patients showed strong preferences for increasing disease control rate, relieving nausea and vomiting, reducing the risk of side effects, and were concerned about monthly out-of-pocket costs. Subgroup analysis indicated that patients with a lower SDM-Q-9 score and those who were satisfied with medical services emphasized more importance of higher disease control rate. Furthermore, most of the patients (90.20%) self-reported a high willingness to use SDM during the decision-making process.</p></div><div><h3>Conclusion</h3><p>In Shanghai, patients mainly preferred SDM and considered disease control rate as the most essential attribute in the TCM treatment of lung cancer. The study findings could underscore the importance of considering patients’ preferences and promote SDM.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 3","pages":"Article 100969"},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5f/f2/main.PMC10400851.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10308768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture-related therapies for protracted opioid abstinence syndrome: A systematic review and meta-analysis","authors":"Lu Ding ,&nbsp;Cui Li ,&nbsp;Peiming Zhang ,&nbsp;Chen Chen ,&nbsp;Jie Zhan ,&nbsp;Jinchun Zeng ,&nbsp;Liming Lu","doi":"10.1016/j.imr.2023.100976","DOIUrl":"10.1016/j.imr.2023.100976","url":null,"abstract":"<div><h3>Background</h3><p>An increasing amount of clinical evidence of acupuncture's effect on protracted opioid abstinence syndrome (POAS) has emerged in recent years. The aim of this study was to evaluating the evidence of efficacy of acupuncture for POAS. clinical and scientific research work.</p></div><div><h3>Methods</h3><p>Four English-language databases (PubMed, Medline, Embase, Cochrane Libraries) and three Chinese-language databases (CNKI, WanFang and VIP Libraries) were searched, with coverage from database inception to March 31, 2022. Randomized clinical trials (RCTs) evaluating the effects of acupuncture and acupuncture-related therapies for prophylaxis or treatment of POAS were included. Data were screened and extracted independently according to pre-set tabular formats. RCT quality was assessed using risk of bias tool in the Cochrane Collaboration. The primary outcome was opiate withdrawal scale. The secondary outcomes are depression, anxiety for assessing protracted symptoms. The scores on the above scales are proportional to the severity of the symptoms.</p></div><div><h3>Results</h3><p>Twenty-eight trials met the inclusion criteria and provided data for the meta-analysis. A total of only 3 studies (11%) were judged to be low-risk overall due to various biases in them. Acupuncture-related therapy showed statistical differences in improving protracted withdrawal symptom scores compared with sham acupuncture (5 studies, Standard mean difference (SMD), -1.85, 95% CI [-3.21, -0.50], <em>P</em> = 0.007), western medicine (7 studies, SMD, -0.72, 95% CI [-1.22, -0.21], <em>P</em> = 0.005) and no treatment (3 studies, SMD,-2.26, 95% CI [-3.82, -0.69], <em>P</em> = 0.005) with high heterogeneity.</p></div><div><h3>Conclusions</h3><p>Acupuncture maybe safe and effective in relieving POAS individuals’ protracted withdrawal symptoms. However, the results of our review should be interpreted with caution because of the high risk of bias of the included trials.</p></div><div><h3>Study registration</h3><p>The protocol of this review has been registered at PROSPERO (CRD42022335505).</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 3","pages":"Article 100976"},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/80/20/main.PMC10448024.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10465126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI Chat bot - ChatGPT-4: A new opportunity and challenges in complementary and alternative medicine","authors":"Tae-Hun Kim ,&nbsp;Jung Won Kang ,&nbsp;Myeong Soo Lee","doi":"10.1016/j.imr.2023.100977","DOIUrl":"https://doi.org/10.1016/j.imr.2023.100977","url":null,"abstract":"","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 3","pages":"Article 100977"},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49813478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of herbal medicine (Binafuxi granules) for the common cold with fever: A multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial","authors":"Xuemei Liu ,&nbsp;Jie Min ,&nbsp;Bin She ,&nbsp;Yan Chen ,&nbsp;Jun Li ,&nbsp;Lei Huang ,&nbsp;Ju Chen ,&nbsp;Ai Luo ,&nbsp;Mei Yang ,&nbsp;Ting Li ,&nbsp;Yanqing Wu ,&nbsp;Daohong Chen ,&nbsp;Hongli Zhong ,&nbsp;Wei Liu ,&nbsp;Bing Mao ,&nbsp;Hongli Jiang","doi":"10.1016/j.imr.2023.100956","DOIUrl":"10.1016/j.imr.2023.100956","url":null,"abstract":"<div><h3>Background</h3><p>Binafuxi granules are a traditional Uighur medicine (TUM) for treating the common cold with fever. However, high-quality clinical studies supporting its efficacy and safety are lacking.</p></div><div><h3>Methods</h3><p>In this multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial, patients with common cold and fever were randomly assigned to a high-dose group, low-dose group, and placebo group in a 1:1:1 ratio. Outcomes were time to fever relief, time to fever clearance, proportion of afebrile patients, time to symptom disappearance, rate of symptom disappearance, effective rate, emergency drug usage and safety assessment.</p></div><div><h3>Results</h3><p>A total of 235 patients were recruited. Of these, 234 were included in the full analysis set (FAS), and 217 were included in the per-protocol set (PPS). In the FAS analysis, the median time to fever relief was 6.00 h, 5.54 h and 10.65 h (<em>P</em> = 0.31) in the high-dose group, low-dose group and placebo group, respectively. The median time to fever clearance was 18.29 h, 20.08 h and 25.00 h (<em>P</em> = 0.0018), respectively, and the proportion of afebrile patients was 92.4%, 89.7% and 71.4% (<em>P</em> = 0.0002), respectively. There was a significant difference in the disappearance time and disappearance rate of all symptoms and of individual symptoms. No serious adverse events were found.</p></div><div><h3>Conclusions</h3><p>Binafuxi granules can dose-dependently shorten the fever course and improve clinical symptoms in patients suffering from the common cold with fever.</p></div><div><h3>Trial Registration</h3><p>This trial was registered at Chinese Clinical Trial Registry (ChiCTR-IIR-17013379).</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 3","pages":"Article 100956"},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f3/4f/main.PMC10285547.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9714664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thread-embedding acupuncture may improve symptom resolution in patients with gastroesophageal reflux disease: A randomized controlled trial","authors":"Dieu-Thuong Thi Trinh ,&nbsp;An Hoa Tran ,&nbsp;Minh-Man Pham Bui ,&nbsp;Nguyen Lam Vuong","doi":"10.1016/j.imr.2023.100971","DOIUrl":"10.1016/j.imr.2023.100971","url":null,"abstract":"<div><h3>Background</h3><p>Various traditional medicine treatments have been investigated to treat GERD. Among those, thread-embedding acupuncture (TEA) has the advantage that patients need to undergo the procedure infrequently; however, its efficacy is unclear. This study evaluated the efficacy of TEA in treating GERD.</p></div><div><h3>Methods</h3><p>A randomized controlled trial was conducted with 66 participants with GERD: 33 received two sessions of TEA + standard therapy (proton-pump inhibitor [PPI]) (TEA+PPI group) and 33 received PPI alone (PPI group). Primary outcomes included GerdQ score and heartburn and regurgitation resolution. Secondary outcomes were antacids requirement, the Frequency Scale for Symptoms of GERD (FSSG) score, and Gastroesophageal Reflux Disease-Health Related Quality of Life (GERD-HRQL) score. The safety outcome was adverse events (AEs).</p></div><div><h3>Results</h3><p>After four weeks of treatment, the TEA+PPI group significantly reduced the GerdQ score (mean difference [MD] and 95% confidence interval [CI]: -1.8 [-2.4, -1.1]) and increased the rate of heartburn and regurgitation resolution compared to PPI (54.5% versus 9.1%, respectively) compared to PPI. The TEA+PPI group also significantly reduced the number of antacid packs used (MD [95%-CI]: -9.4 [-12.1, -6.7]), FSSG score (MD [95%-CI]: -9.4 [-11.0, -7.8]), and GERD-HRQL score (MD [95%-CI]: -5.6 [-7.7, -3.5]) compared to PPI. Five patients experienced AEs, which were mild local complications at the acupoints.</p></div><div><h3>Conclusion</h3><p>TEA combined with PPI is more effective than PPI alone in treating GERD. Further studies with longer follow-ups are required to confirm these findings.</p></div><div><h3>Clinical trials registration information</h3><p>This study was registered at ClinicalTrials.gov, <span>NCT05353933</span><svg><path></path></svg>.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 3","pages":"Article 100971"},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e7/6f/main.PMC10448015.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10164499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}