埋线针刺可改善胃食管反流病患者的症状缓解:一项随机对照试验

IF 2.8 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE
Dieu-Thuong Thi Trinh , An Hoa Tran , Minh-Man Pham Bui , Nguyen Lam Vuong
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引用次数: 1

摘要

背景研究了多种传统药物治疗胃食管反流病的方法。其中,线埋针灸(TEA)的优点是患者不需要经常进行手术;然而,其疗效尚不清楚。本研究评估了TEA治疗GERD的疗效。方法对66名GERD患者进行了随机对照试验:33人接受两次TEA+标准治疗(质子泵抑制剂[PPI])(TEA+PPI组),33人单独接受PPI(PPI组)。主要结果包括GerdQ评分、烧心和反流消退。次要结果是抗酸剂需求、胃食管反流病症状频率量表(FSSG)评分和胃食管反流病健康相关生活质量(GERD-HRQL)评分。安全性结果为不良事件(AE)。结果治疗4周后,TEA+PPI组显著降低了GerdQ评分(平均差[MD]和95%置信区间[CI]:-1.8[-2.4,-1.1]),并与PPI相比增加了烧心率和反流消退率(分别为54.5%和9.1%)。与PPI相比,TEA+PPI组还显著减少了抗酸包的使用次数(MD[95%-CI]:-9.4[-12.1,-6.7])、FSSG评分(MD[90%-CI]:-9.4[-11.0,-7.8])和GERD-HRQL评分(MD-95%-CI]:-5.6[-7.7,-3.5])。5例患者出现AE,为轻微的穴位局部并发症。结论TEA联合PPI治疗GERD疗效优于单纯PPI。需要进一步的研究和更长的随访来证实这些发现。临床试验注册信息本研究注册于ClinicalTrials.gov,NCT05353933。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Thread-embedding acupuncture may improve symptom resolution in patients with gastroesophageal reflux disease: A randomized controlled trial

Thread-embedding acupuncture may improve symptom resolution in patients with gastroesophageal reflux disease: A randomized controlled trial

Thread-embedding acupuncture may improve symptom resolution in patients with gastroesophageal reflux disease: A randomized controlled trial

Background

Various traditional medicine treatments have been investigated to treat GERD. Among those, thread-embedding acupuncture (TEA) has the advantage that patients need to undergo the procedure infrequently; however, its efficacy is unclear. This study evaluated the efficacy of TEA in treating GERD.

Methods

A randomized controlled trial was conducted with 66 participants with GERD: 33 received two sessions of TEA + standard therapy (proton-pump inhibitor [PPI]) (TEA+PPI group) and 33 received PPI alone (PPI group). Primary outcomes included GerdQ score and heartburn and regurgitation resolution. Secondary outcomes were antacids requirement, the Frequency Scale for Symptoms of GERD (FSSG) score, and Gastroesophageal Reflux Disease-Health Related Quality of Life (GERD-HRQL) score. The safety outcome was adverse events (AEs).

Results

After four weeks of treatment, the TEA+PPI group significantly reduced the GerdQ score (mean difference [MD] and 95% confidence interval [CI]: -1.8 [-2.4, -1.1]) and increased the rate of heartburn and regurgitation resolution compared to PPI (54.5% versus 9.1%, respectively) compared to PPI. The TEA+PPI group also significantly reduced the number of antacid packs used (MD [95%-CI]: -9.4 [-12.1, -6.7]), FSSG score (MD [95%-CI]: -9.4 [-11.0, -7.8]), and GERD-HRQL score (MD [95%-CI]: -5.6 [-7.7, -3.5]) compared to PPI. Five patients experienced AEs, which were mild local complications at the acupoints.

Conclusion

TEA combined with PPI is more effective than PPI alone in treating GERD. Further studies with longer follow-ups are required to confirm these findings.

Clinical trials registration information

This study was registered at ClinicalTrials.gov, NCT05353933.

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来源期刊
Integrative Medicine Research
Integrative Medicine Research Medicine-Complementary and Alternative Medicine
CiteScore
6.50
自引率
2.90%
发文量
65
审稿时长
12 weeks
期刊介绍: Integrative Medicine Research (IMR) is a quarterly, peer-reviewed journal focused on scientific research for integrative medicine including traditional medicine (emphasis on acupuncture and herbal medicine), complementary and alternative medicine, and systems medicine. The journal includes papers on basic research, clinical research, methodology, theory, computational analysis and modelling, topical reviews, medical history, education and policy based on physiology, pathology, diagnosis and the systems approach in the field of integrative medicine.
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