针灸相关疗法治疗持续性阿片类药物戒断综合征:系统回顾和荟萃分析

IF 2.8 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE
Lu Ding , Cui Li , Peiming Zhang , Chen Chen , Jie Zhan , Jinchun Zeng , Liming Lu
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引用次数: 0

摘要

背景近年来,越来越多的临床证据表明针灸治疗阿片类药物长期戒断综合征(POAS)。本研究的目的是评估针灸治疗POAS的疗效证据。临床和科研工作。方法检索4个英文数据库(PubMed、Medline、Embase、Cochrane Libraries)和3个中文数据库(CNKI、WanFang和VIP Libraries。随机临床试验(RCT)评估了针灸和针灸相关疗法预防或治疗POAS的效果。根据预设的表格格式对数据进行独立筛选和提取。使用Cochrane协作中的偏倚风险工具评估随机对照试验的质量。主要结果是阿片类药物戒断量表。次要结果是抑郁,评估长期症状的焦虑。上述量表上的分数与症状的严重程度成正比。结果28项试验符合纳入标准,为荟萃分析提供了数据。由于存在各种偏见,总共只有3项研究(11%)被判定为总体低风险。与假针灸相比,针灸相关治疗在改善长期戒断症状评分方面显示出统计学差异(5项研究,标准平均差(SMD),-1.85,95%CI[3.21,-0.50],P=0.007),西药(7项研究,SMD,-0.72,95%CI[1.22,-0.21],P=0.005)和无治疗(3项研究,SMT,-2.26,95%CI[3.82,-0.69],P=0.0005)具有高度异质性。结论针刺对缓解POAS患者的长期戒断症状可能是安全有效的。然而,我们的审查结果应谨慎解读,因为纳入的试验存在较高的偏倚风险。研究注册本次审查的方案已在PROSPERO注册(CRD42022335505)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Acupuncture-related therapies for protracted opioid abstinence syndrome: A systematic review and meta-analysis

Background

An increasing amount of clinical evidence of acupuncture's effect on protracted opioid abstinence syndrome (POAS) has emerged in recent years. The aim of this study was to evaluating the evidence of efficacy of acupuncture for POAS. clinical and scientific research work.

Methods

Four English-language databases (PubMed, Medline, Embase, Cochrane Libraries) and three Chinese-language databases (CNKI, WanFang and VIP Libraries) were searched, with coverage from database inception to March 31, 2022. Randomized clinical trials (RCTs) evaluating the effects of acupuncture and acupuncture-related therapies for prophylaxis or treatment of POAS were included. Data were screened and extracted independently according to pre-set tabular formats. RCT quality was assessed using risk of bias tool in the Cochrane Collaboration. The primary outcome was opiate withdrawal scale. The secondary outcomes are depression, anxiety for assessing protracted symptoms. The scores on the above scales are proportional to the severity of the symptoms.

Results

Twenty-eight trials met the inclusion criteria and provided data for the meta-analysis. A total of only 3 studies (11%) were judged to be low-risk overall due to various biases in them. Acupuncture-related therapy showed statistical differences in improving protracted withdrawal symptom scores compared with sham acupuncture (5 studies, Standard mean difference (SMD), -1.85, 95% CI [-3.21, -0.50], P = 0.007), western medicine (7 studies, SMD, -0.72, 95% CI [-1.22, -0.21], P = 0.005) and no treatment (3 studies, SMD,-2.26, 95% CI [-3.82, -0.69], P = 0.005) with high heterogeneity.

Conclusions

Acupuncture maybe safe and effective in relieving POAS individuals’ protracted withdrawal symptoms. However, the results of our review should be interpreted with caution because of the high risk of bias of the included trials.

Study registration

The protocol of this review has been registered at PROSPERO (CRD42022335505).

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来源期刊
Integrative Medicine Research
Integrative Medicine Research Medicine-Complementary and Alternative Medicine
CiteScore
6.50
自引率
2.90%
发文量
65
审稿时长
12 weeks
期刊介绍: Integrative Medicine Research (IMR) is a quarterly, peer-reviewed journal focused on scientific research for integrative medicine including traditional medicine (emphasis on acupuncture and herbal medicine), complementary and alternative medicine, and systems medicine. The journal includes papers on basic research, clinical research, methodology, theory, computational analysis and modelling, topical reviews, medical history, education and policy based on physiology, pathology, diagnosis and the systems approach in the field of integrative medicine.
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