Integrative Medicine Research最新文献

{"title":"Acupuncture for endometriosis: A systematic review and meta-analysis","authors":"Nora Giese ,&nbsp;Ki Kyung Kwon ,&nbsp;Mike Armour","doi":"10.1016/j.imr.2023.101003","DOIUrl":"https://doi.org/10.1016/j.imr.2023.101003","url":null,"abstract":"<div><h3>Background</h3><p>Current endometriosis treatments do not always provide symptom relief, with many using complementary approaches. This study examined the effectiveness of acupuncture on pain and quality of life in people with endometriosis.</p></div><div><h3>Methods</h3><p>Searches were conducted on Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, Allied and Complementary Medicine Database (AMED) and Embase (Ovid), Epistemonikos, and Cumulative Index to Nursing and Allied Health Literature (CINAHL; EBSCOhost) on 20 March 2023. Trials were included if they used penetrating acupuncture. Risk of bias was assessed with Cochrane RoB2 and GRADE for overall evidence certainty. Random-effects meta-analyses were undertaken, using Hedges’ g or mean difference (MD) both with 95 % confidence intervals (CI).</p></div><div><h3>Results</h3><p>Six studies involving a total of 331 participants were included. Evidence for benefit was found for acupuncture compared to non-specific acupuncture on overall pelvic pain (<em>g</em> = 1.54, 95 % CI 0.92 to 2.16, 3 RCTs, <em>n</em> = 231, low certainty evidence, <em>p</em>&lt;0.001), menstrual pain (<em>g</em> = 1.67, 95 % CI 1.23 to 2.12, 1 RCT, <em>n</em> = 106, moderate certainty evidence, <em>p</em>&lt;0.001), and non-specified pelvic pain (MD -2.77, 95 % CI 2.15 to 3.38, 2 RCTs, <em>n</em> = 125, low certainty evidence, <em>p</em>&lt;0.001), and compared to usual care on menstrual pain (<em>g</em> = 0.9, 95 % CI 0.15 to 1.64, 1 RCT, <em>n</em> = 19, very low certainty evidence, <em>p</em> = 0.02). Most studies reported low rates of adverse events.</p></div><div><h3>Conclusion</h3><p>Acupuncture treatment for endometriosis demonstrated clinically relevant improvements in pelvic pain and should be considered as a potential treatment intervention.</p></div><div><h3>Study registration</h3><p>PROSPERO ID: CRD42023408700.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 4","pages":"Article 101003"},"PeriodicalIF":3.4,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422023000823/pdfft?md5=7e9447f30969daae3f16f7321e5fa465&pid=1-s2.0-S2213422023000823-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91729242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chinese herbal injections in combination with radiotherapy for advanced pancreatic cancer: A systematic review and network meta-analysis","authors":"Yun-Ru Chen ,&nbsp;Ruo-Tong Zhao ,&nbsp;Yi-Fang Xu ,&nbsp;Yin-Jie Ma ,&nbsp;Shao-Bo Hu ,&nbsp;Xue-Hui Wang ,&nbsp;Bing-Bing Fan ,&nbsp;Yan-Ji Zhou ,&nbsp;Yu-Bei Huang ,&nbsp;Nicola Robinson ,&nbsp;Jian-Ping Liu ,&nbsp;Zhao-Lan Liu","doi":"10.1016/j.imr.2023.101004","DOIUrl":"https://doi.org/10.1016/j.imr.2023.101004","url":null,"abstract":"<div><h3>Background</h3><p>Advanced pancreatic cancer (APC) is a fatal disease with limited treatment options. This study aims to evaluate the effectiveness and safety of different Chinese herbal injections (CHIs) as adjuvants for radiotherapy (RT) in APC and compare their treatment potentials using network meta-analysis.</p></div><div><h3>Methods</h3><p>We systematically searched three English and four Chinese databases for randomized controlled trials (RCTs) from inception to July 25, 2023. The primary outcome was the objective response rate (ORR). Secondary outcomes included Karnofsky performance status (KPS) score, overall survival (OS), and adverse events (AEs). The treatment potentials of different CHIs were ranked using the surface under the cumulative ranking curve (SUCRA). The Cochrane RoB 2 tool and CINeMA were used for quality assessment and evidence grading.</p></div><div><h3>Results</h3><p>Eighteen RCTs involving 1199 patients were included. Five CHIs were evaluated. Compound Kushen injection (CKI) combined with RT significantly improved ORR compared to RT alone (RR 1.49, 95 % CrI 1.21–1.86). Kanglaite (KLT) plus RT (RR 1.58, 95 % CrI 1.20–2.16) and CKI plus RT (RR 1.49, 95 % CrI 1.16–1.95) were associated with improved KPS score compared to radiation monotherapy, with KLT+RT being the highest rank (SUCRA 72.28 %). Regarding AEs, CKI plus RT was the most favorable in reducing the incidence of leukopenia (SUCRA 90.37 %) and nausea/vomiting (SUCRA 85.79 %).</p></div><div><h3>Conclusions</h3><p>CKI may be the optimal choice of CHIs to combine with RT for APC as it may improve clinical response, quality of life, and reduce AEs. High-quality trials are necessary to establish a robust body of evidence.</p></div><div><h3>Protocol registration</h3><p>PROSPERO, CRD42023396828.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 4","pages":"Article 101004"},"PeriodicalIF":3.4,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422023000835/pdfft?md5=c012ec98ecae9827618f6a1754040b40&pid=1-s2.0-S2213422023000835-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92100320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of herbal medicines (Eunkyosan/Yin qiao san and Samsoeum/Shen su yin) for treating the common cold: A randomized, placebo-controlled, multicenter clinical trial","authors":"Kwan-Il Kim ,&nbsp;Minna Hong ,&nbsp;Yang-Chun Park ,&nbsp;Beom-Joon Lee ,&nbsp;Kitae Kim ,&nbsp;Byoung Kab Kang ,&nbsp;Jun-Yong Choi","doi":"10.1016/j.imr.2023.101005","DOIUrl":"https://doi.org/10.1016/j.imr.2023.101005","url":null,"abstract":"<div><h3>Background</h3><p><em>Eunkyosan</em> (EKS) and <em>Samsoeum</em> (SSE), which are called <em>Yin qiao san</em> and <em>Shen su yin</em> in Chinese, are commonly used herbal medicines for the common cold in East Asian countries. This study aimed to evaluate the effectiveness and safety of EKS and SSE for treating the common cold.</p></div><div><h3>Methods</h3><p>A randomized, patient-assessor-blind, placebo-controlled, parallel, and multicenter clinical trial was conducted. Adult participants who had one or more cold within 48 h before screening, were randomly allocated to EKS, SSE, or placebo groups. The recruitment goal was planned to be 375 participants. They took an EKS, SSE, or placebo, thrice daily for up to 8 days. The primary outcome was the change in the total score of the Wisconsin Upper Respiratory Symptom Scale-21-Korean version (WURSS-21-K) on day 6 compared to the baseline. The secondary outcomes included visual analog scale (VAS) scores and the duration of symptoms was assessed throughout the trial.</p></div><div><h3>Results</h3><p>A total of 128 participants were enrolled and 44, 42, and 42 were allocated to the EKS, SSE, and placebo groups, respectively. This study was prematurely terminated due to the COVID-19 pandemic, and we were unable to recruit all the planned participants (<em>n</em> = 375). EKS showed significant clinical effectiveness over the placebo group in the treatment of the common cold, as assessed by the total, symptom, and quality of life scores of WURSS-21-K and VAS, whereas SSE showed significant improvement over the placebo group in terms of WURSS-21-K symptom score. No severe adverse events were reported.</p></div><div><h3>Conclusions</h3><p>Although EKS and SSE demonstrated statistically significant clinical effectiveness and safety in patients with the common cold, we failed to recruit our pre-planned number of participants. Future definitive full-scale studies are needed to confirm these results.</p></div><div><h3>Trial registration</h3><p>ClinicalTrials. gov, registration number: NCT04073511. Registered on 29 August 2019.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 4","pages":"Article 101005"},"PeriodicalIF":3.4,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422023000847/pdfft?md5=8952520b884b0121b0f97bd01c85f92e&pid=1-s2.0-S2213422023000847-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92100322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oversimplifying the name of the 12 meridian channels","authors":"In-Seon Lee ,&nbsp;Yeonhee Ryu ,&nbsp;Younbyoung Chae","doi":"10.1016/j.imr.2023.101002","DOIUrl":"https://doi.org/10.1016/j.imr.2023.101002","url":null,"abstract":"","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 4","pages":"Article 101002"},"PeriodicalIF":3.4,"publicationDate":"2023-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422023000811/pdfft?md5=cc0ffd1fb07626e1f65309c5e4ff6199&pid=1-s2.0-S2213422023000811-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91729243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of aromatherapy on sore throat, nasal symptoms and sleep quality in adults infected with COVID-19: A randomized controlled trial","authors":"Hye-Young Kang ,&nbsp;Hye Young Ahn ,&nbsp;Mi-Jung Kang,&nbsp;Myung-Haeng Hur","doi":"10.1016/j.imr.2023.101001","DOIUrl":"https://doi.org/10.1016/j.imr.2023.101001","url":null,"abstract":"<div><h3>Background</h3><p>Patients with coronavirus disease 2019 (COVID-19) usually complain of fever, cough, and sore throat. This study examined the effects of aromatherapy on sore throat, nasal symptoms, stress, fatigue, and sleep quality by administering it to adults with post-COVID-19 condition.</p></div><div><h3>Methods</h3><p>This study was conducted in a randomised controlled design. Its target population were adults who were released from COVID-19 quarantine treatment within 45 days from infection onset and capable of performing daily activities after isolation treatment. The participants were randomised into aromatherapy group (AG) and control group (CG). To test experimental treatment effects, the levels of sore throat, nasal symptoms, stress, fatigue and sleep quality were measured at the baseline (pre-test) and after the trial (post-test), using the numerical rating scale for sore throat, stress and fatigue, the Total Nasal Symptoms Score for nasal symptoms, and the Korean Version of Modified Leeds Sleep Evaluation Questionnaire for quality of sleep.</p></div><div><h3>Results</h3><p>After experimental treatment, there was a significant difference in sore throat in AG compared to CG on the 3rd day (<em>t</em>=-2.022 <em>p</em>=0.048) and 4th day (<em>t</em>=-2.450, <em>p</em>=0.017) of treatment. There was also a significant difference in fatigue between AG and CG on the 2nd day(<em>t</em>=-2.748, <em>p</em>=0.008), 3rd day (<em>t</em>=-2.948, <em>p</em>=0.005) and 4th day (<em>t</em>=-3.084, <em>p</em>=0.003) of treatment. There was no significant difference in TNSS, stress, and sleep quality between the two groups after the experimental treatment.</p></div><div><h3>Conclusion</h3><p>Inhaling aroma essential oils reduced sore throat and fatigue in adults with post-COVID-19 condition, demonstrating the feasibility of aromatherapy as an effective treatment.</p></div><div><h3>Trial registration</h3><p>The study was registered with Clinical Research Information Service (KCT0008029).</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 4","pages":"Article 101001"},"PeriodicalIF":3.4,"publicationDate":"2023-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S221342202300080X/pdfft?md5=2889830582e4761607cc69803a4991f9&pid=1-s2.0-S221342202300080X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91775210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GV16 acupoint stimulation with bee venom reduces peripheral hypersensitivity via activation of α2 adrenoceptors in a nitroglycerin-induced migraine mouse model","authors":"Sol-Ji Kim ,&nbsp;Ji-Hee Yeo ,&nbsp;Seo-Yeon Yoon ,&nbsp;Dae-Hyun Roh","doi":"10.1016/j.imr.2023.100999","DOIUrl":"https://doi.org/10.1016/j.imr.2023.100999","url":null,"abstract":"<div><h3>Background</h3><p>Peripheral hypersensitivities develop in the face and hindpaws of mice with nitroglycerin (NTG)-induced migraine. We evaluated whether diluted bee venom (DBV) injections at acupoints prevented these peripheral hypersensitivities and c-Fos expression in the trigeminal nucleus caudalis (TNC).</p></div><div><h3>Methods</h3><p>NTG (10 mg/kg, intraperitoneal, i.p.) was administered every other day for nine days. DBV (0.1 mg/kg) was subcutaneously injected into the ST36 (Zusanli), LI4 (Hegu), or GV16 (Fengfu) acupoints 75 min after each NTG injection. Mice were pretreated with naloxone (5 mg/kg, i.p.) or yohimbine (5 mg/kg, i.p.) 30 min before the DBV injections.</p></div><div><h3>Results</h3><p>NTG injection caused facial cold allodynia, hindpaw mechanical allodynia, and increased c-Fos-immunoreactive (ir) cells in the TNC. Repetitive DBV injections at GV16, but not the ST36, or LI4 acupoints, suppressed NTG-induced hindpaw mechanical allodynia and facial cold allodynia. The number of c-Fos-ir cells also decreased in response to DBV injections at the GV16 acupoint. Remarkably, pretreatment with yohimbine reversed the anti-allodynic effects of DBV injections and attenuated the decreased c-Fos expression in response to GV16 DBV treatment. Naloxone did not block the effects of GV16 DBV stimulation.</p></div><div><h3>Conclusion</h3><p>These findings demonstrate that repetitive DBV treatment at the GV16 acupoint relieves NTG-induced facial and hindpaw hypersensitivities and decreases in c-Fos expression in the TNC via activation of the alpha-2 adrenoceptors, but not the opioid receptors.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 4","pages":"Article 100999"},"PeriodicalIF":3.4,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422023000781/pdfft?md5=6a1fef8638373f9b2a6df0b1f69c7f98&pid=1-s2.0-S2213422023000781-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91729244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world data analysis on effectiveness of integrative therapies: A practical guide to study design and data analysis using healthcare databases","authors":"Ye-Seul Lee,&nbsp;Yoon Jae Lee,&nbsp;In-Hyuk Ha","doi":"10.1016/j.imr.2023.101000","DOIUrl":"https://doi.org/10.1016/j.imr.2023.101000","url":null,"abstract":"<div><p>Real world data (RWD) is increasingly used to investigate health outcomes and treatment efficacy in the field of integrative medicine. Due to the fact that the majority of RWDs are not intended for research, their secondary use in research necessitates complex study designs to account for bias and confounding. To conduct a robust analysis of RWD in integrative medicine, a comprehensive study design process that reflects the characteristics of integrative therapies is necessary. In this paper, we present a guide for designing comparative effectiveness RWE research in integrative medicine. We discuss key factors to consider when selecting RWDs for research on integrative medicine. We provide practical steps for developing a research question, formulating the PICOT objectives (population, intervention, comparator, outcome, and time horizon), and selecting and defining covariates with a summary table. Specific study designs are depicted with corresponding diagrams. Finally, data analysis procedures are introduced. We hope this article clarifies the importance of RWE research design and related processes in order to improve the rigor of RWD studies in the field of integrative medicine research.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 4","pages":"Article 101000"},"PeriodicalIF":3.4,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422023000793/pdfft?md5=89c1006144dfc63a4bf6a0117602b214&pid=1-s2.0-S2213422023000793-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90029701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Saposhnikovia divaricata root and its major components ameliorate inflammation and altered gut microbial diversity and compositions in DSS-induced colitis","authors":"Saruul Erdenebileg ,&nbsp;Yang-Ju Son ,&nbsp;Myungsuk Kim ,&nbsp;Sarangerel Oidovsambuu ,&nbsp;Kwang Hyun Cha ,&nbsp;Jaeyoung Kwon ,&nbsp;Da Seul Jung ,&nbsp;Chu Won Nho","doi":"10.1016/j.imr.2023.100998","DOIUrl":"https://doi.org/10.1016/j.imr.2023.100998","url":null,"abstract":"<div><h3>Background</h3><p>The root of <em>Saposhnikovia divaricata</em> (Turcz.) Schischk is a well-known traditional medicinal plant, containing various bioactive compounds with anti-inflammatory, antioxidant, and analgesic properties. However, no scientific studies have validated its clinical use as an anti-inflammatory agent against inflammatory bowel disease (IBD). This study aimed to investigate whether the root extract of <em>S. divaricata</em> ameliorates IBD and induces gut microbial alteration, using a RAW 264.7 cell line and a DSS-induced colitis mouse model.</p></div><div><h3>Methods</h3><p>To investigate the anti-inflammatory effects and alleviation of IBD, using a methanol extract of <em>Saposhnikovia divaricata</em> (Turcz.) Schischk. root (MESD), RAW 264.7, murine macrophages and a dextran sodium sulfate (DSS)-induced colitis mouse model were employed. 16S rRNA gene sequencing was conducted to determine the alterations in the gut microbiota of mice with DSS-induced colitis.</p></div><div><h3>Results</h3><p>MESD significantly decreased nitric oxide (NO) and inflammatory cytokine levels in lipopolysaccharide (LPS)-induced RAW 264.7 cells <em>in vitro</em>. Oral administration of MESD reduced the expression of inflammatory cytokines in the colons of mice with DSS-induced colitis. Additionally, MESD inhibited the abundance of <em>Clostridium sensu stricto</em> 1 and enhanced the predicted functional pathways, including <span>l</span>-glutamate degradation VIII (to propanoic acid). Seven compounds with anti-inflammatory properties were isolated from the MESD. Among them, 3′-O-acetylhamaudol and 3′-O-angeloylhamaudol exhibited strong anti-inflammatory effects <em>in vitro</em>.</p></div><div><h3>Conclusion</h3><p>Overall, MESD may be a potential natural product for the treatment of IBD by lowering inflammatory cytokine levels and altering gut microbiota composition.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 4","pages":"Article 100998"},"PeriodicalIF":3.4,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S221342202300077X/pdfft?md5=defe800f4db3bce02c67d4b4f5ab6743&pid=1-s2.0-S221342202300077X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92100321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture for ventilator-dependent patients at a hospital-based respiratory care center: A randomized controlled trial","authors":"Jia-Ming Chen ,&nbsp;Wan-Li Chiang ,&nbsp;Bin-Chuan Ji ,&nbsp;Ruei-Jhe Jhang ,&nbsp;Pei-Hsin Chen ,&nbsp;Ya-Lun Li ,&nbsp;Che-Ju Chang ,&nbsp;Sung-Yen Huang ,&nbsp;Tsung-Chieh Lee ,&nbsp;Chia-Yun Chen ,&nbsp;Ching-Hsiung Lin ,&nbsp;Sheng-Hao Lin","doi":"10.1016/j.imr.2023.100997","DOIUrl":"https://doi.org/10.1016/j.imr.2023.100997","url":null,"abstract":"<div><h3>Background</h3><p>In intensive care units, mechanical ventilation is an important therapy to help patients with dyspnea. However, long-term ventilator dependence would consume huge medical resources and increase the risk of morbidity and mortality. The aim of the study was to examine the efficacy of the acupuncture combined with western medical care on ventilator parameters in ventilator-dependent patients.</p></div><div><h3>Methods</h3><p>In this clinical trial, 80 ventilator-dependent patients aged 20 to 80 years old were randomly assigned to acupuncture group and control group in the respiratory care center (RCC) of Changhua Christian Hospital. Besides regular medical care and therapy, participants in the acupuncture group received acupuncture therapy at the same 17 acu-points for 20 minutes once a day, a total of 12 sessions. The ventilator parameters were recorded to evaluate the respiratory efficiency for all participants. The primary outcome was rapid shallow breathing index (RSBI), and secondary outcomes were respiratory rate (RR), tidal volume (TV) and ventilation per minute (MV),</p></div><div><h3>Results</h3><p>Though there was no significant difference in the parameter between the acupuncture group and the control group, we found the trend of decreasing RSBI in the acupuncture group. In subgroup analyses, the mean of RSBI significantly decreased 16.02 (with the SD in 60.84) in acupuncture group, while it increased 17.84 (with the SD in 39.38) in control group (p=0.036) after 12 sessions.</p></div><div><h3>Conclusion</h3><p>Acupuncture treatment can improve breathing ability of patients with respirator dependence in respiratory care center.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 4","pages":"Article 100997"},"PeriodicalIF":3.4,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422023000768/pdfft?md5=371d4c2d4d36c5ec6fdb7be0ff12d3f0&pid=1-s2.0-S2213422023000768-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134656112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary and herbal supplement consumer health information for pain: A cross-sectional survey and quality assessment of online content","authors":"Jeremy Y Ng,&nbsp;Sahar Popal,&nbsp;Sathurthika Selvanayagam","doi":"10.1016/j.imr.2023.100996","DOIUrl":"https://doi.org/10.1016/j.imr.2023.100996","url":null,"abstract":"<div><h3>Background</h3><p>Patients are increasingly utilizing the internet to learn about dietary and herbal supplements (DHSs) for various diseases/conditions, including pain management. Online health information has been found to be inconsistent and of poor quality in prior studies, which may have detrimental effects on patient health. This study assessed the quality of online DHSs consumer health information for pain.</p></div><div><h3>Methods</h3><p>Six search items related to DHSs and pain were used to generate the first 20 websites on Google across four English-speaking countries. The identified 480 webpages produced 68 eligible websites, which were then evaluated using the DISCERN tool. The mean scores and standard deviations (SD) of the reviewers’ ratings on each of the 15 DISCERN instrument items as well as the overall total score were calculated.</p></div><div><h3>Results</h3><p>The mean summed score for the 68 eligible websites was 46.6 (SD = 10.1), and the mean overall rating was 3.3 (SD = 0.8). Websites lacked information regarding areas of uncertainty, the effects of no treatment being used, and how treatments affect the overall quality of life. These shortcomings were especially apparent across commercial websites, which frequently displayed bias, failed to report the risks of DHS products, and lacked support for shared decision-making regarding the use of DHSs.</p></div><div><h3>Conclusion</h3><p>Variability exists in the quality of online consumer health information regarding DHS use for pain. Healthcare providers should be aware of and provide guidance to patients regarding the identification of reliable online resources so that they can make informed decisions about DHS use for pain management.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 4","pages":"Article 100996"},"PeriodicalIF":3.4,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49709228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}