Integrative Medicine Research最新文献

{"title":"Acupuncture-related therapy for chronic cough: A systematic review and meta-analysis","authors":"Boram Lee ,&nbsp;Chan-Young Kwon ,&nbsp;Yoon Kyoung Jeong ,&nbsp;Na-Yeon Ha ,&nbsp;Kwan-Il Kim ,&nbsp;Beom-Joon Lee ,&nbsp;Jun-Hwan Lee","doi":"10.1016/j.imr.2025.101121","DOIUrl":"10.1016/j.imr.2025.101121","url":null,"abstract":"<div><h3>Background</h3><div>Despite the high prevalence and socioeconomic burden of chronic cough, there has been an unmet medical need. Acupuncture may be promising for treating chronic cough with various pathophysiologies involving several neurotransmission mechanisms. We aimed to systematically compile evidence on the effect and safety of acupuncture-related therapy for chronic cough.</div></div><div><h3>Methods</h3><div>Through a search of 11 databases, randomized controlled trials (RCTs) published until February 15, 2024 that evaluated the effect of acupuncture-related therapy at acupuncture points (including acupuncture, acupoint herbal patching, and moxibustion) for patients with chronic cough were identified and analyzed without restrictions on the cause of cough or age. When there were two or more studies that measured the same outcome measures, a meta-analysis was performed, and the certainty of evidence was evaluated based on the GRADE methodology.</div></div><div><h3>Results</h3><div>A total of 30 RCTs with 2835 participants were included. When acupuncture-related therapy was implemented in addition to conventional treatment including medicine and lifestyle guidance according to symptoms and causes, cough severity, cough-related quality of life, and the total effective rate (TER) were significantly improved with no difference in the incidence of adverse events. Furthermore, compared with conventional treatment, acupuncture-related therapy significantly improved cough severity and the TER. The certainty of the evidence was generally moderate due to the risk of bias. The most frequently used acupuncture points in the included studies were BL13, GV14, CV17, and EX-B1.</div></div><div><h3>Conclusion</h3><div>Acupuncture-related therapy might be an effective and safe treatment for patients with chronic cough of various causes with complex pathophysiologies.</div></div><div><h3>Protocol registration</h3><div>PROSPERO, CRD42024518115. PROSPERO (CRD42024518115).</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101121"},"PeriodicalIF":2.8,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143143019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of acupressure on smoking cessation in young smokers with nicotine dependence: a mixed methods study","authors":"Ying-Ying Zhang ,&nbsp;Yi-Jie Liu ,&nbsp;Yuan Wang ,&nbsp;Chen Shen ,&nbsp;Shi-Bing Liang ,&nbsp;Nicola Robinson ,&nbsp;Hai-Fa Qiao ,&nbsp;Jian-Ping Liu","doi":"10.1016/j.imr.2024.101120","DOIUrl":"10.1016/j.imr.2024.101120","url":null,"abstract":"<div><h3>Background</h3><div>Acupressure has been widely used for quitting smoking for a long time in China. This study explores the feasibility and effects of acupressure on smoking cessation in young smokers with nicotine dependence to inform policy and decision-making.</div></div><div><h3>Methods</h3><div>This was a single group study using pre/post-test design. Participants received four weeks of auricular acupressure treatment, led by a registered acupuncturist. Smoking cravings, nicotine dependence, withdrawal symptoms, and cigarettes per day (CPD) were recorded before and after treatment. Changes in outcomes were analyzed at 2 weeks and 4 weeks using SPSS software version 22.0. Semi-structured interviews were conducted with participants to explore their experience and attitude towards auricular acupressure. Thematic analysis was applied to analyze the data.</div></div><div><h3>Results</h3><div>A total of 20 participants completed this study. A significant reduction was observed in smoking cravings (<em>F</em> = 11.02, <em>P</em> &lt; 0.05), nicotine dependence (<em>F</em> = 11.09, <em>P</em> &lt; 0.05), withdrawal symptoms (<em>F</em> = 11.19, <em>P</em> &lt; 0.05), and CPD (<em>F</em> = 19.03, <em>P</em> &lt; 0.05) over sessions. Additionally, withdrawal symptoms decreased significantly from 2 weeks to 4 weeks (<em>P</em> &lt; 0.05) of acupressure treatment. Three inter-related themes emerged from interviews: personal and external resources, psychological and physical effects of acupressure, and satisfaction with acupressure for smoking cessation.</div></div><div><h3>Conclusion</h3><div>The quantitative and qualitative data suggest that acupressure maybe effective in decreasing nicotine dependence and smoking cravings. However, this was a pilot and single arm study, these effects need to be further verified. The study supports the feasibility and safety of introducing acupressure therapy for smoking cessation in young smokers.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101120"},"PeriodicalIF":2.8,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143143503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Common adverse events of herbal formulas for developing reporting forms for clinical practice and research: An overview of systematic reviews","authors":"Eunbyul Cho ,&nbsp;Sungha Kim ,&nbsp;Mi Ju Son","doi":"10.1016/j.imr.2024.101118","DOIUrl":"10.1016/j.imr.2024.101118","url":null,"abstract":"<div><h3>Background</h3><div>Previous research has mainly focused on the adverse events (AEs) of individual medicinal plants rather than those of herbal formulas. This study investigated AEs associated with herbal formulas composed of two or more herbs by summarizing existing systematic reviews (SRs). We aimed to identify common AEs to develop a comprehensive reporting form for clinical practice and research, improving herbal medicine safety monitoring in South Korea.</div></div><div><h3>Methods</h3><div>Four international (MEDLINE, EMBASE, CENTRAL, CINAHL) and three Korean databases (KISS, ScienceON, OASIS) were searched for SRs on AEs associated with herbal formulas from inception to September 13, 2024. Inclusion criteria were SRs focusing on AEs of herbal formulas composed of two or more herbs. Two researchers independently conducted the search, selection, and data extraction. Methodological and reporting quality were evaluated using A MeaSurement Tool to Assess systematic Reviews 2 and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 checklist. AEs were classified using the System Organ Class of the Medical Dictionary for Regulatory Activities.</div></div><div><h3>Results</h3><div>Thirteen SRs were selected. The most frequently reported organ system was hepatobiliary (9 SRs), followed by nervous and gastrointestinal systems (3 SRs each). Common symptoms in primary studies were nausea (<em>n</em> = 102), diarrhea (<em>n</em> = 80), and vomiting (<em>n</em> = 70). Causality was analyzed in 7 SRs using various scales. The methodological quality of the included SRs was critically low.</div></div><div><h3>Conclusions</h3><div>Our findings provide a foundation for developing a standardized AE reporting form for herbal formulas. Further high-quality reports with specific patient conditions, herbal constituents, and causality assessments are required to enhance herbal medicine safety monitoring and understanding.</div></div><div><h3>Protocol registration</h3><div>PROSPERO, CRD42023478440.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101118"},"PeriodicalIF":2.8,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143143505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-Focused Drug Development and Real World Study","authors":"Haiyin Hu ,&nbsp;Hui Wang ,&nbsp;Lin Ang ,&nbsp;Menglong Shi ,&nbsp;Xiaolei Wu ,&nbsp;Chenyao Zhang ,&nbsp;Mei Han ,&nbsp;Shigang Liu ,&nbsp;Kai Li ,&nbsp;Junhua Zhang ,&nbsp;Zhaochen Ji","doi":"10.1016/j.imr.2024.101119","DOIUrl":"10.1016/j.imr.2024.101119","url":null,"abstract":"<div><h3>Background</h3><div>Patient-focused drug development (PFDD) is an important direction in the field of medical research and is of great significance to the development of medicine. In recent years, PFDD and real-world study (RWS) have gained much interest, of which both have their advantages. This study aims to promote research methods innovation and optimize clinical research design and implementation.</div></div><div><h3>Methods</h3><div>After a brief introduction of PFDD and RWS, this review focused on the comparison of clinical trials of PFDD and RWS in terms of objectives, Population, Intervention, Comparator, Outcome (PICO) elements, research team members, data acquisition, and research key points, and clarified the feasibility and significance of “patient-focused RWS” research model.</div></div><div><h3>Results</h3><div>PFDD emphasized that patients’ needs as well as the willingness and satisfaction of patients should be considered throughout the whole research process and the patient experience data should be collected during the study development and drug use. RWS emphasized the facticity of research implementation environment and the breadth of patient sources, which concerned the problem of the extrapolation of study results, the clinical localization, and patient applicability of the target drug. However, there is a connection between both of the above. Both clinical trials of PFDD and RWS bring benefits to patients.</div></div><div><h3>Conclusions</h3><div>Combining PFDD idea and RWS research method to carry out new research will maximize the benefits for patients. The study model combining the PFDD concept with RWS can facilitate drug development and dissemination, which can be popularized and applied in various research areas. This study can innovate research methods and provide new ideas for future research.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101119"},"PeriodicalIF":2.8,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143143501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing penetrating needles and non-penetrating needles with electrical stimulation combined with exercise training for relief of dyspnea and improving exercise tolerance in chronic obstructive pulmonary disease patients: A single-blind randomized controlled trial","authors":"Ying He ,&nbsp;Gui-yuan Li ,&nbsp;Chun-zhi Tang ,&nbsp;Li-ming Lu ,&nbsp;Guang-yi Xiong ,&nbsp;Yi Gao ,&nbsp;Juan Tong ,&nbsp;Guang-en Zhong","doi":"10.1016/j.imr.2024.101117","DOIUrl":"10.1016/j.imr.2024.101117","url":null,"abstract":"<div><h3>Background</h3><div>Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation. The purpose of this study was to evaluate the effectiveness of penetrating needles with electrical stimulation combined with exercise training on relieving dyspnea and improving exercise tolerance among COPD patients.</div></div><div><h3>Method</h3><div>A total of 85 patients were recruited and randomly assigned to receive either penetrating needles with electrical stimulation (PE) or non-penetrating needles with electrical stimulation (NPE), 3 times a week, for 8 weeks, totaling 24 treatments. Both groups underwent exercise training. The evaluations were conducted at the baseline, after 14 treatments, and after 24 treatments.</div></div><div><h3>Results</h3><div>The PE group showed significant improvement in 6-minute walk distance (6MWD) after the 14^th treatment. For pulmonary function test, MVV%, MEF50%, MEF75% and MEF25% improved in the PE group, especially MVV% was significantly higher than the NPE group. For cardiopulmonary exercise testing, METs%, VO₂/kg%, V_E%, VO₂/HR%, V_Emax, V_E/VO₂ and V_E/VCO₂ in the PE group improved, especially VO₂/kg%, V_E%, V_Emax, V_E/VO₂ and V_E/VCO₂ were significantly higher than the NPE group. The scores of COPD assessment test in the PE group significantly improved. The scores of modified British Medical Research Council in the PE group was better than the NPE group after the treatment.</div></div><div><h3>Conclusion</h3><div>Penetrating needles with electrical stimulation combined with exercise training may be clinically useful for COPD patients in relieving dyspnea and improving exercise tolerance.</div></div><div><h3>Trial Registration</h3><div>Chinese Clinical Trial Registry, ChiCTR1900028627.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101117"},"PeriodicalIF":2.8,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intranasal acupuncture therapy for allergic rhinitis: A systematic review and meta-analysis of randomized controlled trials","authors":"Xiao-ying Chen ,&nbsp;Qian-yun Wang ,&nbsp;Zhan-feng Yan ,&nbsp;Yu-yang Wang ,&nbsp;Xing-ru Pan ,&nbsp;Meng-yuan Ou ,&nbsp;Xue-han Liu ,&nbsp;Jian-ping Liu ,&nbsp;Xin-yan Jin","doi":"10.1016/j.imr.2024.101116","DOIUrl":"10.1016/j.imr.2024.101116","url":null,"abstract":"<div><h3>Background</h3><div>Allergic rhinitis (AR) is a prevalent allergic condition that affects the nasal mucosa. Intranasal acupuncture therapy (IAT), an innovative therapy that involves precisely inserting acupuncture needles into specific nasal acupoints, has demonstrated potential effects in managing AR. The aim of this study is to evaluate the effectiveness and safety of IAT in the management of AR.</div></div><div><h3>Methods</h3><div>Nine databases were systematically searched for randomized controlled trials (RCTs) from their inception to September 2024. We included participants diagnosed with AR who received IAT alone or as add-on treatment to conventional treatment. The Cochrane risk of bias 2.0 tool and GRADE approach were applied to assess methodological qualities. A meta-analysis was performed using RevMan 5.4.1 software.</div></div><div><h3>Results</h3><div>Twenty-one RCTs with 1889 participants were included. The certainty of evidence was generally low and moderate. Compared to sham acupuncture, IAT significantly reduced the total nasal symptom score (MD −2.65, 95% CI −4.01 to −1.29, 1 RCT, 30 participants, moderate evidence). Compared to an antihistamine, IAT was associated with a lower total non-nasal symptom score (MD −0.44, 95% CI −0.64 to −0.25, 5 RCTs, 295 participants, moderate evidence) and a better quality of life measured by the rhinoconjunctivitis quality of life questionnaire (MD −13.72, 95% CI −18.01 to −9.43, 4 RCTs, 255 participants, moderate evidence). No serious adverse events were reported.</div></div><div><h3>Conclusion</h3><div>IAT may be beneficial in improving AR-related symptoms and quality of life. However, the safety of IAT remains unclear due to inadequate reporting. Further high-quality, rigorously designed, and well-reported trials are required.</div></div><div><h3>Protocol registration</h3><div>PROSPERO, CRD42024526357.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101116"},"PeriodicalIF":2.8,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143143506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovering the key symptoms for identifying patterns in functional dyspepsia patients: Doctor's decision and machine learning","authors":"Da-Eun Yoon ,&nbsp;Heeyoung Moon ,&nbsp;In-Seon Lee ,&nbsp;Younbyoung Chae","doi":"10.1016/j.imr.2024.101115","DOIUrl":"10.1016/j.imr.2024.101115","url":null,"abstract":"<div><h3>Background</h3><div>Pattern identification is a crucial diagnostic process in Traditional East Asian Medicine, classifying patients with similar symptom patterns. This study aims to identify key symptoms for distinguishing patterns in patients with functional dyspepsia (FD) using explicit (doctor's decision-based) and implicit (computational model-based) approaches.</div></div><div><h3>Methods</h3><div>Data from twenty-one FD patients were collected from local clinics of traditional Korean Medicine and provided to three doctors in a standardized format. Each doctor identified patterns among three types: spleen-stomach weakness, spleen deficiency with qi stagnation/liver-stomach disharmony, and food retention. Doctors evaluated the importance of the symptoms indicated by items in the Standard Tool for Pattern Identification of Functional Dyspepsia questionnaire. Explicit importance was determined through doctors’ survey by general evaluation and by selecting specific information used for the diagnosis of patient cases. Implicit importance was assessed by feature importance from the random forest classification models, which classify three types for general differentiation and perform binary classification for specific types.</div></div><div><h3>Results</h3><div>Key symptoms for distinguishing FD patterns were identified using two approaches. Explicit importance highlighted dietary and nausea-related symptoms, while implicit importance identified complexion or chest tightness as generally crucial. Specific symptoms important for particular pattern types were also identified, and significant correlation between implicit and explicit importance scores was observed for types 1 and 3.</div></div><div><h3>Conclusion</h3><div>This study showed important clinical information for differentiating FD patients using real patient data. Our findings suggest that these approaches can contribute to developing tools for pattern identification with enhanced accuracy and reliability.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101115"},"PeriodicalIF":2.8,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of a home-based aromatherapy programme for the management of behavioural and psychological symptoms of dementia among older persons with dementia: A randomised controlled trial with process evaluation","authors":"Becky Siu Yin Li ,&nbsp;Ankie Tan Cheung ,&nbsp;Ka Ming Chow ,&nbsp;Carmen Wing Han Chan","doi":"10.1016/j.imr.2024.101113","DOIUrl":"10.1016/j.imr.2024.101113","url":null,"abstract":"<div><h3>Background</h3><div>Behavioural and psychological symptoms of dementia (BPSD) significantly affect older persons with dementia (OPWDs) and their family caregivers. Inhalation aromatherapy is a safe and effective non-pharmacological approach for BPSD management, but it has not been tested in home-based setting for the Chinese population. This study examined the effects of home-based family caregiver-delivered aromatherapy programme on OPWDs and family caregiver.</div></div><div><h3>Methods</h3><div>Eighty OPWD-family caregiver dyads were randomised (1:1) to either aromatherapy programme or wait-list control. The programme involved 1-hour training for caregivers, and 3-week caregiver-delivered aromatherapy intervention for OPWDs, using inhalation of lavender essential oil twice a day. A comprehensive process evaluation was conducted to evaluate programme implementation and participants’ perceptions. The primary outcome was the severity of BPSD in OPWDs, with secondary outcomes being OPWDs’ quality of life (QoL) and caregivers’ distress and care burden.</div></div><div><h3>Results</h3><div>The OPWDs in the intervention group exhibited significantly decreased severity of disinhibition and irritability/lability (two of the BPSD) and improvements in the health and well-being and social relationships domains of QoL. Caregivers also exhibited decreased distress and care burden, but the differences were not statistically significant. The process evaluation revealed that most participants accepted aromatherapy well, and most caregivers were willing to continue aromatherapy after the study.</div></div><div><h3>Conclusion</h3><div>This study demonstrated that aromatherapy is feasible and effective for managing BPSD in a home-based setting, providing a valuable reference for future research and nursing practice in home-based dementia care.</div></div><div><h3>Trial registration</h3><div>This study was registered at ClinicalTrials.gov (NCT05032664) and Chinese Clinical Trial Registry (ChiCTR2100050869).</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 2","pages":"Article 101113"},"PeriodicalIF":2.8,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effectiveness of traditional East Asian medicine treatments for temporomandibular joint disorders: A systematic review and network meta-analysis","authors":"Seojung Ha ,&nbsp;Sung-Woo Kang ,&nbsp;Sanghoon Lee","doi":"10.1016/j.imr.2024.101114","DOIUrl":"10.1016/j.imr.2024.101114","url":null,"abstract":"<div><h3>Background</h3><div>Temporomandibular joint disorders (TMDs) cause pain and functional restrictions in the temporomandibular joint that interfere with daily activities. This study aimed to evaluate and compare the effectiveness and safety of various traditional East Asian medicine treatments, including acupuncture, electroacupuncture, moxibustion, and herbal medicine, in the management of TMD.</div></div><div><h3>Methods</h3><div>We included searches of MEDLINE, CENTRAL, EMBASE, AMED, CINAHL, OASIS, KISS, RISS, KMbase, KCI, CNKI, and CiNii from inception to November 12, 2023, for randomized controlled trials of traditional East Asian medicine treatments in patients with TMD. A network meta-analysis was performed using frequentist methods, and the Confidence In Network Meta-Analysis methodology were employed to assess evidence quality.</div></div><div><h3>Results</h3><div>Forty-five studies with 2,211 participants were finally included. Acupotomy (Mean difference (MD) -5.07, 95 % Confidence interval (CI) -7.37 to -2.78) and acupuncture (MD -1.18, 95 % CI -2.28 to -0.09) showed statistically significant superiority in reducing pain intensity compared to sham treatment. According to the SUCRA rankings, acupotomy was considered the most effective treatment, followed by electroacupuncture, acupuncture, manipulation, laser therapy and occlusal splint. A total of 12 studies reported incidence of adverse events, and none were serious adverse events.</div></div><div><h3>Conclusion</h3><div>Acupotomy and acupuncture could be more beneficial than sham treatment in pain relief and might be a better option than occlusal splint. However, future rigorous, well-designed trials are needed to draw clear conclusions.</div></div><div><h3>Protocol registration</h3><div>PROSPERO (CRD42023467340).</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101114"},"PeriodicalIF":2.8,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143143507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture for acute ischemic stroke: A systematic review and meta-analysis of randomized controlled trials","authors":"Shanshan Huang ,&nbsp;Yuting Wang ,&nbsp;Yifan Wu ,&nbsp;Puchen Huang ,&nbsp;Yu Dong ,&nbsp;Qiao Zhang ,&nbsp;Mengjiao Zhao ,&nbsp;Jingchun Zeng ,&nbsp;Liming Lu ,&nbsp;Xinxia Liu","doi":"10.1016/j.imr.2024.101092","DOIUrl":"10.1016/j.imr.2024.101092","url":null,"abstract":"<div><h3>Objective</h3><div>Assess the safety and effectiveness of acupuncture for acute ischemic stroke (AIS).</div></div><div><h3>Methods</h3><div>We conducted a comprehensive search across the PubMed, Cochrane Library, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), Wanfang, and SinoMed databases from their inception until October 3, 2023. Two reviewers screened eligible randomized controlled trials (RCTs) according to criteria and extracted data using a pre-established form. Cochrane tool was used for risk of bias assessment, and Revman 5.3 was used for subsequent meta-analysis. The GRADE tool will be used to assess the quality of evidence.</div></div><div><h3>Results</h3><div>Thirty-one RCTs were included, involving 3604 patients. Meta-analysis showed that compared with conventional treatments (CTs), acupuncture combined with CTs could improve in National Institutes of Health Stroke Scale (NIHSS) and Efficiency (MD:1.70, 95 %CI [-2.27, -1.14], <em>P</em> &lt; 0.00001;RR: 1.21, 95 %CI [1.12, 1.31], <em>P</em> &lt; 0.00001,);On the Chinese Stroke Scale (CSS) and effectiveness based on CSS, acupuncture showed positive effects (MD:4.33, 95 %CI [-5.67, -2.98], <em>P</em> &lt; 0.00001; RR: 1.26, 95 %CI [1.13, 1.41], <em>P</em> &lt; 0.0001). Furthermore, ADL, Fugl-Meyer Assessment Scale (FMA), prognosis analyses also showed the effectiveness of acupuncture. (SMD: 0.98, 95 % CI [0.64, 1.31], <em>P</em> &lt; 0.00001; MD: 16.46, 95 %CI [12.56, 20.35], <em>P</em> &lt; 0.00001; RR: 0.38, 95 %CI [0.16, 0.89], <em>P</em> = 0.03). However, the certainty of evidence was low.</div></div><div><h3>Conclusion</h3><div>According to current evidence, Acupuncture may be effective and safe for AIS. The future still needs high-quality evidence to support this conclusion.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 4","pages":"Article 101092"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}