Integrative Medicine Research最新文献

{"title":"Safety of medicinal and edible herbs from seed sources for human consumption: A systematic review","authors":"Lixia Yuan ,&nbsp;Bofei Shu ,&nbsp;Jieyi Zhou ,&nbsp;Wenxi Li ,&nbsp;Hui Wang ,&nbsp;Xu Zhou","doi":"10.1016/j.imr.2025.101263","DOIUrl":"10.1016/j.imr.2025.101263","url":null,"abstract":"<div><h3>Background</h3><div>Plant seeds constitute an important category of medicinal and edible herbs. However, assessments regarding their safety for human consumption remain insufficient. This systematic review comprehensively evaluates human safety for 21 medicinal and edible seeds.</div></div><div><h3>Methods</h3><div>Two independent reviewers screened the titles, abstracts, and fulltexts of the retrieved literature against the inclusion and exclusion criteria to identify eligible AE reports in both English (PubMed, Embase, CENTRAL) and Chinese (CNKI, Wanfang, VIP, SinoMed) databases. Search strategies were constructed using the scientific names, common names, and frequent aliases of the medicinal and edible seeds combined with safety evaluation keywords such as \"adverse reaction,\" \"toxicity,\" and \"side effect.\" Any studies describing adverse event (AE) after human intake of specific seeds were included. AE characteristics were summarized. Causality between seed consumption and AEs was assessed.</div></div><div><h3>Results</h3><div>We identified 703 AEs involving eight medicinal and edible seeds. Ginkgo semen and Armeniacae semen amarum caused the most AEs, followed by Persicae semen, Myristicae semen, Sterculiae lychnophorae semen, Canavaliae semen, Cassiae semen, and Ziziphi spinosae semen. Among the AEs, 70.8% occurred in children, and 68.9% were associated with excessive intake. Most AEs manifested as gastrointestinal and/or neurological symptoms. Ninety-six were classified as serious; these were caused by Ginkgo semen (29 cases), Armeniacae semen amarum (60 cases), Persicae semen (4 cases), Canavaliae semen (2 cases), and Myristicae semen (1 case). These SAEs resulted in 15 fatalities and 3 cases of permanent functional impairment. Causality with seed consumption was determined to be \"certain\" for 239 AEs, \"probable\" for 449, and \"possible\" for 15. No AE reports were found for thirteen seeds.</div></div><div><h3>Conclusion</h3><div>Consuming specific medicinal and edible seeds, particularly Ginkgo semen, Armeniacae semen amarum, Persicae semen, Myristicae semen, and Canavaliae semen, poses potential risks, including fatal cases. Excessive dosages, consumption by children, and inappropriate processing were primary causes. Therefore, strengthening safety management for these is warranted.</div></div><div><h3>Protocol registration</h3><div>PROSPERO (No. CRD42023426497).</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"15 2","pages":"Article 101263"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145525682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture electroceuticals: The convergence of traditional acupuncture theory and modern bioelectronic medicine","authors":"Sanghun Lee ,&nbsp;Sunmi Choi","doi":"10.1016/j.imr.2025.101267","DOIUrl":"10.1016/j.imr.2025.101267","url":null,"abstract":"","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"15 2","pages":"Article 101267"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145576166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chinese herbal medicine Ding Kun Dan for menopausal syndrome: A systematic review and meta-analysis of randomized controlled trials","authors":"Youzhu Su ,&nbsp;Jia Liu ,&nbsp;Yuxian Wang ,&nbsp;Xiao Xiao ,&nbsp;Rui Liu ,&nbsp;Xinxin Liu ,&nbsp;Chen Shen ,&nbsp;Rui Su ,&nbsp;Xuefei Wang ,&nbsp;Jianping Liu","doi":"10.1016/j.imr.2025.101254","DOIUrl":"10.1016/j.imr.2025.101254","url":null,"abstract":"<div><h3>Background</h3><div>Menopausal syndrome is a common condition in women during menopause, characterized by hormonal imbalances and various symptoms that negatively impact quality of life. Ding Kun Dan (DKD), a traditional Chinese herbal medicine, has been used to alleviate these symptoms, but its clinical efficacy and safety require further evaluation.</div></div><div><h3>Methods</h3><div>A systematic search of eight databases was conducted through March 15, 2025. Randomized controlled trials (RCTs) were included if DKD was used alone or with conventional Western treatments. The primary outcome was the Kupperman Index; secondary outcomes included the Pittsburgh Sleep Quality Index, SF-36, Self-Rating Anxiety Scale, Self-Rating Depression Scale, estradiol, follicle-stimulating hormone, luteinizing hormone, and adverse events. Meta-analysis was performed using RevMan 5.4.1 and Stata 17.</div></div><div><h3>Results</h3><div>A total of 21 RCTs involving 1981 participants were included. DKD combined with menopause hormone therapy (MHT) demonstrated superior efficacy in improving overall symptoms, sleep quality, quality of life, and reducing anxiety and depression, with a positive impact on hormone levels and fewer adverse events. DKD alone also showed comparable effects to MHT in improving symptoms and hormone levels. Additionally, DKD combined with oryzanol positively impacted hormone levels.</div></div><div><h3>Conclusions</h3><div>DKD, both alone and in combination with MHT or oryzanol, demonstrates potential therapeutic effects for managing menopausal symptoms, but due to the low quality of included studies, results should be interpreted cautiously. Larger, high-quality RCTs are needed to confirm these findings.</div></div><div><h3>Protocol registration</h3><div>PROSPERO, CRD42024621022.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"15 2","pages":"Article 101254"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145270032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional Chinese medicine for non-small cell lung carcinoma: An evidence mapping","authors":"Zelei Dai ,&nbsp;Xi Chen ,&nbsp;Nian Li ,&nbsp;Chenfeng Tan ,&nbsp;Yonggang Zhang ,&nbsp;Ying Wang ,&nbsp;Renjie Zhao ,&nbsp;Kefan Li ,&nbsp;Mike Clarke ,&nbsp;Lei Liu ,&nbsp;Lingmin Chen","doi":"10.1016/j.imr.2025.101281","DOIUrl":"10.1016/j.imr.2025.101281","url":null,"abstract":"<div><h3>Background</h3><div>Although many systematic reviews and meta-analyses have explored Traditional Chinese Medicine (TCM) for non-small cell lung carcinoma (NSCLC), uncertainty remains about the pooled efficacy, safety, and methodological quality of these reviews and the interventions they assessed. This study aimed to address this gap by analyzing TCM treatments for NSCLC using evidence mapping.</div></div><div><h3>Methods</h3><div>A comprehensive search across six databases identified relevant systematic reviews and meta-analyses up to August 2025. The AMSTAR-2 tool was used to assess methodological quality, and Python was used for statistical analysis and visualization. Evidence maps were created to group reviews by treatment types (chemotherapy, targeted therapy, radiotherapy, immunotherapy and supportive care) and by specific outcomes such as objective response rate (ORR), leukopenia, and quality of life (QoL).</div></div><div><h3>Results</h3><div>Out of 196 systematic reviews, 42 TCM interventions and 55 outcomes were identified. Most reviews examined TCM combined with chemotherapy, particularly Aidi, Kanglaite, and Shenqi Fuzheng injections. These combinations showed potential benefits in ORR, QoL, and chemotherapy-induced leukopenia. TCM combined with targeted therapies, such as EGFR-TKIs and Astragalus, also indicated benefits in progression-free survival and immune function. However, most systematic reviews were of \"critically low\" quality, limiting evidence reliability.</div></div><div><h3>Conclusion</h3><div>While TCM shows promise in enhancing conventional NSCLC treatments, high-quality, rigorously conducted randomised trials and reviews are essential to confirm these findings and guide clinical integration.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"15 2","pages":"Article 101281"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Misleading readers without lies: understanding spin and its relevance to acupuncture research","authors":"Inhu Bae ,&nbsp;Yu-jin Ji ,&nbsp;Hyangsook Lee","doi":"10.1016/j.imr.2025.101288","DOIUrl":"10.1016/j.imr.2025.101288","url":null,"abstract":"<div><div>This article provides an overview of spin in general and the current state of spin research in acupuncture studies. We introduce the definition and historical background of spin and provide an overview of its types with illustrative examples. Spin, reporting strategies that emphasise benefits or distract from non-significant results, may still be unfamiliar to many researchers, despite its critical impact on physicians and decision-makers by distorting interpretation and misrepresenting findings. We discuss not only the current state of spin research in the acupuncture field, but also specific types of spin commonly observed in acupuncture publications. Finally, we issue a call to action for researchers, journal editors, reviewers, and decision-makers to prevent spin in research articles. Reducing spin requires multifaceted efforts, including strict adherence to reporting guidelines, rigorous editorial and peer review processes, and increased awareness and training among researchers. By adopting a multidimensional approach, acupuncture researchers can become more alert to misleading reporting practices and ultimately improve the overall quality of reporting.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"15 2","pages":"Article 101288"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145972789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlicensed medical practice as a public health risk: Implications for Korean Medicine","authors":"Yong-Suk Kim","doi":"10.1016/j.imr.2025.101285","DOIUrl":"10.1016/j.imr.2025.101285","url":null,"abstract":"","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"15 2","pages":"Article 101285"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145938812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety of herbal medicine in the postpartum period: A hospital-based single-arm, prospective observational study (SAFEHERE-PC)","authors":"Anna Kim ,&nbsp;Young Eun Kim ,&nbsp;Sumin Seo ,&nbsp;Sungha Kim ,&nbsp;Eunbyul Cho ,&nbsp;Yujeong Kang ,&nbsp;Eunhee Lee ,&nbsp;Mi Ju Son","doi":"10.1016/j.imr.2025.101280","DOIUrl":"10.1016/j.imr.2025.101280","url":null,"abstract":"<div><h3>Background</h3><div>Herbal medicines (HMs) are commonly used during the postpartum period in South Korea; however, comprehensive data regarding their safety remain limited. This study aimed to evaluate the safety of HM use among postpartum women through the “SAFEty of HErbal medicine REgistry in Postpartum Care center” (SAFEHERE-PC) study.</div></div><div><h3>Methods</h3><div>A single-arm, prospective observational study was conducted from March to December 2024, enrolling 186 women within six weeks postpartum who were admitted to the postpartum care center of a Korean Medicine hospital. The study monitored adverse events (AEs) during HM use, collecting demographic information, medical history, herbal prescription details, and AE data. Reported AEs were analyzed using the WHO-UMC causality assessment and the Naranjo algorithm.</div></div><div><h3>Results</h3><div>Of the 186 participants, 4 (2.2 %) experienced AEs following HM administration, all of which were gastrointestinal symptoms (diarrhea, loose stools). Three of the five events were managed with a short course of the herbal formula, and two cases resolved spontaneously without requiring medical intervention. Based on severity and clinical course, the events were classified as mild to moderate. Causality assessment using the WHO-UMC system classified four cases as \"possible\" and one as \"certain\", while the Naranjo scale indicated three cases as \"possible\" and two as \"probable\" in their association with HM use.</div></div><div><h3>Conclusion</h3><div>A low incidence of mild gastrointestinal AEs (2.2 % of patients; 0.6 % of prescriptions) was observed, with no serious AEs reported. These findings provide descriptive safety data specific to the formulations and clinical practices used at this hospital-based postpartum care center.</div></div><div><h3>Trial registration</h3><div>Korean National Clinical Trial Registry Clinical Research Information Service: KCT0009060.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"15 2","pages":"Article 101280"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive value evaluation index system for provincial medical insurance access to traditional Chinese medicine preparations in medical institutions","authors":"Xinyan Jin ,&nbsp;Changgeng Su ,&nbsp;Jiale Zhang ,&nbsp;Yujuan Liu ,&nbsp;Xiaoying Chen ,&nbsp;Rui Zhao","doi":"10.1016/j.imr.2025.101258","DOIUrl":"10.1016/j.imr.2025.101258","url":null,"abstract":"<div><h3>Background</h3><div>This study established a comprehensive value evaluation index system for provincial medical insurance access to traditional Chinese medicine (TCM) preparations in medical institutions from the insurance viewpoint. The system aims to provide a reference for insurance access applications and decision-making.</div></div><div><h3>Methods</h3><div>The index system was first established through systematic evaluation and expert consultation. The Delphi method and analytic hierarchy process were employed to reveal the index system and calculate each indicator’s weight. The indicator selection thresholds were based on the importance score thresholds and the coefficient of variation thresholds. Indicators with importance scores higher than the threshold and coefficient of variation less than the threshold were included in the index system.</div></div><div><h3>Results</h3><div>The researchers retrieved 6201 articles in total, 68 of which were retained following a review of the titles and full text. The initially established index system had six dimensions (i.e., basic information and TCM theory of the preparation, safety, effectiveness, economy, innovation, and fairness), 25 primary indicators, and 55 secondary indicators. Two expert consultation rounds were employed to collect the opinions of 13 and 11 experts. The final index system considered the index system’s aforementioned six dimensions, including safety (30.44 %), effectiveness (43.18 %), economy (14.72 %), innovation (6.48 %), and fairness (5.17 %), along with 22 primary indicators, and 26 secondary indicators. Moreover, the top three weight indicators were the prescription source (secondary indicator), effectiveness evaluation based on real-world evidence (primary indicator), and direct costs (secondary indicator).</div></div><div><h3>Conclusion</h3><div>The proposed index system elucidates the scope of evidence and basic research design for TCM preparations from the insurance viewpoint. It also integrates cost evaluation and value evaluation indicators and improves the definition of reference drugs, thus providing a reference for achieving rational clinical drug usage and a pricing policy for TCM preparations.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"15 2","pages":"Article 101258"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic effects of pomegranate hot-water extract via inhibition of apoptosis and oxidative stress in a DHEA-induced mouse model of PCOS","authors":"Sohee Moon ,&nbsp;Yena Oh ,&nbsp;Hajin Noh ,&nbsp;Soo Dong Kim ,&nbsp;Jae Youl Cho","doi":"10.1016/j.imr.2025.101264","DOIUrl":"10.1016/j.imr.2025.101264","url":null,"abstract":"<div><h3>Background</h3><div>Polycystic ovarian syndrome (PCOS), which affects approximately 10 % of women of reproductive age worldwide, is closely associated with metabolic disturbances such as obesity and insulin resistance. Despite its high prevalence, the pathophysiology of PCOS is still not fully understood, underscoring the need for appropriate animal models and effective therapeutic strategies.</div></div><div><h3>Methods</h3><div>In this study, we established a PCOS mouse model through subcutaneous administration of dehydroepiandrosterone (DHEA) and investigated the therapeutic potential of a pomegranate (<em>Punica granatum</em> L.) hot water extract (Pg-hWE) (also called ESTROBAL®), administered orally.</div></div><div><h3>Results</h3><div>Histological analysis of ovarian tissue sections of mice showed that Pg-hWE improved ovulation function and suppressed cell death of follicles by promoting maintenance and regeneration of corpus luteum and reducing the number of atretic follicles. Furthermore, Pg-hWE showed inhibitory effects on gene and protein levels of apoptosis factors such as BAX, cleaved caspase-3, and cleaved caspase-9 in ovarian and uterine tissues. In addition, in ovarian tissues, it promoted apoptosis such as BAX and inhibited the expression of inflammation-related genes such as IL-6, TNF-α, and IFN-γ, while increasing the expression of Bcl-2, an anti-apoptosis factor. Plus, Pg-hWE demonstrated the ability to modulate hormonal balance by regulating the expression of CYP11A1 and CYP17A1, key genes encoding enzymes involved in androgen biosynthesis. Supporting these findings, studies using CHO-K1 cells confirmed that Pg-hWE exerts both anti-apoptotic and antioxidant effects, thereby linking its roles in mitigating PCOS, suppressing cell death, and controlling oxidative stress.</div></div><div><h3>Conclusion</h3><div>Collectively, these results indicate that Pg-hWE ameliorates PCOS-related pathology by reducing oxidative stress, suppressing apoptosis, and supporting hormonal balance, highlighting its promise as a natural therapeutic candidate.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"15 2","pages":"Article 101264"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145576167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early acupuncture exposure and mortality in older adults with ischemic heart disease: A nationwide cohort study in Korea","authors":"Hyungsun Jun ,&nbsp;Dasol Park ,&nbsp;Haerim Kim ,&nbsp;Ye-Seul Lee ,&nbsp;Jungtae Leem","doi":"10.1016/j.imr.2025.101252","DOIUrl":"10.1016/j.imr.2025.101252","url":null,"abstract":"<div><h3>Background</h3><div>Cardiovascular disease is a leading cause of morbidity and mortality in older adults. However, older adults with ischemic heart disease (IHD) are often exposed to risks associated with polypharmacy, and standard treatments may not fully address their complex clinical needs. Therefore, integrative approaches, such as acupuncture, may play a complementary role. This study assessed the association between early acupuncture exposure and mortality among older adults with newly diagnosed IHD.</div></div><div><h3>Methods</h3><div>Using the Korean National Health Insurance Service database, we identified patients aged ≥65 years with newly diagnosed IHD. Those receiving ≥6 acupuncture sessions within six months post-diagnosis formed the acupuncture group; those without any acupuncture formed the conventional group. Primary outcomes were five-year all-cause and circulatory system disease-specific mortality. Exploratory analyses compared regular and irregular acupuncture exposure.</div></div><div><h3>Results</h3><div>Of 9865 patients, 667 received acupuncture. They were younger, included more females, and had more severe disabilities than the conventional group. After adjustment for confounders, the acupuncture group showed lower all-cause mortality (adjusted hazard ratio [aHR] 0.71, 95 % confidence interval [CI] 0.58–0.88) and circulatory system disease-specific mortality (aHR 0.54, 95 % CI 0.34–0.89). Regular acupuncture use conferred further survival benefits over irregular use and no acupuncture.</div></div><div><h3>Conclusions</h3><div>These findings suggest that early-phase acupuncture intervention may play a meaningful role in improving survival outcomes in this population. Prospective studies are needed to confirm these findings and determine causality.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"15 2","pages":"Article 101252"},"PeriodicalIF":3.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}