Integrative Medicine Research最新文献

{"title":"Patient-Focused Drug Development and Real World Study","authors":"Haiyin Hu ,&nbsp;Hui Wang ,&nbsp;Lin Ang ,&nbsp;Menglong Shi ,&nbsp;Xiaolei Wu ,&nbsp;Chenyao Zhang ,&nbsp;Mei Han ,&nbsp;Shigang Liu ,&nbsp;Kai Li ,&nbsp;Junhua Zhang ,&nbsp;Zhaochen Ji","doi":"10.1016/j.imr.2024.101119","DOIUrl":"10.1016/j.imr.2024.101119","url":null,"abstract":"<div><h3>Background</h3><div>Patient-focused drug development (PFDD) is an important direction in the field of medical research and is of great significance to the development of medicine. In recent years, PFDD and real-world study (RWS) have gained much interest, of which both have their advantages. This study aims to promote research methods innovation and optimize clinical research design and implementation.</div></div><div><h3>Methods</h3><div>After a brief introduction of PFDD and RWS, this review focused on the comparison of clinical trials of PFDD and RWS in terms of objectives, Population, Intervention, Comparator, Outcome (PICO) elements, research team members, data acquisition, and research key points, and clarified the feasibility and significance of “patient-focused RWS” research model.</div></div><div><h3>Results</h3><div>PFDD emphasized that patients’ needs as well as the willingness and satisfaction of patients should be considered throughout the whole research process and the patient experience data should be collected during the study development and drug use. RWS emphasized the facticity of research implementation environment and the breadth of patient sources, which concerned the problem of the extrapolation of study results, the clinical localization, and patient applicability of the target drug. However, there is a connection between both of the above. Both clinical trials of PFDD and RWS bring benefits to patients.</div></div><div><h3>Conclusions</h3><div>Combining PFDD idea and RWS research method to carry out new research will maximize the benefits for patients. The study model combining the PFDD concept with RWS can facilitate drug development and dissemination, which can be popularized and applied in various research areas. This study can innovate research methods and provide new ideas for future research.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101119"},"PeriodicalIF":2.8,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143143501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing penetrating needles and non-penetrating needles with electrical stimulation combined with exercise training for relief of dyspnea and improving exercise tolerance in chronic obstructive pulmonary disease patients: A single-blind randomized controlled trial","authors":"Ying He ,&nbsp;Gui-yuan Li ,&nbsp;Chun-zhi Tang ,&nbsp;Li-ming Lu ,&nbsp;Guang-yi Xiong ,&nbsp;Yi Gao ,&nbsp;Juan Tong ,&nbsp;Guang-en Zhong","doi":"10.1016/j.imr.2024.101117","DOIUrl":"10.1016/j.imr.2024.101117","url":null,"abstract":"<div><h3>Background</h3><div>Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation. The purpose of this study was to evaluate the effectiveness of penetrating needles with electrical stimulation combined with exercise training on relieving dyspnea and improving exercise tolerance among COPD patients.</div></div><div><h3>Method</h3><div>A total of 85 patients were recruited and randomly assigned to receive either penetrating needles with electrical stimulation (PE) or non-penetrating needles with electrical stimulation (NPE), 3 times a week, for 8 weeks, totaling 24 treatments. Both groups underwent exercise training. The evaluations were conducted at the baseline, after 14 treatments, and after 24 treatments.</div></div><div><h3>Results</h3><div>The PE group showed significant improvement in 6-minute walk distance (6MWD) after the 14^th treatment. For pulmonary function test, MVV%, MEF50%, MEF75% and MEF25% improved in the PE group, especially MVV% was significantly higher than the NPE group. For cardiopulmonary exercise testing, METs%, VO₂/kg%, V_E%, VO₂/HR%, V_Emax, V_E/VO₂ and V_E/VCO₂ in the PE group improved, especially VO₂/kg%, V_E%, V_Emax, V_E/VO₂ and V_E/VCO₂ were significantly higher than the NPE group. The scores of COPD assessment test in the PE group significantly improved. The scores of modified British Medical Research Council in the PE group was better than the NPE group after the treatment.</div></div><div><h3>Conclusion</h3><div>Penetrating needles with electrical stimulation combined with exercise training may be clinically useful for COPD patients in relieving dyspnea and improving exercise tolerance.</div></div><div><h3>Trial Registration</h3><div>Chinese Clinical Trial Registry, ChiCTR1900028627.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101117"},"PeriodicalIF":2.8,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intranasal acupuncture therapy for allergic rhinitis: A systematic review and meta-analysis of randomized controlled trials","authors":"Xiao-ying Chen ,&nbsp;Qian-yun Wang ,&nbsp;Zhan-feng Yan ,&nbsp;Yu-yang Wang ,&nbsp;Xing-ru Pan ,&nbsp;Meng-yuan Ou ,&nbsp;Xue-han Liu ,&nbsp;Jian-ping Liu ,&nbsp;Xin-yan Jin","doi":"10.1016/j.imr.2024.101116","DOIUrl":"10.1016/j.imr.2024.101116","url":null,"abstract":"<div><h3>Background</h3><div>Allergic rhinitis (AR) is a prevalent allergic condition that affects the nasal mucosa. Intranasal acupuncture therapy (IAT), an innovative therapy that involves precisely inserting acupuncture needles into specific nasal acupoints, has demonstrated potential effects in managing AR. The aim of this study is to evaluate the effectiveness and safety of IAT in the management of AR.</div></div><div><h3>Methods</h3><div>Nine databases were systematically searched for randomized controlled trials (RCTs) from their inception to September 2024. We included participants diagnosed with AR who received IAT alone or as add-on treatment to conventional treatment. The Cochrane risk of bias 2.0 tool and GRADE approach were applied to assess methodological qualities. A meta-analysis was performed using RevMan 5.4.1 software.</div></div><div><h3>Results</h3><div>Twenty-one RCTs with 1889 participants were included. The certainty of evidence was generally low and moderate. Compared to sham acupuncture, IAT significantly reduced the total nasal symptom score (MD −2.65, 95% CI −4.01 to −1.29, 1 RCT, 30 participants, moderate evidence). Compared to an antihistamine, IAT was associated with a lower total non-nasal symptom score (MD −0.44, 95% CI −0.64 to −0.25, 5 RCTs, 295 participants, moderate evidence) and a better quality of life measured by the rhinoconjunctivitis quality of life questionnaire (MD −13.72, 95% CI −18.01 to −9.43, 4 RCTs, 255 participants, moderate evidence). No serious adverse events were reported.</div></div><div><h3>Conclusion</h3><div>IAT may be beneficial in improving AR-related symptoms and quality of life. However, the safety of IAT remains unclear due to inadequate reporting. Further high-quality, rigorously designed, and well-reported trials are required.</div></div><div><h3>Protocol registration</h3><div>PROSPERO, CRD42024526357.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101116"},"PeriodicalIF":2.8,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143143506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovering the key symptoms for identifying patterns in functional dyspepsia patients: Doctor's decision and machine learning","authors":"Da-Eun Yoon ,&nbsp;Heeyoung Moon ,&nbsp;In-Seon Lee ,&nbsp;Younbyoung Chae","doi":"10.1016/j.imr.2024.101115","DOIUrl":"10.1016/j.imr.2024.101115","url":null,"abstract":"<div><h3>Background</h3><div>Pattern identification is a crucial diagnostic process in Traditional East Asian Medicine, classifying patients with similar symptom patterns. This study aims to identify key symptoms for distinguishing patterns in patients with functional dyspepsia (FD) using explicit (doctor's decision-based) and implicit (computational model-based) approaches.</div></div><div><h3>Methods</h3><div>Data from twenty-one FD patients were collected from local clinics of traditional Korean Medicine and provided to three doctors in a standardized format. Each doctor identified patterns among three types: spleen-stomach weakness, spleen deficiency with qi stagnation/liver-stomach disharmony, and food retention. Doctors evaluated the importance of the symptoms indicated by items in the Standard Tool for Pattern Identification of Functional Dyspepsia questionnaire. Explicit importance was determined through doctors’ survey by general evaluation and by selecting specific information used for the diagnosis of patient cases. Implicit importance was assessed by feature importance from the random forest classification models, which classify three types for general differentiation and perform binary classification for specific types.</div></div><div><h3>Results</h3><div>Key symptoms for distinguishing FD patterns were identified using two approaches. Explicit importance highlighted dietary and nausea-related symptoms, while implicit importance identified complexion or chest tightness as generally crucial. Specific symptoms important for particular pattern types were also identified, and significant correlation between implicit and explicit importance scores was observed for types 1 and 3.</div></div><div><h3>Conclusion</h3><div>This study showed important clinical information for differentiating FD patients using real patient data. Our findings suggest that these approaches can contribute to developing tools for pattern identification with enhanced accuracy and reliability.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101115"},"PeriodicalIF":2.8,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effectiveness of traditional East Asian medicine treatments for temporomandibular joint disorders: A systematic review and network meta-analysis","authors":"Seojung Ha ,&nbsp;Sung-Woo Kang ,&nbsp;Sanghoon Lee","doi":"10.1016/j.imr.2024.101114","DOIUrl":"10.1016/j.imr.2024.101114","url":null,"abstract":"<div><h3>Background</h3><div>Temporomandibular joint disorders (TMDs) cause pain and functional restrictions in the temporomandibular joint that interfere with daily activities. This study aimed to evaluate and compare the effectiveness and safety of various traditional East Asian medicine treatments, including acupuncture, electroacupuncture, moxibustion, and herbal medicine, in the management of TMD.</div></div><div><h3>Methods</h3><div>We included searches of MEDLINE, CENTRAL, EMBASE, AMED, CINAHL, OASIS, KISS, RISS, KMbase, KCI, CNKI, and CiNii from inception to November 12, 2023, for randomized controlled trials of traditional East Asian medicine treatments in patients with TMD. A network meta-analysis was performed using frequentist methods, and the Confidence In Network Meta-Analysis methodology were employed to assess evidence quality.</div></div><div><h3>Results</h3><div>Forty-five studies with 2,211 participants were finally included. Acupotomy (Mean difference (MD) -5.07, 95 % Confidence interval (CI) -7.37 to -2.78) and acupuncture (MD -1.18, 95 % CI -2.28 to -0.09) showed statistically significant superiority in reducing pain intensity compared to sham treatment. According to the SUCRA rankings, acupotomy was considered the most effective treatment, followed by electroacupuncture, acupuncture, manipulation, laser therapy and occlusal splint. A total of 12 studies reported incidence of adverse events, and none were serious adverse events.</div></div><div><h3>Conclusion</h3><div>Acupotomy and acupuncture could be more beneficial than sham treatment in pain relief and might be a better option than occlusal splint. However, future rigorous, well-designed trials are needed to draw clear conclusions.</div></div><div><h3>Protocol registration</h3><div>PROSPERO (CRD42023467340).</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101114"},"PeriodicalIF":2.8,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143143507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture for acute ischemic stroke: A systematic review and meta-analysis of randomized controlled trials","authors":"Shanshan Huang ,&nbsp;Yuting Wang ,&nbsp;Yifan Wu ,&nbsp;Puchen Huang ,&nbsp;Yu Dong ,&nbsp;Qiao Zhang ,&nbsp;Mengjiao Zhao ,&nbsp;Jingchun Zeng ,&nbsp;Liming Lu ,&nbsp;Xinxia Liu","doi":"10.1016/j.imr.2024.101092","DOIUrl":"10.1016/j.imr.2024.101092","url":null,"abstract":"<div><h3>Objective</h3><div>Assess the safety and effectiveness of acupuncture for acute ischemic stroke (AIS).</div></div><div><h3>Methods</h3><div>We conducted a comprehensive search across the PubMed, Cochrane Library, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), Wanfang, and SinoMed databases from their inception until October 3, 2023. Two reviewers screened eligible randomized controlled trials (RCTs) according to criteria and extracted data using a pre-established form. Cochrane tool was used for risk of bias assessment, and Revman 5.3 was used for subsequent meta-analysis. The GRADE tool will be used to assess the quality of evidence.</div></div><div><h3>Results</h3><div>Thirty-one RCTs were included, involving 3604 patients. Meta-analysis showed that compared with conventional treatments (CTs), acupuncture combined with CTs could improve in National Institutes of Health Stroke Scale (NIHSS) and Efficiency (MD:1.70, 95 %CI [-2.27, -1.14], <em>P</em> &lt; 0.00001;RR: 1.21, 95 %CI [1.12, 1.31], <em>P</em> &lt; 0.00001,);On the Chinese Stroke Scale (CSS) and effectiveness based on CSS, acupuncture showed positive effects (MD:4.33, 95 %CI [-5.67, -2.98], <em>P</em> &lt; 0.00001; RR: 1.26, 95 %CI [1.13, 1.41], <em>P</em> &lt; 0.0001). Furthermore, ADL, Fugl-Meyer Assessment Scale (FMA), prognosis analyses also showed the effectiveness of acupuncture. (SMD: 0.98, 95 % CI [0.64, 1.31], <em>P</em> &lt; 0.00001; MD: 16.46, 95 %CI [12.56, 20.35], <em>P</em> &lt; 0.00001; RR: 0.38, 95 %CI [0.16, 0.89], <em>P</em> = 0.03). However, the certainty of evidence was low.</div></div><div><h3>Conclusion</h3><div>According to current evidence, Acupuncture may be effective and safe for AIS. The future still needs high-quality evidence to support this conclusion.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 4","pages":"Article 101092"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and safety of combined treatment with herbal medicines and palliative chemotherapy for advanced gastric cancer: A systematic review, and meta-analysis","authors":"Dong-Hyeon Kim ,&nbsp;Soo-Dam Kim ,&nbsp;Hyeong-Joon Jun ,&nbsp;Eun-Bin Kwag ,&nbsp;Sang-Won Shin ,&nbsp;Hwa-Seung Yoo ,&nbsp;So-Jung Park","doi":"10.1016/j.imr.2024.101098","DOIUrl":"10.1016/j.imr.2024.101098","url":null,"abstract":"<div><h3>Background</h3><div>Advanced gastric cancer (AGC) is a leading cause of cancer-related deaths worldwide, with its treatment complicated by challenges such as high recurrence rates, severe side effects, and limited effectiveness of current therapies. Herbal medicine (HM) has emerged as an adjunct to palliative chemotherapy (PC), potentially improving tumor response and reducing side effects. This study conducted a meta-analysis to evaluate the effectiveness and safety of HM in palliative therapy for inoperable stage Ⅲ and Ⅳ AGC patients.</div></div><div><h3>Methods</h3><div>Databases were searched until August 2023, encompassing 10 electronic databases, including PubMed, Embase, Cochrane Library, CNKI, and ScienceON. The inclusion criteria focused on randomized controlled trials (RCTs) combining herbal medicine with palliative therapy for patients with AGC. Primary outcomes assessed were tumor response rates, overall survival, adverse drug reactions (ADRs), and patients' quality of life (QoL).</div></div><div><h3>Results</h3><div>In our analysis of 101 RCTs comparing PC alone to PC combined with HM, the meta-analysis demonstrated statistically significant improvements in overall response rate (ORR), disease control rate (DCR), survival rates, as well as a reduction in adverse drug reactions (ADRs) and an enhancement in quality of life (QoL) for patients receiving HM in combination with PC (<em>p</em> &lt; 0.00001, I² = 0 %).</div></div><div><h3>Conclusion</h3><div>The combination of HM with PC significantly enhances tumor response and survival rates while reducing overall adverse drug reactions (ADRs) and improving quality of life (QoL) in patients with stage Ⅲ and Ⅳ AGC. HMs not only improve the efficacy of PC but also help alleviate side effects, including myelosuppression, digestive symptoms, nausea, vomiting, diarrhea, liver and renal injuries, and neurotoxicity.</div><div>Protocol registration: PROSPERO, CRD 42022354133.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101098"},"PeriodicalIF":2.8,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143142876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of 8-week Theracurmin Super (TS-P1; Curcumin) supplementation on exercise-induced oxidative stress: A randomised, double-blind, placebo-controlled parallel clinical trial","authors":"Xinxing Li ,&nbsp;Dae Young Kim ,&nbsp;Yunho Sung ,&nbsp;Donghyun Kim ,&nbsp;Seohyun Ahn ,&nbsp;Hyejung Shin ,&nbsp;Nur Afiqah Binti Zulkifli ,&nbsp;Ji-won Seo ,&nbsp;Shu Jiang ,&nbsp;Parivash Jamrasi ,&nbsp;SoYoung Ahn ,&nbsp;Jun Hyun Bae ,&nbsp;HeeKyung Yeo ,&nbsp;Hayoung Park ,&nbsp;Wook Song","doi":"10.1016/j.imr.2024.101099","DOIUrl":"10.1016/j.imr.2024.101099","url":null,"abstract":"<div><h3>Background</h3><div>Given curcumin's antioxidant properties, this study aimed to determine the effectiveness and safety of Theracurmin Super supplementation in mitigating exercise-induced oxidative stress in healthy adults.</div></div><div><h3>Methods</h3><div>Seventy-one healthy adults participated in this study, which was conducted at Seoul National University from April 2022 to March 2023. Eligibility was determined during visit 1 through maximum oxygen consumption assessed using the Bruce Treadmill protocol. In visit 2, participants were randomly allocated to either the Theracurmin Super supplement group (TG, <em>n</em> = 36) or Placebo supplement group (PG, <em>n</em> = 35). Over 8 weeks, participants consumed Theracurmin Super (curcumin, 120 mg/day) or Placebo (curcumin, 0 mg/day) twice daily and visited the laboratory four times. Various parameters, including body composition, vital signs, nutrition quotient for adults, cardiorespiratory endurance, blood biomarkers, and adverse events, were assessed at each visit. Statistical analyses included per-protocol analysis, <em>t</em>-tests for group and within-group differences, and two-way ANOVA.</div></div><div><h3>Results</h3><div>In week 8, blood biomarkers linked to oxidative stress, including TBARs, MDA, 8-OHdG, SOD, TOS, and OSI, showed significant group- and week-related interactions (total oxidant status: resting state <em>P</em> = 0.021; oxidative stress index, resting state <em>P</em> = 0.020, end of exercise, <em>P</em> = 0.013). Notably, the TG showed a significant decrease in total oxidant status (resting state <em>P</em> = 0.041) and oxidative stress index (resting state <em>P</em> = 0.018 and end of exercise <em>P</em> = 0.008) between weeks 0 and 8. However, MDA and 8-OHdG levels did not show statistically significant changes.</div></div><div><h3>Conclusion</h3><div>Theracurmin Super effectively reduced oxidative stress before and after exercise, highlighting curcumin's promising role in managing oxidative stress. Significant improvements in TOS and OSI were observed, although changes in MDA and 8-OHdG levels were not statistically significant. Further research could provide insights into these mixed results across different oxidative biomarkers.</div></div><div><h3>Trial registration</h3><div>Clinical Research Information Service (CRIS): KCT0008731.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101099"},"PeriodicalIF":2.8,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methods for identifying health status from routinely collected health data: An overview","authors":"Mei Liu ,&nbsp;Ke Deng ,&nbsp;Mingqi Wang ,&nbsp;Qiao He ,&nbsp;Jiayue Xu ,&nbsp;Guowei Li ,&nbsp;Kang Zou ,&nbsp;Xin Sun ,&nbsp;Wen Wang","doi":"10.1016/j.imr.2024.101100","DOIUrl":"10.1016/j.imr.2024.101100","url":null,"abstract":"<div><div>Routinely collected health data (RCD) are currently accelerating publications that evaluate the effectiveness and safety of medicines and medical devices. One of the fundamental steps in using these data is developing algorithms to identify health status that can be used for observational studies. However, the process and methodologies for identifying health status from RCD remain insufficiently understood. While most current methods rely on International Classification of Diseases (ICD) codes, they may not be universally applicable. Although machine learning methods hold promise for more accurately identifying the health status, they remain underutilized in RCD studies. To address these significant methodological gaps, we outline key steps and methodological considerations for identifying health statuses in observational studies using RCD. This review has the potential to boost the credibility of findings from observational studies that use RCD.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101100"},"PeriodicalIF":2.8,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The case for data sharing in traditional, complementary, and integrative medicine research","authors":"Jeremy Y. Ng","doi":"10.1016/j.imr.2024.101101","DOIUrl":"10.1016/j.imr.2024.101101","url":null,"abstract":"<div><div>Traditional, complementary, and integrative medicine (TCIM) research encompasses a diverse range of health practices rooted in various cultural, philosophical, and historical frameworks. As global interest in conducting research in this field grows, the need for rigorous research to support the integration of evidence-based TCIM therapies into mainstream healthcare has become essential. Data sharing is critical to advancing TCIM research by enhancing reproducibility, fostering interdisciplinary collaboration, promoting ethical practices, and addressing global health challenges. Despite its benefits, numerous challenges are associated with data sharing in TCIM, including a lack of standardized practices, cultural sensitivity, intellectual property concerns, and technical barriers in resource-limited settings. This editorial explores the unique nature of TCIM research, emphasizing the importance of data sharing while acknowledging the complexities it entails. Implementing the CARE Principles for Indigenous Data Governance, which prioritize collective benefit, authority to control, responsibility, and ethics, offers a framework for ensuring that data sharing respects indigenous knowledge and cultural sensitivities. Strategies for overcoming barriers to data sharing include developing standardized protocols, investing in research infrastructure, and fostering a culture of openness and collaboration within the TCIM community and beyond. By advancing data sharing practices, TCIM research can contribute to evidence-based healthcare solutions and address global health disparities, ultimately improving health outcomes worldwide.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101101"},"PeriodicalIF":2.8,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}