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Discovering the key symptoms for identifying patterns in functional dyspepsia patients: Doctor's decision and machine learning
IF 2.8 4区 医学
Integrative Medicine Research Pub Date : 2024-12-12 DOI: 10.1016/j.imr.2024.101115
Da-Eun Yoon , Heeyoung Moon , In-Seon Lee , Younbyoung Chae
{"title":"Discovering the key symptoms for identifying patterns in functional dyspepsia patients: Doctor's decision and machine learning","authors":"Da-Eun Yoon ,&nbsp;Heeyoung Moon ,&nbsp;In-Seon Lee ,&nbsp;Younbyoung Chae","doi":"10.1016/j.imr.2024.101115","DOIUrl":"10.1016/j.imr.2024.101115","url":null,"abstract":"<div><h3>Background</h3><div>Pattern identification is a crucial diagnostic process in Traditional East Asian Medicine, classifying patients with similar symptom patterns. This study aims to identify key symptoms for distinguishing patterns in patients with functional dyspepsia (FD) using explicit (doctor's decision-based) and implicit (computational model-based) approaches.</div></div><div><h3>Methods</h3><div>Data from twenty-one FD patients were collected from local clinics of traditional Korean Medicine and provided to three doctors in a standardized format. Each doctor identified patterns among three types: spleen-stomach weakness, spleen deficiency with qi stagnation/liver-stomach disharmony, and food retention. Doctors evaluated the importance of the symptoms indicated by items in the Standard Tool for Pattern Identification of Functional Dyspepsia questionnaire. Explicit importance was determined through doctors’ survey by general evaluation and by selecting specific information used for the diagnosis of patient cases. Implicit importance was assessed by feature importance from the random forest classification models, which classify three types for general differentiation and perform binary classification for specific types.</div></div><div><h3>Results</h3><div>Key symptoms for distinguishing FD patterns were identified using two approaches. Explicit importance highlighted dietary and nausea-related symptoms, while implicit importance identified complexion or chest tightness as generally crucial. Specific symptoms important for particular pattern types were also identified, and significant correlation between implicit and explicit importance scores was observed for types 1 and 3.</div></div><div><h3>Conclusion</h3><div>This study showed important clinical information for differentiating FD patients using real patient data. Our findings suggest that these approaches can contribute to developing tools for pattern identification with enhanced accuracy and reliability.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101115"},"PeriodicalIF":2.8,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative effectiveness of traditional East Asian medicine treatments for temporomandibular joint disorders: A systematic review and network meta-analysis
IF 2.8 4区 医学
Integrative Medicine Research Pub Date : 2024-12-02 DOI: 10.1016/j.imr.2024.101114
Seojung Ha , Sung-Woo Kang , Sanghoon Lee
{"title":"Comparative effectiveness of traditional East Asian medicine treatments for temporomandibular joint disorders: A systematic review and network meta-analysis","authors":"Seojung Ha ,&nbsp;Sung-Woo Kang ,&nbsp;Sanghoon Lee","doi":"10.1016/j.imr.2024.101114","DOIUrl":"10.1016/j.imr.2024.101114","url":null,"abstract":"<div><h3>Background</h3><div>Temporomandibular joint disorders (TMDs) cause pain and functional restrictions in the temporomandibular joint that interfere with daily activities. This study aimed to evaluate and compare the effectiveness and safety of various traditional East Asian medicine treatments, including acupuncture, electroacupuncture, moxibustion, and herbal medicine, in the management of TMD.</div></div><div><h3>Methods</h3><div>We included searches of MEDLINE, CENTRAL, EMBASE, AMED, CINAHL, OASIS, KISS, RISS, KMbase, KCI, CNKI, and CiNii from inception to November 12, 2023, for randomized controlled trials of traditional East Asian medicine treatments in patients with TMD. A network meta-analysis was performed using frequentist methods, and the Confidence In Network Meta-Analysis methodology were employed to assess evidence quality.</div></div><div><h3>Results</h3><div>Forty-five studies with 2,211 participants were finally included. Acupotomy (Mean difference (MD) -5.07, 95 % Confidence interval (CI) -7.37 to -2.78) and acupuncture (MD -1.18, 95 % CI -2.28 to -0.09) showed statistically significant superiority in reducing pain intensity compared to sham treatment. According to the SUCRA rankings, acupotomy was considered the most effective treatment, followed by electroacupuncture, acupuncture, manipulation, laser therapy and occlusal splint. A total of 12 studies reported incidence of adverse events, and none were serious adverse events.</div></div><div><h3>Conclusion</h3><div>Acupotomy and acupuncture could be more beneficial than sham treatment in pain relief and might be a better option than occlusal splint. However, future rigorous, well-designed trials are needed to draw clear conclusions.</div></div><div><h3>Protocol registration</h3><div>PROSPERO (CRD42023467340).</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101114"},"PeriodicalIF":2.8,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143143507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acupuncture for acute ischemic stroke: A systematic review and meta-analysis of randomized controlled trials 针刺治疗急性缺血性脑卒中:随机对照试验的系统回顾和荟萃分析
IF 2.8 4区 医学
Integrative Medicine Research Pub Date : 2024-12-01 DOI: 10.1016/j.imr.2024.101092
Shanshan Huang , Yuting Wang , Yifan Wu , Puchen Huang , Yu Dong , Qiao Zhang , Mengjiao Zhao , Jingchun Zeng , Liming Lu , Xinxia Liu
{"title":"Acupuncture for acute ischemic stroke: A systematic review and meta-analysis of randomized controlled trials","authors":"Shanshan Huang ,&nbsp;Yuting Wang ,&nbsp;Yifan Wu ,&nbsp;Puchen Huang ,&nbsp;Yu Dong ,&nbsp;Qiao Zhang ,&nbsp;Mengjiao Zhao ,&nbsp;Jingchun Zeng ,&nbsp;Liming Lu ,&nbsp;Xinxia Liu","doi":"10.1016/j.imr.2024.101092","DOIUrl":"10.1016/j.imr.2024.101092","url":null,"abstract":"<div><h3>Objective</h3><div>Assess the safety and effectiveness of acupuncture for acute ischemic stroke (AIS).</div></div><div><h3>Methods</h3><div>We conducted a comprehensive search across the PubMed, Cochrane Library, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), Wanfang, and SinoMed databases from their inception until October 3, 2023. Two reviewers screened eligible randomized controlled trials (RCTs) according to criteria and extracted data using a pre-established form. Cochrane tool was used for risk of bias assessment, and Revman 5.3 was used for subsequent meta-analysis. The GRADE tool will be used to assess the quality of evidence.</div></div><div><h3>Results</h3><div>Thirty-one RCTs were included, involving 3604 patients. Meta-analysis showed that compared with conventional treatments (CTs), acupuncture combined with CTs could improve in National Institutes of Health Stroke Scale (NIHSS) and Efficiency (MD:1.70, 95 %CI [-2.27, -1.14], <em>P</em> &lt; 0.00001;RR: 1.21, 95 %CI [1.12, 1.31], <em>P</em> &lt; 0.00001,);On the Chinese Stroke Scale (CSS) and effectiveness based on CSS, acupuncture showed positive effects (MD:4.33, 95 %CI [-5.67, -2.98], <em>P</em> &lt; 0.00001; RR: 1.26, 95 %CI [1.13, 1.41], <em>P</em> &lt; 0.0001). Furthermore, ADL, Fugl-Meyer Assessment Scale (FMA), prognosis analyses also showed the effectiveness of acupuncture. (SMD: 0.98, 95 % CI [0.64, 1.31], <em>P</em> &lt; 0.00001; MD: 16.46, 95 %CI [12.56, 20.35], <em>P</em> &lt; 0.00001; RR: 0.38, 95 %CI [0.16, 0.89], <em>P</em> = 0.03). However, the certainty of evidence was low.</div></div><div><h3>Conclusion</h3><div>According to current evidence, Acupuncture may be effective and safe for AIS. The future still needs high-quality evidence to support this conclusion.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 4","pages":"Article 101092"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness and safety of combined treatment with herbal medicines and palliative chemotherapy for advanced gastric cancer: A systematic review, and meta-analysis
IF 2.8 4区 医学
Integrative Medicine Research Pub Date : 2024-11-22 DOI: 10.1016/j.imr.2024.101098
Dong-Hyeon Kim , Soo-Dam Kim , Hyeong-Joon Jun , Eun-Bin Kwag , Sang-Won Shin , Hwa-Seung Yoo , So-Jung Park
{"title":"Effectiveness and safety of combined treatment with herbal medicines and palliative chemotherapy for advanced gastric cancer: A systematic review, and meta-analysis","authors":"Dong-Hyeon Kim ,&nbsp;Soo-Dam Kim ,&nbsp;Hyeong-Joon Jun ,&nbsp;Eun-Bin Kwag ,&nbsp;Sang-Won Shin ,&nbsp;Hwa-Seung Yoo ,&nbsp;So-Jung Park","doi":"10.1016/j.imr.2024.101098","DOIUrl":"10.1016/j.imr.2024.101098","url":null,"abstract":"<div><h3>Background</h3><div>Advanced gastric cancer (AGC) is a leading cause of cancer-related deaths worldwide, with its treatment complicated by challenges such as high recurrence rates, severe side effects, and limited effectiveness of current therapies. Herbal medicine (HM) has emerged as an adjunct to palliative chemotherapy (PC), potentially improving tumor response and reducing side effects. This study conducted a meta-analysis to evaluate the effectiveness and safety of HM in palliative therapy for inoperable stage Ⅲ and Ⅳ AGC patients.</div></div><div><h3>Methods</h3><div>Databases were searched until August 2023, encompassing 10 electronic databases, including PubMed, Embase, Cochrane Library, CNKI, and ScienceON. The inclusion criteria focused on randomized controlled trials (RCTs) combining herbal medicine with palliative therapy for patients with AGC. Primary outcomes assessed were tumor response rates, overall survival, adverse drug reactions (ADRs), and patients' quality of life (QoL).</div></div><div><h3>Results</h3><div>In our analysis of 101 RCTs comparing PC alone to PC combined with HM, the meta-analysis demonstrated statistically significant improvements in overall response rate (ORR), disease control rate (DCR), survival rates, as well as a reduction in adverse drug reactions (ADRs) and an enhancement in quality of life (QoL) for patients receiving HM in combination with PC (<em>p</em> &lt; 0.00001, I² = 0 %).</div></div><div><h3>Conclusion</h3><div>The combination of HM with PC significantly enhances tumor response and survival rates while reducing overall adverse drug reactions (ADRs) and improving quality of life (QoL) in patients with stage Ⅲ and Ⅳ AGC. HMs not only improve the efficacy of PC but also help alleviate side effects, including myelosuppression, digestive symptoms, nausea, vomiting, diarrhea, liver and renal injuries, and neurotoxicity.</div><div>Protocol registration: PROSPERO, CRD 42022354133.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101098"},"PeriodicalIF":2.8,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143142876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of 8-week Theracurmin Super (TS-P1; Curcumin) supplementation on exercise-induced oxidative stress: A randomised, double-blind, placebo-controlled parallel clinical trial
IF 2.8 4区 医学
Integrative Medicine Research Pub Date : 2024-11-15 DOI: 10.1016/j.imr.2024.101099
Xinxing Li , Dae Young Kim , Yunho Sung , Donghyun Kim , Seohyun Ahn , Hyejung Shin , Nur Afiqah Binti Zulkifli , Ji-won Seo , Shu Jiang , Parivash Jamrasi , SoYoung Ahn , Jun Hyun Bae , HeeKyung Yeo , Hayoung Park , Wook Song
{"title":"Effects of 8-week Theracurmin Super (TS-P1; Curcumin) supplementation on exercise-induced oxidative stress: A randomised, double-blind, placebo-controlled parallel clinical trial","authors":"Xinxing Li ,&nbsp;Dae Young Kim ,&nbsp;Yunho Sung ,&nbsp;Donghyun Kim ,&nbsp;Seohyun Ahn ,&nbsp;Hyejung Shin ,&nbsp;Nur Afiqah Binti Zulkifli ,&nbsp;Ji-won Seo ,&nbsp;Shu Jiang ,&nbsp;Parivash Jamrasi ,&nbsp;SoYoung Ahn ,&nbsp;Jun Hyun Bae ,&nbsp;HeeKyung Yeo ,&nbsp;Hayoung Park ,&nbsp;Wook Song","doi":"10.1016/j.imr.2024.101099","DOIUrl":"10.1016/j.imr.2024.101099","url":null,"abstract":"<div><h3>Background</h3><div>Given curcumin's antioxidant properties, this study aimed to determine the effectiveness and safety of Theracurmin Super supplementation in mitigating exercise-induced oxidative stress in healthy adults.</div></div><div><h3>Methods</h3><div>Seventy-one healthy adults participated in this study, which was conducted at Seoul National University from April 2022 to March 2023. Eligibility was determined during visit 1 through maximum oxygen consumption assessed using the Bruce Treadmill protocol. In visit 2, participants were randomly allocated to either the Theracurmin Super supplement group (TG, <em>n</em> = 36) or Placebo supplement group (PG, <em>n</em> = 35). Over 8 weeks, participants consumed Theracurmin Super (curcumin, 120 mg/day) or Placebo (curcumin, 0 mg/day) twice daily and visited the laboratory four times. Various parameters, including body composition, vital signs, nutrition quotient for adults, cardiorespiratory endurance, blood biomarkers, and adverse events, were assessed at each visit. Statistical analyses included per-protocol analysis, <em>t</em>-tests for group and within-group differences, and two-way ANOVA.</div></div><div><h3>Results</h3><div>In week 8, blood biomarkers linked to oxidative stress, including TBARs, MDA, 8-OHdG, SOD, TOS, and OSI, showed significant group- and week-related interactions (total oxidant status: resting state <em>P</em> = 0.021; oxidative stress index, resting state <em>P</em> = 0.020, end of exercise, <em>P</em> = 0.013). Notably, the TG showed a significant decrease in total oxidant status (resting state <em>P</em> = 0.041) and oxidative stress index (resting state <em>P</em> = 0.018 and end of exercise <em>P</em> = 0.008) between weeks 0 and 8. However, MDA and 8-OHdG levels did not show statistically significant changes.</div></div><div><h3>Conclusion</h3><div>Theracurmin Super effectively reduced oxidative stress before and after exercise, highlighting curcumin's promising role in managing oxidative stress. Significant improvements in TOS and OSI were observed, although changes in MDA and 8-OHdG levels were not statistically significant. Further research could provide insights into these mixed results across different oxidative biomarkers.</div></div><div><h3>Trial registration</h3><div>Clinical Research Information Service (CRIS): KCT0008731.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101099"},"PeriodicalIF":2.8,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Methods for identifying health status from routinely collected health data: An overview
IF 2.8 4区 医学
Integrative Medicine Research Pub Date : 2024-11-15 DOI: 10.1016/j.imr.2024.101100
Mei Liu , Ke Deng , Mingqi Wang , Qiao He , Jiayue Xu , Guowei Li , Kang Zou , Xin Sun , Wen Wang
{"title":"Methods for identifying health status from routinely collected health data: An overview","authors":"Mei Liu ,&nbsp;Ke Deng ,&nbsp;Mingqi Wang ,&nbsp;Qiao He ,&nbsp;Jiayue Xu ,&nbsp;Guowei Li ,&nbsp;Kang Zou ,&nbsp;Xin Sun ,&nbsp;Wen Wang","doi":"10.1016/j.imr.2024.101100","DOIUrl":"10.1016/j.imr.2024.101100","url":null,"abstract":"<div><div>Routinely collected health data (RCD) are currently accelerating publications that evaluate the effectiveness and safety of medicines and medical devices. One of the fundamental steps in using these data is developing algorithms to identify health status that can be used for observational studies. However, the process and methodologies for identifying health status from RCD remain insufficiently understood. While most current methods rely on International Classification of Diseases (ICD) codes, they may not be universally applicable. Although machine learning methods hold promise for more accurately identifying the health status, they remain underutilized in RCD studies. To address these significant methodological gaps, we outline key steps and methodological considerations for identifying health statuses in observational studies using RCD. This review has the potential to boost the credibility of findings from observational studies that use RCD.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101100"},"PeriodicalIF":2.8,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The case for data sharing in traditional, complementary, and integrative medicine research 在传统、补充和综合医学研究中共享数据的案例。
IF 2.8 4区 医学
Integrative Medicine Research Pub Date : 2024-11-14 DOI: 10.1016/j.imr.2024.101101
Jeremy Y. Ng
{"title":"The case for data sharing in traditional, complementary, and integrative medicine research","authors":"Jeremy Y. Ng","doi":"10.1016/j.imr.2024.101101","DOIUrl":"10.1016/j.imr.2024.101101","url":null,"abstract":"<div><div>Traditional, complementary, and integrative medicine (TCIM) research encompasses a diverse range of health practices rooted in various cultural, philosophical, and historical frameworks. As global interest in conducting research in this field grows, the need for rigorous research to support the integration of evidence-based TCIM therapies into mainstream healthcare has become essential. Data sharing is critical to advancing TCIM research by enhancing reproducibility, fostering interdisciplinary collaboration, promoting ethical practices, and addressing global health challenges. Despite its benefits, numerous challenges are associated with data sharing in TCIM, including a lack of standardized practices, cultural sensitivity, intellectual property concerns, and technical barriers in resource-limited settings. This editorial explores the unique nature of TCIM research, emphasizing the importance of data sharing while acknowledging the complexities it entails. Implementing the CARE Principles for Indigenous Data Governance, which prioritize collective benefit, authority to control, responsibility, and ethics, offers a framework for ensuring that data sharing respects indigenous knowledge and cultural sensitivities. Strategies for overcoming barriers to data sharing include developing standardized protocols, investing in research infrastructure, and fostering a culture of openness and collaboration within the TCIM community and beyond. By advancing data sharing practices, TCIM research can contribute to evidence-based healthcare solutions and address global health disparities, ultimately improving health outcomes worldwide.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101101"},"PeriodicalIF":2.8,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of electroacupuncture on internal carotid artery blood flow in patients undergoing laparoscopic gallbladder surgery: A randomized clinical trial 电针对腹腔镜胆囊手术患者颈内动脉血流的影响:随机临床试验
IF 2.8 4区 医学
Integrative Medicine Research Pub Date : 2024-11-02 DOI: 10.1016/j.imr.2024.101097
Lili Hu , Yongyan Zhang , Ying Li , Ruiping Wang , Hua Xu
{"title":"Effect of electroacupuncture on internal carotid artery blood flow in patients undergoing laparoscopic gallbladder surgery: A randomized clinical trial","authors":"Lili Hu ,&nbsp;Yongyan Zhang ,&nbsp;Ying Li ,&nbsp;Ruiping Wang ,&nbsp;Hua Xu","doi":"10.1016/j.imr.2024.101097","DOIUrl":"10.1016/j.imr.2024.101097","url":null,"abstract":"<div><h3>Background</h3><div>Little is known about the effect of electroacupuncture (EA) on cerebral blood flow. We investigated this question in patients undergoing laparoscopic cholecystectomy, hypothesizing that EA would increase cerebral blood flow during surgery.</div></div><div><h3>Methods</h3><div>Eighty-two patients undergoing laparoscopic cholecystectomy were randomly divided into receiving electroacupuncture and intravenous anesthesia (EA+IA) and receving intravenous anesthesia alone (IA). The patients in EA+IA were treated with EA at Baihui (GV 20), Shuigou (GV 26), unilateral Neiguan (PC 6) and unilateral Zusanli (ST 36) points 20 min before anesthesia until the end of the operation. The patients in IA received intravenous anesthesia alone. The internal carotid artery blood flow (Q), mean arterial pressure (MAP), end-tidal carbon dioxide pressure (P<sub>ET</sub>CO<sub>2</sub>) and heart rate (HR) were recorded respectively before anesthesia induction (T<sub>1</sub>), 2 min after anesthesia induction (T<sub>2</sub>), 1 min after pneumoperitoneum (T<sub>3</sub>), 1 min after head-up tilt (T<sub>4</sub>) and after anesthesia resuscitation (T<sub>5</sub>).</div></div><div><h3>Results</h3><div>The internal carotid artery blood flow was significantly higher in EA+IA (mean [SD], T<sub>3</sub>, 294.0 [89.6] ml min<sup>-1</sup>; T<sub>4</sub>, 303.8 [90.6] ml min<sup>-1</sup>) than in IA (mean [SD], T<sub>3</sub>, 246.4 [80.9] ml min<sup>-1</sup>; T4, 253.5 [78.4] ml min<sup>-1</sup>) at T<sub>3</sub> and T<sub>4</sub> (<em>P</em> &lt; 0.05). There was no difference in blood flow between the two groups at T<sub>2</sub> and T<sub>5</sub>. As compared with baseline (T<sub>1</sub>), the internal carotid artery blood flow decreased at T<sub>2</sub>-T<sub>4</sub> in two groups (<em>P</em> &lt; 0.05). There were no differences in MAP, P<sub>ET</sub>CO<sub>2</sub>, and HR between the two groups.</div></div><div><h3>Conclusion</h3><div>Electroacupuncture intervention could reduce the decline of internal carotid artery blood flow in patients undergoing laparoscopic cholecystectomy.</div></div><div><h3>Trial registration</h3><div>ChiCTR: 2,100,041,761.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 4","pages":"Article 101097"},"PeriodicalIF":2.8,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142705670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of and factors associated with trauma surgeons' referral and patients' willingness to acupuncture treatment after traumatic rib fractures: A single-center cross-sectional study 创伤性肋骨骨折后外科医生转诊及患者愿意接受针灸治疗的普遍性及相关因素:单中心横断面研究
IF 2.8 4区 医学
Integrative Medicine Research Pub Date : 2024-10-29 DOI: 10.1016/j.imr.2024.101096
Min Ha Kim , Hyun Min Cho , Seon Hee Kim , Youngwoong Kim , Yu Kyung Shin , Kun Hyung Kim
{"title":"Prevalence of and factors associated with trauma surgeons' referral and patients' willingness to acupuncture treatment after traumatic rib fractures: A single-center cross-sectional study","authors":"Min Ha Kim ,&nbsp;Hyun Min Cho ,&nbsp;Seon Hee Kim ,&nbsp;Youngwoong Kim ,&nbsp;Yu Kyung Shin ,&nbsp;Kun Hyung Kim","doi":"10.1016/j.imr.2024.101096","DOIUrl":"10.1016/j.imr.2024.101096","url":null,"abstract":"<div><h3>Background</h3><div>Pain after traumatic rib fractures (TRF) detrimentally affects the injured. Multidisciplinary pain management is crucial for patient care. There is little empirical evidence on acupuncture as a multidisciplinary treatment for patients with TRF. This study aimed to illustrate the characteristics of the patients referred for or received acupuncture and explore the associated factors.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional study of Korean Trauma Data Bank and electronic medical records of patients aged 19 or older with TRF from August 2016 to October 2021 in the regional trauma center of Pusan National University Hospital. The sociodemographic and clinical characteristics of patients referred for acupuncture by trauma surgeons and those who received acupuncture were analysed descriptively. In multivariable logistic regression analyses, associations between covariates and either surgeon referrals for or patient willingness to receive acupuncture were quantitatively estimated.</div></div><div><h3>Results</h3><div>Among 2,937 injured patients, trauma surgeons referred 178 (6.1 %) to acupuncture. Among the referred patients, 111 (72.1 %) underwent acupuncture. Patients with polytrauma (aOR 0.46; 0.30 to 0.68) were less likely to be referred to acupuncture, whereas female patients (aOR 3.92, 1.31 to 11.77) were most likely to receive acupuncture.</div></div><div><h3>Conclusions</h3><div>A small proportion of patients with TRF were referred for acupuncture, but the referred patients were more likely to receive acupuncture. Polytrauma may be an important criterion for referral to acupuncture services from the perspective of trauma surgeons, while the willingness to receive acupuncture may be associated with gender-related factors. Further studies are warranted to investigate the role of acupuncture in the postinjury care of patients with TRF.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 4","pages":"Article 101096"},"PeriodicalIF":2.8,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142705669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-pharmacological interventions of traditional Chinese medicine in treating polycystic ovary syndrome: a group consensus 中医非药物干预治疗多囊卵巢综合征:小组共识
IF 2.8 4区 医学
Integrative Medicine Research Pub Date : 2024-10-22 DOI: 10.1016/j.imr.2024.101093
Tianyi Zhou , Fangfang Wang , Xinfen Xu , Yuhang Zhu , Rong Zhang , Hye Won Lee , Xiao-Yang Mio Hu , Fan Qu , Minchen Dai , Yijing He , Xinyue Li , Zhichun Jin , Yan Yin , Ziming Huang , Kaiqing Lin , Bianba Zhuoma , Xiaoyong Chen , Mali Chen , Longlong Fan , Lanzhong Guo , Dan Pan
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