Integrative Medicine Research最新文献

{"title":"Mindfulness-based interventions for adults with type 2 diabetes mellitus: A systematic review and meta-analysis","authors":"Carolyn C Ee ,&nbsp;Ieman Al-Kanini ,&nbsp;Mike Armour ,&nbsp;Milan K Piya ,&nbsp;Rita McMorrow ,&nbsp;Vibhuti S Rao ,&nbsp;Dhevaksha Naidoo ,&nbsp;Maria-Inti Metzendorf ,&nbsp;Cynthia M Kroeger ,&nbsp;Angelo Sabag","doi":"10.1016/j.imr.2025.101138","DOIUrl":"10.1016/j.imr.2025.101138","url":null,"abstract":"<div><h3>Background</h3><div>Type 2 diabetes mellitus (T2DM) can lead to macro- and microvascular complications. Mindfulness-based interventions (MBIs) may improve metabolic and psychological health in individuals with T2DM. We aimed to assess the efficacy of MBIs for management of T2DM.</div></div><div><h3>Methods</h3><div>We searched five databases and two trial registries using a comprehensive search strategy developed by a multidisciplinary team including an information scientist. We included randomised controlled trials (RCTs) investigating MBIs for important clinical outcomes including psychological outcomes, quality of life, glycaemic control and cardiovascular risk factors in adults with T2DM. Where possible, random effects meta-analyses were conducted. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach was used to assess certainty of the evidence.</div></div><div><h3>Results</h3><div>We included 31 RCTs (2337 participants: 1107 intervention, 1230 control). We found very low certainty evidence that MBIs may reduce stress (standardized mean difference (SMD) –1.01, confidence interval (CI) –1.91 to –0.20, 8 trials, <em>n</em> = 528), depression (SMD –1.26, CI –2.08 to –0.43; 7 trials, <em>n</em> = 570) and anxiety (SMD –0.67, CI –1.27 to –0.08; 4 studies, <em>n</em> = 255) at end of treatment compared to waitlist control/usual care. MBIs may have a small effect on HbA1c and systolic/diastolic blood pressure at end of treatment compared to waitlist control/usual care (HbA1c mean difference (MD) –0.44, 95 % CI –0.71 to –0.17, 9 trials, <em>n</em> = 734; low certainty evidence). There was very low certainty evidence that MBIs + lifestyle may have no effect on HbA1c or body weight compared to lifestyle alone.</div></div><div><h3>Conclusion</h3><div>MBIs may have clinical benefits (particularly psychological) for adults with T2DM, but lack of certainty in the evidence precludes clinical recommendations.</div></div><div><h3>Protocol registration</h3><div>Cochrane Database of Systematic Reviews, DOI: 10.1002/14651858.CD014881.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 2","pages":"Article 101138"},"PeriodicalIF":2.8,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143892235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-pharmacological interventions involving traditional Chinese medicine for assisted reproductive technology: A group consensus","authors":"Xinyue Li ,&nbsp;Hye Won Lee ,&nbsp;Tianyi Zhou ,&nbsp;Nicola Robinson ,&nbsp;Xiao-Yang Mio Hu ,&nbsp;Momir Dunjić ,&nbsp;Fangfang Wang ,&nbsp;Rong Zhang ,&nbsp;Consensus Panel ,&nbsp;Yuhang Zhu ,&nbsp;Fan Qu","doi":"10.1016/j.imr.2025.101137","DOIUrl":"10.1016/j.imr.2025.101137","url":null,"abstract":"<div><h3>Background</h3><div>Assisted reproductive technologies (ART) are being increasingly utilized for mitigating fertility problems. Nonpharmacological interventions of traditional Chinese medicine (TCM) are widely used as an adjunct to ART, which may improve the rate of pregnancy. Currently, no standard treatment guidelines or consensus are available for non-pharmacological interventions of TCM for patients undergoing ART. The aim of this study was to establish a consensus on the use of non-pharmacological TCM interventions during the ART treatment cycle.</div></div><div><h3>Methods</h3><div>This study utilized existing data and developed a consensus among a panel of experts on non-pharmacological interventions of TCM for ART. Through face-to-face or online contact, the listed recommendations were revised one by one, and a consensus was reached when &gt;70 % of the experts agreed with the recommendation. The writing group of the expert panel then created the first draft of the expert consensus based on the discussion in the first round. The second round was held to reach a consensus on content improvements based on the opinions of the experts in the previous round.</div></div><div><h3>Results</h3><div>After the literature search, a total of 873 related articles were retrieved, and 59 studies were ultimately included according to the inclusion and exclusion criteria. After two rounds of the survey, a total of 24 experts from 18 Chinese provinces across China and five international experts from the United Kingdom, Korea, and Serbia provided vital insight and support for the formulation of this consensus. The consensus outlines eight non-pharmacological interventions for seven different stages of the ART cycle and three major complications during ART, involving 23 items of clinical practice recommendations.</div></div><div><h3>Conclusions</h3><div>Expert consensus provides a foundation for integrating non-pharmacological TCM interventions into clinical practice during ART. As more high-quality, large-scale, multicenter clinical trials are conducted, these recommendations may be refined and updated to better inform clinical guidelines and improve patient outcomes in ART.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 2","pages":"Article 101137"},"PeriodicalIF":2.8,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143760398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative medicine and perinatal outcomes among women giving birth: A national population-based study in South Korea","authors":"Seongju Kim ,&nbsp;Jiae Choi ,&nbsp;Hye Won Lee ,&nbsp;Sunju Park","doi":"10.1016/j.imr.2025.101135","DOIUrl":"10.1016/j.imr.2025.101135","url":null,"abstract":"<div><h3>Background</h3><div>The aim of this study was to examine the effects of integrative medicine (IM) on perinatal outcomes and health care utilization in women who gave birth in Korea.</div></div><div><h3>Methods</h3><div>This study used National Health Insurance Sharing Service (NHISS) claims data and established a retrospective cohort of all women who gave birth in Korea from January to December 2021. The women were categorized into IM and conventional medicine (CM) groups according to the nature of their health institution visits before delivery. To assess the risk of adverse perinatal outcomes between the two groups, a logistic regression model was used to estimate the odds ratio (OR) and the corresponding 95 % confidence interval (CI).</div></div><div><h3>Results</h3><div>A total of 171,136 women were divided into the IM (<em>n</em> = 91,902) and CM (<em>n</em> = 79,234) groups. Among the 9,608,545 claims analyzed, respiratory system disease was the most common primary diagnosis, followed by genitourinary system diseases. In the IM group, 19,153 claims were associated with infertility diagnosis codes, with the most frequent primary diagnoses being female infertility associated with anovulation and female infertility of other origins. Compared with the CM group, the IM group had significantly greater rates of assisted reproductive technology (ART) use (aOR, 1.25 [95 % CI, 1.21, 1.29]; <em>P</em> &lt; 0.0001) and cesarean delivery (aOR, 1.08 [95 % CI, 1.06, 1.11]; <em>P</em> &lt; 0.0001)<del>.</del></div></div><div><h3>Conclusion</h3><div>The study findings support that dual health care system use is not associated with the health outcomes of women who gave birth. The findings are expected to be valuable for establishing national health and medical policies or promoting health care utilization for women who give birth in South Korea.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 2","pages":"Article 101135"},"PeriodicalIF":2.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143679655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the potential of acupuncture practice education using artificial intelligence","authors":"Kyeong Han Kim ,&nbsp;Hyein Jeong ,&nbsp;Gyeong Seo Lee ,&nbsp;Seung-Hee Lee","doi":"10.1016/j.imr.2025.101123","DOIUrl":"10.1016/j.imr.2025.101123","url":null,"abstract":"<div><div>Generative artificial intelligence (AI) is being applied in various areas such as education, clinical practice, and research within the medical field. This review explores the potential use of AI models in acupuncture practice education. Recent and relevant findings were searched from literature. Active research on the use of AI in acupuncture education, particularly in areas such as acupoint selection and acupuncture manipulation, is ongoing. Additionally, AI-powered educational tools are being developed in the field of traditional medicine. The development of AI-driven educational tools for acupuncture education holds significant potential to enhance the effectiveness and efficiency of traditional medicine education.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101123"},"PeriodicalIF":2.8,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143143502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concerns about the use of verum acupuncture points in sham acupuncture studies for pain conditions: Findings and insights from network meta-analysis","authors":"Boram Lee ,&nbsp;Chan-Young Kwon ,&nbsp;Hye Won Lee ,&nbsp;Arya Nielsen ,&nbsp;L Susan Wieland ,&nbsp;Tae-Hun Kim ,&nbsp;Stephen Birch ,&nbsp;Terje Alraek ,&nbsp;Myeong Soo Lee","doi":"10.1016/j.imr.2025.101122","DOIUrl":"10.1016/j.imr.2025.101122","url":null,"abstract":"","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101122"},"PeriodicalIF":2.8,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143143504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture-related therapy for chronic cough: A systematic review and meta-analysis","authors":"Boram Lee ,&nbsp;Chan-Young Kwon ,&nbsp;Yoon Kyoung Jeong ,&nbsp;Na-Yeon Ha ,&nbsp;Kwan-Il Kim ,&nbsp;Beom-Joon Lee ,&nbsp;Jun-Hwan Lee","doi":"10.1016/j.imr.2025.101121","DOIUrl":"10.1016/j.imr.2025.101121","url":null,"abstract":"<div><h3>Background</h3><div>Despite the high prevalence and socioeconomic burden of chronic cough, there has been an unmet medical need. Acupuncture may be promising for treating chronic cough with various pathophysiologies involving several neurotransmission mechanisms. We aimed to systematically compile evidence on the effect and safety of acupuncture-related therapy for chronic cough.</div></div><div><h3>Methods</h3><div>Through a search of 11 databases, randomized controlled trials (RCTs) published until February 15, 2024 that evaluated the effect of acupuncture-related therapy at acupuncture points (including acupuncture, acupoint herbal patching, and moxibustion) for patients with chronic cough were identified and analyzed without restrictions on the cause of cough or age. When there were two or more studies that measured the same outcome measures, a meta-analysis was performed, and the certainty of evidence was evaluated based on the GRADE methodology.</div></div><div><h3>Results</h3><div>A total of 30 RCTs with 2835 participants were included. When acupuncture-related therapy was implemented in addition to conventional treatment including medicine and lifestyle guidance according to symptoms and causes, cough severity, cough-related quality of life, and the total effective rate (TER) were significantly improved with no difference in the incidence of adverse events. Furthermore, compared with conventional treatment, acupuncture-related therapy significantly improved cough severity and the TER. The certainty of the evidence was generally moderate due to the risk of bias. The most frequently used acupuncture points in the included studies were BL13, GV14, CV17, and EX-B1.</div></div><div><h3>Conclusion</h3><div>Acupuncture-related therapy might be an effective and safe treatment for patients with chronic cough of various causes with complex pathophysiologies.</div></div><div><h3>Protocol registration</h3><div>PROSPERO, CRD42024518115. PROSPERO (CRD42024518115).</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101121"},"PeriodicalIF":2.8,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143143019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of acupressure on smoking cessation in young smokers with nicotine dependence: a mixed methods study","authors":"Ying-Ying Zhang ,&nbsp;Yi-Jie Liu ,&nbsp;Yuan Wang ,&nbsp;Chen Shen ,&nbsp;Shi-Bing Liang ,&nbsp;Nicola Robinson ,&nbsp;Hai-Fa Qiao ,&nbsp;Jian-Ping Liu","doi":"10.1016/j.imr.2024.101120","DOIUrl":"10.1016/j.imr.2024.101120","url":null,"abstract":"<div><h3>Background</h3><div>Acupressure has been widely used for quitting smoking for a long time in China. This study explores the feasibility and effects of acupressure on smoking cessation in young smokers with nicotine dependence to inform policy and decision-making.</div></div><div><h3>Methods</h3><div>This was a single group study using pre/post-test design. Participants received four weeks of auricular acupressure treatment, led by a registered acupuncturist. Smoking cravings, nicotine dependence, withdrawal symptoms, and cigarettes per day (CPD) were recorded before and after treatment. Changes in outcomes were analyzed at 2 weeks and 4 weeks using SPSS software version 22.0. Semi-structured interviews were conducted with participants to explore their experience and attitude towards auricular acupressure. Thematic analysis was applied to analyze the data.</div></div><div><h3>Results</h3><div>A total of 20 participants completed this study. A significant reduction was observed in smoking cravings (<em>F</em> = 11.02, <em>P</em> &lt; 0.05), nicotine dependence (<em>F</em> = 11.09, <em>P</em> &lt; 0.05), withdrawal symptoms (<em>F</em> = 11.19, <em>P</em> &lt; 0.05), and CPD (<em>F</em> = 19.03, <em>P</em> &lt; 0.05) over sessions. Additionally, withdrawal symptoms decreased significantly from 2 weeks to 4 weeks (<em>P</em> &lt; 0.05) of acupressure treatment. Three inter-related themes emerged from interviews: personal and external resources, psychological and physical effects of acupressure, and satisfaction with acupressure for smoking cessation.</div></div><div><h3>Conclusion</h3><div>The quantitative and qualitative data suggest that acupressure maybe effective in decreasing nicotine dependence and smoking cravings. However, this was a pilot and single arm study, these effects need to be further verified. The study supports the feasibility and safety of introducing acupressure therapy for smoking cessation in young smokers.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101120"},"PeriodicalIF":2.8,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143143503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Common adverse events of herbal formulas for developing reporting forms for clinical practice and research: An overview of systematic reviews","authors":"Eunbyul Cho ,&nbsp;Sungha Kim ,&nbsp;Mi Ju Son","doi":"10.1016/j.imr.2024.101118","DOIUrl":"10.1016/j.imr.2024.101118","url":null,"abstract":"<div><h3>Background</h3><div>Previous research has mainly focused on the adverse events (AEs) of individual medicinal plants rather than those of herbal formulas. This study investigated AEs associated with herbal formulas composed of two or more herbs by summarizing existing systematic reviews (SRs). We aimed to identify common AEs to develop a comprehensive reporting form for clinical practice and research, improving herbal medicine safety monitoring in South Korea.</div></div><div><h3>Methods</h3><div>Four international (MEDLINE, EMBASE, CENTRAL, CINAHL) and three Korean databases (KISS, ScienceON, OASIS) were searched for SRs on AEs associated with herbal formulas from inception to September 13, 2024. Inclusion criteria were SRs focusing on AEs of herbal formulas composed of two or more herbs. Two researchers independently conducted the search, selection, and data extraction. Methodological and reporting quality were evaluated using A MeaSurement Tool to Assess systematic Reviews 2 and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 checklist. AEs were classified using the System Organ Class of the Medical Dictionary for Regulatory Activities.</div></div><div><h3>Results</h3><div>Thirteen SRs were selected. The most frequently reported organ system was hepatobiliary (9 SRs), followed by nervous and gastrointestinal systems (3 SRs each). Common symptoms in primary studies were nausea (<em>n</em> = 102), diarrhea (<em>n</em> = 80), and vomiting (<em>n</em> = 70). Causality was analyzed in 7 SRs using various scales. The methodological quality of the included SRs was critically low.</div></div><div><h3>Conclusions</h3><div>Our findings provide a foundation for developing a standardized AE reporting form for herbal formulas. Further high-quality reports with specific patient conditions, herbal constituents, and causality assessments are required to enhance herbal medicine safety monitoring and understanding.</div></div><div><h3>Protocol registration</h3><div>PROSPERO, CRD42023478440.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101118"},"PeriodicalIF":2.8,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143143505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-Focused Drug Development and Real World Study","authors":"Haiyin Hu ,&nbsp;Hui Wang ,&nbsp;Lin Ang ,&nbsp;Menglong Shi ,&nbsp;Xiaolei Wu ,&nbsp;Chenyao Zhang ,&nbsp;Mei Han ,&nbsp;Shigang Liu ,&nbsp;Kai Li ,&nbsp;Junhua Zhang ,&nbsp;Zhaochen Ji","doi":"10.1016/j.imr.2024.101119","DOIUrl":"10.1016/j.imr.2024.101119","url":null,"abstract":"<div><h3>Background</h3><div>Patient-focused drug development (PFDD) is an important direction in the field of medical research and is of great significance to the development of medicine. In recent years, PFDD and real-world study (RWS) have gained much interest, of which both have their advantages. This study aims to promote research methods innovation and optimize clinical research design and implementation.</div></div><div><h3>Methods</h3><div>After a brief introduction of PFDD and RWS, this review focused on the comparison of clinical trials of PFDD and RWS in terms of objectives, Population, Intervention, Comparator, Outcome (PICO) elements, research team members, data acquisition, and research key points, and clarified the feasibility and significance of “patient-focused RWS” research model.</div></div><div><h3>Results</h3><div>PFDD emphasized that patients’ needs as well as the willingness and satisfaction of patients should be considered throughout the whole research process and the patient experience data should be collected during the study development and drug use. RWS emphasized the facticity of research implementation environment and the breadth of patient sources, which concerned the problem of the extrapolation of study results, the clinical localization, and patient applicability of the target drug. However, there is a connection between both of the above. Both clinical trials of PFDD and RWS bring benefits to patients.</div></div><div><h3>Conclusions</h3><div>Combining PFDD idea and RWS research method to carry out new research will maximize the benefits for patients. The study model combining the PFDD concept with RWS can facilitate drug development and dissemination, which can be popularized and applied in various research areas. This study can innovate research methods and provide new ideas for future research.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101119"},"PeriodicalIF":2.8,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143143501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing penetrating needles and non-penetrating needles with electrical stimulation combined with exercise training for relief of dyspnea and improving exercise tolerance in chronic obstructive pulmonary disease patients: A single-blind randomized controlled trial","authors":"Ying He ,&nbsp;Gui-yuan Li ,&nbsp;Chun-zhi Tang ,&nbsp;Li-ming Lu ,&nbsp;Guang-yi Xiong ,&nbsp;Yi Gao ,&nbsp;Juan Tong ,&nbsp;Guang-en Zhong","doi":"10.1016/j.imr.2024.101117","DOIUrl":"10.1016/j.imr.2024.101117","url":null,"abstract":"<div><h3>Background</h3><div>Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation. The purpose of this study was to evaluate the effectiveness of penetrating needles with electrical stimulation combined with exercise training on relieving dyspnea and improving exercise tolerance among COPD patients.</div></div><div><h3>Method</h3><div>A total of 85 patients were recruited and randomly assigned to receive either penetrating needles with electrical stimulation (PE) or non-penetrating needles with electrical stimulation (NPE), 3 times a week, for 8 weeks, totaling 24 treatments. Both groups underwent exercise training. The evaluations were conducted at the baseline, after 14 treatments, and after 24 treatments.</div></div><div><h3>Results</h3><div>The PE group showed significant improvement in 6-minute walk distance (6MWD) after the 14^th treatment. For pulmonary function test, MVV%, MEF50%, MEF75% and MEF25% improved in the PE group, especially MVV% was significantly higher than the NPE group. For cardiopulmonary exercise testing, METs%, VO₂/kg%, V_E%, VO₂/HR%, V_Emax, V_E/VO₂ and V_E/VCO₂ in the PE group improved, especially VO₂/kg%, V_E%, V_Emax, V_E/VO₂ and V_E/VCO₂ were significantly higher than the NPE group. The scores of COPD assessment test in the PE group significantly improved. The scores of modified British Medical Research Council in the PE group was better than the NPE group after the treatment.</div></div><div><h3>Conclusion</h3><div>Penetrating needles with electrical stimulation combined with exercise training may be clinically useful for COPD patients in relieving dyspnea and improving exercise tolerance.</div></div><div><h3>Trial Registration</h3><div>Chinese Clinical Trial Registry, ChiCTR1900028627.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101117"},"PeriodicalIF":2.8,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}