Integrative Medicine Research最新文献

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Exploring the potential effect of electroacupuncture on cardiovascular function and lipid profiles in spontaneously hypertensive rats 探索电针对自发性高血压大鼠心血管功能和血脂谱的潜在影响
IF 3.4 4区 医学
Integrative Medicine Research Pub Date : 2024-06-01 DOI: 10.1016/j.imr.2024.101041
Hye-Yoom Kim , Sarah Shin , Jung-Joo Yoon , You-Mee Ahn , Ji-Hye Song , Da-Som Lee , Ji-Yeun Park , Ho-Sub Lee , Jeeyoun Jung
{"title":"Exploring the potential effect of electroacupuncture on cardiovascular function and lipid profiles in spontaneously hypertensive rats","authors":"Hye-Yoom Kim ,&nbsp;Sarah Shin ,&nbsp;Jung-Joo Yoon ,&nbsp;You-Mee Ahn ,&nbsp;Ji-Hye Song ,&nbsp;Da-Som Lee ,&nbsp;Ji-Yeun Park ,&nbsp;Ho-Sub Lee ,&nbsp;Jeeyoun Jung","doi":"10.1016/j.imr.2024.101041","DOIUrl":"10.1016/j.imr.2024.101041","url":null,"abstract":"<div><h3>Background</h3><p>Investigating the effects of electroacupuncture (EA) treatment on cardiovascular function and aortic lipid profiles in spontaneously hypertensive rats (SHR) constitutes the foundational focus of this study. The overarching goal is to comprehensively elucidate the alterations brought about by EA treatment and to assess its potential as an alternative therapy for hypertension.</p></div><div><h3>Methods</h3><p>Consecutive EA treatments were administered to SHR, and the effects on systolic blood pressure, cardiac function, and hypertension-related neuronal signals were assessed. Aortic lipid profiles in vehicle-treated SHR and EA-treated SHR groups were analyzed using mass spectrometry-based lipid profiling. Additionally, the expression of Cers2 and GNPAT, enzymes involved in the synthesis of specific aortic lipids, was examined.</p></div><div><h3>Results</h3><p>The study demonstrated that consecutive EA treatments restored systolic blood pressure, improved cardiovascular function, and normalized hypertension-related neuronal signals in SHR. Analysis of the aortic lipid profiles revealed distinct differences between the vehicle-treated SHR group and the EA-treated SHR group. Specifically, EA treatment significantly altered the levels of aortic sphingomyelin and phospholipids, including very long-chain fatty acyl-ceramides and ether phosphatidylcholines. These changes in aortic lipid profiles correlated significantly with systolic blood pressure and cardiac function indicators. Furthermore, EA treatment significantly altered the expression of Cers2 and GNPAT.</p></div><div><h3>Conclusions</h3><p>The findings suggest that EA may influence cardiovascular functions and aortic lipid profiles in SHR.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422024000210/pdfft?md5=0c621b08f750fd40a6e13020d9c46980&pid=1-s2.0-S2213422024000210-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140407449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adding thread-embedding acupuncture to auricular acupuncture enhances short-term weight reduction in overweight and obesity: A double-blinded, randomized, sham-controlled trial 在耳针的基础上加入绣线针灸可增强超重和肥胖症患者的短期减重效果:双盲随机临床试验与假对照试验
IF 3.4 4区 医学
Integrative Medicine Research Pub Date : 2024-06-01 DOI: 10.1016/j.imr.2024.101050
Dieu-Thuong Thi Trinh , Quoc-Viet Kieu , An Hoa Tran , Minh-Man Pham Bui , Nguyen Lam Vuong
{"title":"Adding thread-embedding acupuncture to auricular acupuncture enhances short-term weight reduction in overweight and obesity: A double-blinded, randomized, sham-controlled trial","authors":"Dieu-Thuong Thi Trinh ,&nbsp;Quoc-Viet Kieu ,&nbsp;An Hoa Tran ,&nbsp;Minh-Man Pham Bui ,&nbsp;Nguyen Lam Vuong","doi":"10.1016/j.imr.2024.101050","DOIUrl":"10.1016/j.imr.2024.101050","url":null,"abstract":"<div><h3>Background</h3><p>Auricular acupuncture (AA) has been widely used in overweight and obesity management due to its safety and effectiveness. The combination of other acupuncture therapies with thread-embedding acupuncture (TEA) has shown enhanced effects. However, there is a lack of evidence regarding AA plus TEA for overweight and obesity. This study was conducted to address this question.</p></div><div><h3>Methods</h3><p>A randomized placebo-controlled trial was conducted involving 66 overweight or obese participants, divided into two groups: 33 received AA plus TEA, and 33 received AA plus sham TEA over eight weeks. The primary outcome was body weight (BW) reduction. Secondary outcomes included changes in body mass index (BMI) and waist circumference (WC), hip circumference (HC), waist-hip ratio (WHR), food cravings questionnaire-trait-reduced (FCQ-Tr) and food craving visual analog scale (VAS) scores. Safety outcomes were adverse events (AEs).</p></div><div><h3>Results</h3><p>After eight weeks, BW decreased by a mean (SD) of -4.45 (1.29) kg and -2.05 (1.33) kg in the AA plus TEA and AA plus sham TEA groups, respectively (MD [95 % CI]: 2.40 [1.75; 3.05]). BMI, WC, WHR, and food craving VAS score decreased significantly more in the AA plus TEA group than in the AA plus sham TEA group. No significant differences were found in FCQ-Tr and HC between groups. Seven AEs were recorded that were mild and resolved without treatment.</p></div><div><h3>Conclusion</h3><p>The addition of TEA to AA is a safe and effective management of overweight and obesity. Further studies should incorporate dietary and lifestyle modifications and follow-up after the intervention to assess long-term effectiveness.</p></div><div><h3>Trial registration</h3><p>The study protocol had been registered on ClinicalTrials.gov (NCT06091761).</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422024000301/pdfft?md5=bb19a2b472a0c453df1ce5315a756b61&pid=1-s2.0-S2213422024000301-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141274267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fidelity to the acupuncture intervention protocol in the ACUpuncture In The EmergencY department for pain management (ACUITY) trial: Expanding the gold standard of STRICTA and CONSORT guidelines ACUpuncture In The EmergencY Department for Pain Management (ACUITY) 试验中针灸干预方案的忠实性:扩展 STRICTA 和 CONSORT 指南的黄金标准。
IF 3.4 4区 医学
Integrative Medicine Research Pub Date : 2024-06-01 DOI: 10.1016/j.imr.2024.101048
Arya Nielsen , Natalie L. Dyer , Claudia Lechuga , M. Diane McKee , Jeffery A. Dusek
{"title":"Fidelity to the acupuncture intervention protocol in the ACUpuncture In The EmergencY department for pain management (ACUITY) trial: Expanding the gold standard of STRICTA and CONSORT guidelines","authors":"Arya Nielsen ,&nbsp;Natalie L. Dyer ,&nbsp;Claudia Lechuga ,&nbsp;M. Diane McKee ,&nbsp;Jeffery A. Dusek","doi":"10.1016/j.imr.2024.101048","DOIUrl":"10.1016/j.imr.2024.101048","url":null,"abstract":"<div><h3>Background</h3><p>Acupuncture shows promise as an effective nonpharmacologic option for reduction of acute pain in the emergency department (ED). Following CONSORT and STRICTA guidelines, randomized controlled trials (RCTs) generally report intervention details and acupoint options, but fidelity to acupuncture interventions, critical to reliability in intervention research, is rarely reported.</p></div><div><h3>Methods</h3><p>ACUITY is an NCCIH-funded, multi-site feasibility RCT of acupuncture in 3 EDs (Cleveland, Nashville, and San Diego). ACUITY acupuncturists were trained in study design, responsive acupuncture manualization protocol, logistics and real-time recording of session details via REDCap forms created to track fidelity.</p></div><div><h3>Results</h3><p>Across 3 recruiting sites, 79 participants received acupuncture: 51 % women, 43 % Black/African American, with heterogeneous acute pain sites at baseline: 32 % low back, 22 % extremity, 20 % abdominal, 10 % head. Pragmatically, participants were treated in ED common areas (52 %), private rooms (39 %), and semi-private rooms (9 %). Objective tracking found 98 % adherence to the six components of the acupuncture manualization protocol: staging, number of insertion points (<em>M</em> = 13.2, range 2–22), needle retention time (<em>M</em> = 23.5 min, range 4–52), session length (<em>M</em> = 40.3 min, range 20–66), whether general recommendations were provided and completion of the session form.</p></div><div><h3>Conclusion</h3><p>To the best of our knowledge, this is the first RCT to assess and report fidelity to an acupuncture protocol. Fidelity monitoring will be fundamental for ACUITY2, which would be a future definitive, multi-site RCT. Furthermore, we recommend that fidelity to acupuncture interventions be added to CONSORT and STRICTA reporting guidelines in future RCTs.</p></div><div><h3>Protocol registration</h3><p>The protocol of this study is registered at clinicaltrials.gov: NCT04880733.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422024000283/pdfft?md5=45d4178ee38812a25e7a30a0677b79b7&pid=1-s2.0-S2213422024000283-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141043946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of acupuncture on pain and function in patients with subacromial impingement syndrome: A randomized sham-controlled trial 针灸对肩峰下撞击综合征患者疼痛和功能的影响:随机假对照试验
IF 3.4 4区 医学
Integrative Medicine Research Pub Date : 2024-06-01 DOI: 10.1016/j.imr.2024.101049
Duygu Silte Karamanlioglu, Meryem Yilmaz Kaysin, Feyza Akan Begoglu, Pinar Akpinar, Feyza Unlu Ozkan, Ilknur Aktas
{"title":"Effects of acupuncture on pain and function in patients with subacromial impingement syndrome: A randomized sham-controlled trial","authors":"Duygu Silte Karamanlioglu,&nbsp;Meryem Yilmaz Kaysin,&nbsp;Feyza Akan Begoglu,&nbsp;Pinar Akpinar,&nbsp;Feyza Unlu Ozkan,&nbsp;Ilknur Aktas","doi":"10.1016/j.imr.2024.101049","DOIUrl":"https://doi.org/10.1016/j.imr.2024.101049","url":null,"abstract":"<div><h3>Background</h3><p>Subacromial impingement syndrome (SIS) is the most common cause of shoulder pain. Acupuncture is a traditional medicine that is effective on pain. This study aimed to evaluate the effect of acupuncture treatment on pain, function, range of motion (ROM) and quality of life compared to sham acupuncture in patients diagnosed with SIS.</p></div><div><h3>Methods</h3><p>A randomized, prospective, double-blinded, sham-controlled trial was conducted. In acupuncture group 40 participants received acupuncture treatment plus exercise therapy while in control group 40 participants received sham acupuncture plus exercise therapy. Primary outcomes included pain-rest, activity and night pain. Secondary outcomes included function [Shoulder Pain and Disability Index (SPADI) and The Disabilities of the Arm, Shoulder and Hand Score (Quick DASH)], ROM, and quality of life [The Western Ontario Rotator Cuff Index (WORC)] in patients with SIS.</p></div><div><h3>Results</h3><p>Both groups had significant improvements for pain-rest, activity night pain scores, SPADI, Quick DASH and WORC after treatment and at the first month follow-up. Significant improvements were recorded in the acupuncture group for all ROM after treatment and at the first month follow-up while in control group only in passive internal rotation. Acupuncture group had better improvements for Quick DASH, WORC and all ROM parameters after the treatment, as well as for all parameters except pain-night and passive flexion at the first month follow-up.</p></div><div><h3>Conclusion</h3><p>This study suggest that acupuncture treatment is a safe, effective and non-invasive treatment option in patients with SIS.</p></div><div><h3>Trial registration</h3><p>The study protocol is registered at clinicaltrials.gov (NCT05794633).</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422024000295/pdfft?md5=917f9cf14124045800a260d93359a088&pid=1-s2.0-S2213422024000295-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A synergistic effect of herb and acupuncture on the methamphetamine 中草药和针灸对甲基苯丙胺的协同作用
IF 2.8 4区 医学
Integrative Medicine Research Pub Date : 2024-06-01 DOI: 10.1016/j.imr.2024.101052
{"title":"A synergistic effect of herb and acupuncture on the methamphetamine","authors":"","doi":"10.1016/j.imr.2024.101052","DOIUrl":"10.1016/j.imr.2024.101052","url":null,"abstract":"<div><h3>Background</h3><p>Herbal medicine Ja-Geum-Jeong (JGJ) has been used for the treatment of detoxification in Eastern Asia. However, the mechanisms involved are not clearly defined. The purpose of the present study was to investigate if herb medication inhibits Methamphetamine (METH)’s reinforcing effect and also examined if a combination of herb medication and acupuncture produces a synergistic effect on METH.</p></div><div><h3>Methods</h3><p>Male Sprague-Dawley rats were given acute METH intraperitoneally and the locomotor activity and ultrasonic vocalization (USV) calls were measured. Rats were administered JGJ orally and acupuncture was given at HT7 or SI5. Monosodium glutamate (MSG) and gamma-aminobutyric acid (GABA) agonists were injected into the Central amygdala (CeA) to investigate a possible neuroscientific mechanism. Tyrosine hydroxylase (TH) and fast scan cyclic voltammetry (FSCV) were measured to immunohistochemically and electrically confirm the behavioral data.</p></div><div><h3>Results</h3><p>Locomotor activity and USV calls were increased by METH (<em>P</em> &lt; 0.05) and these increases were inhibited by JGJ (<em>P</em> &lt; 0.05). Also, JGJ had no effect on the normal group given saline, and acupuncture at SI5 acupoint, but not at HT7 acupoint, produced a synergistic effect when combined with JGJ (<em>P</em> &lt; 0.05). The JGJ's inhibition was blocked by the inactivation of CeA (<em>P</em> &lt; 0.05), and MSG mimicked JGJ (<em>P</em> &lt; 0.05). TH and FSCV measures showed the same pattern with the behavioral data (<em>P</em> &lt; 0.05).</p></div><div><h3>Conclusion</h3><p>Results of the present study suggest that JGJ had inhibitory effects on the METH which was mediated through the activation of CeA and that combination of acupuncture and herb produced synergistic effect.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422024000325/pdfft?md5=eb4a2e5b9a4044646159f4670e8d8a37&pid=1-s2.0-S2213422024000325-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141279108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peripheral Rho-associated protein kinase activation mediates acupuncture analgesia 外周Rho相关蛋白激酶激活介导针灸镇痛
IF 2.8 4区 医学
Integrative Medicine Research Pub Date : 2024-05-31 DOI: 10.1016/j.imr.2024.101051
Ji-Yeun Park , Jae-Hwan Jang , Yang-Hwa Kang , Songhee Jeon , Seung-Nam Kim , Yeon-Hee Ryu , Hi-Joon Park
{"title":"Peripheral Rho-associated protein kinase activation mediates acupuncture analgesia","authors":"Ji-Yeun Park ,&nbsp;Jae-Hwan Jang ,&nbsp;Yang-Hwa Kang ,&nbsp;Songhee Jeon ,&nbsp;Seung-Nam Kim ,&nbsp;Yeon-Hee Ryu ,&nbsp;Hi-Joon Park","doi":"10.1016/j.imr.2024.101051","DOIUrl":"10.1016/j.imr.2024.101051","url":null,"abstract":"<div><h3>Background</h3><p>Acupuncture has been proven effective for various types of pain, and peripheral molecular signals around acupuncture-treated areas have been suggested to contribute to the analgesic effects of acupuncture. However, the underlying mechanism from these peripheral molecular signals to central ones remains unclear. The purpose of this study was to investigate whether peripheral Rho-associated protein kinase (ROCK) activation induced by acupuncture treatment mediates acupuncture analgesia, and also to investigate the relationship between ROCK activation and extracellular signal-regulated kinase (ERK), which has previously been proven to mediate acupuncture analgesia and other related molecular changes during acupuncture.</p></div><div><h3>Methods</h3><p>Acupuncture was treated at the bilateral GB34 acupoints of C57BL/6 mice, after which changes in ROCK activation and the location of its expression in the skin were analyzed. To verify the role of ROCK in acupuncture analgesia, we administrated ROCK inhibitor Y-27632 (0.3 μg/ul) into the skin before acupuncture treatment with formalin and complete Freund adjuvant (CFA) induced pain models, then the nociceptive responses were analyzed.</p></div><div><h3>Results</h3><p>Acupuncture treatment produced ROCK2 activation in the skin after 30 and 60 min, and the histological analyses revealed that ROCK2 was activated in the fibroblast of the dermis. The acupuncture-induced ROCK2 expression was significantly attenuated by the ERK inhibitor, whereas phospho-ERK expression was not inhibited by ROCK inhibitor. In both the formalin- and CFA-induced mouse pain models, acupuncture analgesia was blocked by ROCK inhibitor administration.</p></div><div><h3>Conclusion</h3><p>Acupuncture treatment-induced ROCK2 expression is a downstream effector of phospho-ERK in the skin and plays a crucial role in acupuncture analgesia.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422024000313/pdfft?md5=076c13229f5183f86580521085313c36&pid=1-s2.0-S2213422024000313-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141932808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using PRECIS-2 in Chinese herbal medicine randomized controlled trials for irritable bowel syndrome: A methodological exploration based on literature 在治疗肠易激综合征的中药随机对照试验中使用 PRECIS-2:基于文献的方法学探索
IF 2.8 4区 医学
Integrative Medicine Research Pub Date : 2024-05-31 DOI: 10.1016/j.imr.2024.101053
Minjing Luo , Yingqiao Wang , Jinghan Huang , Yilin Li , Wenjie Li , He Li , Zhihan Liu , Meijun Liu , Yunci Tao , Jianping Liu , Yutong Fei
{"title":"Using PRECIS-2 in Chinese herbal medicine randomized controlled trials for irritable bowel syndrome: A methodological exploration based on literature","authors":"Minjing Luo ,&nbsp;Yingqiao Wang ,&nbsp;Jinghan Huang ,&nbsp;Yilin Li ,&nbsp;Wenjie Li ,&nbsp;He Li ,&nbsp;Zhihan Liu ,&nbsp;Meijun Liu ,&nbsp;Yunci Tao ,&nbsp;Jianping Liu ,&nbsp;Yutong Fei","doi":"10.1016/j.imr.2024.101053","DOIUrl":"10.1016/j.imr.2024.101053","url":null,"abstract":"<div><h3>Background</h3><p>The pragmatism levels of randomized controlled trials (RCTs) mean how similar the interventions delivered in the trial setting match those in the setting where the results will be applied. We aimed to investigate the association between the consistency of pragmatism among the characteristics of RCT design and its effect size of results in Chinese herbal medicine (CHM) for irritable bowel syndrome (IBS).</p></div><div><h3>Methods</h3><p>Eight English and Chinese language databases were searched for RCTs on CHM for IBS. Six reviewers independently assessed the pragmatism of trials using the pragmatic-explanatory continuum indicator summary 2 (PRECIS-2) tool. The consistency of pragmatism levels among the characteristics of RCT design was calculated using the coefficient of variation. Linear regression models were adopted to explore influence factors of the pragmatism of RCTs.</p></div><div><h3>Results</h3><p>78 RCTs were included. The level of consistency in the pragmatism for RCT's design was significantly correlated with the effect size of the results (binary outcome, r = -0.413; <em>P</em> = 0.005; continuous outcome, r = -0.779, <em>P</em> &lt; 0.001). PRECIS-2 score was higher in trials with individualized interventions than fixed interventions (3.29 [0.32] vs 2.90 [0.32]; Cohen's <em>d</em> relative effect size, 0.52; P &lt; 0.001) and in standard or usual-treatment-controlled trials than placebo-controlled (3.05 [0.37] vs 2.83 [0.28]; Cohen's <em>d</em> relative effect size, 0.32; P = 0.048).</p></div><div><h3>Conclusion</h3><p>The consistency of pragmatism level across the 9 domains of the PRECIS-2 tool in CHM IBS RCTs was positively correlated with the effect size of the results.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422024000337/pdfft?md5=d4822e815f5ff4295ed3c32c35046d45&pid=1-s2.0-S2213422024000337-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141932837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Open science practices in traditional, complementary, and integrative medicine research: A path to enhanced transparency and collaboration 传统医学、补充医学和综合医学研究中的开放科学实践:提高透明度与合作的途径
IF 3.4 4区 医学
Integrative Medicine Research Pub Date : 2024-05-09 DOI: 10.1016/j.imr.2024.101047
Jeremy Y. Ng , L. Susan Wieland , Myeong Soo Lee , Jian-ping Liu , Claudia M. Witt , David Moher , Holger Cramer
{"title":"Open science practices in traditional, complementary, and integrative medicine research: A path to enhanced transparency and collaboration","authors":"Jeremy Y. Ng ,&nbsp;L. Susan Wieland ,&nbsp;Myeong Soo Lee ,&nbsp;Jian-ping Liu ,&nbsp;Claudia M. Witt ,&nbsp;David Moher ,&nbsp;Holger Cramer","doi":"10.1016/j.imr.2024.101047","DOIUrl":"https://doi.org/10.1016/j.imr.2024.101047","url":null,"abstract":"<div><p>This educational article explores the convergence of open science practices and traditional, complementary, and integrative medicine (TCIM), shedding light on the potential benefits and challenges of open science for the development, dissemination, and implementation of evidence-based TCIM. We emphasize the transformative shift in medical science towards open and collaborative practices, highlighting the limited application of open science in TCIM research despite its growing acceptance among patients. We define open science practices and discuss those that are applicable to TCIM, including: study registration; reporting guidelines; data, code and material sharing; preprinting; publishing open access; and reproducibility/replication studies. We explore the benefits of open science in TCIM, spanning improved research quality, increased public trust, accelerated innovation, and enhanced evidence-based decision-making. We also acknowledge challenges such as data privacy concerns, limited resources, and resistance to cultural change. We propose strategies to overcome these challenges, including ethical guidelines, education programs, funding advocacy, interdisciplinary dialogue, and patient engagement. Looking to the future, we envision the maturation of open science in TCIM, the development of TCIM-specific guidelines for open science practices, advancements in data sharing platforms, the integration of open data and artificial intelligence in TCIM research, and changes in the context of policy and regulation. We foresee a future where open science in TCIM leads to a better evidence base, informed decision-making, interdisciplinary collaboration, and transformative impacts on healthcare and research methodologies, highlighting the promising synergy between open science and TCIM for holistic, evidence-based healthcare solutions.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422024000271/pdfft?md5=47de9ef462d474c8f077ac90009cb852&pid=1-s2.0-S2213422024000271-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140950564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Methodological proposals for developing trustworthy recommendations of integrative Chinese-Western medicine 制定值得信赖的中西医结合建议的方法建议
IF 3.4 4区 医学
Integrative Medicine Research Pub Date : 2024-05-01 DOI: 10.1016/j.imr.2024.101046
Honghao Lai , Mingyao Sun , Bei Pan , Baojin Han , Tingting Lu , Lei Fang , Jie Liu , Long Ge
{"title":"Methodological proposals for developing trustworthy recommendations of integrative Chinese-Western medicine","authors":"Honghao Lai ,&nbsp;Mingyao Sun ,&nbsp;Bei Pan ,&nbsp;Baojin Han ,&nbsp;Tingting Lu ,&nbsp;Lei Fang ,&nbsp;Jie Liu ,&nbsp;Long Ge","doi":"10.1016/j.imr.2024.101046","DOIUrl":"https://doi.org/10.1016/j.imr.2024.101046","url":null,"abstract":"<div><h3>Background</h3><p>To refine the methods of developing clinical practice guidelines (CPGs) for integrative Chinese-Western medicine (ICWM), promoting the formation of trustworthy, implementable recommendations that integrate the strengths of Chinese and Western medicine.</p></div><div><h3>Methods</h3><p>Using a nominal group technique (NGT) approach, a multidisciplinary expert panel was established. The panel identified key methodological issues in ICWM-CPG development through literature review and iterative discussions, and formulated methodological proposals to address these issues. The final set of proposals was achieved through consensus among the panel members.</p></div><div><h3>Results</h3><p>The collaborative effort resulted in the identification of five pivotal methodological issues and the subsequent establishment of 22 specific recommendations. These encompass strict adherence to renowned standards, such as those proposed by the Institute of Medicine (IOM) and Guidelines International Network (G-I-N), the employment of methodologies like the GRADE approach and RIGHT statement, the strategic constitution of a balanced development group, the adept identification of ICWM-focused clinical inquiries, the nuanced integration of diverse evidence sources, and the detailed crafting of transparent, implementable recommendations.</p></div><div><h3>Conclusions</h3><p>This study concentrates on the most crucial and prevalent methodological issues in ICWM-CPG development, proposing a series of recommendations. These suggestions result from a multidisciplinary expert consensus, aiming to provide methodological guidance for ICWM-CPG developers, building upon the current foundational methodologies.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S221342202400026X/pdfft?md5=aa378a74e4f710bc3404c417a15fdafe&pid=1-s2.0-S221342202400026X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140950563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Traditional Chinese medicine for post-viral olfactory dysfunction: A systematic review 中药治疗病毒后嗅觉功能障碍:系统综述
IF 3.4 4区 医学
Integrative Medicine Research Pub Date : 2024-04-25 DOI: 10.1016/j.imr.2024.101045
Xiang-yun Zou , Xue-han Liu , Chun-li Lu , Xin-yan Jin , Bai-xiang He , Yi-lei Liao , Ting Liu , Yi-dan Dai , Shi-hao Qi , Zhu-jun Sheng , Zhan-feng Yan , Guo-Yan Yang , Trine Stub , Jian-ping Liu
{"title":"Traditional Chinese medicine for post-viral olfactory dysfunction: A systematic review","authors":"Xiang-yun Zou ,&nbsp;Xue-han Liu ,&nbsp;Chun-li Lu ,&nbsp;Xin-yan Jin ,&nbsp;Bai-xiang He ,&nbsp;Yi-lei Liao ,&nbsp;Ting Liu ,&nbsp;Yi-dan Dai ,&nbsp;Shi-hao Qi ,&nbsp;Zhu-jun Sheng ,&nbsp;Zhan-feng Yan ,&nbsp;Guo-Yan Yang ,&nbsp;Trine Stub ,&nbsp;Jian-ping Liu","doi":"10.1016/j.imr.2024.101045","DOIUrl":"10.1016/j.imr.2024.101045","url":null,"abstract":"<div><h3>Background</h3><p>Post-viral olfactory dysfunction (PVOD) is the common symptoms of long COVID, lacking of effective treatments. Traditional Chinese medicine (TCM) is claimed to be effective in treating olfactory dysfunction, but the evidence has not yet been critically appraised. We conducted a systematic review to evaluate the effectiveness and safety of TCM for PVOD.</p></div><div><h3>Methods</h3><p>We searched eight databases to identified clinical controlled studies about TCM for PVOD. The Cochrane risk of bias tools and GRADE were used to evaluate the quality of evidence. Risk ratio (RR), mean differences (MD), and 95 % confidence interval (CI), were used for effect estimation and RevMan 5.4.1 was used for data analysis.</p></div><div><h3>Results</h3><p>Six randomized controlled trials (RCTs) (545 participants), two non-randomized controlled trials (non-RCTs) (112 participants), and one retrospective cohort study (30 participants) were included. The overall quality of included studies was low. Acupuncture (<em>n</em> = 8) and acupoint injection (<em>n</em> = 3) were the mainly used TCM therapies. Five RCTs showed a better effect in TCM group. Four trials used acupuncture, and three trials used acupoint injection. The results of two non-RCTs and one cohort study were not statistically significant. Two trials reported mild to moderate adverse events (pain and brief syncope caused by acupuncture or acupoint injection).</p></div><div><h3>Conclusions</h3><p>Limited evidence focus on acupuncture and acupoint injection for PVOD and suggests that acupuncture and acupoint injection may be effective in improving PVOD. More well-designed trials should focus on acupuncture to confirm the benefit.</p></div><div><h3>Protocol registration</h3><p>The protocol of this review was registered at PROSPERO: CRD42022366776.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422024000258/pdfft?md5=4ff481750c4342768d8fb8158fd624a7&pid=1-s2.0-S2213422024000258-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140764333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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