针灸治疗与台湾类风湿关节炎患者痴呆症风险的降低有关：倾向分数匹配队列研究

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research Pub Date : 2024-09-08 DOI:10.1016/j.imr.2024.101086

Hou-Hsun Liao , Ming-Cheng Huang , Yu-Chen Lee , Cheng-Li Lin , Mei-Yao Wu , Peter Karl Mayer , Hung-Rong Yen

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引用次数: 0

摘要

背景本研究旨在了解针灸能否降低类风湿性关节炎（RA）患者的痴呆风险。方法我们利用台湾国民健康保险研究数据库的登记资料，对2000年至2010年间确诊的RA患者进行了1:1倾向得分匹配队列研究。接受针灸治疗的患者被归类为针灸使用者（n = 9919），其他患者被归类为非针灸使用者（n = 19331）。经过倾向分数匹配后，最终样本包括两组中的 9218 名匹配参与者，并对这些参与者进行随访至 2011 年底。我们使用 Cox 回归模型对年龄、性别、合并症和常规药物进行了调整，并比较了针灸组和非针灸组患痴呆症的危险比（HRs）。经过倾向分数匹配后，两组的人口统计学特征相当。针灸使用者患痴呆症的风险低于非针灸使用者（调整HR：0.55，95% CI：0.46-0.66）。针灸组痴呆的累积发病率明显低于非针灸组（对数秩检验，P < 0.001）。与仅接受常规药物治疗的患者相比，接受常规药物和针灸联合治疗的患者患痴呆症的风险明显降低（调整HR：0.64，95% CI：0.56-0.73）。结论针灸治疗与降低RA患者痴呆风险有关，还需要进一步的临床和机理研究。

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Acupuncture treatment is associated with a decreased risk of dementia in patients with rheumatoid arthritis in Taiwan: A propensity-score matched cohort study

Background

The purpose of this study was to understand whether acupuncture can decrease the risk of dementia in patients with rheumatoid arthritis (RA).

Methods

Using the registry from the National Health Insurance Research Database of Taiwan, we carried out a 1:1 propensity-score matched cohort study to analyze patients with RA diagnosed between 2000 and 2010. The patients who received acupuncture therapy were grouped as acupuncture users (n = 9,919), while the others were grouped as non-acupuncture users (n = 19,331). After propensity-score matching, the final sample included 9,218 matched participants in both groups, and these participants were followed up until the end of 2011. We used a Cox regression model to adjust for age, sex, comorbidiy, and conventional drugs and compared the hazard ratios (HRs) of developing dementia in the acupuncture and non-acupuncture groups.

Results

Acupuncture users tended to be more female-dominant and younger than non-acupuncture users. After propensity-score matching, both groups have comparable demographic characteristics. Acupuncture users had a lower risk of dementia than non-acupuncture users (adjusted HR: 0.55, 95% CI: 0.46–0.66). The cumulative incidence of dementia in the acupuncture group was significantly lower than that in the non-acupuncture group (log-rank test, p < 0.001). Patients who received the combinational treatment of conventional drugs and acupuncture had a significantly lower risk of developing dementia (adjusted HR: 0.64, 95% CI: 0.56–0.73) compared to those who only received conventional drugs.

Conclusion

Acupuncture therapy is associated with a reduced risk of dementia in patients with RA. Further clinical and mechanistic studies are needed.

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来源期刊

Integrative Medicine Research Medicine-Complementary and Alternative Medicine

CiteScore

6.50

自引率

2.90%

发文量

审稿时长

12 weeks

期刊介绍： Integrative Medicine Research (IMR) is a quarterly, peer-reviewed journal focused on scientific research for integrative medicine including traditional medicine (emphasis on acupuncture and herbal medicine), complementary and alternative medicine, and systems medicine. The journal includes papers on basic research, clinical research, methodology, theory, computational analysis and modelling, topical reviews, medical history, education and policy based on physiology, pathology, diagnosis and the systems approach in the field of integrative medicine.