Protective effect of Korean red ginseng water extract on levothyroxine-induced hyperthyroidism and propylthiouracil-induced hypothyroidism in rats

IF 2.8 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE
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引用次数: 0

Abstract

Background

Korean red ginseng extract (KRGE) (Family: Araliaceae) is one of the most widely used traditional herbs in Asia. Multiple studies have shown that KRGE has anti-inflammation, anti-fatigue, anti-obesity, anti-oxidant, and anti-cancer effects.

Methods

Sprague-Dawley rats were divided into five groups for PTU-induced hypothyroidism and six groups for LT4-induced hyperthyroidism. At the experiment's conclusion, rats were sacrificed, and blood, thyroid gland, and liver samples were collected. Body weight was recorded weekly, and serum hormone levels were assessed using enzyme-linked immunoassay. Thyroid gland and liver tissues were stained with hematoxylin and eosin. KRGE was prepared in 0.5% CMC and stored at 4 °C before administration.

Results

In the LT4-induced hyperthyroidism model, KRGE prevented decreases in body weight, thyroid gland weight, liver weight, serum glucose, and thyroid hormone levels compared to the PTU group. It also reduced increases in T3, T4, and serum aspartate aminotransferase levels after LT4 treatment. Additionally, KRGE improved thyroid gland and liver histopathology, effects not observed in the PTU-induced hypothyroidism model.

Conclusion

All things considered, our research points to KRGE's potential protective role in rat hyperthyroidism caused by LT4 by lowering thyroid hormone production.

高丽红参水提取物对左甲状腺素诱导的甲状腺功能亢进和丙基硫氧嘧啶诱导的甲状腺功能减退大鼠的保护作用
背景韩国红参提取物(KRGE)(五加科)是亚洲使用最广泛的传统草药之一。方法将Sprague-Dawley大鼠分为5组进行PTU诱导的甲状腺功能减退症实验,6组进行LT4诱导的甲状腺功能亢进症实验。实验结束后,处死大鼠并采集血液、甲状腺和肝脏样本。每周记录体重,并使用酶联免疫法评估血清激素水平。甲状腺和肝组织用苏木精和伊红染色。结果 在 LT4 诱导的甲亢模型中,与 PTU 组相比,KRGE 可防止体重、甲状腺重量、肝脏重量、血清葡萄糖和甲状腺激素水平的下降。它还能降低 LT4 治疗后 T3、T4 和血清天冬氨酸氨基转移酶水平的升高。此外,KRGE 还能改善甲状腺和肝脏组织病理学,这在 PTU 诱导的甲状腺功能减退症模型中没有观察到。
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来源期刊
Integrative Medicine Research
Integrative Medicine Research Medicine-Complementary and Alternative Medicine
CiteScore
6.50
自引率
2.90%
发文量
65
审稿时长
12 weeks
期刊介绍: Integrative Medicine Research (IMR) is a quarterly, peer-reviewed journal focused on scientific research for integrative medicine including traditional medicine (emphasis on acupuncture and herbal medicine), complementary and alternative medicine, and systems medicine. The journal includes papers on basic research, clinical research, methodology, theory, computational analysis and modelling, topical reviews, medical history, education and policy based on physiology, pathology, diagnosis and the systems approach in the field of integrative medicine.
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