Long-term follow-up of the treatment for severe COVID-19 with qigong exercise and acupressure: A randomized controlled trial

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research Pub Date : 2024-09-05 DOI:10.1016/j.imr.2024.101084

Shuting Liu , Ranran Zhu , Chongjie Yao , Chao Zhan , Jinxiang Wang , Min Fang , Lei Fang

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引用次数: 0

Abstract

Background

Most clinical trials have reported significant short-term effects of traditional medicine therapies on COVID-19 patients. However, there is no clinical trial to determine the long-term effects of traditional medicine therapies on severe COVID-19 patients.

Methods

A total of 128 patients with severe COVID-19, who were recruited in our previous clinical trial following hospital discharge, were monitored at months 14 and 28. This trial aims to evaluate the long-term effect of an early Qigong exercise and acupressure rehabilitation program on patients with severe COVID-19.The intervention group received qigong exercise and acupressure therapy, plus standard therapies. The control group received standard therapies.The study was a single-center, parallel, randomized, prospective follow-up study. The outcomes of the study included changes in the modified Borg dyspnea scale (MBS), the modified Medical Research Council dyspnea scale (mMRC), the patient health questionnaire-9 scale (PHQ-9), the activity of daily living (ADL), the remaining clinical symptoms and any intervention related adverse events.

Results

The intervention group showed a statistically significant improvement in the mMRC scores (−0.4, 95 % CI (−0.6, 0.2), P < 0.001) and the MBS scores (−0.6, 95 % CI (−0.9, −0.3), P < 0.001) after 14 months of discharge compared with the control group. At 28 months of discharge, the intervention group, compared with the control group alone, significantly increased their MBS scores (−0.4, 95 % CI (−0.7, −0.1), P = 0.024) and a significantly decreased positive rate of dyspnea symptoms after 14 months of discharge (P < 0.05). However, ADL and PHQ-9 scores showed no significant difference between the two groups during the follow-up (P > 0.05).

Conclusions

QARP had long-term sustained efficacy for dyspnea, chest tightness, and cough in patients with COVID-19, especially in young and middle-aged patients, and the effect was significant at the 14th month of follow-up.

Trial registration

This trial was registered at the China Clinical Trial Registry (ChiCTR2100044572).

查看原文本刊更多论文

气功锻炼和穴位按摩治疗重度 COVID-19 的长期随访：随机对照试验

背景大多数临床试验报告了传统药物疗法对COVID-19患者的短期疗效。方法我们在之前的临床试验中招募了 128 名出院后的重度 COVID-19 患者，对他们进行了第 14 个月和第 28 个月的监测。本试验旨在评估早期气功锻炼和穴位按摩康复计划对重度COVID-19患者的长期影响。该研究是一项单中心、平行、随机、前瞻性随访研究。研究结果包括改良博格呼吸困难量表（MBS）、改良医学研究委员会呼吸困难量表（mMRC）、患者健康问卷-9量表（PHQ-9）、日常生活活动能力（ADL）、其余临床症状以及任何与干预相关的不良事件的变化。结果与对照组相比，干预组在出院 14 个月后的 mMRC 评分（-0.4，95 % CI (-0.6, 0.2)，P < 0.001）和 MBS 评分（-0.6，95 % CI (-0.9, -0.3)，P < 0.001）均有统计学意义上的显著改善。出院 28 个月时，干预组与对照组相比，出院 14 个月后，干预组的 MBS 评分显著增加（-0.4，95 % CI (-0.7，-0.1)，P = 0.024），呼吸困难症状阳性率显著下降（P < 0.05）。结论QARP对COVID-19患者，尤其是中青年患者的呼吸困难、胸闷和咳嗽有长期持续疗效，在随访第14个月时疗效显著。

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来源期刊

Integrative Medicine Research Medicine-Complementary and Alternative Medicine

CiteScore

6.50

自引率

2.90%

发文量

审稿时长

12 weeks

期刊介绍： Integrative Medicine Research (IMR) is a quarterly, peer-reviewed journal focused on scientific research for integrative medicine including traditional medicine (emphasis on acupuncture and herbal medicine), complementary and alternative medicine, and systems medicine. The journal includes papers on basic research, clinical research, methodology, theory, computational analysis and modelling, topical reviews, medical history, education and policy based on physiology, pathology, diagnosis and the systems approach in the field of integrative medicine.