Integrative Medicine Research最新文献

{"title":"Oversimplifying the name of the 12 meridian channels","authors":"In-Seon Lee , Yeonhee Ryu , Younbyoung Chae","doi":"10.1016/j.imr.2023.101002","DOIUrl":"https://doi.org/10.1016/j.imr.2023.101002","url":null,"abstract":"","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422023000811/pdfft?md5=cc0ffd1fb07626e1f65309c5e4ff6199&pid=1-s2.0-S2213422023000811-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91729243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of aromatherapy on sore throat, nasal symptoms and sleep quality in adults infected with COVID-19: A randomized controlled trial","authors":"Hye-Young Kang ,&nbsp;Hye Young Ahn ,&nbsp;Mi-Jung Kang,&nbsp;Myung-Haeng Hur","doi":"10.1016/j.imr.2023.101001","DOIUrl":"https://doi.org/10.1016/j.imr.2023.101001","url":null,"abstract":"<div><h3>Background</h3><p>Patients with coronavirus disease 2019 (COVID-19) usually complain of fever, cough, and sore throat. This study examined the effects of aromatherapy on sore throat, nasal symptoms, stress, fatigue, and sleep quality by administering it to adults with post-COVID-19 condition.</p></div><div><h3>Methods</h3><p>This study was conducted in a randomised controlled design. Its target population were adults who were released from COVID-19 quarantine treatment within 45 days from infection onset and capable of performing daily activities after isolation treatment. The participants were randomised into aromatherapy group (AG) and control group (CG). To test experimental treatment effects, the levels of sore throat, nasal symptoms, stress, fatigue and sleep quality were measured at the baseline (pre-test) and after the trial (post-test), using the numerical rating scale for sore throat, stress and fatigue, the Total Nasal Symptoms Score for nasal symptoms, and the Korean Version of Modified Leeds Sleep Evaluation Questionnaire for quality of sleep.</p></div><div><h3>Results</h3><p>After experimental treatment, there was a significant difference in sore throat in AG compared to CG on the 3rd day (<em>t</em>=-2.022 <em>p</em>=0.048) and 4th day (<em>t</em>=-2.450, <em>p</em>=0.017) of treatment. There was also a significant difference in fatigue between AG and CG on the 2nd day(<em>t</em>=-2.748, <em>p</em>=0.008), 3rd day (<em>t</em>=-2.948, <em>p</em>=0.005) and 4th day (<em>t</em>=-3.084, <em>p</em>=0.003) of treatment. There was no significant difference in TNSS, stress, and sleep quality between the two groups after the experimental treatment.</p></div><div><h3>Conclusion</h3><p>Inhaling aroma essential oils reduced sore throat and fatigue in adults with post-COVID-19 condition, demonstrating the feasibility of aromatherapy as an effective treatment.</p></div><div><h3>Trial registration</h3><p>The study was registered with Clinical Research Information Service (KCT0008029).</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S221342202300080X/pdfft?md5=2889830582e4761607cc69803a4991f9&pid=1-s2.0-S221342202300080X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91775210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GV16 acupoint stimulation with bee venom reduces peripheral hypersensitivity via activation of α2 adrenoceptors in a nitroglycerin-induced migraine mouse model","authors":"Sol-Ji Kim ,&nbsp;Ji-Hee Yeo ,&nbsp;Seo-Yeon Yoon ,&nbsp;Dae-Hyun Roh","doi":"10.1016/j.imr.2023.100999","DOIUrl":"https://doi.org/10.1016/j.imr.2023.100999","url":null,"abstract":"<div><h3>Background</h3><p>Peripheral hypersensitivities develop in the face and hindpaws of mice with nitroglycerin (NTG)-induced migraine. We evaluated whether diluted bee venom (DBV) injections at acupoints prevented these peripheral hypersensitivities and c-Fos expression in the trigeminal nucleus caudalis (TNC).</p></div><div><h3>Methods</h3><p>NTG (10 mg/kg, intraperitoneal, i.p.) was administered every other day for nine days. DBV (0.1 mg/kg) was subcutaneously injected into the ST36 (Zusanli), LI4 (Hegu), or GV16 (Fengfu) acupoints 75 min after each NTG injection. Mice were pretreated with naloxone (5 mg/kg, i.p.) or yohimbine (5 mg/kg, i.p.) 30 min before the DBV injections.</p></div><div><h3>Results</h3><p>NTG injection caused facial cold allodynia, hindpaw mechanical allodynia, and increased c-Fos-immunoreactive (ir) cells in the TNC. Repetitive DBV injections at GV16, but not the ST36, or LI4 acupoints, suppressed NTG-induced hindpaw mechanical allodynia and facial cold allodynia. The number of c-Fos-ir cells also decreased in response to DBV injections at the GV16 acupoint. Remarkably, pretreatment with yohimbine reversed the anti-allodynic effects of DBV injections and attenuated the decreased c-Fos expression in response to GV16 DBV treatment. Naloxone did not block the effects of GV16 DBV stimulation.</p></div><div><h3>Conclusion</h3><p>These findings demonstrate that repetitive DBV treatment at the GV16 acupoint relieves NTG-induced facial and hindpaw hypersensitivities and decreases in c-Fos expression in the TNC via activation of the alpha-2 adrenoceptors, but not the opioid receptors.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422023000781/pdfft?md5=6a1fef8638373f9b2a6df0b1f69c7f98&pid=1-s2.0-S2213422023000781-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91729244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world data analysis on effectiveness of integrative therapies: A practical guide to study design and data analysis using healthcare databases","authors":"Ye-Seul Lee,&nbsp;Yoon Jae Lee,&nbsp;In-Hyuk Ha","doi":"10.1016/j.imr.2023.101000","DOIUrl":"https://doi.org/10.1016/j.imr.2023.101000","url":null,"abstract":"<div><p>Real world data (RWD) is increasingly used to investigate health outcomes and treatment efficacy in the field of integrative medicine. Due to the fact that the majority of RWDs are not intended for research, their secondary use in research necessitates complex study designs to account for bias and confounding. To conduct a robust analysis of RWD in integrative medicine, a comprehensive study design process that reflects the characteristics of integrative therapies is necessary. In this paper, we present a guide for designing comparative effectiveness RWE research in integrative medicine. We discuss key factors to consider when selecting RWDs for research on integrative medicine. We provide practical steps for developing a research question, formulating the PICOT objectives (population, intervention, comparator, outcome, and time horizon), and selecting and defining covariates with a summary table. Specific study designs are depicted with corresponding diagrams. Finally, data analysis procedures are introduced. We hope this article clarifies the importance of RWE research design and related processes in order to improve the rigor of RWD studies in the field of integrative medicine research.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422023000793/pdfft?md5=89c1006144dfc63a4bf6a0117602b214&pid=1-s2.0-S2213422023000793-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90029701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Saposhnikovia divaricata root and its major components ameliorate inflammation and altered gut microbial diversity and compositions in DSS-induced colitis","authors":"Saruul Erdenebileg ,&nbsp;Yang-Ju Son ,&nbsp;Myungsuk Kim ,&nbsp;Sarangerel Oidovsambuu ,&nbsp;Kwang Hyun Cha ,&nbsp;Jaeyoung Kwon ,&nbsp;Da Seul Jung ,&nbsp;Chu Won Nho","doi":"10.1016/j.imr.2023.100998","DOIUrl":"https://doi.org/10.1016/j.imr.2023.100998","url":null,"abstract":"<div><h3>Background</h3><p>The root of <em>Saposhnikovia divaricata</em> (Turcz.) Schischk is a well-known traditional medicinal plant, containing various bioactive compounds with anti-inflammatory, antioxidant, and analgesic properties. However, no scientific studies have validated its clinical use as an anti-inflammatory agent against inflammatory bowel disease (IBD). This study aimed to investigate whether the root extract of <em>S. divaricata</em> ameliorates IBD and induces gut microbial alteration, using a RAW 264.7 cell line and a DSS-induced colitis mouse model.</p></div><div><h3>Methods</h3><p>To investigate the anti-inflammatory effects and alleviation of IBD, using a methanol extract of <em>Saposhnikovia divaricata</em> (Turcz.) Schischk. root (MESD), RAW 264.7, murine macrophages and a dextran sodium sulfate (DSS)-induced colitis mouse model were employed. 16S rRNA gene sequencing was conducted to determine the alterations in the gut microbiota of mice with DSS-induced colitis.</p></div><div><h3>Results</h3><p>MESD significantly decreased nitric oxide (NO) and inflammatory cytokine levels in lipopolysaccharide (LPS)-induced RAW 264.7 cells <em>in vitro</em>. Oral administration of MESD reduced the expression of inflammatory cytokines in the colons of mice with DSS-induced colitis. Additionally, MESD inhibited the abundance of <em>Clostridium sensu stricto</em> 1 and enhanced the predicted functional pathways, including <span>l</span>-glutamate degradation VIII (to propanoic acid). Seven compounds with anti-inflammatory properties were isolated from the MESD. Among them, 3′-O-acetylhamaudol and 3′-O-angeloylhamaudol exhibited strong anti-inflammatory effects <em>in vitro</em>.</p></div><div><h3>Conclusion</h3><p>Overall, MESD may be a potential natural product for the treatment of IBD by lowering inflammatory cytokine levels and altering gut microbiota composition.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S221342202300077X/pdfft?md5=defe800f4db3bce02c67d4b4f5ab6743&pid=1-s2.0-S221342202300077X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92100321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture for ventilator-dependent patients at a hospital-based respiratory care center: A randomized controlled trial","authors":"Jia-Ming Chen ,&nbsp;Wan-Li Chiang ,&nbsp;Bin-Chuan Ji ,&nbsp;Ruei-Jhe Jhang ,&nbsp;Pei-Hsin Chen ,&nbsp;Ya-Lun Li ,&nbsp;Che-Ju Chang ,&nbsp;Sung-Yen Huang ,&nbsp;Tsung-Chieh Lee ,&nbsp;Chia-Yun Chen ,&nbsp;Ching-Hsiung Lin ,&nbsp;Sheng-Hao Lin","doi":"10.1016/j.imr.2023.100997","DOIUrl":"https://doi.org/10.1016/j.imr.2023.100997","url":null,"abstract":"<div><h3>Background</h3><p>In intensive care units, mechanical ventilation is an important therapy to help patients with dyspnea. However, long-term ventilator dependence would consume huge medical resources and increase the risk of morbidity and mortality. The aim of the study was to examine the efficacy of the acupuncture combined with western medical care on ventilator parameters in ventilator-dependent patients.</p></div><div><h3>Methods</h3><p>In this clinical trial, 80 ventilator-dependent patients aged 20 to 80 years old were randomly assigned to acupuncture group and control group in the respiratory care center (RCC) of Changhua Christian Hospital. Besides regular medical care and therapy, participants in the acupuncture group received acupuncture therapy at the same 17 acu-points for 20 minutes once a day, a total of 12 sessions. The ventilator parameters were recorded to evaluate the respiratory efficiency for all participants. The primary outcome was rapid shallow breathing index (RSBI), and secondary outcomes were respiratory rate (RR), tidal volume (TV) and ventilation per minute (MV),</p></div><div><h3>Results</h3><p>Though there was no significant difference in the parameter between the acupuncture group and the control group, we found the trend of decreasing RSBI in the acupuncture group. In subgroup analyses, the mean of RSBI significantly decreased 16.02 (with the SD in 60.84) in acupuncture group, while it increased 17.84 (with the SD in 39.38) in control group (p=0.036) after 12 sessions.</p></div><div><h3>Conclusion</h3><p>Acupuncture treatment can improve breathing ability of patients with respirator dependence in respiratory care center.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422023000768/pdfft?md5=371d4c2d4d36c5ec6fdb7be0ff12d3f0&pid=1-s2.0-S2213422023000768-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134656112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary and herbal supplement consumer health information for pain: A cross-sectional survey and quality assessment of online content","authors":"Jeremy Y Ng,&nbsp;Sahar Popal,&nbsp;Sathurthika Selvanayagam","doi":"10.1016/j.imr.2023.100996","DOIUrl":"https://doi.org/10.1016/j.imr.2023.100996","url":null,"abstract":"<div><h3>Background</h3><p>Patients are increasingly utilizing the internet to learn about dietary and herbal supplements (DHSs) for various diseases/conditions, including pain management. Online health information has been found to be inconsistent and of poor quality in prior studies, which may have detrimental effects on patient health. This study assessed the quality of online DHSs consumer health information for pain.</p></div><div><h3>Methods</h3><p>Six search items related to DHSs and pain were used to generate the first 20 websites on Google across four English-speaking countries. The identified 480 webpages produced 68 eligible websites, which were then evaluated using the DISCERN tool. The mean scores and standard deviations (SD) of the reviewers’ ratings on each of the 15 DISCERN instrument items as well as the overall total score were calculated.</p></div><div><h3>Results</h3><p>The mean summed score for the 68 eligible websites was 46.6 (SD = 10.1), and the mean overall rating was 3.3 (SD = 0.8). Websites lacked information regarding areas of uncertainty, the effects of no treatment being used, and how treatments affect the overall quality of life. These shortcomings were especially apparent across commercial websites, which frequently displayed bias, failed to report the risks of DHS products, and lacked support for shared decision-making regarding the use of DHSs.</p></div><div><h3>Conclusion</h3><p>Variability exists in the quality of online consumer health information regarding DHS use for pain. Healthcare providers should be aware of and provide guidance to patients regarding the identification of reliable online resources so that they can make informed decisions about DHS use for pain management.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49709228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What is integrative medicine? Establishing the decision criteria for an operational definition of integrative medicine for general practice health services research in Australia","authors":"Jennifer Hunter ,&nbsp;Joanna E. Harnett ,&nbsp;Wai-Jo Jocelin Chan ,&nbsp;Marie Pirotta","doi":"10.1016/j.imr.2023.100995","DOIUrl":"https://doi.org/10.1016/j.imr.2023.100995","url":null,"abstract":"<div><h3>Background</h3><p>Operational definitions outline how a conceptual definition will be measured for consistent, reproducible data collection and analysis. This article reports the decision criteria that will be used for an operational definition of integrative medicine (IM) in a secondary analysis of an Australian national survey of general practitioner activity.</p></div><div><h3>Methods</h3><p>A multidisciplinary team applied an iterative approach, informed by expert knowledge and literature reviews to establish decision criteria for categorizing the terms in the Australian clinical interface terminology of the International Classification of Primary Care, second edition (ICPC-2 PLUS) and the Coding Atlas for Pharmaceutical Substances, according to whether they reflected IM, conventional/mainstream medicine (MM), or both IM and MM (IM/MM).</p></div><div><h3>Results</h3><p>The final decision criteria categorized all terms for examinations, investigations, advice/counselling, and drugs with synthetic ingredients, and terms for referrals to secondary care services and healthcare practitioners that are not a traditional or complementary medicine practitioner as MM. Terms that could apply to both styles of clinical practice (e.g., preventive health, lifestyle medicine, psychosocial and some drugs with natural ingredients) were categorised as IM/MM. The remaining terms, that mostly reflected the World Health Organization's theoretical definitions of traditional and complementary medicine, were categorized as IM.</p></div><div><h3>Conclusion</h3><p>Differentiating between integrative and conventional/mainstream medicine in general practice is context specific and not always possible. The category IM/MM proposes integrative medicine as an extension, rather than an alternative. The rationale for the integrative medicine operational definition has relevance for researchers and health services in Australia, and internationally.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49729391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture treatment for functional gastrointestinal disorders: Identification of major acupoints using network analysis","authors":"Heeyoung Moon ,&nbsp;Yeonhee Ryu ,&nbsp;In-Seon Lee ,&nbsp;Younbyoung Chae","doi":"10.1016/j.imr.2023.100970","DOIUrl":"10.1016/j.imr.2023.100970","url":null,"abstract":"<div><h3>Background</h3><p>Using network analysis, we sought to determine the acupoints most commonly used to treat functional gastrointestinal disorders (FGIDs), particularly functional dyspepsia (FD) and irritable bowel syndrome (IBS).</p></div><div><h3>Methods</h3><p>To explore the acupoint patterns used for FGID, data on acupoint combinations for FD and IBS were gathered from systematic reviews. Network analysis was used to determine the degree, closeness centrality, betweenness centrality, and eigenvector centrality of each acupoint. The most common acupoint combinations for FD and IBS were examined based on the eigenvector centrality.</p></div><div><h3>Results</h3><p>Network analysis revealed that CV12, ST25, ST36, CV10, and LR3, which had the highest eigenvector centrality values, were the main acupoints for treating FGID. CV12 was the main acupoint for treating FD, while ST25 was the hub acupoint for treating IBS in the abdomen. ST36, LR3, and PC6 were the key peripheral acupoints for FD and IBS.</p></div><div><h3>Conclusions</h3><p>Using network analysis, we provided data that will aid the selection of both general and specific acupoints for FD and IBS, along with spatial information (i.e., the positions of acupoints on a body map). These findings could be applied in future acupuncture research on therapy for gastrointestinal system dysfunction. They may also help bridge the gap between the traditional meridian theory, which assumes that there is a link between diseases/symptoms and the specific body region being treated, and real-world clinical evidence.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/18/a1/main.PMC10407428.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10026930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moxibustion for medical personnel with negative emotion and insomnia during COVID-19 pandemic: A randomized, controlled trial","authors":"Xiying Li ,&nbsp;Xiaojuan Li ,&nbsp;Xian Wang ,&nbsp;Xuan Yin ,&nbsp;Shanshan Li ,&nbsp;Junyi Wu ,&nbsp;Xiumei Ren ,&nbsp;Wei Zhang ,&nbsp;Yiqun Mi ,&nbsp;Shifen Xu","doi":"10.1016/j.imr.2023.100974","DOIUrl":"10.1016/j.imr.2023.100974","url":null,"abstract":"<div><h3>Background</h3><p>We conducted this randomized controlled trial (RCT) to evaluate the effectiveness and safety of moxibustion at Sanyinjiao (SP6) acupoint for treatment of negative mood and sleep quality in healthcare workers during the 2019 coronavirus disease (COVID-19).</p></div><div><h3>Methods</h3><p>A total of 180 participants were divided in a 1:1 ratio into two groups, the treatment group (for moxibustion) and the control group (for no treatment). The treatment group had a 30-minute moxibustion therapy once a day for two weeks, followed by a two-week follow-up. The Hamilton Anxiety Scale (HAMA) was used to assess the degree of the participants' anxiety, and the Patient Health Questionnaire-9 (PHQ-9) was utilized to examine their depressed condition. The Maslach Burnout Inventory-General Survey (MBI-GS) was used to measure the level of burnout among healthcare workers. To determine the severity of insomnia, the Sleep Dysfunction Rating Scale (SDRS) was utilized. At baseline, week 2, and week 4, all scales were evaluated.</p></div><div><h3>Results</h3><p>Compared to the control group, the treatment group improved more significantly in the HAMA at week 2 (MD = -19.01, 95% CI: -21.89 to -16.14; <em>P</em>&lt;0.001) and at week 4 follow-up visits (MD = -8.96, 95% CI: -11.19 to -6.73; <em>P</em>&lt;0.001). A subgroup study of HAMA scores revealed that position and education had significant impact on treatment effectiveness. During the 2-week intervention period, the treatment group showed more significant improvements in depressive symptoms measured by PHQ-9 (13.00±2.41 vs. 15.60±3.65; <em>P</em>&lt;0.001), work burnout symptoms measured by MBI-GS (MD = -11.88, 95% CI, -15.73 to -8.03; <em>P</em>&lt;0.001), and insomnia symptoms measured by SDRS (MD = -2.45, 95% CI, -4.24 to -0.66; <em>P</em>&lt;0.01). There were no significant adverse effects reported.</p></div><div><h3>Conclusion</h3><p>Moxibustion at SP6 may be an effective treatment to improve anxiety, depression, sleep quality, and quality of life for healthcare workers during COVID-19.</p></div><div><h3>Trial registration</h3><p>This trial was registered at Chinese Clinical Trial Registry (ChiCTR): ChiCTR-2200059327.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/44/9a/main.PMC10448013.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10464641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}