Integrative Medicine Research最新文献

{"title":"Efficacy and safety of herbal medicine Gongjin-Dan and Ssanghwa-Tang in patients with chronic fatigue: A randomized, double-blind, placebo-controlled, clinical trial","authors":"Jun-Yong Choi ,&nbsp;Bom Choi ,&nbsp;Ojin Kwon ,&nbsp;Chang-Seob Seo ,&nbsp;Ae-Ran Kim ,&nbsp;Hyeun-kyoo Shin ,&nbsp;Kibong Kim","doi":"10.1016/j.imr.2024.101025","DOIUrl":"10.1016/j.imr.2024.101025","url":null,"abstract":"<div><h3>Background</h3><p>Gongjin-dan (GJD, also known as Gongchen-dan) and Ssanghwa-tang (SHT, also known as Shuanghe-tang or Souwa-to) are herbal medicines that are widely used in Korea for treating fatigue. However, few studies have evaluated the efficacy and safety of GJD and SHT in the treatment of chronic fatigue.</p></div><div><h3>Methods</h3><p>In this randomized, double-blind, placebo-controlled clinical trial, 90 individuals with persistent (≥6 months) chronic fatigue of unknown cause and a Fatigue Severity Scale (FSS) score of ≥4 were randomly assigned to GJD group, SHT group, and control group in a 1:1:1 ratio. Outcomes were the changes in the self-reported fatigue questionnaire scores, levels of fatigue-related biomarkers and safety assessment.</p></div><div><h3>Results</h3><p>Out of 103 patients recruited, 90 were included in the analysis. A significant improvement in the Social Functioning (SF) score of Short-Form 36 Health Survey (SF-36) at week 4 was observed in the GJD group; similarly, a significant improvement compared with that in the Control group was observed in the Role Emotional (RE) score of SF-36 at weeks 4 and 6 and the Physical Functioning (PF) score of SF-36 at week 6 in the SHT group. Laboratory tests revealed no abnormalities, and serious intervention-related adverse events were not reported.</p></div><div><h3>Conclusions</h3><p>It is suggested that SHT can effectively treat chronic mental and physical fatigue, whereas GJD can effectively treat chronic mental and social fatigue. Furthermore, this study presents evidence supporting the safety of the long-term use of GJD and SHT (up to 4 weeks).</p></div><div><h3>Trial registration</h3><p>This study was registered at Clinical Research Information Service (CRIS) of Korea with the registration number KCT0007515.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 1","pages":"Article 101025"},"PeriodicalIF":3.4,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422024000052/pdfft?md5=0180e2aec9ae7d2e2114f8bded2ad2bb&pid=1-s2.0-S2213422024000052-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139927571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional, complementary, and integrative medicine and artificial intelligence: Novel opportunities in healthcare","authors":"Jeremy Y. Ng ,&nbsp;Holger Cramer ,&nbsp;Myeong Soo Lee ,&nbsp;David Moher","doi":"10.1016/j.imr.2024.101024","DOIUrl":"https://doi.org/10.1016/j.imr.2024.101024","url":null,"abstract":"<div><p>The convergence of traditional, complementary, and integrative medicine (TCIM) with artificial intelligence (AI) is a promising frontier in healthcare. TCIM is a patient-centric approach that combines conventional medicine with complementary therapies, emphasizing holistic well-being. AI can revolutionize healthcare through data-driven decision-making and personalized treatment plans. This article explores how AI technologies can complement and enhance TCIM, aligning with the shared objectives of researchers from both fields in improving patient outcomes, enhancing care quality, and promoting holistic wellness. This integration of TCIM and AI introduces exciting opportunities but also noteworthy challenges. AI may augment TCIM by assisting in early disease detection, providing personalized treatment plans, predicting health trends, and enhancing patient engagement. Challenges at the intersection of AI and TCIM include data privacy and security, regulatory complexities, maintaining the human touch in patient-provider relationships, and mitigating bias in AI algorithms. Patients' trust, informed consent, and legal accountability are all essential considerations. Future directions in AI-enhanced TCIM include advanced personalized medicine, understanding the efficacy of herbal remedies, and studying patient-provider interactions. Research on bias mitigation, patient acceptance, and trust in AI-driven TCIM healthcare is crucial. In this article, we outlined that the merging of TCIM and AI holds great promise in enhancing healthcare delivery, personalizing treatment plans, preventive care, and patient engagement. Addressing challenges and fostering collaboration between AI experts, TCIM practitioners, and policymakers, however, is vital to harnessing the full potential of this integration.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 1","pages":"Article 101024"},"PeriodicalIF":3.4,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422024000040/pdfft?md5=b8cbf1adb83572dbee54fa4b37730fde&pid=1-s2.0-S2213422024000040-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139743281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recommendations and guidelines of integrative medicine for COVID-19 care: The APEC project outcome","authors":"Libin Jia ,&nbsp;Michelle Beidelschies ,&nbsp;Joel M. Evans ,&nbsp;Richard C. Niemtzow ,&nbsp;Songxuan Zhou Niemtzow ,&nbsp;Jeffery A. Dusek ,&nbsp;Yufang Lin ,&nbsp;Charles Wu ,&nbsp;Yi-Chang Su ,&nbsp;C. Jason Wang ,&nbsp;Chien-Yu Lin ,&nbsp;Peristiwan Ridha Widhi Astana ,&nbsp;Danang Ardiyanto ,&nbsp;Rusmiyati Hardjoutomo ,&nbsp;Khwanchai Visithanon ,&nbsp;Jagravudh Puagkong ,&nbsp;Julalak Chokpaisarn ,&nbsp;Martha Villar Lopez ,&nbsp;Hiroshi Yotsuyanagi ,&nbsp;Myeong Soo Lee ,&nbsp;Cecilia C. Maramba-Lazarte","doi":"10.1016/j.imr.2024.101022","DOIUrl":"https://doi.org/10.1016/j.imr.2024.101022","url":null,"abstract":"<div><p>This article - Recommendations and Guidelines of Integrative Medicine (IM) for COVID-19 Care - was one of the outcomes from an Asia-Pacific Economic Cooperation (APEC) Project (Integrative Medicine (IM) and COVID -19 Care) during the time between May 2022 and March 2023. With the efforts from care providers, researchers, health policy makers and healthcare administrative leaders among APEC economies, the purpose of this file was to provide comprehensive IM systems for COVID-19 care as recommendations and suggestive guidelines including care methods, tools, procedures, symptom conditions and targets selections, and points need to be considered during care applications. All cited COVID-19 care practices have confirmed their efficacy and usefulness either used alone or combined with conventional medicine. This article provides current useful medical information on IM for COVID-19 care which could benefit APEC economies and world health communities on their healthcare system.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 1","pages":"Article 101022"},"PeriodicalIF":3.4,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422024000027/pdfft?md5=810297852db3200d2ed65099f89cf9a7&pid=1-s2.0-S2213422024000027-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139975972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture treatment for Hashimoto's thyroiditis: An exploratory randomized controlled trial","authors":"Shanze Wang ,&nbsp;Chao Yang ,&nbsp;Weimei Zeng ,&nbsp;Hongfang Tian ,&nbsp;Shihao Du ,&nbsp;Jiping Zhao","doi":"10.1016/j.imr.2024.101023","DOIUrl":"10.1016/j.imr.2024.101023","url":null,"abstract":"<div><h3>Background</h3><p>Hashimoto's thyroiditis (HT) has a high incidence rate and unresolved clinical symptoms. Although Hand Yangming Meridian Penetrating Acupuncture has been used to treat thyroid diseases in China, there is no randomized controlled trial (RCT) on HT.</p></div><div><h3>Methods</h3><p>This exploratory RCT aims to preliminarily evaluate the efficacy, safety, and feasibility of Hand Yangming Meridian Penetrating Acupuncture in the treatment of HT. Included subjects were randomly assigned to the acupuncture group and the waiting treatment group at a ratio of 1:1. Subjects in the acupuncture group received 16 weeks of acupuncture treatment, followed by a 16-week follow-up observation phase. Subjects in the waiting group received thyroxine supplementation for 16 weeks, followed by 16 weeks of compensation treatment. Serum thyroid peroxidase antibody (TPOab) and thyroglobulin antibody (TGab) levels were the main indicators, and Thyroid-Related Patient-Reported Outcome short form (ThyPRO-39), MOS Item Short Form Health Survey (SF-36), and Hospital Anxiety and Depression Scale (HADS) scores were also recorded.</p></div><div><h3>Results</h3><p>In total, 58 subjects were included. After 16 weeks of treatment, there was no statistical difference in the changes in TPOab levels between the two groups, but the TGab level in the acupuncture group was significantly lower than in the waiting group (difference: −141.97 [95 % CI: −222.4 to −61.5]<em>, P</em> = 0.011). Moreover, the total ThyPRO-39 and SF-36 scores were statistically different between the two groups (<em>P</em>_ThyPRO-39 &lt; 0.001, <em>P</em>_SF-36 = 0.005). There was no statistical difference in HADS between the two groups.</p></div><div><h3>Conclusions</h3><p>Hand Yangming Meridian Penetrating Acupuncture may be safe and feasible for HT hypothyroidism to improve symptoms and reduce TGab levels.</p></div><div><h3>Trial registration number</h3><p>This trial was registered at Acupuncture-Moxibustion Clinical Trial Registry: AMCTR-IOR-19000308 (ChiCTR1900026830, <span>https://www.chictr.org.cn/searchprojEN.html</span><svg><path></path></svg>).</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 1","pages":"Article 101023"},"PeriodicalIF":3.4,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422024000039/pdfft?md5=46d85862d2dae13130ef55fe03b3b5ba&pid=1-s2.0-S2213422024000039-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139754365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture for response and complete pain relief time of acute renal colic: Secondary analysis of a randomized controlled trial","authors":"Xue-Zhou Wang ,&nbsp;Cun-Zhi Liu ,&nbsp;Li-Qiong Wang ,&nbsp;Zhi-Cheng Qu ,&nbsp;Ying Cao ,&nbsp;Shi-Yan Yan ,&nbsp;Jing-Wen Yang ,&nbsp;Jian-Feng Tu","doi":"10.1016/j.imr.2024.101021","DOIUrl":"10.1016/j.imr.2024.101021","url":null,"abstract":"<div><h3>Background</h3><p>The integration of acupuncture with intramuscular injection of diclofenac sodium can expedite the onset of analgesia in treating acute renal colic caused by urolithiasis. However, it remains unclear whether acupuncture can accelerate pain relief constantly until complete remission. This study aimed to explore the extent to which acupuncture can expedite the onset time of response or complete pain relief in treating acute renal colic, and the predictive value of patient characteristics for treatment efficacy.</p></div><div><h3>Methods</h3><p>This secondary analysis utilized data from a prior randomized controlled trial. Eighty patients with acute renal colic were randomly assigned 1:1 to the acupuncture group or the sham acupuncture group. After intramuscular injection of diclofenac sodium, acupuncture or sham acupuncture was delivered to patients. The outcomes included time to response (at least a 50 % reduction in pain) and complete pain relief. Between-group comparison under the 2 events was estimated by Kaplan-Meier methodology. Subgroup analysis was performed utilizing the Cox proportional hazards model.</p></div><div><h3>Results</h3><p>The median response time and complete pain relief time in the acupuncture group were lower than those in the sham acupuncture group (5 vs 30 min, Log Rank <em>P</em> &lt; 0.001; 20 min vs not observed, Log Rank <em>P</em> &lt; 0.001, respectively). Hazard Ratios (HRs) for response across all subgroups favored the acupuncture group. All HRs for complete pain relief favored acupuncture, expect large stone and moderate pain at baseline. No interaction was found in either event.</p></div><div><h3>Conclusion</h3><p>Acupuncture can accelerate the response time and complete pain relief time for patients with acute renal colic, with the efficacy universally.</p></div><div><h3>Trial registration</h3><p>This study has been registered at Chinese Clinical Trial Registry: ChiCTR1900025202.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 1","pages":"Article 101021"},"PeriodicalIF":3.4,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422024000015/pdfft?md5=ee00c056134e72095dbd3da8043d8b0c&pid=1-s2.0-S2213422024000015-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139507269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curcuma xanthorrhiza extract and xanthorrhizol ameliorate cancer-induced adipose wasting in CT26-bearing mice by regulating lipid metabolism and adipose tissue browning","authors":"Haeun Kim ,&nbsp;Dong-Woo Lee ,&nbsp;Jae-Kwan Hwang","doi":"10.1016/j.imr.2023.101020","DOIUrl":"10.1016/j.imr.2023.101020","url":null,"abstract":"<div><h3>Background</h3><p>Cancer cachexia—characterized by anorexia, body weight loss, skeletal muscle atrophy, and fat loss—affects nearly 80% of cancer patients and accounts for 20% of cancer deaths. <em>Curcuma xanthorrhiza</em>, known as Java turmeric, and its active compound xanthorrhizol (XAN) exhibit anticancer, anti-inflammatory, and antioxidant properties. However, the ameliorative effects of <em>C. xanthorrhiza</em> extract (CXE) and XAN on cancer-associated adipose atrophy remain unexplored. This study aimed to evaluate the therapeutic effects of CXE and XAN on cancer cachexia-induced adipose tissue wasting in CT26 tumor-bearing mice.</p></div><div><h3>Methods</h3><p>CT26 cells were injected subcutaneously into the right flank of BALB/c mice to establish a cancer cachexia model. To evaluate the inhibitory effects of CXE and XAN on cancer cachexia, 50 and 100 mg/kg CXE and 15 mg/kg XAN were administered orally every day for 1 week.</p></div><div><h3>Results</h3><p>CXE and XAN administration significantly attenuated the loss of body weight and epidydimal fat mass by cancer cachexia. In epididymal adipose tissues, administration of CXE or XAN inhibited white adipose tissue browning by repressing expression of the thermogenic genes. Simultaneously, CXE or XAN attenuated fat catabolism through the downregulation of lipolytic genes. The administration of CXE or XAN induced the expression of genes associated with adipogenesis and lipogenesis-related genes. Moreover, CXE or XAN treatment was associated with maintaining metabolic homeostasis; regulating the expression of adipokines and AMP-activated protein kinase (AMPK).</p></div><div><h3>Conclusions</h3><p>CXE and XAN mitigate cancer-induced adipose tissue atrophy, primarily by modulating lipid metabolism and WAT browning, indicating their therapeutic potential for cachectic cancer patients.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 1","pages":"Article 101020"},"PeriodicalIF":3.4,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422023000999/pdfft?md5=45e7aae2ce23721f60bbb95812194cda&pid=1-s2.0-S2213422023000999-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139036846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional Chinese medicine diagnostic prediction model for holistic syndrome differentiation based on deep learning","authors":"Zhe Chen ,&nbsp;Dong Zhang ,&nbsp;Chunxiang Liu ,&nbsp;Hui Wang ,&nbsp;Xinyao Jin ,&nbsp;Fengwen Yang ,&nbsp;Junhua Zhang","doi":"10.1016/j.imr.2023.101019","DOIUrl":"10.1016/j.imr.2023.101019","url":null,"abstract":"<div><h3>Background</h3><p>With the development of traditional Chinese medicine (TCM) syndrome knowledge accumulation and artificial intelligence (AI), this study proposes a holistic TCM syndrome differentiation model for the classification prediction of multiple TCM syndromes based on deep learning and accelerates the construction of modern foundational TCM equipment.</p></div><div><h3>Methods</h3><p>We searched publicly available TCM guidelines and textbooks for expert knowledge and validated these sources using ten-fold cross-validation. Based on the BERT and CNN models, with the classification constraints from TCM holistic syndrome differentiation, the TCM-BERT-CNN model was constructed, which completes the end-to-end TCM holistic syndrome text classification task through symptom input and syndrome output. We assessed the performance of the model using precision, recall, and F1 scores as evaluation metrics.</p></div><div><h3>Results</h3><p>The TCM-BERT-CNN model had a higher precision (0.926), recall (0.9238), and F1 score (0.9247) than the BERT, TextCNN, LSTM RNN, and LSTM ATTENTION models and achieved superior results in model performance and predictive classification of most TCM syndromes. Symptom feature visualization demonstrated that the TCM-BERT-CNN model can effectively identify the correlation and characteristics of symptoms in different syndromes with a strong correlation, which conforms to the diagnostic characteristics of TCM syndromes.</p></div><div><h3>Conclusions</h3><p>The TCM-BERT-CNN model proposed in this study is in accordance with the TCM diagnostic characteristics of holistic syndrome differentiation and can effectively complete diagnostic prediction tasks for various TCM syndromes. The results of this study provide new insights into the development of deep learning models for holistic syndrome differentiation in TCM.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 1","pages":"Article 101019"},"PeriodicalIF":3.4,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422023000987/pdfft?md5=99cd836599379ae327efed4c3301b406&pid=1-s2.0-S2213422023000987-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138745678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to understand and report heterogeneity in a meta-analysis: The difference between I-squared and prediction intervals","authors":"Michael Borenstein","doi":"10.1016/j.imr.2023.101014","DOIUrl":"10.1016/j.imr.2023.101014","url":null,"abstract":"<div><p>In any meta-analysis it is important to report not only the mean effect size but also how the effect size varies across studies. A treatment that has a moderate clinical impact in all studies is very different than a treatment where the impact is moderate on average, but in some studies is large and in others is trivial (or even harmful). A treatment that has no impact in any studies is very different than a treatment that has no impact on average because it is helpful in some studies but harmful in others. The majority of meta-analyses use the I-squared index to quantify heterogeneity. While this practice is common it is nevertheless incorrect. I-squared does not tell us how much the effect size varies (except when I-squared is zero percent). The statistic that does convey this information is the prediction interval. It allows us to report, for example, that a treatment has a clinically trivial or moderate effect in roughly 10 % of studies, a large effect in roughly 50 %, and a very large effect in roughly 40 %. This is the information that researchers or clinicians have in mind when they ask about heterogeneity. It is the information that researchers believe (incorrectly) is provided by I-squared.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 4","pages":"Article 101014"},"PeriodicalIF":3.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422023000938/pdfft?md5=e4a81bd65e0c133ffa3fa698f4f8c8a9&pid=1-s2.0-S2213422023000938-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138536280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herbal medicine (Oryeongsan) for fluid and sodium balance in renal cortex of spontaneously hypertensive rats","authors":"You Mee Ahn ,&nbsp;Hye Yoom Kim ,&nbsp;Dae Gill Kang ,&nbsp;Kyung Woo Cho ,&nbsp;Ho Sub Lee","doi":"10.1016/j.imr.2023.101007","DOIUrl":"10.1016/j.imr.2023.101007","url":null,"abstract":"<div><h3>Background</h3><p>Herbal medicine Oryeongsan (ORS), also known as Wulingsan in Chinesehas been used for the treatment of impaired body fluid balance. However, the mechanisms involved are not clearly defined. The purpose of the present study was to identify the actions of ORS on the renal excretory function and blood pressure (BP) and to define the mechanisms involved in association with renin-angiotensin system (RAS) and natriuretic peptide system (NPS) in spontaneously hypertensive rats (SHR), an animal model of human essential hypertension.</p></div><div><h3>Methods</h3><p>Changes in urine volume (UV), excretion of electrolytes including Na⁺ (urinary excretion of Na⁺ (U_NaV)) were measured. RT-PCR was performed to trace the changes in expression of RAS, NPS and sodium (Na⁺)-hydrogen (H⁺) exchanger 3 (NHE3) in the renal cortex.</p></div><div><h3>Results</h3><p>In the SHR treated with vehicle (SHR-V) group, UV and U_NaV were suppressed and the Na⁺ balance was maintained at the higher levels leading to an increase in BP compared to WKY-V group. These were accompanied by an increase in NHE3 expression with an accentuation of angiotensin I converting enzyme-angiotensin II type 1 (ACE-AT₁) receptor and concurrent suppression of angiotensin II type 2 (AT₂) receptor/ACE2-Mas receptor expression in the renal cortex. Chronic treatment with ORS increased UV and U_NaV, and decreased the Na⁺ and water balance with a decrease in BP in the ORS-treated SHR-ORS group compared to SHR-V. These were accompanied by a decrease in NHE3 expression with a suppression of ACE-AT₁ receptor and concurrent accentuation of AT₂/ACE2-Mas receptor.</p></div><div><h3>Conclusion</h3><p>The present study shows that ORS reduced BP with a decrease in Na⁺ and water retention by a suppression of NHE3 expression via modulation of RAS and NPS in SHR. The present study provides pharmacological rationale for the treatment of hypertension with ORS in SHR.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 1","pages":"Article 101007"},"PeriodicalIF":3.4,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422023000860/pdfft?md5=0c9cd122c13cfac60634d2df0b47ce73&pid=1-s2.0-S2213422023000860-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138536285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep electroacupuncture of neurogenic spots attenuates immobilization stress-induced acute hypertension in rats","authors":"Cong Zhan ,&nbsp;Han Byeol Jang ,&nbsp;DanBi Ahn ,&nbsp;Suchan Chang ,&nbsp;Yeonhee Ryu ,&nbsp;Hyung Kyu Kim ,&nbsp;Bong Hyo Lee ,&nbsp;Xiaowei Guan ,&nbsp;Yu Fan ,&nbsp;Bae Hwan Lee ,&nbsp;Hee Young Kim","doi":"10.1016/j.imr.2023.101006","DOIUrl":"10.1016/j.imr.2023.101006","url":null,"abstract":"<div><h3>Background</h3><p>Our previous studies proved that neurogenic inflammatory spots (or neurogenic spots) have the same physiological features as acupuncture points and that neurogenic spot stimulation generates therapeutic effects in various animal models. However, it is unclear how deeply the neurogenic spots should be stimulated to generate therapeutic effects.</p></div><div><h3>Methods</h3><p>The effects of acupuncture at various needle depths below the neurogenic spot were examined in a rat immobilization stress-induced hypertension (IMH) model. Electroacupuncture was applied to a neurogenic spot at depths of 1, 2, or 3 mm using a concentric bipolar electrode.</p></div><div><h3>Results</h3><p>Electrical stimulation of the neurogenic spot at a 3-mm depth most effectively lowered blood pressure compared with controls and stimulation at 1- and 2-mm depths, which was inhibited by pretreatment with a local anesthetic lidocaine. Electrical stimulation of the neurogenic spot or injection of substance P (SP) at a 3-mm depth significantly excited the rostral ventrolateral medulla (rVLM) compared with superficial stimulation. Electrical stimulation applied at a 3-mm depth on neurogenic spots dominantly caused c-fos expression from rVLM and ventrolateral periaqueductal gray (vlPAG) in IMH rats. Pretreatment with resiniferatoxin (RTX) injection into the neurogenic spot to ablate SP or calcitonin gene-related peptide (CGRP) prevented the effects of 3-mm neurogenic spot stimulation on blood pressure in IMH rats. Conversely, artificial injection of SP or CGRP generated anti-hypertensive effects in IMH rats.</p></div><div><h3>Conclusion</h3><p>Our data suggest that neurogenic spot stimulation at a 3-mm depth generated anti-hypertensive effects through the local release of SP and CGRP and activation of rVLM and vlPAG.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 1","pages":"Article 101006"},"PeriodicalIF":3.4,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422023000859/pdfft?md5=c21f1979ec1868c76b8ef02365b3c358&pid=1-s2.0-S2213422023000859-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138536286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}