Integrative Medicine Research最新文献

{"title":"Open science practices in traditional, complementary, and integrative medicine research: A path to enhanced transparency and collaboration","authors":"Jeremy Y. Ng ,&nbsp;L. Susan Wieland ,&nbsp;Myeong Soo Lee ,&nbsp;Jian-ping Liu ,&nbsp;Claudia M. Witt ,&nbsp;David Moher ,&nbsp;Holger Cramer","doi":"10.1016/j.imr.2024.101047","DOIUrl":"https://doi.org/10.1016/j.imr.2024.101047","url":null,"abstract":"<div><p>This educational article explores the convergence of open science practices and traditional, complementary, and integrative medicine (TCIM), shedding light on the potential benefits and challenges of open science for the development, dissemination, and implementation of evidence-based TCIM. We emphasize the transformative shift in medical science towards open and collaborative practices, highlighting the limited application of open science in TCIM research despite its growing acceptance among patients. We define open science practices and discuss those that are applicable to TCIM, including: study registration; reporting guidelines; data, code and material sharing; preprinting; publishing open access; and reproducibility/replication studies. We explore the benefits of open science in TCIM, spanning improved research quality, increased public trust, accelerated innovation, and enhanced evidence-based decision-making. We also acknowledge challenges such as data privacy concerns, limited resources, and resistance to cultural change. We propose strategies to overcome these challenges, including ethical guidelines, education programs, funding advocacy, interdisciplinary dialogue, and patient engagement. Looking to the future, we envision the maturation of open science in TCIM, the development of TCIM-specific guidelines for open science practices, advancements in data sharing platforms, the integration of open data and artificial intelligence in TCIM research, and changes in the context of policy and regulation. We foresee a future where open science in TCIM leads to a better evidence base, informed decision-making, interdisciplinary collaboration, and transformative impacts on healthcare and research methodologies, highlighting the promising synergy between open science and TCIM for holistic, evidence-based healthcare solutions.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 2","pages":"Article 101047"},"PeriodicalIF":3.4,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422024000271/pdfft?md5=47de9ef462d474c8f077ac90009cb852&pid=1-s2.0-S2213422024000271-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140950564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological proposals for developing trustworthy recommendations of integrative Chinese-Western medicine","authors":"Honghao Lai ,&nbsp;Mingyao Sun ,&nbsp;Bei Pan ,&nbsp;Baojin Han ,&nbsp;Tingting Lu ,&nbsp;Lei Fang ,&nbsp;Jie Liu ,&nbsp;Long Ge","doi":"10.1016/j.imr.2024.101046","DOIUrl":"https://doi.org/10.1016/j.imr.2024.101046","url":null,"abstract":"<div><h3>Background</h3><p>To refine the methods of developing clinical practice guidelines (CPGs) for integrative Chinese-Western medicine (ICWM), promoting the formation of trustworthy, implementable recommendations that integrate the strengths of Chinese and Western medicine.</p></div><div><h3>Methods</h3><p>Using a nominal group technique (NGT) approach, a multidisciplinary expert panel was established. The panel identified key methodological issues in ICWM-CPG development through literature review and iterative discussions, and formulated methodological proposals to address these issues. The final set of proposals was achieved through consensus among the panel members.</p></div><div><h3>Results</h3><p>The collaborative effort resulted in the identification of five pivotal methodological issues and the subsequent establishment of 22 specific recommendations. These encompass strict adherence to renowned standards, such as those proposed by the Institute of Medicine (IOM) and Guidelines International Network (G-I-N), the employment of methodologies like the GRADE approach and RIGHT statement, the strategic constitution of a balanced development group, the adept identification of ICWM-focused clinical inquiries, the nuanced integration of diverse evidence sources, and the detailed crafting of transparent, implementable recommendations.</p></div><div><h3>Conclusions</h3><p>This study concentrates on the most crucial and prevalent methodological issues in ICWM-CPG development, proposing a series of recommendations. These suggestions result from a multidisciplinary expert consensus, aiming to provide methodological guidance for ICWM-CPG developers, building upon the current foundational methodologies.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 2","pages":"Article 101046"},"PeriodicalIF":3.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S221342202400026X/pdfft?md5=aa378a74e4f710bc3404c417a15fdafe&pid=1-s2.0-S221342202400026X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140950563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional Chinese medicine for post-viral olfactory dysfunction: A systematic review","authors":"Xiang-yun Zou ,&nbsp;Xue-han Liu ,&nbsp;Chun-li Lu ,&nbsp;Xin-yan Jin ,&nbsp;Bai-xiang He ,&nbsp;Yi-lei Liao ,&nbsp;Ting Liu ,&nbsp;Yi-dan Dai ,&nbsp;Shi-hao Qi ,&nbsp;Zhu-jun Sheng ,&nbsp;Zhan-feng Yan ,&nbsp;Guo-Yan Yang ,&nbsp;Trine Stub ,&nbsp;Jian-ping Liu","doi":"10.1016/j.imr.2024.101045","DOIUrl":"10.1016/j.imr.2024.101045","url":null,"abstract":"<div><h3>Background</h3><p>Post-viral olfactory dysfunction (PVOD) is the common symptoms of long COVID, lacking of effective treatments. Traditional Chinese medicine (TCM) is claimed to be effective in treating olfactory dysfunction, but the evidence has not yet been critically appraised. We conducted a systematic review to evaluate the effectiveness and safety of TCM for PVOD.</p></div><div><h3>Methods</h3><p>We searched eight databases to identified clinical controlled studies about TCM for PVOD. The Cochrane risk of bias tools and GRADE were used to evaluate the quality of evidence. Risk ratio (RR), mean differences (MD), and 95 % confidence interval (CI), were used for effect estimation and RevMan 5.4.1 was used for data analysis.</p></div><div><h3>Results</h3><p>Six randomized controlled trials (RCTs) (545 participants), two non-randomized controlled trials (non-RCTs) (112 participants), and one retrospective cohort study (30 participants) were included. The overall quality of included studies was low. Acupuncture (<em>n</em> = 8) and acupoint injection (<em>n</em> = 3) were the mainly used TCM therapies. Five RCTs showed a better effect in TCM group. Four trials used acupuncture, and three trials used acupoint injection. The results of two non-RCTs and one cohort study were not statistically significant. Two trials reported mild to moderate adverse events (pain and brief syncope caused by acupuncture or acupoint injection).</p></div><div><h3>Conclusions</h3><p>Limited evidence focus on acupuncture and acupoint injection for PVOD and suggests that acupuncture and acupoint injection may be effective in improving PVOD. More well-designed trials should focus on acupuncture to confirm the benefit.</p></div><div><h3>Protocol registration</h3><p>The protocol of this review was registered at PROSPERO: CRD42022366776.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 2","pages":"Article 101045"},"PeriodicalIF":3.4,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422024000258/pdfft?md5=4ff481750c4342768d8fb8158fd624a7&pid=1-s2.0-S2213422024000258-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140764333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and safety of hominis placental pharmacopuncture for chronic temporomandibular disorder: A multi-center randomized controlled trial","authors":"Kyoung Sun Park ,&nbsp;Eun-San Kim ,&nbsp;Koh-Woon Kim ,&nbsp;Jae-Heung Cho ,&nbsp;Yoon Jae Lee ,&nbsp;Jinho Lee ,&nbsp;In-Hyuk Ha","doi":"10.1016/j.imr.2024.101044","DOIUrl":"10.1016/j.imr.2024.101044","url":null,"abstract":"<div><h3>Background</h3><p>Hominis placental (HPP) extract has been approved by the Ministry of Food and Drug Safety in Korea for treating chronic liver diseases and postmenopausal syndrome. However, its efficacy and safety for treating chronic temporomandibular disorder (TMD) remains unclear. We aimed to assess the effectiveness and safety of HPP for treating chronic TMD compared with physical therapy (PT).</p></div><div><h3>Methods</h3><p>This study is a 2-arm parallel, multi-center, randomized controlled trial. We enrolled 82 chronic TMD patients from 2 Korean medicine hospitals between December 2019 and January 2021. We included patients with chronic TMD and randomly assigned them to undergo HPP or PT. The primary outcome was the difference in the scores for temporomandibular joint (TMJ) pain at baseline and week 6. The secondary outcomes were the scores for TMJ pain and bothersomeness, TMJ range of motion, the Korean version of Beck's depression index-Ⅱ, jaw functional limitation scale (JFLS) score, patient global impression of change (PGIC) scores, EuroQoL 5-dimension 5-level score, and short form-12 health survey (SF-12) scores.</p></div><div><h3>Results</h3><p>Compared with PT, HPP showed significantly superior effects on TMJ pain and bothersomeness, protrusive movement pain, JFLS (verbal, emotional, and global), SF-12, and PGIC scores at week 6 (<em>P</em> &lt; 0.05). Compared with the PT group, the HPP group showed a significantly higher recovery rate (≥50 % reduction in the scores for TMJ pain at the 24-week follow-up).</p></div><div><h3>Conclusion</h3><p>HPP was more effective than PT managing pain and improving function and quality of life. Our findings demonstrate the effectiveness and safety of HPP for TMD treatment.</p></div><div><h3>Trial registration</h3><p>This study has been registered at clinicalTrials.gov (NCT04087005), Clinical Research Information Service (CRIS) (KCT0004437), and Ministry of Food and Drug Safety (No. 31886).</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 2","pages":"Article 101044"},"PeriodicalIF":3.4,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422024000246/pdfft?md5=391253d1b3ba8293ad6650b8d4edff76&pid=1-s2.0-S2213422024000246-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140772940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prior acupuncture experience among elderly participants enrolled in a clinical trial of acupuncture for chronic low back pain: Implications for future trials","authors":"Prince Ziyi Wang ,&nbsp;Alice Pressman ,&nbsp;Gabriela Sanchez ,&nbsp;Crystal Aparicio ,&nbsp;Arya Nielsen ,&nbsp;Andrew Avins","doi":"10.1016/j.imr.2024.101042","DOIUrl":"10.1016/j.imr.2024.101042","url":null,"abstract":"<div><h3>Background</h3><p>The effectiveness of acupuncture for chronic low back pain (cLBP) has not been studied specifically in the 65-and-older population. To inform the validity and generalizability of future acupuncture studies among older adults, we characterized elderly participants’ prior experience with and views toward acupuncture and tested for clinical and sociodemographic differences between acupuncture-naïve and non-naïve participants.</p></div><div><h3>Methods</h3><p>Data for this study were collected during the baseline telephone interview from the participants enrolled in the Kaiser Permanente Northern California site of an NIH-funded, multicenter clinical trial of acupuncture for cLBP in older adults.</p></div><div><h3>Results</h3><p>Nearly two-thirds (65.6 %) of participants surveyed reported they had previously received acupuncture treatment with the vast majority seeking acupuncture treatment for pain-related issues (84.8 %). The majority of these participants reported relatively modest levels of exposure to acupuncture with most participants (63.1 %) reporting fewer than 10 treatment sessions over their lifetimes. There were no significant differences in age, sex, race, ethnicity, disability scores, income levels, or pain levels between the acupuncture-naïve and non-naïve groups.</p></div><div><h3>Conclusion</h3><p>Contextual consideration for prior acupuncture utilization rates is warranted and may be higher than expected or previously reported. We found few differences in baseline characteristics between participants who were acupuncture-naïve and those with prior acupuncture experience; thus, future pragmatic clinical trials might relax previous acupuncture-use considerations in their recruitment criteria. For trials focused on acupuncture-naive patients, it may be more feasible to expand the definition of \"acupuncture-naive\" based on lifetime acupuncture visits or time since last treatment.</p></div><div><h3>Trial registration</h3><p>The protocol was registered at clinicaltrials.gov (#NCT04982315).</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 2","pages":"Article 101042"},"PeriodicalIF":3.4,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422024000222/pdfft?md5=88c37a653e135dd35b3ba05f54c7c1a8&pid=1-s2.0-S2213422024000222-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140792544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug trials are more likely to disclose full placebo control information than non-drug trials: A cross-sectional study of participant information leaflets of placebo-controlled trials","authors":"Jiyoon Won ,&nbsp;Ji-Yeon Han ,&nbsp;Yu-jin Ji ,&nbsp;Dohyung Ha ,&nbsp;Bong Jae Han ,&nbsp;Hyangsook Lee","doi":"10.1016/j.imr.2024.101043","DOIUrl":"10.1016/j.imr.2024.101043","url":null,"abstract":"<div><h3>Background</h3><p>This study aimed to investigate whether placebo control is differently disclosed in drug and non-drug randomised clinical trial (RCT) participant information leaflets (PILs) and how this might affect participant blinding and direction of study outcomes.</p></div><div><h3>Methods</h3><p>PILs were obtained from trials registered in the International Standard Randomised Controlled Trial Number database via email. Placebo descriptions in PILs were categorised as Full Disclosure (FD), Partial Disclosure (PD), or Missing Information (MI). Associations between intervention type (drug or non-drug)/placebo disclosure (FD or PD/MI) and participant blinding success/trial outcome direction (positive or non-positive) were examined using a two-sided Fisher's exact test.</p></div><div><h3>Results</h3><p>Of 116 collected PILs, 56 % were for drug trials and 44 % were for non-drug trials. Among them, 88 PILs had the corresponding publications available and 68 reports specified primary outcomes. Drug trials were more likely to fully disclose placebo information than non-drug trials (92.3 % vs. 74.5 %, <em>p</em> &lt; 0.05). However, the success rate of blinding was only reported in 3 out of 88 trial publications (3.4 %), precluding further analysis. Furthermore, there was no significant association between the direction of trial results and the type of intervention or placebo disclosure.</p></div><div><h3>Conclusion</h3><p>Our study findings suggest that drug and non-drug RCTs might differ in the way they reveal placebo control information. Further research is warranted to understand what leads to more common PD of placebo information in non-drug trials than drug trials and to determine the optimal placebo control disclosure in specific trial context.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 2","pages":"Article 101043"},"PeriodicalIF":3.4,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422024000234/pdfft?md5=13159ddb3fea15c5dcd0f4fd680e1da0&pid=1-s2.0-S2213422024000234-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140789870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How does pretreatment expectancy influence pain outcomes with electroacupuncture and battlefield acupuncture in cancer survivors?","authors":"Xiaotong Li ,&nbsp;Raymond E. Baser ,&nbsp;Karolina Bryl ,&nbsp;Lindsay Amann ,&nbsp;Susan Chimonas ,&nbsp;Jun J. Mao","doi":"10.1016/j.imr.2024.101040","DOIUrl":"10.1016/j.imr.2024.101040","url":null,"abstract":"<div><h3>Background</h3><p>Outcome expectancy is an important component of non-specific effect that may play an important role in pain research and clinical care. We sought to evaluate whether pretreatment expectancy predicts pain reduction in cancer survivors receiving electroacupuncture (EA) or battlefield acupuncture (BFA).</p></div><div><h3>Methods</h3><p>We analyzed data from a randomized clinical trial that compared EA and BFA versus wait list control (WLC) for chronic musculoskeletal pain in cancer survivors. Expectancy was measured by the Acupuncture Expectancy Scale (AES) at baseline. Pain severity was assessed using the Brief Pain Inventory (BPI) at baseline and week 12. For each treatment arm, multivariable regression models were used to evaluate the association between pretreatment expectancy and week 12 pain severity, controlling for baseline pain severity, age, sex, race, and education.</p></div><div><h3>Results</h3><p>Among 360 participants enrolled, the mean age was 62.1 years (SD 12.7), with 251 (69.7 %) women and 88 (24.4 %) non-white survivors. Pretreatment expectancy was similar for all groups at baseline (EA: 13.9 ± 3.6; BFA: 13.2 ± 3.7, WLC:12.8 ± 3.3, <em>p</em> = 0.14). Greater pretreatment expectancy was not significantly associated with greater pain reduction in any group, after adjusting for co-variates (EA: Coef. = -0.05, 95 % CI = -0.14 – 0.04, <em>p</em> = 0.28; BFA: Coef. = -0.07, 95 % CI = -0.16 – 0.02, <em>p</em> = 0.15; WLC: Coef. = -0.09, 95 % CI = -0.25 – 0.06, <em>p</em> = 0.23).</p></div><div><h3>Conclusions</h3><p>Pretreatment expectancy did not predict pain reduction for either EA or BFA in cancer survivors. Our study contributes to the interpretation of analgesic effects of EA or BFA, beyond the notion of a mere 'placebo effect'.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 2","pages":"Article 101040"},"PeriodicalIF":3.4,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422024000209/pdfft?md5=a2d025fb5c7b0f24740e5c8f75335613&pid=1-s2.0-S2213422024000209-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140400621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional, complementary and integrative medicine for fatigue post COVID-19 infection: A systematic review of randomized controlled trials","authors":"Xiao-ying Chen ,&nbsp;Chun-li Lu ,&nbsp;Qian-yun Wang ,&nbsp;Xing-ru Pan ,&nbsp;Yang-yang Zhang ,&nbsp;Jia-le Wang ,&nbsp;Jun-Ya Liao ,&nbsp;Nai-chong Hu ,&nbsp;Chen-yang Wang ,&nbsp;Bing-jie Duan ,&nbsp;Xue-han Liu ,&nbsp;Xin-yan Jin ,&nbsp;Jennifer Hunter ,&nbsp;Jian-ping Liu","doi":"10.1016/j.imr.2024.101039","DOIUrl":"https://doi.org/10.1016/j.imr.2024.101039","url":null,"abstract":"<div><h3>Background</h3><p>Chronic fatigue is a predominant symptom of post COVID-19 condition, or long COVID. We aimed to evaluate the efficacy and safety of Traditional, Complementary and Integrative Medicine (TCIM) for fatigue post COVID-19 infection.</p></div><div><h3>Methods</h3><p>Ten English and Chinese language databases and grey literature were searched up to 12 April 2023 for randomized controlled trials (RCTs). Cochrane “Risk of bias” (RoB) tool was applied. Evidence certainty was assessed using Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Effect estimates were presented as risk ratio (RR) or mean difference (MD) with 95% confidence interval (CI).</p></div><div><h3>Results</h3><p>Thirteen RCTs with 1632 participants were included. One RCT showed that Bufei Huoxue herbal capsules reduced fatigue (n=129, MD -14.90, 95%CI -24.53 to -5.27), one RCT reported that Ludangshen herbal liquid lowered fatigue (n=184, MD -1.90, 95%CI -2.38 to -1.42), and the other one RCT shown that fatigue disappearance rate was higher with Ludangshen herbal liquid (n=184, RR 4.19, 95%CI 2.06 to 8.53). Compared to traditional Chinese medicine rehabilitation (TCM-rahab) alone, one RCT showed that fatigue symptoms were lower following Qingjin Yiqi granules plus TCM-rehab (n=388, MD -0.48, 95%CI -0.50 to -0.46). Due to concerns with RoB and/or imprecision, the certainty in this evidence was low to very low. No serious adverse events was reported.</p></div><div><h3>Conclusions</h3><p>Limited evidence suggests that various TCIM interventions might reduce post COVID-19 fatigue. Larger, high quality RCTs of longer duration are required to confirm these preliminary findings.</p></div><div><h3>Study Registration</h3><p>The protocol of this review has been registered at PROSPERO: CRD42022384136.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 2","pages":"Article 101039"},"PeriodicalIF":3.4,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422024000192/pdfft?md5=bc76ea5e2313a749574bd58c0233f6ff&pid=1-s2.0-S2213422024000192-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140879247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ameliorative effects of Tagetes erecta Linn. flower against desiccation stress-induced dry eye symptoms in the mice model","authors":"Hyesook Lee ,&nbsp;Hyun Hwangbo ,&nbsp;Jin-Won Hyun ,&nbsp;Jung-Hyun Shim ,&nbsp;Sun-Hee Leem ,&nbsp;Gi-Young Kim ,&nbsp;Yung Hyun Choi","doi":"10.1016/j.imr.2024.101038","DOIUrl":"10.1016/j.imr.2024.101038","url":null,"abstract":"<div><h3>Background</h3><p>Tagetes erecta Linn, popularly known as Marigold, has various pharmacological effects. It is used as a dietary supplement, especially for the posterior segment of the eye. However, the effect of T. erecta Linn on ocular disorders is still unknown. The purpose of this study was to investigate the effect of oral administration of ethanol extract of <em>T. erecta</em> Linn flower (TE) for dry eye syndrome (DED) in a murine model.</p></div><div><h3>Methods</h3><p>Twenty-four mice were subjected to desiccation stress (DS) to induce DED and subcutaneous injection of scopolamine hydrobromide was administered 4 times a day for 21 days. TE and cyclosporine A (CsA) were administered for an additional 14 days under DS conditions. Mice were randomly divided into four groups: control, TE200, TE400, and CsA. Changes in tear production and corneal fluorescein staining were measured at baseline, after 7 days of DS, and after treatment for 7 and 14 days.</p></div><div><h3>Results</h3><p>DS significantly decreased tear production and increased corneal fluorescein score; the parameters were significantly reversed in the TE400 (oral administration of 400 mg TE/kg body weight) group. TE markedly improved DS-induced changes including corneal epithelial detachment and lacrimal gland inflammation. The anti-inflammatory effect of TE 400 supplementation was similar to that of CsA.</p></div><div><h3>Conclusions</h3><p>Our findings suggest that oral administration of TE may protect against DS-induced DED <em>via</em> stabilization of the tear film and suppression of inflammation. This study provides an experimental basis for further studies on the potential clinical use of TE in preventing DED.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 2","pages":"Article 101038"},"PeriodicalIF":3.4,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422024000180/pdfft?md5=0c1067b98ff7ae394de01323ba6a8e26&pid=1-s2.0-S2213422024000180-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140150903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using the right design controls for acupuncture trials: Methodological rigor and validity in research","authors":"Younbyoung Chae ,&nbsp;Jun-Hwan Lee ,&nbsp;Myeong Soo Lee","doi":"10.1016/j.imr.2024.101026","DOIUrl":"https://doi.org/10.1016/j.imr.2024.101026","url":null,"abstract":"<div><p>Acupuncture treatment can be defined as a medical procedure with an acupuncture needle at acupoints. Establishing suitable control settings is essential, based on the target elements of the acupuncture therapy. In order to properly design a clinical trial or an experiment, a control group must be established. Here, we overview the significance of the control group and its limitations in acupuncture research. Clinical trials have employed a variety of study designs and controls for acupuncture treatment in order to compare the effects of actual treatments with control groups that include no treatment or treatment as usual, sham acupuncture at true acupoints, real acupuncture at non-acupoints, and sham acupuncture at non-acupoints. In order to determine the point-specificity of acupuncture, real acupuncture at non-acupoints should be taken into consideration, whereas sham acupuncture at the same true acupoints should be used to determine the needling-specific effect of acupuncture. It is crucial to choose the optimum control for acupuncture treatments depending on the study's main goal and to interpret the results in accordance with the research design.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 1","pages":"Article 101026"},"PeriodicalIF":3.4,"publicationDate":"2024-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213422024000064/pdfft?md5=f9cce0036e86b6ddf4f91f1598c56b9f&pid=1-s2.0-S2213422024000064-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139942456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}