LIPOSA-T药物穿刺术通过调节脂肪代谢对局部脂肪的影响

IF 3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research Pub Date : 2025-07-14 DOI:10.1016/j.imr.2025.101201

Mi Hye Kim , Seong Chul Jin , Woong Mo Yang

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引用次数: 0

摘要

背景：已知在局部肥胖中过量的脂肪沉积会诱发严重的医学疾病以及美学问题。最近，LIPOSA-T药物穿刺，一种由桑皮质和厚朴树皮组成的新型草药药物穿刺，被开发为一种非手术注射，用于溶解局部脂肪沉积。方法采用网络药理学分析方法，对白芍和officinalis成分靶基因集进行分析。将雄性C57BL/6 J小鼠诱导肥胖，并在腹股沟脂肪垫注射LIPOSA-T药物穿刺。用双能x线吸收仪分析脂肪的重量和大小。结果在KEGG pathway数据库中发现LIPOSA-T可能的作用途径和机制主要与脂肪酸生物合成、糖酵解和糖生成有关。皮下注射LIPOSA-T药物穿刺可显著降低腹股沟脂肪组织重量，增大脂肪细胞大小。此外，通过注射LIPOSA-T，磷酸化的IRS与PEPCK和G6p的表达增加。随着AMPK表达的增加，脂肪酸合成酶和脂溶酶受到LIPOSA-T的调控。综上所述，LIPOSA-T通过调节葡萄糖生成、脂质合成和TAG水解对肥胖脂肪沉积发挥分解代谢作用，与预测结果一致。基于这些发现，LIPOSA-T药物穿刺有望成为局部脂肪的溶解性注射。

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Effects of LIPOSA-T pharmacopuncture on localized fat as a fat dissolving injection via regulation of fat metabolism

Background

Excessive fat deposition in localized adiposity is known to induce severe medical diseases as well as aesthetic problems. Of late, LIPOSA-T pharmacopuncture, a new herbal pharmacopuncture consisting of the cortex of Morus alba and bark of Magnolia officinalis, is developed as a non-surgical injection for dissolving localized fat deposits.

Methods

The network pharmacology analysis was carried out with the target gene sets of constituents of M. alba and M. officinalis. Male C57BL/6 J mice were induced obesity and injected LIPOSA-T pharmacopuncture into inguinal fat pad. The fat weight and size were analyzed using dual energy X-ray absorptiometry.

Results

The possible pathways and mechanism of action of LIPOSA-T were found to be mainly related to the fatty acid biosynthesis, glycolysis and glycogenesis in KEGG Pathways database. Subcutaneous injection of the LIPOSA-T pharmacopuncture significantly reduced the inguinal fat tissues weight and enlarged adipocyte size. In addition, the phosphorylated IRS with the PEPCK and G6p expressions were increased by the LIPOSA-T injection. Following the increase of AMPK expression, the fatty acid synthesis enzyme and lipolytic enzymes were regulated by the LIPOSA-T.

Conclusions

Taken together, LIPOSA-T exerted the catabolic effects on fat deposition in obesity by regulating the glucose production, lipid synthesis and TAG hydrolysis in consistent with the prediction results. Based on the findings, LIPOSA-T pharmacopuncture is expected to be a dissolving injection for localized fat.

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来源期刊

Integrative Medicine Research Medicine-Complementary and Alternative Medicine

CiteScore

6.50

自引率

2.90%

发文量

审稿时长

12 weeks

期刊介绍： Integrative Medicine Research (IMR) is a quarterly, peer-reviewed journal focused on scientific research for integrative medicine including traditional medicine (emphasis on acupuncture and herbal medicine), complementary and alternative medicine, and systems medicine. The journal includes papers on basic research, clinical research, methodology, theory, computational analysis and modelling, topical reviews, medical history, education and policy based on physiology, pathology, diagnosis and the systems approach in the field of integrative medicine.