Infectious diseases now最新文献

{"title":"The new 2024 French guidelines for respiratory transmission Prevention: Present-day limitations and the need to implement new standard precautions","authors":"Martin Martinot","doi":"10.1016/j.idnow.2024.105014","DOIUrl":"10.1016/j.idnow.2024.105014","url":null,"abstract":"","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 1","pages":"Article 105014"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality, functional outcome and health-related quality of life in patients with necrotizing skin- and soft tissue infections in the ICU: Protocol of a multinational prospective cohort study (SKIN-ICU)","authors":"Tomas Urbina ,&nbsp;Martin Bruun Madsen ,&nbsp;Camille Hua ,&nbsp;Christian Eckmann ,&nbsp;Muhammed Elhadi ,&nbsp;Mohan Gurjar ,&nbsp;Gennaro De Pascale ,&nbsp;Farid Zand ,&nbsp;Johanna Hästbacka ,&nbsp;Ricard Ferrer Rocca ,&nbsp;José Artur Paiva ,&nbsp;Adam Mikstacki ,&nbsp;Richard Layese ,&nbsp;Olivier Chosidow ,&nbsp;Florence Canoui-Poitrine ,&nbsp;Jan De Waele ,&nbsp;Nicolas de Prost ,&nbsp;SKIN-ICU investigators","doi":"10.1016/j.idnow.2025.105033","DOIUrl":"10.1016/j.idnow.2025.105033","url":null,"abstract":"<div><h3>Background</h3><div>Necrotizing soft tissue infections (NSTI) are rare and life-threatening bacterial infections characterized by necrosis of subcutaneous tissue, fascia, or muscle. Few prospective studies have been conducted. The primary objective is to assess the 90-day mortality rate and to identify prognostic factors in patients with NSTI in an international setting. Secondary objectives are <em>i)</em> to characterize the clinical and microbiological presentation and management; <em>ii)</em> to assess the risk of limb amputation and associated factors; and <em>iii)</em> to assess functional and health-related quality of life (HRQoL) outcomes and associated factors.</div></div><div><h3>Methods</h3><div>We are conducting a multinational, prospective, non-interventional cohort study. We plan to enroll 1,033 consecutive patients admitted to 85 hospitals with surgically proven NSTI between November 2021 and December 2024 in 17 countries over three continents. Data will be collected prospectively on a secure web-based server. The primary outcome measure will be the day-90 mortality. Secondary outcomes include need for limb amputation, the activity of daily living scale and health-related quality of life at day-90 (EQ-5D-5L questionnaire). Baseline characteristics associated with outcomes will be identified by multivariable analyses. Exploratory analyses will be conducted to assess the impact of therapeutic interventions on day-90 mortality and secondary outcomes. The study protocol has been approved by an ethics committee in each participating country.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 2","pages":"Article 105033"},"PeriodicalIF":2.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial Resistance on Ships: A Narrative Review","authors":"Yusuff Adebayo Adebisi ,&nbsp;Adeola Bamisaiye ,&nbsp;Don Eliseo-Lucero Prisno III","doi":"10.1016/j.idnow.2025.105027","DOIUrl":"10.1016/j.idnow.2025.105027","url":null,"abstract":"<div><div>Antimicrobial resistance (AMR) poses a global health challenge, particularly in maritime environments where unique conditions foster its emergence and spread. Characterized by confined spaces, high population density, and extensive global mobility, ships create a setting ripe for the development and dissemination of resistant pathogens. This review aims to analyse the contributing factors, epidemiological challenges, mitigation strategies specific to AMR on ships and to propose future research directions, bridging a significant gap in the literature. Maritime environments facilitate the propagation of AMR through interconnected factors. The confined and communal nature of ships allows resistant pathogens to spread rapidly among diverse populations. The inappropriate and often empirical use of broad-spectrum antibiotics, compounded by limited access to diagnostic tools, accelerates the selection of resistant strains. Poor infection control practices, including inadequate sanitation and ineffective isolation measures, exacerbate the risks. Environmental contamination through untreated wastewater and ballast water discharge introduces resistant bacteria and genes into marine ecosystems, posing additional public health and ecological threats. Surveillance of AMR on ships is hampered by logistical barriers, including the lack of standardized protocols and reporting systems. Documented outbreaks of resistant pathogens, such as methicillin-resistant <em>Staphylococcus aureus</em>, underline the public health risks associated with AMR in maritime settings, alongside significant operational disruptions and environmental impacts. Despite advancements in portable diagnostic technologies, their adoption on ships remains minimal, leaving critical gaps in detection and management. Effective management of AMR in maritime settings necessitates the integration of stewardship programs tailored to shipboard environments, reinforced infection control measures, and advanced wastewater treatment.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 2","pages":"Article 105027"},"PeriodicalIF":2.9,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delta and Omicron SARS-CoV-2 pneumonia: Comparison of clinical and radiological features","authors":"Jonathan Pehlivan ,&nbsp;Pierre Berge ,&nbsp;Anne-Laurence Gourdier ,&nbsp;Michael Phelippeau ,&nbsp;Pierre Danneels ,&nbsp;Rafael Mahieu ,&nbsp;Vincent Dubée","doi":"10.1016/j.idnow.2025.105026","DOIUrl":"10.1016/j.idnow.2025.105026","url":null,"abstract":"<div><h3>Background</h3><div>Computed tomography (CT) is a critical tool for the diagnosis of pneumonia caused by SARS-CoV-2. The Delta and Omicron variants show distinct clinical features, but the radiological differences between pneumonia caused by these variants have not been extensively studied in patients with oxygen-dependent pneumonia.</div></div><div><h3>Objective</h3><div>To compare the radiological and clinical features of pneumonia in patients hospitalized with oxygen-dependent SARS-CoV-2 infection caused by the Delta and Omicron variants.</div></div><div><h3>Methods</h3><div>We performed a retrospective single-center study, including patients hospitalized with oxygen-dependent SARS-CoV-2 pneumonia between October 2021 and February 2022. Clinical and radiological data were collected and compared between patients infected with the Delta variant and those with the Omicron variant. CT scans were reviewed by a radiologist and a pulmonologist blinded to clinical and variant information.</div></div><div><h3>Results</h3><div>A total of 135 patients with the Delta variant and 48 with the Omicron variant were included. Patients infected with Omicron were older (median age 75 years [68–83.2] vs 69 years [62–77.5], p = 0.004), more immunocompromised (52 % vs. 25 %, p &lt; 0.001), and had higher vaccination rates (73 % vs. 51 %, p = 0.009). Radiologically, ground-glass opacities were present in 95 % of patients. There were no significant differences in the degree of lung involvement, type of lesions and their predominance. Unilateral lung involvement was more common in Omicron-infected patients (8.3 % vs 0.74 %, p = 0.02).</div></div><div><h3>Conclusion</h3><div>While Omicron oxygen-dependent pneumonia occurred in older and more comorbid patients, its clinical and radiological features were largely indistinguishable from those caused by the Delta variant, except for a higher rate of unilateral lung involvement.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 2","pages":"Article 105026"},"PeriodicalIF":2.9,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143038272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-level primary clarithromycin resistance of Helicobacter pylori in Reunion Island","authors":"Arthur Charazac ,&nbsp;Raphael Delage ,&nbsp;Maxime Pichon ,&nbsp;Laure Kamus ,&nbsp;Benoit Pichard ,&nbsp;Laura Peyret-Moreau ,&nbsp;Olivier Belmonte ,&nbsp;Guillaume Miltgen ,&nbsp;Christophe Burucoa","doi":"10.1016/j.idnow.2025.105025","DOIUrl":"10.1016/j.idnow.2025.105025","url":null,"abstract":"<div><h3>Introduction</h3><div>The increasing resistance of <em>Helicobacter pylori</em> to clarithromycin leads to an ongoing adaptation of empirical first-line treatment for <em>H. pylori</em> infections.</div></div><div><h3>Patients and methods</h3><div>Prospective study (2022–2023) of 364 patients with no previous treatment for <em>H. pylori</em> infection, addressed for gastroduodenal endoscopy to the University Hospital of Reunion Island.</div></div><div><h3>Results</h3><div>PCR tests (Allplex^TM <em>H. pylori</em> &amp; ClariRAssay, Seegene) performed on gastric biopsy samples detected <em>H. pylori</em> DNA in 100 samples (100/364; 27.5 %) and mutations conferring resistance to clarithromycin in 10 of the positive samples (10/100; 10 %). Prevalence of resistance determined by MICs (E-test method) was 41.2 % for metronidazole, 13.2 % for levofloxacin, 8.8 % for clarithromycin. No resistance was detected for tetracycline, rifampicin, and amoxicillin.</div></div><div><h3>Conclusion</h3><div>The prevalence of primary clarithromycin-resistant <em>H. pylori</em> in Reunion Island is below 15 %. Recommendation for the standard clarithromycin-based triple therapy as a first-line treatment can thus be maintained, even though antimicrobial susceptibility testing seems preferable.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 2","pages":"Article 105025"},"PeriodicalIF":2.9,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introduction of molecular point-of-care testing for SARS-CoV-2 in a triage unit of a large maternity hospital: An evaluation of staff experiences","authors":"M. Howarth-Maddison ,&nbsp;I.N. Okoliegbe ,&nbsp;N. El Sakka","doi":"10.1016/j.idnow.2025.105024","DOIUrl":"10.1016/j.idnow.2025.105024","url":null,"abstract":"<div><h3>Context</h3><div>Recent advances in the development of rapid SARS-CoV-2 point of care (POC) testing provided an opportunity to aid clinical decision making in front-line healthcare settings. Perspectives of POC COVID-19 screening of pregnant women are under-researched.</div></div><div><h3>Objective</h3><div>To assess the impact of a SARS-CoV-2 POC testing platform implemented in a busy maternity hospital, with limited isolation capacity, during the third wave of the COVID-19 pandemic.</div></div><div><h3>Methods</h3><div>We conducted a before and after comparison of two consecutive 12-month periods and a retrospective evaluation of staff attitudes and POC test acceptance. Turnaround Time (TAT) and testing numbers were assessed by computer audit. Qualitative data was collected using confidential questionnaires.</div></div><div><h3>Results</h3><div>Mean TAT for the POC platform was 5.3x quicker (p &lt; 0.001, chi-square test) when compared with local virus laboratory PCR testing. Samples sent for laboratory testing reduced by almost one third, following introduction of the POC device. A total of 27 staff members completed a POC testing satisfaction survey, which documented ease of use and benefits for diagnosis assistance, patient management and patient experience.</div><div>Conclusion.</div><div>In this single-center maternity setting, POC testing decreased laboratory testing volume and SARS-Cov-2 result TAT for symptomatic women and those awaiting crucial investigations. POC COVID-19 investigation was deemed acceptable by the clinical team for facilitating patient placement, management, and use of limited isolation capacity.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 2","pages":"Article 105024"},"PeriodicalIF":2.9,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WPV1 resurgence in Pakistan: Endangering the global polio eradication goal","authors":"Rafay Ali Syed,&nbsp;Javaria Qazi","doi":"10.1016/j.idnow.2025.105022","DOIUrl":"10.1016/j.idnow.2025.105022","url":null,"abstract":"","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 2","pages":"Article 105022"},"PeriodicalIF":2.9,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ACKNOWLEDGING OUR 2024 REVIEWERS","authors":"","doi":"10.1016/S2666-9919(24)00179-9","DOIUrl":"10.1016/S2666-9919(24)00179-9","url":null,"abstract":"","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 8","pages":"Article 105012"},"PeriodicalIF":2.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143145384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic therapy and prophylaxis of infective endocarditis – A SPILF-AEPEI position statement on the ESC 2023 guidelines","authors":"Vincent Le Moing ,&nbsp;Éric Bonnet ,&nbsp;Vincent Cattoir ,&nbsp;Catherine Chirouze ,&nbsp;Laurène Deconinck ,&nbsp;Xavier Duval ,&nbsp;Bruno Hoen ,&nbsp;Nahéma Issa ,&nbsp;Raphaël Lecomte ,&nbsp;Pierre Tattevin ,&nbsp;Asmaa Tazi ,&nbsp;François Vandenesch ,&nbsp;Christophe Strady","doi":"10.1016/j.idnow.2024.105011","DOIUrl":"10.1016/j.idnow.2024.105011","url":null,"abstract":"","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 1","pages":"Article 105011"},"PeriodicalIF":2.9,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimising detection of thrombosis in paediatric Staphylococcus aureus bacteraemia: A prospective interventional sub-study protocol","authors":"Keerthi Anpalagan ,&nbsp;Asha C. Bowen ,&nbsp;Leanne Lamborn ,&nbsp;Derek Roebuck ,&nbsp;Tina Carter ,&nbsp;Jeffrey W. Cannon ,&nbsp;Caitlin Symons ,&nbsp;Jane McNally ,&nbsp;Gillian Woods ,&nbsp;Brendan McMullan ,&nbsp;Amanda Gwee ,&nbsp;Steven Y.C. Tong ,&nbsp;Joshua S. Davis ,&nbsp;Anita J. Campbell","doi":"10.1016/j.idnow.2024.105010","DOIUrl":"10.1016/j.idnow.2024.105010","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Staphylococcus aureus</em> bacteraemia (SAB) is the most common cause of sepsis, contributing to paediatric intensive care unit admission in Australia and New Zealand. While deep venous thrombosis (DVT) has been reported in children with invasive <em>S. aureus</em> infections, the actual frequency and possible effects of thrombosis on disease severity and outcome in paediatric SAB remain unknown. Moreover, guidance regarding imaging for paediatric SAB management are poorly defined.</div></div><div><h3>Methods and analysis</h3><div>We report the protocol for the SNOOPY (<em>Staphylococcus aureus</em> Network; ultrasOund for diagnOsis of endovascular disease in Paediatrics and Youth) study. SNOOPY is a pilot prospective single-arm interventional study that aims to investigate the proportion of children with SAB that have venous thrombosis detected using whole body doppler ultrasound.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 1","pages":"Article 105010"},"PeriodicalIF":2.9,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}