Infectious diseases now最新文献

{"title":"Increased shedding of PECAM-1 associated with elevated serum MMP-14 levels as new blood indicators of dengue disease manifestation","authors":"Vignesh Mariappan ,&nbsp;Lokesh Shanmugam ,&nbsp;Siva Ranganathan Green ,&nbsp;Joshy M Easow ,&nbsp;Srinivasa Rao Mutheneni ,&nbsp;Anitha Thirugnanasambandhar Sivasubramanian ,&nbsp;Agieshkumar Balakrishna Pillai","doi":"10.1016/j.idnow.2024.104964","DOIUrl":"10.1016/j.idnow.2024.104964","url":null,"abstract":"<div><h3>Objectives</h3><p>Host factors that regulate plasma leakage during severe dengue (SD) are under investigation. While PECAM-1 and MMP-14 have been reported to regulate vascular integrity, their role in dengue pathogenesis remains unexplored. This study aims to assess the association of soluble PECAM-1 and MMP-14 with dengue severity symptoms.</p></div><div><h3>Patients and methods</h3><p>Serum levels of PECAM-1 and MMP-14 were evaluated in dengue (N-25) comprising 10 severe dengue (SD) and 15 non-severe dengue, 10 other febrile illnesses along with healthy controls (N-10) using ELISA. Protein levels were assessed using in vitro models.</p></div><div><h3>Results</h3><p>From febrile to critical phase, a significant increase in PECAM-1 (P≤0.01) &amp; MMP-14 (P≤0.001) levels were observed in SD cases compared to non-severe or other controls. Serum levels of PECAM-1 and MMP 14 were found to be positively (P≤0.001) associated. Soluble PECAM-1 levels of severe defervescence showed a positive correlation (P≤0.001) with plasma leakage and an inverse relationship (P≤0.001) with platelet count. In vitro analysis revealed elevated expression of study proteins in endothelial cells activated with severe serum samples. To the best of our knowledge, this is the first report to explore PECAM-1 or MMP-14 dynamics and their association with dengue severity.</p></div><div><h3>Conclusion</h3><p>Higher shedding of sPECAM-1 accompanied with increased levels of MMP-14 is strongly associated with severe dengue. However, the exact role of serum PECAM-1 in disease prognosis requires further studies.</p></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 7","pages":"Article 104964"},"PeriodicalIF":2.9,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666991924001313/pdfft?md5=3a52df23b76714e59c0d9d20926eac88&pid=1-s2.0-S2666991924001313-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New guidelines reduce the risk of hospitalization for adult patients with uncomplicated Plasmodium falciparum malaria: An observational, multicenter, retrospective French study","authors":"Sally Oceane Minka ,&nbsp;Gilles Cottrell ,&nbsp;Michel Cot ,&nbsp;Fadi Hillary Minka ,&nbsp;Marc Thellier ,&nbsp;Christophe Choquet ,&nbsp;Sandrine Houze","doi":"10.1016/j.idnow.2024.104963","DOIUrl":"10.1016/j.idnow.2024.104963","url":null,"abstract":"<div><h3>Objectives</h3><p>We aimed to evaluate the impact of malaria declaration year (before or after 2017) on the frequency of hospitalization in metropolitan France of patients with uncomplicated non-vomiting <em>P.<!--> <!-->falciparum</em> malaria.</p></div><div><h3>Patients and methods</h3><p>An observational, multicenter, retrospective study was carried out, using the database from the French National Reference Centre for Malaria. Descriptive analysis and multivariate analysis by logistic regression were performed using the multiple imputation by chained equation method to handle missing data.</p></div><div><h3>Results</h3><p>More than 2000 <strong>(</strong>2184) uncomplicated non-vomiting <em>P.<!--> <!-->falciparum</em> malaria cases were recorded. Our multivariate analysis showed an association between the year 2018 and reduced risk of hospitalization (OR: 0.89; 95% CI: 0.81–0.97).</p></div><div><h3>Conclusion</h3><p>Compared to 2016, during 2018 we observed a trend toward ambulatory care for patients presenting with uncomplicated non-vomiting <em>P.<!--> <!-->falciparum</em> malaria.</p></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 7","pages":"Article 104963"},"PeriodicalIF":2.9,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666991924001301/pdfft?md5=ffd81ae3761ef2f1d33ff56445605347&pid=1-s2.0-S2666991924001301-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Excessive prescription duration is a major contributor of inappropriate antibiotic use in primary care","authors":"Emmanuel Piednoir ,&nbsp;Pascal Thibon ,&nbsp;Marianne Delestre ,&nbsp;Élise Fiaux ,&nbsp;François Lebas ,&nbsp;Renaud Verdon ,&nbsp;Pierre Tattevin","doi":"10.1016/j.idnow.2024.104962","DOIUrl":"10.1016/j.idnow.2024.104962","url":null,"abstract":"<div><h3>Objectives</h3><p>In France, 75% of systemic antibiotics are prescribed by general practitioners (GPs) in primary care. We aimed to estimate the burden of inappropriate use related to excessive prescription duration.</p></div><div><h3>Patients and methods</h3><p>In 2021, we performed a cross-sectional and pharmaco-economic study of a network of six GPs. The references for optimal durations were those of the French national guidelines for antibiotic prescription.</p></div><div><h3>Results</h3><p>Out of 196 antibiotic prescriptions, 33.7 % were of excessive duration, with a mean excess of 0.9 [0.86–0.94] to 1.6 [1.45–1.72] days per prescription. Ear, nose, and throat, respiratory tract, and skin and skin structure infections were the main infections associated with excessive prescription. The pharmaco-economic analysis showed that the cost of excessive prescription duration would range from an estimated 151 to 262 million € in France in 2021.</p></div><div><h3>Conclusion</h3><p>Addressing excessive antibiotic prescription duration by GPs may represent a powerful and cost-saving tool in antimicrobial stewardship programs.</p></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 7","pages":"Article 104962"},"PeriodicalIF":2.9,"publicationDate":"2024-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666991924001295/pdfft?md5=650b57687865e7aab7a51c4536e5a11d&pid=1-s2.0-S2666991924001295-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discussion on ‘External validation of two clinical prediction models for mortality in COVID-19 patients (4C and NEWS2), in three centers in Medellín, Colombia: Assessing the impact of vaccination over time’","authors":"Hai-Feng Liu,&nbsp;Hong-Min Fu","doi":"10.1016/j.idnow.2024.104960","DOIUrl":"10.1016/j.idnow.2024.104960","url":null,"abstract":"","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 6","pages":"Article 104960"},"PeriodicalIF":2.9,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666991924001271/pdfft?md5=fd5bb413b976ad1263acafbe91a11fd8&pid=1-s2.0-S2666991924001271-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141889062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pertussis vaccination in adults in France: Overview and suggestions for improvement","authors":"E. Blanchard ,&nbsp;D. Chavade ,&nbsp;B. de Wazières ,&nbsp;P. Bakhache ,&nbsp;T. Fumet ,&nbsp;N. Guiso","doi":"10.1016/j.idnow.2024.104961","DOIUrl":"10.1016/j.idnow.2024.104961","url":null,"abstract":"<div><p>In France, the goal of the pertussis vaccination program is to protect newborns. All infants are vaccinated under the program and then given booster shots up to the age of 25 years. Pregnant women are likewise vaccinated, with the cocooning strategy reserved for infants born to unvaccinated mothers. Real-world data shows (i) inadequate coverage among adolescents and adults under 25; (ii) improper use of the tetanus, diphtheria, and polio (Td/IPV) vaccine in children under six years, adolescents, and young adults; and (iii) underdiagnosis of pertussis in adults. Older patients or those with specific chronic medical conditions are at risk of developing severe disease. Improving the diagnosis and surveillance of pertussis in adults and seniors would be one of the first steps in the right direction. Aligning pertussis vaccination in adults with the Td/IPV program (boosters at 45, 65 years of age, and then every 10 years) would make the vaccination schedule simpler, easier to understand, and easier to implement. Large-scale awareness campaigns targeting this population would increase coverage, thereby boosting the effectiveness of the other measures.</p></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 6","pages":"Article 104961"},"PeriodicalIF":2.9,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666991924001283/pdfft?md5=0281cc0b984f76438980b4a72fc245b7&pid=1-s2.0-S2666991924001283-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141889063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tick-borne diseases at the crossroads of the Middle East and central Europe","authors":"Pavle Banović ,&nbsp;Dejan Jakimovski ,&nbsp;Ivana Bogdan ,&nbsp;Verica Simin ,&nbsp;Dragana Mijatović ,&nbsp;Mile Bosilkovski ,&nbsp;Sofija Mateska ,&nbsp;Adrian A. Díaz-Sánchez ,&nbsp;Angelique Foucault-Simonin ,&nbsp;Zbigniew Zając ,&nbsp;Jaonna Kulisz ,&nbsp;Sara Moutailler ,&nbsp;Alejandro Cabezas-Cruz","doi":"10.1016/j.idnow.2024.104959","DOIUrl":"10.1016/j.idnow.2024.104959","url":null,"abstract":"<div><h3>Objectives</h3><p>The Balkan Peninsula, acting as a crossroad between central Europe and the Middle East, presents diverse ecosystems supporting various tick species capable of transmitting TBDs. This study focuses on Serbia and North Macedonia, both endemic for TBDs, aiming to investigate human-biting ticks’ prevalence, TBD prevalence, and major TBPs in blood samples.</p></div><div><h3>Patients and Methods</h3><p>This prospective observational study was conducted in 2022 at two medical centers, involving 45 patients from Novi Sad, Serbia, and 17 patients from Skopje, North Macedonia. All participants had either a tick still attached or had had one removed within the preceding 48 h. The study consisted in clinical evaluations of patients and testing of patient samples and ticks for tick-borne pathogens using a High-Throughput pathogen detection system based on microfluidic real-time PCR. In addition, the study assessed the genetic diversity of the identified pathogens.</p></div><div><h3>Results</h3><p><em>Ixodes ricinus</em> was the most prevalent tick species, with varying infestation rates across various body parts. Tick species and feeding times differed between Novi Sad and Skopje. TBPs were prevalent, with <em>Rickettsia</em> spp. dominant in Skopje and a mix including <em>Rickettsia aeschlimannii</em>, <em>Rickettsia monacensis</em>, <em>Anaplasma phagocytophilum</em>, and <em>Borrelia afzelii</em> in Novi Sad. Subclinical bacteremia occurred in 8.06% of cases, mostly involving <em>Anaplasma</em> spp. Clinical manifestations, primarily local hypersensitivity reactions, were observed in six patients. Phylogenetic analysis confirmed <em>R. aeschlimannii</em> and <em>R. monacensis</em> identity, highlighting genetic differences in <em>gltA</em> gene sequences.</p></div><div><h3>Conclusions</h3><p>This study sheds light on the prevalence and diversity of TBPs in tick-infested individuals from Serbia and North Macedonia, contributing valuable insights into the epidemiology of TBDs in the Balkan region.</p></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 6","pages":"Article 104959"},"PeriodicalIF":2.9,"publicationDate":"2024-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266699192400126X/pdfft?md5=4bfaccef84674d5c315cf85f4501de4e&pid=1-s2.0-S266699192400126X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141848835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of pharmacist-led interventions in a multidisciplinary consultation meeting for bone and joint infection","authors":"Anne Elisabeth Royere ,&nbsp;Xavier Pourrat ,&nbsp;Louis-Romée Le Nail ,&nbsp;Marie-Frederique Lartigue ,&nbsp;Adrien Lemaignen ,&nbsp;Vianney Tuloup ,&nbsp;Marion Lacasse ,&nbsp;upon members of the Tours CRIOAC","doi":"10.1016/j.idnow.2024.104958","DOIUrl":"10.1016/j.idnow.2024.104958","url":null,"abstract":"<div><h3>Introduction</h3><p>Management of bone and joint infections (BJI) requires prolonged and high-dose antibiotic therapy to achieve target concentrations in bone tissue. However, these therapies often lead to adverse effects in patients who are frequently fragile, with multiple comorbidities and associated medications. The decision to treat these complex cases is made during a multidisciplinary team meeting at the reference centre for complex osteoarticular infections (CRIOAC).</p></div><div><h3>Material and Methods</h3><p>Elaborated by a pharmacist during CRIOAC meetings, a single-centre before-and-after comparative study of drug-related issues observed during pharmaceutical interventions (PIs), was conducted. For each patient included, a retrospective case was added. PIs were independently evaluated by a committee of infectiologists and pharmacists to assess their criticality.</p></div><div><h3>Results</h3><p>Sixty patients were included in the intervention group, with 59 controls. The population was homogeneous, with a median age of 65 years. Most BJI cases were complex (65.5 %), primarily involving prosthetic joint infections. Staphylococcus species were the predominant pathogens. Antibiotic therapy adapted to antibiograms was orally relayed for 74 % of patients, with 5.9 % requiring re-hospitalization due to adverse effects. Sixty-two PIs were performed, representing an average of 1.8 PIs per meeting or 34.4 % of patients. Dosage adjustment accounted for 42 % of PIs, drug interactions for 46 %, and treatment availability in community pharmacies for 8 %.</p><p>Regarding criticality, three PIs were classified as vital, 22 as major, 22 as moderate, and 15 as minor in both groups, with the same distribution between the intervention and control groups.</p></div><div><h3>Conclusion</h3><p>This study demonstrates that by collaborating with surgeons and infectiologists, pharmacists participating in CRIOAC meetings can strongly help to prevent drug-related problems in patients with BJIs.</p></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 7","pages":"Article 104958"},"PeriodicalIF":2.9,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666991924001258/pdfft?md5=e38a893390776cb3de063e37f3de922a&pid=1-s2.0-S2666991924001258-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New medical staff in the post-COVID-19 period entailed altered quality of antibiotic therapy","authors":"Pierre-Marie Roger ,&nbsp;Nathalie Challut ,&nbsp;Marc-Antoine Hennet ,&nbsp;Arnaud Lemasson ,&nbsp;Diane Lesselingue","doi":"10.1016/j.idnow.2024.104957","DOIUrl":"10.1016/j.idnow.2024.104957","url":null,"abstract":"<div><h3>Objective</h3><p>Our aim was to audit antibiotic prescriptions from renewed medical staff.</p></div><div><h3>Methods</h3><p>A retrospective multicenter audit of antibiotic therapies was performed in four institutions with similar antimicrobial stewardship programs. We compared antibiotic prescriptions from physicians practicing before and after the pandemic. Antibiotic prescriptions were classified as optimal (OAT), suboptimal (SAT) or unnecessary antibiotic therapy (UAT).</p></div><div><h3>Results</h3><p>All in all, 165 antibiotic courses was audited in 2023: OAT, SAT and UAT rates were 21, 42 and 38% respectively. Sixty-seven out of 165 (41%) prescriptions were given by new physicians. In multivariate analysis, antibiotic prescriptions from the latter compared to former were associated with less diagnosis of infection written in patient charts: AOR [CI 95%] 3.68 [1.53–8.83], and with UAT: 2.76 [1.34–5.68].</p></div><div><h3>Conclusions</h3><p>Ensuring adequate antibiotic prescriptions with renewed medical staff requires a high level of education and training.</p></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 6","pages":"Article 104957"},"PeriodicalIF":2.9,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666991924001246/pdfft?md5=26c64663b3cf791fefb53ce3bb8c69fb&pid=1-s2.0-S2666991924001246-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141765978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Voriconazole as an alternative oral treatment in fluconazole-resistant urinary candidiasis","authors":"Christelle Boglione-Kerrien ,&nbsp;Audrey Le Bot ,&nbsp;David Luque Paz ,&nbsp;Marie-Clémence Verdier ,&nbsp;Hélène Guegan ,&nbsp;Jean-Pierre Gangneux ,&nbsp;Eric Bellissant ,&nbsp;Florian Lemaitre","doi":"10.1016/j.idnow.2024.104955","DOIUrl":"10.1016/j.idnow.2024.104955","url":null,"abstract":"<div><h3>Objectives</h3><p>This study aims to assess the urinary diffusion and clinical effectiveness of voriconazole in patients with fluconazole-resistant urinary candidiasis.</p></div><div><h3>Patients and methods</h3><p>In this prospective pilot study, we utilized a validated chromatography method to measure voriconazole in urine over a 12-hour period between two administrations of the drug and in plasma at trough.</p></div><div><h3>Results</h3><p>Thirty-five patients, including five with fluconazole-resistant urinary candidiasis, were included. Urine and plasma voriconazole concentrations, mean 1.7 mg/L (range: 0.3–12.6) and mean 2.0 mg/L (range: 0.1–11.1) respectively, exhibited a strong correlation (R² = 0.88). None of the five patients treated for candidiasis experienced clinical or microbiological failure following treatment, with urine concentrations ranging from 0.5 to 2.7 mg/L.</p></div><div><h3>Conclusions</h3><p>The urinary diffusion of voriconazole resulted in drug exposure above the target minimum inhibitory concentration (MIC) in the five patients treated for voriconazole-susceptible <em>Candida</em> strains in urine. Therapeutic drug monitoring may allow optimize <em>in situ</em> concentrations.</p></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 6","pages":"Article 104955"},"PeriodicalIF":2.9,"publicationDate":"2024-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666991924001222/pdfft?md5=c667b9de3b211c54d14cbdcee0c50a36&pid=1-s2.0-S2666991924001222-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Underdiagnosis of arbovirus infections in returned travelers in an area with growing circulation of Aedes albopictus in North-Eastern France","authors":"Assilina Parfut ,&nbsp;Pierre Gantner ,&nbsp;Baptiste Hoellinger ,&nbsp;Lorraine Ferreira ,&nbsp;Morgane Biry ,&nbsp;Yves Hansmann ,&nbsp;Denis Filisetti ,&nbsp;Samira Fafi-Kremer ,&nbsp;Julie Brunet ,&nbsp;Aurélie Velay","doi":"10.1016/j.idnow.2024.104956","DOIUrl":"10.1016/j.idnow.2024.104956","url":null,"abstract":"<div><h3>Background</h3><p>Vector-borne diseases such as malaria and arboviruses are common etiologies of post-travel fever.</p></div><div><h3>Methods</h3><p>After excluding malaria, we retrospectively analyzed the diagnosis of dengue virus (DENV), chikungunya virus (CHIKV), and zika virus (ZIKV) infections following recent travel by patients treated at the Strasbourg University Hospital between 2014 and 2023. Available serums (n = 35) sampled in 2023 were retrospectively tested for DENV, CHIKV, and ZIKV infections.</p></div><div><h3>Results</h3><p>Our results showed that 78% of the 915 malaria-negative patients without changes over the course of ten years had not undergone arbovirus infection testing. Retrospective testing revealed missing arbovirus infections: two DENV infections and one CHIKV infection, representing 8.6% (3/35) of patients for whom no mandatory declaration or vector control could be undertaken.</p></div><div><h3>Conclusion</h3><p>Our results highlight the need for early case detection, particularly in the context of the upcoming 2024 Olympic Games.</p></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 7","pages":"Article 104956"},"PeriodicalIF":2.9,"publicationDate":"2024-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666991924001234/pdfft?md5=f8477c493ba03e51a56cfb540159b864&pid=1-s2.0-S2666991924001234-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}