Infectious diseases now最新文献

{"title":"Acute hepatitis E virus infection in adults, Cayenne, French Guiana, 2015–2022","authors":"Clotilde de Colnet ,&nbsp;Alolia Aboikoni ,&nbsp;Mathieu Nacher ,&nbsp;Loïc Epelboin ,&nbsp;Céline Michaud ,&nbsp;Alexia Barbry ,&nbsp;Jacques Izopet ,&nbsp;Paul Le Turnier","doi":"10.1016/j.idnow.2025.105087","DOIUrl":"10.1016/j.idnow.2025.105087","url":null,"abstract":"<div><h3>Objectives</h3><div>French Guiana (FG), a French overseas territory located in the Amazon region, is characterized by a high level of precariousness, which may be conducive to hepatitis E virus (HEV) transmission, but no recent relevant data exist.</div></div><div><h3>Patients and methods</h3><div>We conducted a retrospective study to determine the incidence of acute HEV infection diagnosed at Cayenne Hospital, FG between 2015 and 2022.</div></div><div><h3>Results</h3><div>Among 934 tested individuals, 12 had positive anti-HEV IgM (positivity rate of 1.28 % CI95 [0.66–2.23]). RT-PCR was rarely performed and no results was positive. Median age was 41 years and half of the subjects were female. No fulminant hepatitis occurred. Neurological manifestations were reported in two patients. Acute forms of HEV infection were rarely diagnosed during the study period.</div></div><div><h3>Conclusions</h3><div>Earlier and more extensive use of RT-PCR could help to better understand the epidemiology of acute HEV infection. The modes of transmission and genotypes of HEV in FG remain uncertain.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 5","pages":"Article 105087"},"PeriodicalIF":2.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143947078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing the research value and clinical utility of suPAR in COVID-19","authors":"Hai-Feng Liu ,&nbsp;Ting-Yun Yuan ,&nbsp;Hong-Min Fu","doi":"10.1016/j.idnow.2025.105083","DOIUrl":"10.1016/j.idnow.2025.105083","url":null,"abstract":"","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 5","pages":"Article 105083"},"PeriodicalIF":2.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143941984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strengthening hepatitis B follow-up: Insights and experiences from China","authors":"Haohui Deng,&nbsp;Xiaoting Liang,&nbsp;Shuyuan Dang","doi":"10.1016/j.idnow.2025.105082","DOIUrl":"10.1016/j.idnow.2025.105082","url":null,"abstract":"","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 5","pages":"Article 105082"},"PeriodicalIF":2.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143947080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of delaying PCV20 implementation in France’s pediatric national immunization program: A population-based Markov model","authors":"Johnna Perdrizet ,&nbsp;Emmanuelle Blanc ,&nbsp;Jessica Y. El Khoury ,&nbsp;Maud Beillat ,&nbsp;Ayman Sabra ,&nbsp;Aleksandar Ilic ,&nbsp;Stéphane Fiévez","doi":"10.1016/j.idnow.2025.105084","DOIUrl":"10.1016/j.idnow.2025.105084","url":null,"abstract":"<div><h3>Objectives</h3><div>We assessed the public health and economic impacts in France for infants below 1-year of delaying PCV20 (3 + 1) implementation compared to continuous use of PCV15 (2 + 1) and PCV13 (2 + 1).</div></div><div><h3>Patients and methods</h3><div>Population-based Markov model was adapted for French pediatric population. Outcomes included pneumococcal disease cases, deaths, and direct costs. Impact of a PCV20 two-year implementation delay was reported by month, quarter, and year.</div></div><div><h3>Results</h3><div>Delaying PCV20 implementation in French children was estimated to result in preventable 15,356 disease cases and 1,489 deaths over two years, with cost of €117.4 million, versus the continuous use of PCV15. PCV20 versus PCV13 results were slightly reduced but followed a similar trend.</div></div><div><h3>Conclusions</h3><div>Rapid implementation of PCV20 is estimated to prevent thousands of cases and deaths over two years compared to the continuous PCV15 or PCV13 use, reducing significant negative impact to public health outcomes and waste of health care resources.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 5","pages":"Article 105084"},"PeriodicalIF":2.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143947079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspiration pneumonia guidelines – Société de Pathologie Infectieuse de Langue Française 2025","authors":"Sylvain Diamantis ,&nbsp;Thibaut Fraisse ,&nbsp;Eric Bonnet ,&nbsp;Virginie Prendki ,&nbsp;Claire Andréjak ,&nbsp;Marianne Auquier ,&nbsp;Carla Garcia Carmona ,&nbsp;Eric Farfour ,&nbsp;Pierre Fillatre ,&nbsp;Sébastien Gallien ,&nbsp;Gaëtan Gavazzi ,&nbsp;Anne-Laure Houist ,&nbsp;Julie Lourtet ,&nbsp;Mathilde Perrin ,&nbsp;Emilie Piet ,&nbsp;Stanislas Rebaudet ,&nbsp;Yves Rolland ,&nbsp;Jean-Philippe Lanoix ,&nbsp;Alain Putot","doi":"10.1016/j.idnow.2025.105081","DOIUrl":"10.1016/j.idnow.2025.105081","url":null,"abstract":"","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 5","pages":"Article 105081"},"PeriodicalIF":2.9,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143941983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and safety of oral antibiotics as a decolonization strategy for carbapenem-resistant Enterobacteriaceae: A systematic review of randomized and non-randomized studies","authors":"Daniela Rodríguez Feria ,&nbsp;Cándida Rosa Diaz Brochero ,&nbsp;Oscar Muñoz Velandia ,&nbsp;José Manuel Verhelst López ,&nbsp;Javier Ricardo Garzón Herazo","doi":"10.1016/j.idnow.2025.105080","DOIUrl":"10.1016/j.idnow.2025.105080","url":null,"abstract":"<div><h3>Introduction</h3><div>Carbapenem-resistant Enterobacteriaceae (CRE) infections are associated with increased mortality and higher healthcare costs in hospitalized patients, making it reasonable to explore the effectiveness of strategies for decolonization of intestinal carriage.</div></div><div><h3>Objective</h3><div>To evaluate the effectiveness and safety of oral and/or intravenous antibiotics in adults colonized by CRE.</div></div><div><h3>Methods</h3><div>We conducted a systematic review of randomized clinical trials and nonrandomized studies comparing oral and/or intravenous antibiotic therapy versus no treatment or placebo in adults colonized by CRE. Outcomes assessed included eradication, infection rate, mortality, length of hospital stay, and adverse events. Searches were performed in the Embase, MEDLINE (PubMed), and Cochrane Library. Quality assessment was conducted using the ROB1 or ROBINS-I tool. Meta-analysis was performed using a random effects model in Review Manager, and the certainty of evidence was evaluated using the GRADE methodology.</div></div><div><h3>Results</h3><div>Seven studies comprising 728 participants were included. Decolonization therapy was significantly associated with intestinal carriage eradication (OR: 2.66; 95% CI: 1.55–4.55; I²: 0%). There was a trend toward a reduced infection rate (OR: 0.66; 95% CI: 0.26–1.65; I²: 4%). Data on mortality and adverse events were limited and insufficient to draw conclusions about differences between groups. The certainty of evidence ranged from moderate to very low.</div></div><div><h3>Conclusion</h3><div>This study suggests that decolonization therapy may be effective in eradicating CRE intestinal carriage state, but current evidence is insufficient to determine its impact on infection rates, mortality, or adverse events<em>.</em> Larger, high-quality randomized clinical trials are necessary to generate robust evidence supporting its clinical use.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 5","pages":"Article 105080"},"PeriodicalIF":2.9,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143912305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infectious foodborne disease outbreaks and sporadic cases in Saudi Arabia: A 2017–2023 trend analysis","authors":"Amjad Alfaleh ,&nbsp;Abdullah Alkattan ,&nbsp;Abrar Alzaher ,&nbsp;Khlood Sagor ,&nbsp;Saud Almarshoud ,&nbsp;Mona H. Ibrahim","doi":"10.1016/j.idnow.2025.105079","DOIUrl":"10.1016/j.idnow.2025.105079","url":null,"abstract":"<div><h3>Aim</h3><div>The present study aims to precisely indicate the status of infectious foodborne disease in Saudi Arabia between 2017 and 2023.</div></div><div><h3>Subject and methods</h3><div>A trend analysis was conducted based on epidemiologic data in Saudi Arabia during 2017–2023. The data include reports from governmental and private health agencies regarding Saudi citizens and residents, whatever their ages, who were diagnosed with infectious foodborne disease. Outbreak and sporadic patients were evaluated. Saudi Arabian crude incidence rates per 100,000 inhabitants and foodborne pathogens were established.</div></div><div><h3>Results</h3><div>All in all, 42,079 infectious foodborne illnesses were reported in Saudi Arabia between 2017 and 2023; the crude incidence rate averaged 18.0 ± 5.7 per 100,000. In 2017–2023, there were 12,710 foodborne outbreaks with a mean incidence rate of 5.4 ± 2.2 per 100,000. Results also indicate 29,369 sporadic cases reported during 2017–2023, with a mean crude incidence rate of 12.6 ± 3.9 per 100,000. The most widely described pathogen was <em>Entamoeba</em> spp. (mean crude incidence rate of 6.3 per 100,000), followed by <em>Salmonella</em> spp. (5.6 per 100,000), Hepatitis A virus (0.5 per 100,000), and <em>Shigella</em> spp. (0.2 per 100,000).</div></div><div><h3>Conclusion</h3><div>This research presents trends regarding for confirmed infectious foodborne cases in Saudi regions from 2017 to 2023. Outbreak-related and sporadic cases have decreased in recent years. Given the high incidence of <em>Entamoeba</em> and <em>Salmonella</em> spp. in foodborne sporadic cases, health agencies are called upon to use diagnostic tools for frequently reported microbes in view of identifying and locating foodborne outbreaks.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 5","pages":"Article 105079"},"PeriodicalIF":2.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravenous administration of antibiotics by prolonged and continuous perfusion in a pediatric context","authors":"Clément Ourghanlian ,&nbsp;Marion Caséris ,&nbsp;Elise d’Huart ,&nbsp;Robert Cohen ,&nbsp;Sylvain Diamantis","doi":"10.1016/j.idnow.2025.105077","DOIUrl":"10.1016/j.idnow.2025.105077","url":null,"abstract":"","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 5","pages":"Article 105077"},"PeriodicalIF":2.9,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143900004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recommended gentamicin peak plasma levels rarely reached, even with recommended dosages","authors":"Quentin Perrier ,&nbsp;Anne-Flore Dumas ,&nbsp;Hélène Pluchart ,&nbsp;Mireille Bartoli ,&nbsp;Elodie Gautier ,&nbsp;Pierrick Bedouch ,&nbsp;Olivier Epaulard","doi":"10.1016/j.idnow.2025.105076","DOIUrl":"10.1016/j.idnow.2025.105076","url":null,"abstract":"<div><h3>Introduction</h3><div>The recommended gentamicin peak plasma concentration range is 32–40 mg/L; we aimed to determine how frequently it was reached, and for which gentamicin doses.</div></div><div><h3>Patients and methods</h3><div>We retrospectively reviewed 601 gentamicin peak plasma concentrations in 501 patients aged ≥15 in our institution between 2013 and 2023.</div></div><div><h3>Results</h3><div>Median gentamicin dose was 5.9 mg/kg [IQR 4.1–7.9]. Median peak plasma concentration was 16.5 mg/L [IQR 10.8–22.8] and was strongly correlated with dose (p &lt; 0.0001). Only 5.7 % of values were ≥32 mg/L, including 22.8 % for dose ≥10 mg/kg.</div></div><div><h3>Conclusion</h3><div>This suggests that existing recommendations regarding either dose or target concentration for gentamicin should be modified.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 4","pages":"Article 105076"},"PeriodicalIF":2.9,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143887319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic and clinical utility of [18F] FDG PET/CT in management of Staphylococcus aureus bacteremia","authors":"Yui Okamura ,&nbsp;Chisato Numa ,&nbsp;Kota Tokunaga ,&nbsp;Tomonari M. Shimoda ,&nbsp;Hiroshi Ito","doi":"10.1016/j.idnow.2025.105075","DOIUrl":"10.1016/j.idnow.2025.105075","url":null,"abstract":"","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 4","pages":"Article 105075"},"PeriodicalIF":2.9,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}