即使使用推荐剂量，庆大霉素的血浆峰值水平也很少达到

IF 2.9 4区医学 Q2 INFECTIOUS DISEASES

Infectious diseases now Pub Date : 2025-04-26 DOI:10.1016/j.idnow.2025.105076

Quentin Perrier , Anne-Flore Dumas , Hélène Pluchart , Mireille Bartoli , Elodie Gautier , Pierrick Bedouch , Olivier Epaulard

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引用次数: 0

摘要

庆大霉素推荐的血药峰浓度范围为32 ~ 40mg /L；我们的目的是确定到达的频率，以及庆大霉素的剂量。患者和方法我们回顾性分析了2013 - 2023年间501例≥15岁患者的601例庆大霉素血药浓度峰值。结果庆大霉素中位剂量为5.9 mg/kg [IQR 4.1 ~ 7.9]。中位峰血药浓度为16.5 mg/L [IQR 10.8-22.8]，与剂量密切相关(p <；0.0001)。≥32mg /L的占5.7%，其中≥10mg /kg的占22.8%。结论现有的庆大霉素剂量和靶浓度建议均应修改。

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Recommended gentamicin peak plasma levels rarely reached, even with recommended dosages

Introduction

The recommended gentamicin peak plasma concentration range is 32–40 mg/L; we aimed to determine how frequently it was reached, and for which gentamicin doses.

Patients and methods

We retrospectively reviewed 601 gentamicin peak plasma concentrations in 501 patients aged ≥15 in our institution between 2013 and 2023.

Results

Median gentamicin dose was 5.9 mg/kg [IQR 4.1–7.9]. Median peak plasma concentration was 16.5 mg/L [IQR 10.8–22.8] and was strongly correlated with dose (p < 0.0001). Only 5.7 % of values were ≥32 mg/L, including 22.8 % for dose ≥10 mg/kg.