Infectious diseases now最新文献

{"title":"National survey on aspiration pneumonia in elderly hospitalized or institutionalized patients in France in 2023.","authors":"L Vieilledent, T Fraisse, G Gavazzi, C Roubaud Baudron, S Diamantis, S Gallien, J P Lanoix, A Putot, V Prendki, S Gaujard","doi":"10.1016/j.idnow.2025.105113","DOIUrl":"https://doi.org/10.1016/j.idnow.2025.105113","url":null,"abstract":"<p><strong>Background: </strong>Aspiration pneumonia is not specifically addressed in French guidelines on pneumonia, despite it being a frequent infection affecting specific populations. The French Infectious Diseases Society's (French acronym SPILF) Recommendations Group and the Infectio-Geriatrics Group (GinGER-SPILF SFGG) have published the first recommendations on this topic in 2025. The objective of this study was to describe practices of French physicians to manage aspiration pneumonia in hospitalized or institutionalized people aged over 75 years.</p><p><strong>Methods: </strong>A nationwide survey conducted from June to November 2023 was distributed to physicians working in hospitals or medico-social facilities to assess their habits from diagnosis to prevention.</p><p><strong>Results: </strong>A total of 452 physicians responded (mainly geriatricians, infectious disease specialists, and family physicians). Diagnostic criteria were consensual: presence of vomiting, swallowing disorders, or a history of inhalation pneumonia. Seventy-eight per cent of physicians reported prescribing complementary examinations. Imaging examinations (74%) were prioritized over bacteriology (19%). Oral amoxicillin-clavulanic acid was the first-line antibiotic (82%). Significant differences were found in the use of metronidazole and of the subcutaneous route, which were more frequently used by geriatricians. Geriatricians referred significantly more patients to speech therapists. The most commonly used swallowing test was the water test (92%). Screening and management of swallowing disorders, secondary prevention, and nutritional management varied according to specialties and practice settings.</p><p><strong>Conclusion: </strong>This survey shows consensus regarding diagnostic criteria and antibiotic therapy. However, the significant variation in prevention and nutritional management across specialties and practice settings highlights the need for specific recommendations.</p>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":" ","pages":"105113"},"PeriodicalIF":2.9,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of left-sided prosthetic valve endocarditis by suppressive antibiotic therapy: A retrospective monocentric real-world study","authors":"A. Sebestyen ,&nbsp;M. Boisson ,&nbsp;D. Rhem ,&nbsp;M. Korabi ,&nbsp;A. Behouche ,&nbsp;M. Blanc ,&nbsp;O. Chavanon","doi":"10.1016/j.idnow.2025.105112","DOIUrl":"10.1016/j.idnow.2025.105112","url":null,"abstract":"<div><h3>Objectives</h3><div>Prosthetic valve endocarditis has a poor prognosis, with high risks of relapse complicating management. Suppressive antibiotic therapy is increasingly considered as a means of treatment for infected devices that cannot be removed. We compared i) early mortality and ii) one-year overall and relapse-free survival between different strategies in real-world management of prosthetic valve endocarditis, one of them being suppressive antibiotic therapy.</div></div><div><h3>Patients and methods</h3><div>This single-center retrospective study included patients with aortic or mitral prosthetic valve endocarditis managed between 2019 and 2021. Each strategy was patient-centered and decided on by a multidisciplinary team. At first, we divided the population between surgically and conservatively managed patients. Initial intravenous antibiotic therapy lasted at least six weeks, and we compared early mortality having occurred prior to its completion. At a later stage, we divided the conservatively managed survivors between those who received suppressive antibiotic therapy and those who did not, and we compared survival and relapse rates during the first year subsequent to adaptation of each strategy.</div></div><div><h3>Results</h3><div>Seventy-five patients were included. Biological prostheses (33 %) for aortic valve replacement (95 %) predominated. The 17 (22.3 %) surgically managed patients were younger. Among the 58 conservatively managed patients, 42 had a theoretical indication for surgery. Eleven (14.6 %) patients died before having completed their course of intravenous antibiotic therapy, with no difference between surgical and conservative strategies (17.6 % vs. 13.8 %, p = 0.7043). Out of the 50 conservatively managed survivors, 35 received suppressive antibiotic therapy. Overall one-year survival was 73.9 % [64.1–85.2] and did not differ from one strategy to the next. Only six relapses occurred within the first year, including one (7.1 %) in surgically managed survivors and two (5.6 %) among the conservatively managed survivors receiving suppressive antibiotic therapy (5.6 %).</div></div><div><h3>Conclusions</h3><div>While surgery remains the gold standard for prosthetic valve endocarditis, especially in complicated cases, suppressive antibiotic therapy appeared suitable for selected patients for whom the surgical option seemed excessively risky.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 6","pages":"Article 105112"},"PeriodicalIF":2.9,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New epidemio-clinical insights into cutaneous leishmaniasis caused by Leishmania infantum in Casablanca, Morocco","authors":"Bouchra Baghad ,&nbsp;Zineb Mouhsine ,&nbsp;Fatima Zahra Chekairi ,&nbsp;Bouchra Amine ,&nbsp;Imane El Idrissi Saik ,&nbsp;Kaltoum Lemkhayar ,&nbsp;Meryem Lemrani ,&nbsp;Maha Soussi Abdallaoui ,&nbsp;Soumiya Chiheb ,&nbsp;Myriam Riyad","doi":"10.1016/j.idnow.2025.105111","DOIUrl":"10.1016/j.idnow.2025.105111","url":null,"abstract":"<div><h3>Background</h3><div>Cutaneous leishmaniasis (CL) represents a global public health challenge. In Morocco, the disease raises several concerns, such as geographical expansion, clinical heterogeneity, and the emergence of new <em>Leishmania</em> species. Our objective was to describe a new epidemiological and clinical profile caused by <em>Leishmania infantum</em> in patients diagnosed in Casablanca, Morocco.</div></div><div><h3>Methods</h3><div>We performed a cross-sectional study from 2012 to 2023. Epidemiological and clinical data were collected from patients meeting the inclusion criteria using a standardized clinical and epidemiological data collection tool. Parasitological and molecular analyses were performed on samples obtained from each patient. Only patients with confirmed positive polymerase chain reaction (PCR) and genotyping results were included in the study.</div></div><div><h3>Results</h3><div>PCR identified <em>L. infantum</em> as the causative agent of CL in 20 patients, who were predominantly female and from various rural regions across Morocco. All patients resided in areas characterized by inadequate sanitation and the presence of stray dogs. Clinical presentations were diverse, with the papulonodular form being the most frequently observed. Parasitological examinations yielded positive results in 70% of cases.</div></div><div><h3>Conclusions</h3><div>This study underscores the emergence of CL due to <em>L. infantum</em> as a growing public health concern in Morocco. It highlights the urgent need for enhanced awareness, targeted surveillance, preventive measures to mitigate the spread of the disease, and therapeutic strategies that consider its visceralizing potential.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 6","pages":"Article 105111"},"PeriodicalIF":2.9,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection, evaluation and management of the sequelae of infectious encephalitis in adults.","authors":"Marion Le Marechal, Pauline Dumez, Noémie Martinez-Almoyna, Philippe Azouvi, Thomas D E Broucker, Vincent Dubee, Lola Dubrule, Guillaume Eskenazi, Pierre Fillatre, Isabelle Gueit, Laurent Martinez-Almoyna, Jean-Paul Stahl, Mélanie Cogne, Alexandra Mailles","doi":"10.1016/j.idnow.2025.105110","DOIUrl":"https://doi.org/10.1016/j.idnow.2025.105110","url":null,"abstract":"","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":" ","pages":"105110"},"PeriodicalIF":2.9,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous infections with Corynebacterium diphtheriae in France: A cohort study","authors":"Héloise Mazoyer ,&nbsp;Emma d’Anglejan ,&nbsp;Noémie Blumenthal ,&nbsp;Alexander Younes ,&nbsp;Anne-Laure Roux ,&nbsp;Isabelle Bourgault Villada ,&nbsp;Marlène Amara ,&nbsp;Hélène Mascitti ,&nbsp;Aurélien Dinh","doi":"10.1016/j.idnow.2025.105109","DOIUrl":"10.1016/j.idnow.2025.105109","url":null,"abstract":"<div><h3>Introduction</h3><div>Cutaneous diphtheria typically develops on preexisting skin lesions and presents as painful, well-defined ulcers covered by false membranes or as exudate, usually on the limbs.</div></div><div><h3>Patients and methods</h3><div>We report on six cases of cutaneous diphtheria recently diagnosed in France. Diagnosis was confirmed through microbiological testing of skin swabs, which identified<!--> <em>Corynebacterium diphtheriae</em> non-toxigenic strains.</div></div><div><h3>Results</h3><div>All patients presented with painful ulcerations with identified<!--> <em>Corynebacterium diphtheriae</em> non-toxigenic strains. All patients were treated with a 14-day course of amoxicillin or amoxicillin-clavulanate for polymicrobial cases. In our cohort, the immunocompromised patients (2/6) experienced fatal outcomes, while non-immunocompromised individuals (4/6) responded well to antibiotic treatment.</div></div><div><h3>Conclusion</h3><div>Physicians should remain vigilant for cutaneous diphtheria in travelers and immunocompromised patients. However, accurate diagnosis can be challenging due to the presence of polymicrobial infections and common co-pathogens. Actual incidence of cutaneous diphtheria may be underestimated, underscoring a need for heightened awareness and vigilance. Vaccination programs should be implemented, notwithstanding their ineffectiveness on non-toxigenic strains.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 6","pages":"Article 105109"},"PeriodicalIF":2.9,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological changes in the incidence of human leptospirosis in Thailand: Findings from the National Disease Surveillance System from 2013 to 2022","authors":"Chanasan Sawangpol ,&nbsp;Natnaree Aimyong ,&nbsp;Arthit Phosri","doi":"10.1016/j.idnow.2025.105108","DOIUrl":"10.1016/j.idnow.2025.105108","url":null,"abstract":"<div><h3>Objectives</h3><div>To describe the epidemiological changes in leptospirosis incidence from 2013 to 2022, and to further quantify factors associated with leptospirosis mortality in Thailand.</div></div><div><h3>Methods</h3><div>We analyzed the epidemiological trends of leptospirosis incidence using data from the National Disease Surveillance System from January 2013 to December 2022 and estimated potential factors associated with leptospirosis mortality using a multiple logistic regression model.</div></div><div><h3>Results</h3><div>A total of 25,006 cases were reported during the study period, with an average incidence rate of 3.8 cases per 100,000 population. The incidence rate gradually decreased from 2013 to 2021, followed by a sharp increase in 2022. The case fatality rate increased steadily from 2013 to 2015 and then began to decline after 2015. A higher incidence rate was observed in men than in women, in individuals aged ≥15 years than in children &lt;15 years, in residents of rural areas than urban areas, in people living in the southwestern region than in those living in other regions, and in individuals engaged in agriculture. We also observed that age groups, regions of residence, healthcare facilities and services, and duration from symptom onset to treatment initiation were significantly associated with a mortality risk from leptospirosis.</div></div><div><h3>Conclusion</h3><div>A decreasing trend in leptospirosis incidence was observed from 2013 to 2021, followed by a recent increase in 2022, indicating that it is crucial to enhance the current surveillance system for implementing targeted interventions and to develop appropriate guidelines for reducing leptospirosis incidence and mortality by controlling the associated prognostic factors.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 6","pages":"Article 105108"},"PeriodicalIF":2.9,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The health economic burden of dengue in Germany: a retrospective analysis of statutory health insurance claims data","authors":"E. Goodman ,&nbsp;K.M. Schneider ,&nbsp;L. Lang ,&nbsp;S. Schnaidt ,&nbsp;T. Viering ,&nbsp;W. Greiner ,&nbsp;C. Jacob","doi":"10.1016/j.idnow.2025.105107","DOIUrl":"10.1016/j.idnow.2025.105107","url":null,"abstract":"<div><h3>Background</h3><div>Dengue is a mosquito-borne disease primarily affecting tropical and subtropical regions. Due to climate change, spread of Aedes albopictus into Europe, and increased global travel, concern about dengue’s burden in non-endemic countries has been growing. This study describes the health economic burden of dengue in Germany from the perspective of Statutory Health Insurance (SHI).</div></div><div><h3>Methods</h3><div>A retrospective data analysis using an anonymized SHI claims database representing 11.0 % of the German SHI population was conducted; 440 dengue patients diagnosed between January 1st, 2015, and December 31st, 2018 were identified using ICD-10-GM codes. Propensity scoring matched cases to controls. Healthcare resource utilization and costs in the year following diagnosis were compared.</div></div><div><h3>Results</h3><div>One-year administrative incidence rate of dengue ranged from 1.4 to 1.7 per 100,000 individuals. Cases tended to be young (50.0 % were 18–34 years old), urban (69.1 %) individuals from southwestern Germany (60.7 %). Almost all cases were non-severe. Compared to controls, dengue patients had significantly higher healthcare resource utilization, including 3.2 times higher probability of being hospitalized, 8.2 more outpatient visits, and 9.5 additional sick leave days (all p &lt; 0.001). Costs for total healthcare (€769.8), inpatient (€237.3) and outpatient (€368.6) care also increased significantly (all p &lt; 0.001). Inpatient costs accounted for 50.1 % of total costs.</div></div><div><h3>Conclusion</h3><div>Dengue poses a sizable health economic burden in Germany in the year following diagnosis as it increases healthcare resource utilization, sick leave days, and healthcare-related costs compared to individuals without dengue. The findings highlight the need for targeted public health interventions to mitigate the impact of dengue.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 6","pages":"Article 105107"},"PeriodicalIF":2.9,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multicenter audit of 1295 daptomycin prescriptions in the Auvergne-Rhône-Alpes region","authors":"Renan Le Cras ,&nbsp;Brice Solomovici ,&nbsp;Philippe Lesprit ,&nbsp;Luc Foroni","doi":"10.1016/j.idnow.2025.105106","DOIUrl":"10.1016/j.idnow.2025.105106","url":null,"abstract":"<div><h3>Objective</h3><div>We conducted an audit of daptomycin prescriptions for patients hospitalized in the Auvergne-Rhône-Alpes region. The audit was performed in the scope of contracts designed to improve the quality and efficiency of patient care between hospitals and the regional health agency.</div></div><div><h3>Patients and method</h3><div>This retrospective multicenter study was conducted using the clinical audit method on data collected in 2023. The local referent healthcare professional assessed prescription appropriateness with regard to guidelines, based on data available in computerized medical records.</div></div><div><h3>Results</h3><div>All in all, 1295 daptomycin prescriptions from 50 hospitals were included. Median patient age was 72 years (61–80). A majority of prescriptions were initiated for bone and joint infections (n = 573, 44.2 %), most often in orthopedic wards (n = 445, 34.4 %). Bacteriological documentation was obtained in 40.5 % (n = 524) of cases. The prescription was considered appropriate in 87.1 % (n = 1128).</div><div>A total of 132 inappropriate prescriptions for 120 patients were identified by the local referent healthcare professional: 33.3 % (n = 44) were inappropriate indications, 25 % (n = 33) were due to a lack of de-escalation following microbiological documentation, 16.7 % (n = 22) involved inappropriate dosing and 15.9 % (n = 21) concerned inappropriate treatment duration. Written recommendations for treatment of an infectious disease physician were found for 38.8 % (n = 503) of prescriptions; they were associated with higher appropriateness (386/410 (94.1 %) <em>vs.</em> 65/93 (69.9 %), p &lt; 0.01).</div></div><div><h3>Conclusion</h3><div>This study found that while appropriateness of daptomycin prescriptions in Auvergne-Rhône-Alpes was generally satisfactory, it was limited by the self-evaluation method applied. In addition, areas for with potential for improvement in daptomycin prescription were identified.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 6","pages":"Article 105106"},"PeriodicalIF":2.9,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevention of aspiration pneumonia recurrences","authors":"Thibaut Fraisse ,&nbsp;V. Prendki ,&nbsp;A. Putot ,&nbsp;C. Garcia-Carmona ,&nbsp;M. Perrin ,&nbsp;N. Chebib ,&nbsp;C. Andrejak ,&nbsp;M. Matta ,&nbsp;G. Gavazzi ,&nbsp;Y. Rolland ,&nbsp;S. Diamantis","doi":"10.1016/j.idnow.2025.105102","DOIUrl":"10.1016/j.idnow.2025.105102","url":null,"abstract":"<div><h3>Context</h3><div>Aspiration pneumonia occurs after a documented aspiration or in patients with aspiration risk factors, suggesting a potential oropharyngeal portal of entry for the responsible pathogens. Strategies aimed at preventing recurrences are based on the identification of risk factors, their modification, and the implementation of appropriate corrective measures.</div></div><div><h3>Methods</h3><div>A comprehensive review of the literature (2000–2025) on the prevention of aspiration pneumonia was conducted.</div></div><div><h3>Results</h3><div>Treatments likely to exacerbate swallowing disorders must be reassessed, particularly anticholinergics, sedatives, and psychotropic drugs. No treatment was significantly effective in directly preventing aspiration pneumonia. Nutritional requirements are met using enteral nutrition, but it increases oral bacterial colonization, oral biofilm thickness, and muscle weakness. A series of measures (semi-sitting positioning in patients with impaired awareness or enteral nutrition, speech therapy, rehabilitation, and elimination of dental biofilm) were significantly effective in preventing aspiration pneumonia. Adapting food texture and thickening liquids are measures being considered to reduce the risks, despite the potential impact on the quality of life and on nutritional intake.</div></div><div><h3>Conclusion</h3><div>A multidisciplinary assessment is recommended after an episode of pneumonia in the elderly to identify the pathogen’s route of entry and to establish a plan to prevent recurrences. Future research will need to determine priorities among the various measures proposed to optimize management strategies.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 6","pages":"Article 105102"},"PeriodicalIF":2.9,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computed tomography for the diagnosis of HIV-associated gastro-intestinal histoplasmosis","authors":"Domitille Droz-Bartholet ,&nbsp;Lorenzo Garzelli ,&nbsp;Ugo Françoise ,&nbsp;Alolia Aboikoni ,&nbsp;Antoine Adenis ,&nbsp;Magaly Zappa","doi":"10.1016/j.idnow.2025.105105","DOIUrl":"10.1016/j.idnow.2025.105105","url":null,"abstract":"<div><h3>Introduction</h3><div>Disseminated histoplasmosis is one of the leading opportunistic infections among people living with human immunodeficiency virus (PLHIV) in Latin America. Intestinal involvement is common, but its computed tomography findings have not been properly described. We aimed to provide a computed tomography description of histoplasmosis intestinal involvement.</div></div><div><h3>Patients and methods</h3><div>We performed a retrospective observational study of patients with disseminated histoplasmosis and proven intestinal involvement.</div></div><div><h3>Results</h3><div>A total of 18 patients with an available contrast-enhanced abdominal computed tomography (8 women, mean age 44 years) were included. Seventeen had intestinal parietal thickening (94 %), with a mean thickening of 14 <!--> <!-->mm, unifocal or multifocal, frequently circumferential (71 %). The most commonly affected segments were the cecum and right colon in 13/17 (76 %) of patients each. Adenomegaly was constant, mostly homogeneous.</div></div><div><h3>Conclusion</h3><div>These computed tomography features in patients with advanced HIV disease may be key findings for an early diagnosis in the absence of proven histoplasmosis.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 6","pages":"Article 105105"},"PeriodicalIF":2.9,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}