Infectious diseases now最新文献

{"title":"CV2 : Editorial board","authors":"","doi":"10.1016/S2666-9919(25)00074-0","DOIUrl":"10.1016/S2666-9919(25)00074-0","url":null,"abstract":"","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 4","pages":"Article 105095"},"PeriodicalIF":2.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144154341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Appropriateness of piperacillin-tazobactam prescriptions: a prospective multicentre study","authors":"Pierre-Marie Roger ,&nbsp;Catherine Lechiche ,&nbsp;Pauline Quint ,&nbsp;Agnès Simand ,&nbsp;Jacques Roghi ,&nbsp;Sylvie Comparot ,&nbsp;Marc-Antoine Hennet ,&nbsp;Catherine Beranger ,&nbsp;Pierre Mignonat ,&nbsp;Laure Belmondo ,&nbsp;Eric Denes","doi":"10.1016/j.idnow.2025.105103","DOIUrl":"10.1016/j.idnow.2025.105103","url":null,"abstract":"<div><h3>Introduction</h3><div>Our aim was to determine the reasons for appropriate Piperacillin-tazobactam (Pip-Taz) prescriptions.</div></div><div><h3>Method</h3><div>This was a prospective multicentre study of two-month Pip-Taz prescription in France. Reading of patient charts allowed for classification of diagnoses as definitive, suspected or unknown. Appropriateness of Pip-Taz was defined according to eight indications: post-operative infection in digestive surgery or urology, fever in onco-hematological patients, healthcare-associated infections (HCAI) in intensive care units, polymicrobial HCAI, infection due to multidrug-resistant bacteria, avoidance of carbapenem use, pulmonary infection in patients with chronic pulmonary disease, and following an internal guideline. Antibiotic reassessment was defined by any modification of Pip-Taz. Risk factors for erroneous Pip-Taz prescription were identified through a multivariate analysis, and participating physicians were interrogated on the subject.</div></div><div><h3>Results</h3><div>From April to July 2024, 259 prescriptions from 14 institutions were included. The diagnosis of infection was definitive in 127 cases (49 %), suspected in 97 (37 %), and unknown in 37 (14 %). Prescriptions were deemed appropriate in 204 cases (79 %). In logistic regression, appropriate Pip-Taz prescription was associated with definitive diagnoses, HCAI, microbiological investigations, advice by infectious disease specialists, and antibiotic reassessment (all adjusted OR ≥ 2.19). All in all, 37/55 prescriptions outside the scope of guidelines were elucidated by the prescribers, the main reason for them being “out of habit” (13/37), and we found a relationship between “unknown diagnosis” and no explanation for Pip-Taz prescription (<em>p</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Pip-Taz appropriateness was associated with correct management, <em>i.e.</em> written diagnosis, microbiological investigation, and reassessment, while prescriptions outside guidelines were related to physician habits, including no written diagnosis.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 6","pages":"Article 105103"},"PeriodicalIF":2.9,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of high-sensitivity C-reaction protein in the prediction of long-term mortality in people living with HIV: Results from the IDEA-TB cohort study in Kenya","authors":"Fausto Ciccacci ,&nbsp;Benjamin Welu ,&nbsp;Harrison Ndoi ,&nbsp;Irene Karea ,&nbsp;Anna Maria Doro Altan ,&nbsp;Davide Brambilla ,&nbsp;Kenneth Munene ,&nbsp;Brenda Opanga ,&nbsp;Aiban Ronoh ,&nbsp;Scolastica Mukwanjagi ,&nbsp;Raymond Mwiraria ,&nbsp;Giovanni Guidotti ,&nbsp;Stefano Orlando","doi":"10.1016/j.idnow.2025.105100","DOIUrl":"10.1016/j.idnow.2025.105100","url":null,"abstract":"","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 6","pages":"Article 105100"},"PeriodicalIF":2.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cirrhotic patients with bone and joint infections: A 10-year cohort study from a reference center","authors":"V. Tuloup ,&nbsp;C. Doumit ,&nbsp;M.F. Lartigue ,&nbsp;L.R. Le Nail ,&nbsp;M. Lacasse ,&nbsp;A. Lemaignen ,&nbsp;among the Tours CRIOAC centre","doi":"10.1016/j.idnow.2025.105099","DOIUrl":"10.1016/j.idnow.2025.105099","url":null,"abstract":"<div><h3>Introduction</h3><div>Bone and joint infections (BJI) require long-term and frequently high-dose antimicrobial treatment, often with heightened risk of drug-drug or drug-disease interactions. However, in some cases, notably regarding cirrhotic patients, these infections have yet to be adequately described. Cirrhosis is a major cause of end-stage chronic liver disease, entailing massive disorders in hepatic metabolism and a high rate of infections and comorbidities. We aimed to characterize the cirrhosis − BJI population treated over the last 10 years in our reference centre.</div></div><div><h3>Material and methods</h3><div>A descriptive monocentric retrospective study analysed routine care data extracted from our computer files. Patients labelled with a chronic hepatic disease were included. Biological, clinical and survival rate were researched. Drug-drug and drug-disease interactions were compiled and analysed using the exposure ratio, according to the Child-Pugh scale.</div></div><div><h3>Results</h3><div>Eighteen patients were included, for 28 presentations. Twelve were Child-Pugh B or C. Only two out of the 18 patients had their antimicrobial dosage adjusted. No patient who had not received the recommended dose adjustment was admitted to the emergency department or for consultation for an antibiotic-related adverse event. During the 1st year, two patients (11.1 %) required hospitalization for revision surgery. Neither relapsed a second time. Six patients (33.3 %) died during follow-up, but none of the deaths were related to infection (four cancers, two ischemic events).</div></div><div><h3>Conclusion</h3><div>We have shown that cirrhotic patients with BJI are infected with the same pathogens as the general population. Dose adjustments remain unclear, and further studies are required. BJI infections are particularly complex, and require enhanced multidisciplinary management.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 6","pages":"Article 105099"},"PeriodicalIF":2.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of the antibiotic advice provided by referral centres in France: a prospective audit","authors":"Pierre-Marie Roger ,&nbsp;Nicolas Lesaffre ,&nbsp;Timothé Thiel ,&nbsp;Assi Assi ,&nbsp;Eric Denes","doi":"10.1016/j.idnow.2025.105089","DOIUrl":"10.1016/j.idnow.2025.105089","url":null,"abstract":"<div><h3>Objectives</h3><div>Our aim was to determine the quality of antibiotic advice given by antibiotic referral centres (RC) to general practitioners (GP).</div></div><div><h3>Method</h3><div>A prospective multicentre audit of antibiotic advice on four urinary tract infections (UTI) and four respiratory infections delivered to GPs by RCs was carried out from May to August 2024. Recommendations were put forward by three senior infectious disease specialists in accordance with the existing guidelines.</div></div><div><h3>Results</h3><div>Fourteen RCs were asked to provide 112 recommendations, and 106 responses were obtained (95 %). Advice was given by a senior physician in 76 cases (72 %) and a resident in the 30 others (38 %). The mean score/5 [± std deviation] <em>per</em> clinical case was 2.7 ± 1.9, with a difference between UTI and respiratory infections: 3.5 ± 1.7 versus 3.0 ± 1.1, p = 0.043, and a higher score for senior physicians as compared to residents: 2.9 ± 1.8 versus 2.0 ± 1.9, p = 0.019.</div></div><div><h3>Conclusion</h3><div>The quality of antibiotic-related advice provided by RCs to GPs appeared heterogeneous, and improvement could be facilitated by favouring senior physician intervention.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 5","pages":"Article 105089"},"PeriodicalIF":2.9,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro susceptibility of aztreonam/avibactam against metallo-β-Lactamase-producing Enterobacterales in a Croatian tertiary care hospital","authors":"Ivana Majdandžić ,&nbsp;Ivana Mareković ,&nbsp;Ana Budimir","doi":"10.1016/j.idnow.2025.105092","DOIUrl":"10.1016/j.idnow.2025.105092","url":null,"abstract":"","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 5","pages":"Article 105092"},"PeriodicalIF":2.9,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144098780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bictegravir use during pregnancy.","authors":"Emmanuel Mortier, Margaux Froidefond, Roger Serhal, Christine Chan Chee, Sarah Permal, Mohamadou Niang","doi":"10.1016/j.idnow.2025.105093","DOIUrl":"https://doi.org/10.1016/j.idnow.2025.105093","url":null,"abstract":"","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":" ","pages":"105093"},"PeriodicalIF":2.9,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Climate crossroads: How global warming drives coronavirus emergence, the long COVID crisis of tomorrow, and AI’s role in navigating our future","authors":"Thorsten Rudroff","doi":"10.1016/j.idnow.2025.105091","DOIUrl":"10.1016/j.idnow.2025.105091","url":null,"abstract":"<div><div>This narrative review examines the critical nexus between climate change, coronavirus emergence, and Long COVID—a triad that may shape public health outcomes for generations. Climate change disrupts ecological balances that have historically limited viral spillover events, creating novel interfaces between wildlife reservoirs and human populations. The coronavirus family presents particular concern due to its diversity, adaptability, and demonstrated capacity for cross-species transmission. With over 200 coronaviruses identified in bat populations alone, this vast reservoir of genetic diversity, combined with the family’s propensity for recombination, creates substantial pandemic potential that climate disruption may further amplify. Long COVID has revealed another dimension of the coronavirus threat: the potential for significant chronic disease burden following acute infection. This complex multisystem condition affects a substantial portion of SARS-CoV-2 infected individuals, with mechanisms including viral persistence, autoimmunity, microclot formation, and mitochondrial dysfunction. Future projections suggest that climate change could increase global viral spillover risk by 30–45% by 2070, particularly in Southeast Asia, Central Africa, and parts of South America. Artificial intelligence offers promising tools for addressing these interconnected challenges through enhanced surveillance, accelerated therapeutic development, and optimized healthcare delivery. Understanding the climate-coronavirus-chronic illness nexus has become essential to the development of resilient health systems and effective planetary health policies face to an uncertain future.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 6","pages":"Article 105091"},"PeriodicalIF":2.9,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the impact of artificial intelligence in antimicrobial stewardship: a comparative meta-analysis with traditional risk scoring systems","authors":"Antonio Pinto ,&nbsp;Flavia Pennisi ,&nbsp;Giovanni Emanuele Ricciardi ,&nbsp;Carlo Signorelli ,&nbsp;Vincenza Gianfredi","doi":"10.1016/j.idnow.2025.105090","DOIUrl":"10.1016/j.idnow.2025.105090","url":null,"abstract":"<div><h3>Objectives</h3><div>The growing challenge of antimicrobial resistance (AMR) has underscored the urgent need for robust antimicrobial stewardship programs (AMS). Artificial intelligence (AI) and machine learning (ML) have emerged as promising tools to support enhanced decision-making in AMS. This systematic review and meta-analysis aims to evaluate the impact of AI in AMS and compare its effectiveness with traditional risk systems.</div></div><div><h3>Methods</h3><div>PubMed/MEDLINE, Scopus, EMBASE, and Web of Science were searched to identify studies published up to July 2024. Any studies that evaluated the use of AI/ML in AMS compared with conventional decision-making approaches were eligible. Outcomes of interested were predictive performance metrics and diagnostic accuracy. The meta-estimate was performed pooling standardized mean difference, and effect size (ES) measured as Cohen’s d with a 95% confidence interval (CI). The risk of bias was assessed using the QUADAS-AI tool.</div></div><div><h3>Results</h3><div>Out of 3,458 studies, 27 were included, demonstrating that ML models outperform traditional methods in terms of sensitivity [1.93 (0.48–3.39) <em>p</em> = 0.009], and negative predictive value [1.66 (0.86–2.46), <em>p</em> &lt; 0.001] but not in terms of area under the curve, accuracy, specificity, positive predictive value, when random effect models were applied.</div></div><div><h3>Conclusions</h3><div>Our results revealed that ML tools offer promising enhancements to traditional AMS strategies. However, high heterogeneity, inconsistent results between fixed and random effect models, and limited use of external validation in retrieved studies raise concerns about the generalizability of the findings. Furthermore, the lack of representation from outpatient and pediatric settings highlights a critical equity gap in the application of these technologies.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 5","pages":"Article 105090"},"PeriodicalIF":2.9,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144072691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adapting pneumococcal conjugate vaccines to serotype replacement: are we always one step behind?","authors":"Zein Assad ,&nbsp;Nathanaël Hozé ,&nbsp;Thibaut Morel-Journel ,&nbsp;Naïm Ouldali","doi":"10.1016/j.idnow.2025.105085","DOIUrl":"10.1016/j.idnow.2025.105085","url":null,"abstract":"","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 5","pages":"Article 105085"},"PeriodicalIF":2.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}