Infectious diseases now最新文献

{"title":"A multicenter audit of 1295 daptomycin prescriptions in the Auvergne-Rhône-Alpes region.","authors":"Renan Le Cras, Brice Solomovici, Phillipe Lesprit, Luc Foroni","doi":"10.1016/j.idnow.2025.105106","DOIUrl":"https://doi.org/10.1016/j.idnow.2025.105106","url":null,"abstract":"<p><strong>Objective: </strong>We conducted an audit of daptomycin prescriptions for patients hospitalized in the Auvergne-Rhône-Alpes region. The audit was performed in the scope of contracts designed to improve the quality and efficiency of patient care between hospitals and the regional health agency.</p><p><strong>Patients and method: </strong>This retrospective multicenter study was conducted using the clinical audit method on data collected in 2023. The local referent healthcare professional assessed prescription appropriateness with regard to guidelines, based on data available in computerized medical records.</p><p><strong>Results: </strong>All in all, 1295 daptomycin prescriptions from 50 hospitals were included. Median patient age was 72 years (61-80). A majority of prescriptions were initiated for bone and joint infections (n = 573, 44.2 %), most often in orthopedic wards (n = 445, 34.4 %). Bacteriological documentation was obtained in 40.5 % (n = 524) of cases. The prescription was considered appropriate in 87.1 % (n = 1128). A total of 132 inappropriate prescriptions for 120 patients were identified: 33.3 % (n = 44) were inappropriate indications, 25 % (n = 33) were due to a lack of de-escalation following microbiological documentation, 16.7 % (n = 22) involved inappropriate dosing and 15.9 % (n = 21) concerned inappropriate treatment duration. Written recommendations for treatment of an infectious disease recommendation were found for 38.8 % (n = 503) of prescriptions; they were associated with higher appropriateness (386/410 (94.1 %) vs. 65/93 (69.9 %), p < 0.00001).</p><p><strong>Conclusion: </strong>This study found that while appropriateness of daptomycin prescriptions in Auvergne-Rhône-Alpes was generally satisfactory, it was limited by the self-evaluation method applied. In addition, areas for with potential for improvement in daptomycin prescription were identified.</p>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":" ","pages":"105106"},"PeriodicalIF":2.9,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevention of aspiration pneumonia recurrences","authors":"Thibaut Fraisse ,&nbsp;V. Prendki ,&nbsp;A. Putot ,&nbsp;C. Garcia-Carmona ,&nbsp;M. Perrin ,&nbsp;N. Chebib ,&nbsp;C. Andrejak ,&nbsp;M. Matta ,&nbsp;G. Gavazzi ,&nbsp;Y. Rolland ,&nbsp;S. Diamantis","doi":"10.1016/j.idnow.2025.105102","DOIUrl":"10.1016/j.idnow.2025.105102","url":null,"abstract":"<div><h3>Context</h3><div>Aspiration pneumonia occurs after a documented aspiration or in patients with aspiration risk factors, suggesting a potential oropharyngeal portal of entry for the responsible pathogens. Strategies aimed at preventing recurrences are based on the identification of risk factors, their modification, and the implementation of appropriate corrective measures.</div></div><div><h3>Methods</h3><div>A comprehensive review of the literature (2000–2025) on the prevention of aspiration pneumonia was conducted.</div></div><div><h3>Results</h3><div>Treatments likely to exacerbate swallowing disorders must be reassessed, particularly anticholinergics, sedatives, and psychotropic drugs. No treatment was significantly effective in directly preventing aspiration pneumonia. Nutritional requirements are met using enteral nutrition, but it increases oral bacterial colonization, oral biofilm thickness, and muscle weakness. A series of measures (semi-sitting positioning in patients with impaired awareness or enteral nutrition, speech therapy, rehabilitation, and elimination of dental biofilm) were significantly effective in preventing aspiration pneumonia. Adapting food texture and thickening liquids are measures being considered to reduce the risks, despite the potential impact on the quality of life and on nutritional intake.</div></div><div><h3>Conclusion</h3><div>A multidisciplinary assessment is recommended after an episode of pneumonia in the elderly to identify the pathogen’s route of entry and to establish a plan to prevent recurrences. Future research will need to determine priorities among the various measures proposed to optimize management strategies.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 6","pages":"Article 105102"},"PeriodicalIF":2.9,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computed tomography for the diagnosis of HIV-associated gastro-intestinal histoplasmosis","authors":"Domitille Droz-Bartholet ,&nbsp;Lorenzo Garzelli ,&nbsp;Ugo Françoise ,&nbsp;Alolia Aboikoni ,&nbsp;Antoine Adenis ,&nbsp;Magaly Zappa","doi":"10.1016/j.idnow.2025.105105","DOIUrl":"10.1016/j.idnow.2025.105105","url":null,"abstract":"<div><h3>Introduction</h3><div>Disseminated histoplasmosis is one of the leading opportunistic infections among people living with human immunodeficiency virus (PLHIV) in Latin America. Intestinal involvement is common, but its computed tomography findings have not been properly described. We aimed to provide a computed tomography description of histoplasmosis intestinal involvement.</div></div><div><h3>Patients and methods</h3><div>We performed a retrospective observational study of patients with disseminated histoplasmosis and proven intestinal involvement.</div></div><div><h3>Results</h3><div>A total of 18 patients with an available contrast-enhanced abdominal computed tomography (8 women, mean age 44 years) were included. Seventeen had intestinal parietal thickening (94 %), with a mean thickening of 14 <!--> <!-->mm, unifocal or multifocal, frequently circumferential (71 %). The most commonly affected segments were the cecum and right colon in 13/17 (76 %) of patients each. Adenomegaly was constant, mostly homogeneous.</div></div><div><h3>Conclusion</h3><div>These computed tomography features in patients with advanced HIV disease may be key findings for an early diagnosis in the absence of proven histoplasmosis.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 6","pages":"Article 105105"},"PeriodicalIF":2.9,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CoCliP-BJI study: cost avoidance of clinical pharmacist-led interventions in patients with bone and joint infections","authors":"Eloïse Couvé ,&nbsp;Marin Lahouati ,&nbsp;Julie Leitao ,&nbsp;Vasco Dias Meireles ,&nbsp;Fréderic-Antoine Dauchy ,&nbsp;Fabien Xuereb","doi":"10.1016/j.idnow.2025.105104","DOIUrl":"10.1016/j.idnow.2025.105104","url":null,"abstract":"<div><h3>Objectives</h3><div>Patients with bone and joint infections (BJI) are part of a complex care pathway. This study aimed to evaluate the economic impact of clinical pharmacist-led interventions in the management of BJI patients.</div></div><div><h3>Patients and Methods</h3><div>We performed a retrospective study documenting all pharmacist-led interventions (PI). Their impact was assessed using the clinical economic and organizational scale (CLEO SFPC). The probability of adverse drug events (ADE) in the absence of PI was assessed by a panel of three experts. Cost avoidance was calculated for PIs with major clinical impact using a cost of €5,331 per event, multiplied by the probability of ADE occurrence.</div></div><div><h3>Results</h3><div>A total of 41 PIs had a major clinical impact. Cost avoidance associated with the intervention of a pharmacist was estimated at €83,750.01 during the study.</div></div><div><h3>Conclusion</h3><div>The implementation of pharmacist-led interventions in the management of patients with BJI helps avoid preventable healthcare costs.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 6","pages":"Article 105104"},"PeriodicalIF":2.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CV2 : Editorial board","authors":"","doi":"10.1016/S2666-9919(25)00074-0","DOIUrl":"10.1016/S2666-9919(25)00074-0","url":null,"abstract":"","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 4","pages":"Article 105095"},"PeriodicalIF":2.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144154341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Appropriateness of piperacillin-tazobactam prescriptions: a prospective multicentre study","authors":"Pierre-Marie Roger ,&nbsp;Catherine Lechiche ,&nbsp;Pauline Quint ,&nbsp;Agnès Simand ,&nbsp;Jacques Roghi ,&nbsp;Sylvie Comparot ,&nbsp;Marc-Antoine Hennet ,&nbsp;Catherine Beranger ,&nbsp;Pierre Mignonat ,&nbsp;Laure Belmondo ,&nbsp;Eric Denes","doi":"10.1016/j.idnow.2025.105103","DOIUrl":"10.1016/j.idnow.2025.105103","url":null,"abstract":"<div><h3>Introduction</h3><div>Our aim was to determine the reasons for appropriate Piperacillin-tazobactam (Pip-Taz) prescriptions.</div></div><div><h3>Method</h3><div>This was a prospective multicentre study of two-month Pip-Taz prescription in France. Reading of patient charts allowed for classification of diagnoses as definitive, suspected or unknown. Appropriateness of Pip-Taz was defined according to eight indications: post-operative infection in digestive surgery or urology, fever in onco-hematological patients, healthcare-associated infections (HCAI) in intensive care units, polymicrobial HCAI, infection due to multidrug-resistant bacteria, avoidance of carbapenem use, pulmonary infection in patients with chronic pulmonary disease, and following an internal guideline. Antibiotic reassessment was defined by any modification of Pip-Taz. Risk factors for erroneous Pip-Taz prescription were identified through a multivariate analysis, and participating physicians were interrogated on the subject.</div></div><div><h3>Results</h3><div>From April to July 2024, 259 prescriptions from 14 institutions were included. The diagnosis of infection was definitive in 127 cases (49 %), suspected in 97 (37 %), and unknown in 37 (14 %). Prescriptions were deemed appropriate in 204 cases (79 %). In logistic regression, appropriate Pip-Taz prescription was associated with definitive diagnoses, HCAI, microbiological investigations, advice by infectious disease specialists, and antibiotic reassessment (all adjusted OR ≥ 2.19). All in all, 37/55 prescriptions outside the scope of guidelines were elucidated by the prescribers, the main reason for them being “out of habit” (13/37), and we found a relationship between “unknown diagnosis” and no explanation for Pip-Taz prescription (<em>p</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Pip-Taz appropriateness was associated with correct management, <em>i.e.</em> written diagnosis, microbiological investigation, and reassessment, while prescriptions outside guidelines were related to physician habits, including no written diagnosis.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 6","pages":"Article 105103"},"PeriodicalIF":2.9,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of high-sensitivity C-reaction protein in the prediction of long-term mortality in people living with HIV: Results from the IDEA-TB cohort study in Kenya","authors":"Fausto Ciccacci ,&nbsp;Benjamin Welu ,&nbsp;Harrison Ndoi ,&nbsp;Irene Karea ,&nbsp;Anna Maria Doro Altan ,&nbsp;Davide Brambilla ,&nbsp;Kenneth Munene ,&nbsp;Brenda Opanga ,&nbsp;Aiban Ronoh ,&nbsp;Scolastica Mukwanjagi ,&nbsp;Raymond Mwiraria ,&nbsp;Giovanni Guidotti ,&nbsp;Stefano Orlando","doi":"10.1016/j.idnow.2025.105100","DOIUrl":"10.1016/j.idnow.2025.105100","url":null,"abstract":"","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 6","pages":"Article 105100"},"PeriodicalIF":2.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cirrhotic patients with bone and joint infections: A 10-year cohort study from a reference center","authors":"V. Tuloup ,&nbsp;C. Doumit ,&nbsp;M.F. Lartigue ,&nbsp;L.R. Le Nail ,&nbsp;M. Lacasse ,&nbsp;A. Lemaignen ,&nbsp;among the Tours CRIOAC centre","doi":"10.1016/j.idnow.2025.105099","DOIUrl":"10.1016/j.idnow.2025.105099","url":null,"abstract":"<div><h3>Introduction</h3><div>Bone and joint infections (BJI) require long-term and frequently high-dose antimicrobial treatment, often with heightened risk of drug-drug or drug-disease interactions. However, in some cases, notably regarding cirrhotic patients, these infections have yet to be adequately described. Cirrhosis is a major cause of end-stage chronic liver disease, entailing massive disorders in hepatic metabolism and a high rate of infections and comorbidities. We aimed to characterize the cirrhosis − BJI population treated over the last 10 years in our reference centre.</div></div><div><h3>Material and methods</h3><div>A descriptive monocentric retrospective study analysed routine care data extracted from our computer files. Patients labelled with a chronic hepatic disease were included. Biological, clinical and survival rate were researched. Drug-drug and drug-disease interactions were compiled and analysed using the exposure ratio, according to the Child-Pugh scale.</div></div><div><h3>Results</h3><div>Eighteen patients were included, for 28 presentations. Twelve were Child-Pugh B or C. Only two out of the 18 patients had their antimicrobial dosage adjusted. No patient who had not received the recommended dose adjustment was admitted to the emergency department or for consultation for an antibiotic-related adverse event. During the 1st year, two patients (11.1 %) required hospitalization for revision surgery. Neither relapsed a second time. Six patients (33.3 %) died during follow-up, but none of the deaths were related to infection (four cancers, two ischemic events).</div></div><div><h3>Conclusion</h3><div>We have shown that cirrhotic patients with BJI are infected with the same pathogens as the general population. Dose adjustments remain unclear, and further studies are required. BJI infections are particularly complex, and require enhanced multidisciplinary management.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 6","pages":"Article 105099"},"PeriodicalIF":2.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of the antibiotic advice provided by referral centres in France: a prospective audit","authors":"Pierre-Marie Roger ,&nbsp;Nicolas Lesaffre ,&nbsp;Timothé Thiel ,&nbsp;Assi Assi ,&nbsp;Eric Denes","doi":"10.1016/j.idnow.2025.105089","DOIUrl":"10.1016/j.idnow.2025.105089","url":null,"abstract":"<div><h3>Objectives</h3><div>Our aim was to determine the quality of antibiotic advice given by antibiotic referral centres (RC) to general practitioners (GP).</div></div><div><h3>Method</h3><div>A prospective multicentre audit of antibiotic advice on four urinary tract infections (UTI) and four respiratory infections delivered to GPs by RCs was carried out from May to August 2024. Recommendations were put forward by three senior infectious disease specialists in accordance with the existing guidelines.</div></div><div><h3>Results</h3><div>Fourteen RCs were asked to provide 112 recommendations, and 106 responses were obtained (95 %). Advice was given by a senior physician in 76 cases (72 %) and a resident in the 30 others (38 %). The mean score/5 [± std deviation] <em>per</em> clinical case was 2.7 ± 1.9, with a difference between UTI and respiratory infections: 3.5 ± 1.7 versus 3.0 ± 1.1, p = 0.043, and a higher score for senior physicians as compared to residents: 2.9 ± 1.8 versus 2.0 ± 1.9, p = 0.019.</div></div><div><h3>Conclusion</h3><div>The quality of antibiotic-related advice provided by RCs to GPs appeared heterogeneous, and improvement could be facilitated by favouring senior physician intervention.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 5","pages":"Article 105089"},"PeriodicalIF":2.9,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro susceptibility of aztreonam/avibactam against metallo-β-Lactamase-producing Enterobacterales in a Croatian tertiary care hospital","authors":"Ivana Majdandžić ,&nbsp;Ivana Mareković ,&nbsp;Ana Budimir","doi":"10.1016/j.idnow.2025.105092","DOIUrl":"10.1016/j.idnow.2025.105092","url":null,"abstract":"","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 5","pages":"Article 105092"},"PeriodicalIF":2.9,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144098780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}