Infectious diseases now最新文献

{"title":"Antibiotic therapy and prophylaxis of infective endocarditis – A SPILF-AEPEI position statement on the ESC 2023 guidelines","authors":"Vincent Le Moing , Éric Bonnet , Vincent Cattoir , Catherine Chirouze , Laurène Deconinck , Xavier Duval , Bruno Hoen , Nahéma Issa , Raphaël Lecomte , Pierre Tattevin , Asmaa Tazi , François Vandenesch , Christophe Strady","doi":"10.1016/j.idnow.2024.105011","DOIUrl":"10.1016/j.idnow.2024.105011","url":null,"abstract":"","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 1","pages":"Article 105011"},"PeriodicalIF":2.9,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimising detection of thrombosis in paediatric Staphylococcus aureus bacteraemia: A prospective interventional sub-study protocol","authors":"Keerthi Anpalagan ,&nbsp;Asha C. Bowen ,&nbsp;Leanne Lamborn ,&nbsp;Derek Roebuck ,&nbsp;Tina Carter ,&nbsp;Jeffrey W. Cannon ,&nbsp;Caitlin Symons ,&nbsp;Jane McNally ,&nbsp;Gillian Woods ,&nbsp;Brendan McMullan ,&nbsp;Amanda Gwee ,&nbsp;Steven Y.C. Tong ,&nbsp;Joshua S. Davis ,&nbsp;Anita J. Campbell","doi":"10.1016/j.idnow.2024.105010","DOIUrl":"10.1016/j.idnow.2024.105010","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Staphylococcus aureus</em> bacteraemia (SAB) is the most common cause of sepsis, contributing to paediatric intensive care unit admission in Australia and New Zealand. While deep venous thrombosis (DVT) has been reported in children with invasive <em>S. aureus</em> infections, the actual frequency and possible effects of thrombosis on disease severity and outcome in paediatric SAB remain unknown. Moreover, guidance regarding imaging for paediatric SAB management are poorly defined.</div></div><div><h3>Methods and analysis</h3><div>We report the protocol for the SNOOPY (<em>Staphylococcus aureus</em> Network; ultrasOund for diagnOsis of endovascular disease in Paediatrics and Youth) study. SNOOPY is a pilot prospective single-arm interventional study that aims to investigate the proportion of children with SAB that have venous thrombosis detected using whole body doppler ultrasound.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"55 1","pages":"Article 105010"},"PeriodicalIF":2.9,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parkinsonism plus syndrome in neurosyphilis: Clinical insights and brain imaging","authors":"Wenjing Zhang ,&nbsp;Kaiyu Qin ,&nbsp;Ran Miao ,&nbsp;Canglin Song ,&nbsp;Xiaoyang Ma ,&nbsp;Cheng Kou ,&nbsp;Dongmei Xu","doi":"10.1016/j.idnow.2024.105009","DOIUrl":"10.1016/j.idnow.2024.105009","url":null,"abstract":"<div><h3>Background</h3><div>While Parkinsonism plus syndrome (PPS) is one of several atypical manifestations in neurosyphilis patients, its clinical features and brain-related manifestations are inadequately documented. In this cross-sectional study, we endeavored to indicate some key clinical and imaging features of neurosyphilis patients, particularly those specific to PPS.</div></div><div><h3>Methods</h3><div>We retrospectively included all syphilis patients enrolled in the study from January 2021 to February 2024. All in all, 54 neurosyphilis patients with PPS were recruited. Their socio-demographical features, clinical status, presentations, laboratory manifestations and neuroimaging were analyzed retrospectively.</div></div><div><h3>Results</h3><div>The predominant phenotype was general paresis (GP). Median age at onset was 50 years, and 87.0 % of the patients were male. Bradykinesia (53.7 %) was the most common manifestation of PPS in neurosyphilis patients. The most frequent physical sign was orofacial dyskinesia (the Candy sign), which accounted for 51.9 % of cases.</div><div>In nearly three quarters (71.1 %), magnetic resonance imagery revealed temporal, hippocampal lobe, or whole brain atrophy, while 13.3 % exhibited basal ganglia lacunar infarction, and 22.2 % cases had focal demyelination in the cerebral peduncle, cerebellum, frontal lobe, parietal lobe, hippocampus and/or lateral vertical.</div></div><div><h3>Conclusions</h3><div>Neurosyphilis patients exhibited PPS in involving bradykinesia, tremor rigidity and, in most cases, GP. Brain atrophy and basal ganglia lesion were the most common imaging findings in neurosyphilis patients with PPS. Our results should help to elucidate PPS characteristics PPS and neuroimaging mechanisms in neurosyphilis patients with PPS.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 8","pages":"Article 105009"},"PeriodicalIF":2.9,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A step further: Antibiotic stewardship programme in home hospital","authors":"Leonor Moreno Núñez ,&nbsp;Cristina Garmendia Fernández ,&nbsp;Manuel Ruiz Muñoz ,&nbsp;Jesús Collado Álvarez ,&nbsp;Carmen Jimeno Griño ,&nbsp;Álvaro Prieto Callejero ,&nbsp;Elia Pérez Fernández ,&nbsp;Isabel González Anglada ,&nbsp;Juan Emilio Losa García","doi":"10.1016/j.idnow.2024.105008","DOIUrl":"10.1016/j.idnow.2024.105008","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the adequacy of empirical antibiotic prescription and the duration of antibiotic therapy for infected patients admitted for conventional hospitalization (CH) and Hospitalization at Home (HaH) after implementation of an antibiotic stewardship programs (ASP) in HaH.</div></div><div><h3>Design</h3><div>Retrospective cohort study.</div></div><div><h3>Patients</h3><div>Patients admitted for infection to Emergency Department between October and December 2023. “CH-ASP cohort” was admitted to CH with ASP intervention, “CH cohort” was admitted to CH without ASP intervention, “HaH cohort” was admitted to HaH (integrated daily ASP intervention).</div></div><div><h3>Results</h3><div>Ninety-one patients were analyzed in CH-ASP, 60 in CH, and 101 in HaH. The ASP made recommendations on empirical antibiotic therapy for 175 patients (92 %) with a 98 % acceptance rate. For 111 patients (44 %) the ASP made recommendations on antibiotic duration (24 % CH-ASP vs 89 % HaH, p &lt; 0.001), with a 73 % acceptance rate (41 % CH-ASP vs 81 % HaH, p &lt; 0.001). Empirical antibiotic adequacy was 94 % (93 % CH-ASP vs 87 % CH vs 100 % HaH, p = 0.006). Median duration of antibiotic therapy was nine days in CH-ASP and CH vs seven in HaH (p &lt; 0.001). There were no differences in mortality and readmissions. In the multivariate analysis, patients in CH-ASP and CH had total duration of antibiotic therapy of 2.2 (95 % CI: 0.2–4.2) and 3 days more (95 % CI: 0.8–5.3) respectively as compared to HaH.</div></div><div><h3>Conclusions</h3><div>ASP improves empirical antibiotic adequacy in patients admitted for infection. ASP in HaH, because of high acceptance of intervention regarding antibiotic duration, achieves shorter treatment durations without increased mortality or readmission.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 8","pages":"Article 105008"},"PeriodicalIF":2.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of EUCAST Rapid Antimicrobial Susceptibility Testing (RAST) on optimal antimicrobial therapy in gram-negative bloodstream infections","authors":"Özge Özgen Top ,&nbsp;Beyza Çifci ,&nbsp;Merve Büyükkörük ,&nbsp;Handan Can ,&nbsp;Pınar Aysert Yıldız ,&nbsp;Halil Furkan Martlı ,&nbsp;Elif Ayça Şahin ,&nbsp;Kayhan Çağlar ,&nbsp;Hasan Selçuk Özger","doi":"10.1016/j.idnow.2024.105007","DOIUrl":"10.1016/j.idnow.2024.105007","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the possible impact of RAST on optimal antimicrobial therapy via de-escalation or escalation, and to determine the reduction in antibiotic susceptibility reporting time with RAST.</div></div><div><h3>Methods</h3><div>In this single-center, prospective descriptive study, RAST was performed on clinical blood cultures containing <em>E. coli</em>, <em>Klebsiella pneumoniae, Pseudomonas aeruginosa</em>, and <em>Acinetobacter baumannii</em> isolates. Very major error, major error, and categorical agreements with VITEK 2 were analyzed.</div></div><div><h3>Results</h3><div>One hundred and three isolates were included in the study, out of which 29.1 % were carbapenem-resistant and 36.9 % were multidrug-resistant according to VITEK 2. Categorical agreement of the RAST method with standard antimicrobial susceptibility test (AST) was &gt; 90 % at 6 h, except for piperacillin/tazobactam. Antibiotic revision could be carried out in 79.6 % of the patients either by de-escalation (61.2 %) or escalation (18.4 %) for optimal therapy based on the RAST 6 h result. RAST could provide carbapenem-sparing therapy in 24 % of patients. Reduction in antibiotic susceptibility reporting time was 41.5 h (38.8 to 63.2, median (IQR)).</div></div><div><h3>Conclusions</h3><div>RAST can provide early antibiotic revision in a majority of patients with significantly reduced antibiotic susceptibility reporting time. Six hours is the shortest optimal time for antibiotic revision with RAST. In countries where empirical broad-spectrum antibiotics are prevalent due to high antibiotic resistance pressure, RAST should be proposed primarily in de-escalation and carbapenem-sparing strategies.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 8","pages":"Article 105007"},"PeriodicalIF":2.9,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of carbapenemase-producing Enterobacteriaceae reservoirs in wet hospital environments as a potential factor in patient acquisition: A cross-sectional study in a French university hospital in 2023","authors":"Léna Sleiman ,&nbsp;Cédric Dananché ,&nbsp;Sophie Gardes ,&nbsp;Isabelle Fredenucci ,&nbsp;Camille Duval ,&nbsp;Isabelle Durieu ,&nbsp;Fabien Zoulim ,&nbsp;Philippe Vanhems ,&nbsp;Pierre Cassier ,&nbsp;Christelle Elias","doi":"10.1016/j.idnow.2024.104998","DOIUrl":"10.1016/j.idnow.2024.104998","url":null,"abstract":"<div><h3>Objectives</h3><div>Wet hospital environments have been documented as potential reservoirs for Carbapenemase-producing Enterobacteriaceae (CPE), possibly contributing to outbreaks among inpatients. Our objectives were to assess the prevalence of CPE reservoirs in a hospital’s wet environments and to investigate the contamination of adjacent dry surfaces.</div></div><div><h3>Methods</h3><div>From March to August 2023, we conducted a cross-sectional study in two hospital wards experiencing ongoing large outbreaks. Sampling of the environment was undertaken in two distinct phases. During phase 1, 38 shower drains and 38 toilet bowls, defined as the wet environment, were sampled using swabs. Phase 2 consisted in sampling adjacent dry surfaces, using wipes in rooms that had tested positive during phase 1. Samples were plated on a selective medium (chromID®CARBASMART, bioMérieux). Species were identified using the matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) technique. Carbapenemases were detected by OKNVI RESIST-5® (CORIS BioConcept).</div></div><div><h3>Results</h3><div>From the 38 patient rooms, 76 samples were taken during phase 1. All in all, 33 (86.8%) rooms presented at least one CPE reservoir in the wet environment; there were 32 (84.2%) contaminated shower drains and six (15.8%) contaminated toilet bowls. Among 57 identified CPEs, the most frequent strain was <em>Enterobacter cloacae</em> VIM (13, 22.8%). During phase 2, 11 (8.3%) out of 132 samples tested positive for CPE. <em>Enterobacter cloacae complex</em> VIM accounted for six (54.5%) of the CPE strains.</div></div><div><h3>Conclusion</h3><div>These findings suggest that the wet hospital environments were broadly contaminated with CPE, mostly <em>Enterobacter cloacae</em> VIM. The spread of CPE from wet environments to dry surfaces seemed limited.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 8","pages":"Article 104998"},"PeriodicalIF":2.9,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142561084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic shortages","authors":"Robert Cohen,&nbsp;Remy Gauzit,&nbsp;Jean Paul Stahl","doi":"10.1016/j.idnow.2024.104997","DOIUrl":"10.1016/j.idnow.2024.104997","url":null,"abstract":"","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 8","pages":"Article 104997"},"PeriodicalIF":2.9,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual detection of Neoehrlichia mikurensis and Anaplasma phagocytophilum: How biplex PCR led in France to the diagnosis of neoehrlichiosis in post-tick bite fever","authors":"Martin Martinot ,&nbsp;Marc Astrie ,&nbsp;Mahsa. Mohseni-Zadeh ,&nbsp;Dominique De Briel ,&nbsp;Benoit Jaulhac ,&nbsp;Pierre Boyer","doi":"10.1016/j.idnow.2024.104995","DOIUrl":"10.1016/j.idnow.2024.104995","url":null,"abstract":"<div><h3>Objectives</h3><div><em>Neoehrlichia</em> mikurensis (NM) is an emerging intracellular bacterium member of the <em>Anaplasmatacecae</em> family. So far, only four cases have been described in France, all of them retrospectively.</div></div><div><h3>Methods</h3><div>This study describes two new cases of NM discovered following implementation of a biplex PCR targeting both <em>Anaplasma</em> and NM.</div></div><div><h3>Results</h3><div>Two immunocompetent patients developed a flu-like illness within 14 days after an identified tick bite. Both had negative <em>Anaplasma</em> PCR, but by using this biplex PCR NM, infection was diagnosed in both cases. One patient recovered spontaneously while the second was successfully treated by a seven-day course of doxycycline.</div></div><div><h3>Conclusion</h3><div>Present in Eastern France, NM is underdiagnosed. Biplex PCR screening of NM with <em>A.<!--> <!-->phagocytophilum</em> could effectively address this issue.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 8","pages":"Article 104995"},"PeriodicalIF":2.9,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142441925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clostridium symbiosum: A novel pathogen causing central nervous system infections in encephalitis patients","authors":"Jinhua Zhang ,&nbsp;Bei Wang ,&nbsp;Jingjing Wang ,&nbsp;Xiaoming Yao ,&nbsp;Yueru Tian","doi":"10.1016/j.idnow.2024.104996","DOIUrl":"10.1016/j.idnow.2024.104996","url":null,"abstract":"","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 8","pages":"Article 104996"},"PeriodicalIF":2.9,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in early HIV/AIDS mortality rates in people initiating antiretroviral treatment between 2013 and 2023: A 10-year multicenter survival study in Senegal","authors":"Bruce Shinga Wembulua ,&nbsp;Viviane Marie Pierre Cisse ,&nbsp;Daye Ka ,&nbsp;Ndeye Fatou Ngom ,&nbsp;Ahmadou Mboup ,&nbsp;Ibrahima Diao ,&nbsp;Aminata Massaly ,&nbsp;Catherine Sarr ,&nbsp;Kalilou Diallo ,&nbsp;Mouhamadou Baïla Diallo ,&nbsp;Moustapha Diop ,&nbsp;Papa Samba Ba ,&nbsp;Noël Magloire Manga ,&nbsp;Stanislas Okitotsho Wembonyama ,&nbsp;Zacharie Kibendelwa Tsongo ,&nbsp;Moussa Seydi","doi":"10.1016/j.idnow.2024.104990","DOIUrl":"10.1016/j.idnow.2024.104990","url":null,"abstract":"<div><h3>Background</h3><div>HIV/AIDS-related early mortality has long been a significant challenge. Subsequent to recent policy changes and treatment advancements, we aimed to assess changes in early mortality rates in 2017–19 and 2020-23 compared to 2013–16.</div></div><div><h3>Methods</h3><div>This is a 10-year multicenter survival study in people living with human immunodeficiency virus having initiated ART between 2013 and 2023. We used frailty-based competing risk models to estimate adjusted early (6-month and one-year) mortality hazard ratios (HRs) in people living with HIV (PwHIV) having initiated ART in 2013–16 (comparator), 2017–19, and 2020–23.</div></div><div><h3>Results</h3><div>We enrolled 4006 persons of whom 2281 (56.9 %) were female; median age was 40 years (IQR: 31–50); 635 (15.9 %) were at WHO clinical stage IV and 934 (23.3 %) had a CD4 count &lt;200 cells/mm³. Median follow-up was 80.4 months (IQR: 48.6–106.7). All in all, 463 participants died (4.37 deaths per 100 person-years), including 296 at one year of follow-up (7.4 % [95 % CI: 6.6–8.2]). ART initiation in 2016–19 and 2020–23 was associated with 27 % (adjusted HR [aHR]: 0.73; 95 % CI: 0.55–0.98) and 63 % (aHR: 0.37; 95 % CI: 0.25–0.56) reductions in one-year mortality rates, respectively, compared to the 2013–16 period.</div></div><div><h3>Conclusion</h3><div>Early mortality risk has significantly decreased over time in Senegal. However, the proportion of PwHIV with AIDS-defining conditions remains concerning. Continued efforts to ensure early diagnosis and prompt linkage to care are needed for more impact.</div></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 8","pages":"Article 104990"},"PeriodicalIF":2.9,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142390240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}