Infectious diseases now最新文献_第10页

Relationship between blood culture time to positivity, mortality rate, and severity of bacteremia 血培养时间与阳性、死亡率和菌血症严重程度的关系。

IF 3.5 4区医学

Infectious diseases now Pub Date : 2023-12-01 DOI: 10.1016/j.idnow.2023.104843

N. Deguchi , K. Ishikawa , S. Tokioka , D. Kobayashi , N. Mori

{"title":"Relationship between blood culture time to positivity, mortality rate, and severity of bacteremia","authors":"N. Deguchi , K. Ishikawa , S. Tokioka , D. Kobayashi , N. Mori","doi":"10.1016/j.idnow.2023.104843","DOIUrl":"10.1016/j.idnow.2023.104843","url":null,"abstract":"<div><h3>Objectives</h3><p>We investigated the association between patient severity or mortality and time to positivity in bacteremia caused by various pathogens.</p></div><div><h3>Patients and methods</h3><p>This single-center retrospective study included patients with positive blood culture results.</p></div><div><h3>Results</h3><p>Longer time to positivity was associated with 30-day mortality for <em>Staphylococcus aureus</em> (221 cases, time to positivity: 17.4 h in the 30-day mortality group vs. 14.1 h in the survival group). Age, chronic kidney disease, cerebrovascular disease, hypertensive drug use, consciousness disorder, and minimal systolic blood pressure were significant predictors of 30-day mortality. For <em>S. aureus</em>, mortality within 30 days was significantly higher when time to positivity was > 24 h (p = 0.04). The time to positivity of <em>Streptococcus pneumoniae</em>, α, β-hemolytic <em>Streptococcu</em>s, <em>Enterococcus</em> sp., Enterobacteriaceae, glucose-nonfermenting Gram-negative rods, <em>Candida</em> sp., and anaerobe was not significantly associated with 30-day mortality.</p></div><div><h3>Conclusions</h3><p>Among various pathogens, time to positivity > 24 h was associated with 30-day mortality for <em>S. aureus</em>.</p></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 2","pages":"Article 104843"},"PeriodicalIF":3.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666991923002051/pdfft?md5=9bd3277ce89b2461dbdab0253634bbce&pid=1-s2.0-S2666991923002051-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138477599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early picc-line infections in non-neutropenic patients are mainly due to E. coli suggesting that third-generation cephalosporin may be used as a first-line antibiotic therapy 非中性粒细胞减少患者的早期picc-line感染主要由大肠杆菌引起，提示第三代头孢菌素可作为一线抗生素治疗。

IF 3.5 4区医学

Infectious diseases now Pub Date : 2023-11-29 DOI: 10.1016/j.idnow.2023.104842

Victoria Volpari , Meghann Gallouche , Yvan Caspar , Anne Thiebaut-Bertrand , Olivier Épaulard , Patricia Pavese , Caroline Landelle , Marion Le Maréchal

{"title":"Early picc-line infections in non-neutropenic patients are mainly due to E. coli suggesting that third-generation cephalosporin may be used as a first-line antibiotic therapy","authors":"Victoria Volpari , Meghann Gallouche , Yvan Caspar , Anne Thiebaut-Bertrand , Olivier Épaulard , Patricia Pavese , Caroline Landelle , Marion Le Maréchal","doi":"10.1016/j.idnow.2023.104842","DOIUrl":"10.1016/j.idnow.2023.104842","url":null,"abstract":"<div><h3>Purpose</h3><p>To describe the rate of peripherally inserted central catheter (PICC) -associated bloodstream infections, and the pathogens involved.</p></div><div><h3>Methods</h3><p>We prospectively analyzed data collected from all adult patients with a PICC insertion in a hematology unit in a tertiary care center between January 1, 2017 and June 30, 2020.</p></div><div><h3>Results</h3><p>A total of 370 PICCs were inserted in 275 patients with hematological malignancies: 54 (15 %) confirmed cases of central-line associated bloodstream infection (CLABSI) were identified. Enterobacteria were the most frequent bacteria identified, involved in 35 % of CLABSIs. Group 1 enterobacteria bacteremia occurred a much shorter time after insertion (median time to CLABSI 16 days) than group 2 or group 3 enterobacteria (median time to CLABSI 64 days, p-value = 0.049).</p></div><div><h3>Conclusion</h3><p>Among Gram-negative bacilli CLABSI among non-neutropenic patients, <em>E. coli</em> identification was the most frequent and occurred earlier after insertion, suggesting that third-generation cephalosporin may be used as a first-line antibiotic therapy for enterobacteria bacteremia among non-neutropenic patients.</p></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 2","pages":"Article 104842"},"PeriodicalIF":3.5,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266699192300204X/pdfft?md5=b0b0da8c2cae69756573cdb43c363bb3&pid=1-s2.0-S266699192300204X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138470159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Costs associated with informal health care pathway for patients with suspected Lyme borreliosis 疑似莱姆病螺旋体患者非正式卫生保健途径的相关费用。

IF 3.5 4区医学

Infectious diseases now Pub Date : 2023-11-25 DOI: 10.1016/j.idnow.2023.104841

Lamriss Hamadou , Fantine Buteau , Evelina Petrosyan , Delphine Martineau , Léo Sauvat , Martine Audibert , Olivier Lesens

{"title":"Costs associated with informal health care pathway for patients with suspected Lyme borreliosis","authors":"Lamriss Hamadou , Fantine Buteau , Evelina Petrosyan , Delphine Martineau , Léo Sauvat , Martine Audibert , Olivier Lesens","doi":"10.1016/j.idnow.2023.104841","DOIUrl":"10.1016/j.idnow.2023.104841","url":null,"abstract":"<div><h3>Objectives</h3><p>To compare the direct and indirect medical costs for patients with suspected Lyme borreliosis according to whether or not they had used an informal care pathway.</p></div><div><h3>Patients and methods</h3><p>We retraced the care pathways of participating patients by a prospective questionnaire survey and a retrospective analysis of care records. Direct and indirect costs were estimated using a micro-costing method from different perspectives. We compared the costs of patients who had consulted a “Lyme Doctor” (informal care pathway) with those who had only used the formal care pathway. Non-parametric tests were appraised the significance of the differences between the two groups of patients.</p></div><div><h3>Results</h3><p>Out of 103 eligible patients, 49 (including 12 having used an informal health care pathway) agreed to be investigated. Five expenditure items entirely borne by patients were significantly higher for patients following an informal care pathway: productivity loss (3041 ± 6580 vs 194 ± 1177 euros, p = 0.01), alternative therapies (3484 ± 7308 vs 369 ± 956 euros), biological tests sent abroad (571 ± 1415 vs 17 ± 92 euros, p < 0.01), self-medication (918 ± 1998 vs 133 ± 689, p = 0.02) and transport (3 094 ± 3456 vs 1 123 ± 1903p = 0.01).</p></div><div><h3>Conclusions</h3><p>From the patient’s standpoint, the informal care pathway involving consultation with a Lyme Doctor is far more expensive than the formal care pathway. More specifically, the patient has to bear the costs of alternative treatments and repeated, non-recommended examinations.</p></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 2","pages":"Article 104841"},"PeriodicalIF":3.5,"publicationDate":"2023-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666991923002038/pdfft?md5=66a9603eb2463f95073f8e50a36a18fe&pid=1-s2.0-S2666991923002038-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138444543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Could the changes of immunity induced by SARS-CoV-2 infections explain the rebound of infectious disease after the relaxation of non-pharmaceutical interventions? SARS-CoV-2感染引起的免疫变化能否解释非药物干预放松后传染病的反弹?

IF 3.5 4区医学

Infectious diseases now Pub Date : 2023-11-18 DOI: 10.1016/j.idnow.2023.104836

Robert Cohen, Corinne Levy

引用次数: 0

The outbreak of seasonal influenza after the COVID-19 pandemic in China: Unraveling the “Immunity debt” 新冠肺炎疫情后中国季节性流感的爆发:解开“免疫债务”

IF 3.5 4区医学

Infectious diseases now Pub Date : 2023-11-14 DOI: 10.1016/j.idnow.2023.104834

Qingchun Pan, Xiaohua Chen, Yongsheng Yu, Guoqing Zang, Zhenghao Tang

引用次数: 1

Clinical features and outcomes in adults with COVID-19 during the pre-Omicron and Omicron waves 在欧米克隆前波和欧米克隆波期间成人COVID-19的临床特征和结局

IF 3.5 4区医学

Infectious diseases now Pub Date : 2023-11-14 DOI: 10.1016/j.idnow.2023.104833

M. Martinot , A. Schieber , J.C. Ongagna , A. Henric , M. Eyriey , M. Mohseni-Zadeh , C. Ion , K demesmay , S. Gravier , C. Kempf

{"title":"Clinical features and outcomes in adults with COVID-19 during the pre-Omicron and Omicron waves","authors":"M. Martinot , A. Schieber , J.C. Ongagna , A. Henric , M. Eyriey , M. Mohseni-Zadeh , C. Ion , K demesmay , S. Gravier , C. Kempf","doi":"10.1016/j.idnow.2023.104833","DOIUrl":"10.1016/j.idnow.2023.104833","url":null,"abstract":"<div><h3>Objectives</h3><p>We conducted a single-center retrospective study to compare patient characteristics and death rates during the Omicron (O, December 01, 2021, to September 30, 2022) and pre-Omicron (PO, March 01, 1920, to October 31, 2021) periods.</p></div><div><h3>Patients and Methods</h3><p>We retrospectively analyzed the data of 2932 patients (1242 (O) and 1690 (PO)) hospitalized (>24 h) with laboratory-confirmed COVID.</p></div><div><h3>Results</h3><p>Compared to the PO period, O period patients were less frequently men, had a lower body mass index and fewer comorbidities except for immunosuppression and pregnancy. Nosocomial COVID-19 accounted for 18.2 % (O) and 15.4 % (PO) of cases (p = 0.05). Patient mortality rates during the O and PO periods were 11.0 % and 16.9 % (p < 0.001), respectively. Unvaccinated status (p < 0.001), existence of comorbidities, (p < 0.001) and high LDH value at baseline (p = 0.015), but not the period, were identified as factors likely to explain death.</p></div><div><h3>Conclusion</h3><p>During the Omicron period, the inpatient death rate remained > 10 %, especially among unvaccinated and comorbid patients. Nosocomial cases were more frequent.</p></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 2","pages":"Article 104833"},"PeriodicalIF":3.5,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666991923001951/pdfft?md5=d831863458bc10f97e3860dc925b5810&pid=1-s2.0-S2666991923001951-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135765646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dalbavancin as salvage therapy in difficult-to-treat patients for diabetes-related foot osteomyelitis Dalbavancin作为难治性糖尿病相关性足部骨髓炎患者的补救性治疗

IF 3.5 4区医学

Infectious diseases now Pub Date : 2023-11-14 DOI: 10.1016/j.idnow.2023.104835

Anne Boucher , Maxime Pradier , Barthelemy Lafondesmurs , Pauline Thill , Pierre Patoz , Nicolas Blondiaux , Donatienne Joulie , Benjamin Hennart , Olivier Robineau , Eric Senneville

{"title":"Dalbavancin as salvage therapy in difficult-to-treat patients for diabetes-related foot osteomyelitis","authors":"Anne Boucher , Maxime Pradier , Barthelemy Lafondesmurs , Pauline Thill , Pierre Patoz , Nicolas Blondiaux , Donatienne Joulie , Benjamin Hennart , Olivier Robineau , Eric Senneville","doi":"10.1016/j.idnow.2023.104835","DOIUrl":"10.1016/j.idnow.2023.104835","url":null,"abstract":"<div><h3>Objectives</h3><p>We aimed to describe the efficacy and safety of dalbavancin in treatment of patients with diabetes-related foot osteomyelitis with bone culture confirmation.</p></div><div><h3>Patients and methods</h3><p>Between January 2019 and December 2021, all consecutive patients receiving at least one 1500 mg dose of dalbavancin for diabetes-related foot osteomyelitis were included in a retrospective study. Remission was defined as absence of relapsing infection or need for surgery at the initial or a contiguous site during 6-month follow-up from the last dose of dalbavancin.</p></div><div><h3>Results</h3><p>Thirteen patients were included. Eleven (85%) patients were surgically treated. Six (46%) patients received dalbavancin as first-line treatment and 7 (54%) as second-line treatment due to adverse events related to previous treatments. One adverse event was reported. At 6-month follow-up, 11 patients were evaluable and 9 (82%) were in remission.</p></div><div><h3>Conclusions</h3><p>In the study, dalbavancin was well-tolerated and showed microbiological and clinical efficacy.</p></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 1","pages":"Article 104835"},"PeriodicalIF":3.5,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666991923001975/pdfft?md5=56a4a528d9a789d9120d4199d0cf9d1e&pid=1-s2.0-S2666991923001975-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135764395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The importance of COVID-19 vaccination during lactation 哺乳期接种COVID-19疫苗的重要性

IF 3.5 4区医学

Infectious diseases now Pub Date : 2023-11-10 DOI: 10.1016/j.idnow.2023.104831

Maria Isabel Valverde-Merino , Manuel Gomez-Guzman , Celia Piquer-Martinez , Maria Dolores Cabezas Lopez , Maria Jose Zarzuelo

引用次数: 0

Clinical practice recommendations for infectious disease management of diabetic foot infection (DFI) – 2023 SPILF 糖尿病足部感染的传染病管理临床实践建议(DFI) - 2023 SPILF。

IF 3.5 4区医学

Infectious diseases now Pub Date : 2023-11-10 DOI: 10.1016/j.idnow.2023.104832

E. Bonnet , L. Maulin , E. Senneville , B. Castan , C. Fourcade , P. Loubet , D. Poitrenaud , S. Schuldiner , A. Sotto , J.P. Lavigne , P. Lesprit , the review group

{"title":"Clinical practice recommendations for infectious disease management of diabetic foot infection (DFI) – 2023 SPILF","authors":"E. Bonnet , L. Maulin , E. Senneville , B. Castan , C. Fourcade , P. Loubet , D. Poitrenaud , S. Schuldiner , A. Sotto , J.P. Lavigne , P. Lesprit , the review group","doi":"10.1016/j.idnow.2023.104832","DOIUrl":"10.1016/j.idnow.2023.104832","url":null,"abstract":"<div><p>In march 2020, the International Working Group on the Diabetic Foot (IWGDF) published an update of the 2015 guidelines on the diagnosis and management of diabetic foot infection (DFI). While we (the French ID society, SPILF) endorsed some of these recommendations, we wanted to update our own 2006 guidelines and specifically provide informative elements on modalities of microbiological diagnosis and antibiotic treatment (especially first- and second-line regiments, oral switch and duration).</p><p>The recommendations put forward in the present guidelines are addressed to healthcare professionals managing patients with DFI and more specifically focused on infectious disease management of this type of infection, which clearly needs a multidisciplinary approach.</p><p>Staging of the severity of the infection is mandatory using the classification drawn up by the IWGDF. Microbiological samples should be taken only in the event of clinical signs suggesting infection in accordance with a strict preliminarily established protocol.</p><p>Empirical antibiotic therapy should be chosen according to the IWGDF grade of infection and duration of the wound, but must always cover methicillin-sensitive <em>Staphylococcus aureus.</em> Early reevaluation of the patient is a fundamental step, and duration of antibiotic therapy can be shortened in many situations.</p><p>When osteomyelitis is suspected, standard foot radiograph is the first-line imagery examination and a bone biopsy should be performed for microbiological documentation. Histological analysis of the bone sample is no longer recommended. High dosages of antibiotics are recommended in cases of confirmed osteomyelitis.</p></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 1","pages":"Article 104832"},"PeriodicalIF":3.5,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266699192300194X/pdfft?md5=d4e74d1584b63c4563816a8f0406a7b4&pid=1-s2.0-S266699192300194X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89718142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anogenital distribution of mucosal HPV in males and females before and after renal transplantation 肾移植前后男性和女性肛门生殖器粘膜HPV的分布。

IF 3.5 4区医学

Infectious diseases now Pub Date : 2023-11-09 DOI: 10.1016/j.idnow.2023.104830

Jean-Luc Prétet , Antoine Touzé , Lionel Pazart , Guillaume Boiteux , Véronique Fournier , Chrystelle Vidal , Françoise Arnold , Didier Ducloux , Quentin Lepiller , Christiane Mougin

{"title":"Anogenital distribution of mucosal HPV in males and females before and after renal transplantation","authors":"Jean-Luc Prétet , Antoine Touzé , Lionel Pazart , Guillaume Boiteux , Véronique Fournier , Chrystelle Vidal , Françoise Arnold , Didier Ducloux , Quentin Lepiller , Christiane Mougin","doi":"10.1016/j.idnow.2023.104830","DOIUrl":"10.1016/j.idnow.2023.104830","url":null,"abstract":"<div><h3>Introduction</h3><p>Immunosuppressive drugs taken by transplant recipients may favor HPV infection at anogenital sites. HPV-type prevalence was studied in males and females before and after renal transplantation.</p></div><div><h3>Patients and methods</h3><p>Anal, cervical and penile samples were taken from 62 patients before transplantation and from 41 patients after transplantation. HPV DNA was investigated using the INNO-LiPA HPV genotyping extra test and HPV-type distribution determined.</p></div><div><h3>Results</h3><p>Before transplantation, up to 30% of analyzed samples harbored HPV DNA, with the highest prevalence found in cervical specimens (60%). After transplantation, a trend toward HPV clearance was observed in females. By contrast, a trend toward incident infections by a wide variety of HPV genotypes at the penis and anal level was documented in men.</p></div><div><h3>Conclusion</h3><p>High prevalence of HPV at anogenital sites was documented before and after renal transplantation. Immunosuppressive drugs taken after transplantation may impact HPV acquisition or reactivation, especially in males. Special attention should be paid in view of preventing HPV-associated diseases in this vulnerable population.</p></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 1","pages":"Article 104830"},"PeriodicalIF":3.5,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666991923001926/pdfft?md5=cae5092a319e9f0179829b33c11d99a2&pid=1-s2.0-S2666991923001926-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72209178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0