Infectious diseases now最新文献

{"title":"Toward an optimization of empirical antibiotic therapy in acute graft pyelonephritis: A retrospective multicenter study","authors":"Pauline Martinet ,&nbsp;Luca Lanfranco ,&nbsp;Anne Coste ,&nbsp;Didier Tandé ,&nbsp;Pierre Danneels ,&nbsp;Léa Picard ,&nbsp;Clément Danthu ,&nbsp;Simon Jamard ,&nbsp;Benjamin Gaborit ,&nbsp;Jean-François Faucher ,&nbsp;Jean-Philippe Talarmin ,&nbsp;Yannick Le Meur ,&nbsp;Truong An Nguyen ,&nbsp;Christophe Masset ,&nbsp;Clarisse Kerleau ,&nbsp;Séverine Ansart ,&nbsp;Schéhérazade Rezig ,&nbsp;on behalf of the EPAGGO study group","doi":"10.1016/j.idnow.2024.104922","DOIUrl":"10.1016/j.idnow.2024.104922","url":null,"abstract":"<div><h3>Objective</h3><p>Acute graft pyelonephritis (AGPN) is the most frequent infectious complication in kidney transplant recipients (KTR). The treatment of acute community-acquired (CA) pyelonephritis is based on third-generation cephalosporins (3GC) and fluoroquinolones. Cefepime or a piperacillin-tazobactam combination are more often used in healthcare-associated (HCA) infections. However, these recommendations do not consider the resistance observed in KTRs. The objective of our study was to define the most appropriate empirical antibiotherapy for AGPN in KTRs according to the CA and HCA settings. To answer this question, we assessed the prevalence of resistance to different antibiotics usually recommended for urinary tract infections (UTIs) in the general population.</p></div><div><h3>Methods</h3><p>Observational, retrospective, multicenter study covering all episodes of AGPN occurring in hospitalized KTRs in 2019.</p></div><div><h3>Results</h3><p>A total of 210 patients were included in 7 centers and 244 episodes of AGPN were analyzed (158 CA-AGPN and 86 HCA-AGPN). The prevalence of 3GC and fluoroquinolone resistance was 23 % (n = 36) and 30 % (n = 50) in CA infections (n = 158), and 47 % (n = 40) and 31 % (n = 27) in HCA infections (n = 86), respectively. Cefepime resistance rate was 19 % (n = 30) in CA-AGPN and 29 % (n = 25) in HCA-AGPN. Piperacillin-tazobactam combination had resistance rates &gt; 15 % in both CA and HCA infections. The only antimicrobials with resistance rates &lt; 10 % were aminoglycosides and carbapenems.</p></div><div><h3>Conclusion</h3><p>None of the antibiotics recommended in empirical treatment in UTIs has shown a resistance rate of less than 10% with regard to AGPN. Therefore, none of them should be used as monotherapy. A combination therapy including amikacin could be an appropriate strategy in this setting.</p></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 5","pages":"Article 104922"},"PeriodicalIF":3.5,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666991924000794/pdfft?md5=1a4c3860ef75a9c5786e9806ef5edb07&pid=1-s2.0-S2666991924000794-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140957261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External validation of two clinical prediction models for mortality in COVID-19 patients (4C and NEWS2), in three centers in Medellín, Colombia: Assessing the impact of vaccination over time","authors":"Paola Andrea Gallego Aristizabal ,&nbsp;Tania Paola Lujan Chavarría ,&nbsp;Sara Isabel Vergara Hernández ,&nbsp;Federico Rincón Acosta ,&nbsp;María Paula Sánchez Carmona ,&nbsp;Paula Andrea Salazar Ospina ,&nbsp;Carlos Jose Atencia Florez ,&nbsp;Carlos Mario Barros Liñán ,&nbsp;Fabián Jaimes","doi":"10.1016/j.idnow.2024.104921","DOIUrl":"https://doi.org/10.1016/j.idnow.2024.104921","url":null,"abstract":"<div><h3>Objectives</h3><p>External validation of the 4C and NEWS2 scores for the prediction of in-hospital mortality in COVID-19 patients, and evaluation of its operational performance in two time periods: before and after the start of the vaccination program in Colombia.</p></div><div><h3>Methods</h3><p>Retrospective cohort in three high complexity hospitals in the city of Medellín, Colombia, between June 2020 and April 2022.</p></div><div><h3>Results</h3><p>The areas under the ROC curve (AUC) for the 4C mortality risk score and the NEWS2 were 0.75 (95% CI 0.73–0.78) and 0.68 (95% CI 0.66–0.71), respectively. For the 4C score, the AUC for the first and second periods was 0.77 (95% CI 0.74–0.80) and 0.75 (95% CI 0.71–0.78); whilst for the NEWS2 score, it was 0.68 (95% CI 0.65–0.71) and 0.69 (95% CI 0.64–0.73). The calibration for both scores was adequate, albeit with reduced performance during the second period.</p></div><div><h3>Conclusions</h3><p>The 4C mortality risk score proved to be the more adequate predictor of in-hospital mortality in COVID-19 patients in this Latin American population. The operational performance during both time periods remained similar, which shows its utility notwithstanding major changes, including vaccination, as the pandemic evolved.</p></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 5","pages":"Article 104921"},"PeriodicalIF":3.5,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666991924000782/pdfft?md5=5cb197dbc079f4cabcfce636c26fe560&pid=1-s2.0-S2666991924000782-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140824578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The increasing healthcare burden of enteric fever in a low-incidence setting","authors":"Seung Y Lee ,&nbsp;Annaleise R Howard-Jones ,&nbsp;Venkata LN Lavu ,&nbsp;Sophie Norton ,&nbsp;Vitali Sintchenko ,&nbsp;Philip N Britton ,&nbsp;Shopna Bag ,&nbsp;Ameneh Khatami","doi":"10.1016/j.idnow.2024.104919","DOIUrl":"10.1016/j.idnow.2024.104919","url":null,"abstract":"<div><h3>Objectives</h3><p>Enteric fever carries appreciable morbidity in non-endemic settings, particularly in returned travelers. This study aimed to characterize the healthcare burden of enteric fever in a low-incidence setting and to identify risk factors and opportunities for preventative interventions.</p></div><div><h3>Methods</h3><p>Analysis of a retrospective case series from a tertiary pediatric center (2015–2019), augmented by public health notification and microbiological laboratory data (2018–2019), from Western Sydney, Australia, a region with frequent travel links to South Asia.</p></div><div><h3>Results</h3><p>Eighty-nine <strong>(</strong>89) patients were diagnosed with enteric fever, including 43 children with complete demographic and travel data. Enteric fever cases increased over time (by 4.9 % per year) and incidence was three times higher in the pediatric population (&lt;15 years old) compared to adults. Travel to India and visiting friends and relatives (VFR) travel were risk factors. Few children received enteric fever vaccination prior to travel, as pre-travel advice most commonly was not sought.</p></div><div><h3>Conclusions</h3><p>Children visiting relatives in high-incidence countries are increasingly at risk for enteric fever, particularly when travelling to South Asia. Targeted health advice to travelers visiting friends and relatives is warranted to mitigate the healthcare burden of enteric fever in low-incidence settings.</p></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 4","pages":"Article 104919"},"PeriodicalIF":3.5,"publicationDate":"2024-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666991924000769/pdfft?md5=d07271f131d121a22c3d09dc1618b5db&pid=1-s2.0-S2666991924000769-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140780427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there an interest in systematic serum screening for aspergillosis in COVID-19 patients in a medical ward?","authors":"Victor Gerber ,&nbsp;Louis Boehn ,&nbsp;Marcela Sabou ,&nbsp;Antoine Studer ,&nbsp;Axel Ursenbach ,&nbsp;Yves Hansmann ,&nbsp;Raoul Herbrecht ,&nbsp;Nicolas Lefebvre ,&nbsp;Valérie Letscher-Bru ,&nbsp;François Danion","doi":"10.1016/j.idnow.2024.104918","DOIUrl":"https://doi.org/10.1016/j.idnow.2024.104918","url":null,"abstract":"<div><h3>Purpose</h3><p>We evaluated the interest of systematic screening of serum fungal markers in patients hospitalized in a medical ward.</p></div><div><h3>Methods</h3><p>We retrospectively analyzed all patients hospitalized in our infectious disease department from October 1st to October 31st, 2020 for COVID-19 without prior ICU admission, and for whom systematic screening of serum fungal markers was performed.</p></div><div><h3>Results</h3><p>Thirty patients were included. The majority of patients received corticosteroids (96.7%). The galactomannan antigen assay was positive for 1/30 patients at D0, and 0/24, 0/16, 0/13 and 0/2 at D4, D7, D10 and D14 respectively. 1,3-ß-D-glucan was positive for 0/30, 1/24, 1/12, 0/12, 0/2 at D0, D4, D7, D10 and D14 respectively. No <em>Aspergillus fumigatus</em> PCR was positive. No cases of aspergillosis were retained.</p></div><div><h3>Conclusion</h3><p>Our study does not support the interest of systematic screening of fungal markers in immunocompetent patients with COVID-19 in a conventional unit.</p></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 4","pages":"Article 104918"},"PeriodicalIF":3.5,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666991924000757/pdfft?md5=6625c2ae90df49374a4facefa0017fee&pid=1-s2.0-S2666991924000757-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140621983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Open Access status on journal metrics in infectious diseases and clinical microbiology – A cross-sectional study","authors":"Noam Tau ,&nbsp;Marin Moutel ,&nbsp;Maiwenn Petithomme-Nanrocki ,&nbsp;Maxime Hentzien ,&nbsp;Dafna Yahav","doi":"10.1016/j.idnow.2024.104909","DOIUrl":"https://doi.org/10.1016/j.idnow.2024.104909","url":null,"abstract":"<div><h3>Introduction</h3><p>While Open Access (OA) journals provide free access to articles, they entail high article processing charges (APC), limiting opportunities for young researchers and those from low-middle income countries to publish OA.</p></div><div><h3>Methods</h3><p>Cross-sectional study, evaluating APC and academic impact of full OA (FOA) journals in infectious diseases (ID) and clinical microbiology (CM) compared to hybrid journals. Data were collected from Journal Citation Reports and journals’ websites.</p></div><div><h3>Results</h3><p>Among 255 journals, median APC was 2850 (interquartile range [IQR] 1325–3654$). Median APC for 120 FOA journals was significantly lower than for 119 hybrid journals (2000, IQR 648–2767$ versus 3550, IQR 2948–4120$, p &lt; 0.001). FOA journals had lower citation numbers and impact metrics compared to hybrid journals.</p></div><div><h3>Conclusion</h3><p>While FOA ID/CM journals have lower APCs, they also lower academic impact compared to hybrid journals. These findings highlight the need for reforms in the publication process in view of achieving equitable data dissemination.</p></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 4","pages":"Article 104909"},"PeriodicalIF":3.5,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666991924000642/pdfft?md5=547c21cbce0d039bd70bb4525b89de05&pid=1-s2.0-S2666991924000642-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140555452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Providing parents with HPV vaccine information from a male perspective may render them more inclined to have their daughters vaccinated","authors":"Sandra Chyderiotis ,&nbsp;Sarah Derhy ,&nbsp;Julie Gaillot ,&nbsp;Alexandre Cobigo ,&nbsp;Laura Zanetti ,&nbsp;Clément Piel ,&nbsp;Judith E. Mueller","doi":"10.1016/j.idnow.2024.104908","DOIUrl":"https://doi.org/10.1016/j.idnow.2024.104908","url":null,"abstract":"<div><h3>Objectives</h3><p>Several high-income countries have implemented a gender-neutral vaccination program against human papillomavirus (HPV) infections. The impact of a gender-neutral program (GNP) on parental intention to vaccinate their daughters has not been studied, especially in countries with low HPV vaccine coverage among girls.</p></div><div><h3>Patients and methods</h3><p>In July 2019, before a GNP was implemented in France (2021), the French National Cancer Institute (INCa) conducted a survey on HPV vaccine acceptance among parents of children aged 11–19 years living in France. In the sample of girls’ parents (n = 1424 parents, 1726 girls), we investigated whether parents who declared no initial intention to have their daughter(s) vaccinated changed their minds after reading information including a male perspective on HPV consisting in description of HPV-related disease among men and in ascertainment of the fact that in some countries, the HPV vaccine is recommended for boys, after which they were once again asked about their intentions “if the vaccine were recommended to boys and girls alike”.</p></div><div><h3>Results</h3><p>As regards 295 (25.7 %) of the 1147 unvaccinated girls, their parents declared no intention to have them vaccinated, while 509 (44.4 %) were not sure. Among the parents of the 804 girls whose parents had not intended to have them vaccinated, 134 (16.7 %) changed their minds after reading about HPV among men. Fathers were more likely than mothers to change their minds, and finally intend to have their daughters vaccinated (adjusted relative risk, 1.74 [95 % confidence interval, 1.20,2.54]).</p></div><div><h3>Conclusions</h3><p>These results suggest that parents, and fathers in particular, could be more motivated to have their daughters vaccinated against HPV if the information with which they were provided included a male perspective and a recommendation of vaccination for boys as well as girls.</p></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 4","pages":"Article 104908"},"PeriodicalIF":3.5,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666991924000630/pdfft?md5=f2035ff43fdcd9f289e6a85c4d547b4f&pid=1-s2.0-S2666991924000630-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140558935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ChatGPT ability and urinary tract infection-related questions: Comment","authors":"Hinpetch Daungsupawong ,&nbsp;Viroj Wiwanitkit","doi":"10.1016/j.idnow.2024.104907","DOIUrl":"https://doi.org/10.1016/j.idnow.2024.104907","url":null,"abstract":"","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 4","pages":"Article 104907"},"PeriodicalIF":3.5,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666991924000629/pdfft?md5=206ad51ef669ed5257e7d69a10298b2e&pid=1-s2.0-S2666991924000629-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140533583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the impact of telehealth intervention in patients with bone and joint infection","authors":"Philippine Marque ,&nbsp;Julie Leitao ,&nbsp;Fréderic-Antoine Dauchy ,&nbsp;Olivier Gerbouin ,&nbsp;Thierry Fabre ,&nbsp;Fabien Xuereb ,&nbsp;Marin Lahouati","doi":"10.1016/j.idnow.2024.104906","DOIUrl":"https://doi.org/10.1016/j.idnow.2024.104906","url":null,"abstract":"<div><h3>Objectives</h3><p>Patients with bone and joint infections (BJI) are involved in a complex care pathway and require prolonged antimicrobial treatment. Some studies have suggested that a pharmacist-led telehealth intervention (TI) could help to ensure better follow-up of chronic diseases. To our knowledge, there are no data on the effects of pharmacist-led TI on patients with BJI. The aim of this study is to assess the impact of a TI on patients treated for BJIs at three weeks after hospital discharge.</p></div><div><h3>Patients and Methods</h3><p>Patients encountered during hospitalization and receiving standardized care including TI were included in the study. All adverse events (AE) reported by patients during TI were evaluated. Impact of pharmaceutical interventions (PIs) provided by a clinical pharmacist following TI was evaluated by CLEO© (CLinical, Economic and Organizational) scale. Patient satisfaction concerning TI was assessed by an anonymous questionnaire following medical consultation at the end of antimicrobial treatment.</p></div><div><h3>Results</h3><p>Over a 4-month period, 36 patients received TI. Fifty-two AEs were identified in 21 patients (58%). Two patients were hospitalized due to an AE. Clinical pharmacists provided 34 pharmaceutical interventions (PIs) for 23 patients (64%). According to CLEO scale, 11 PIs had a major clinical impact (32%), 6 PIs (18%) had a favorable impact on the direct cost of treatment and 27 PIs (79%) had positive organizational impact. Concerning TI process, patients were satisfied or very satisfied, with an average score of 9.6/10.</p></div><div><h3>Conclusion</h3><p>TI led to a high number of pharmaceutical interventions (PIs), with a meaningful clinical, organizational, and economic impact. Patients were also highly satisfied with this intervention.</p></div>","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 4","pages":"Article 104906"},"PeriodicalIF":3.5,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666991924000617/pdfft?md5=8bb52774d90244caa5488f212079ba91&pid=1-s2.0-S2666991924000617-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140533582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From imprecise “immune debt” to nuanced “immune shortage”?","authors":"Luwen Zhang","doi":"10.1016/j.idnow.2024.104894","DOIUrl":"10.1016/j.idnow.2024.104894","url":null,"abstract":"","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 5","pages":"Article 104894"},"PeriodicalIF":3.5,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666991924000496/pdfft?md5=5abcdab9741932d83bdd80614f3b950d&pid=1-s2.0-S2666991924000496-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140318207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune debt or immune shortage: The controversy continues – “Season 3 episode 1”","authors":"Robert Cohen,&nbsp;Corinne Levy","doi":"10.1016/j.idnow.2024.104897","DOIUrl":"10.1016/j.idnow.2024.104897","url":null,"abstract":"","PeriodicalId":13539,"journal":{"name":"Infectious diseases now","volume":"54 5","pages":"Article 104897"},"PeriodicalIF":3.5,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666991924000526/pdfft?md5=00857bd86d2d975b9a30abbb383e9d29&pid=1-s2.0-S2666991924000526-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140326553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}