Is there an interest in systematic serum screening for aspergillosis in COVID-19 patients in a medical ward?

IF 2.9 4区医学 Q2 INFECTIOUS DISEASES

Infectious diseases now Pub Date : 2024-04-16 DOI:10.1016/j.idnow.2024.104918

Victor Gerber , Louis Boehn , Marcela Sabou , Antoine Studer , Axel Ursenbach , Yves Hansmann , Raoul Herbrecht , Nicolas Lefebvre , Valérie Letscher-Bru , François Danion

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Abstract

Purpose

We evaluated the interest of systematic screening of serum fungal markers in patients hospitalized in a medical ward.

Methods

We retrospectively analyzed all patients hospitalized in our infectious disease department from October 1st to October 31st, 2020 for COVID-19 without prior ICU admission, and for whom systematic screening of serum fungal markers was performed.

Results

Thirty patients were included. The majority of patients received corticosteroids (96.7%). The galactomannan antigen assay was positive for 1/30 patients at D0, and 0/24, 0/16, 0/13 and 0/2 at D4, D7, D10 and D14 respectively. 1,3-ß-D-glucan was positive for 0/30, 1/24, 1/12, 0/12, 0/2 at D0, D4, D7, D10 and D14 respectively. No Aspergillus fumigatus PCR was positive. No cases of aspergillosis were retained.

Conclusion

Our study does not support the interest of systematic screening of fungal markers in immunocompetent patients with COVID-19 in a conventional unit.

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在内科病房对 COVID-19 患者进行系统的曲霉菌病血清筛查是否有意义？

方法我们回顾性分析了 2020 年 10 月 1 日至 10 月 31 日期间因 COVID-19 在我院感染性疾病科住院的所有患者，这些患者事先未入住 ICU，并对其进行了血清真菌标志物系统筛查。大多数患者接受了皮质类固醇治疗（96.7%）。半乳甘露聚糖抗原检测在 D0 时有 1/30 患者呈阳性，在 D4、D7、D10 和 D14 时分别为 0/24、0/16、0/13 和 0/2。1,3-ß-D-葡聚糖在 D0、D4、D7、D10 和 D14 时分别有 0/30、1/24、1/12、0/12 和 0/2 呈阳性。没有曲霉菌 PCR 呈阳性。结论：我们的研究并不支持在常规病房对免疫功能正常的 COVID-19 患者进行系统的真菌标记物筛查。

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