Acute hepatitis E virus infection in adults, Cayenne, French Guiana, 2015–2022

IF 2.2 4区医学 Q2 INFECTIOUS DISEASES

Infectious diseases now Pub Date : 2025-05-09 DOI:10.1016/j.idnow.2025.105087

Clotilde de Colnet , Alolia Aboikoni , Mathieu Nacher , Loïc Epelboin , Céline Michaud , Alexia Barbry , Jacques Izopet , Paul Le Turnier

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Abstract

Objectives

French Guiana (FG), a French overseas territory located in the Amazon region, is characterized by a high level of precariousness, which may be conducive to hepatitis E virus (HEV) transmission, but no recent relevant data exist.

Patients and methods

We conducted a retrospective study to determine the incidence of acute HEV infection diagnosed at Cayenne Hospital, FG between 2015 and 2022.

Results

Among 934 tested individuals, 12 had positive anti-HEV IgM (positivity rate of 1.28 % CI95 [0.66–2.23]). RT-PCR was rarely performed and no results was positive. Median age was 41 years and half of the subjects were female. No fulminant hepatitis occurred. Neurological manifestations were reported in two patients. Acute forms of HEV infection were rarely diagnosed during the study period.

Conclusions

Earlier and more extensive use of RT-PCR could help to better understand the epidemiology of acute HEV infection. The modes of transmission and genotypes of HEV in FG remain uncertain.

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成人急性戊型肝炎病毒感染，卡宴，法属圭亚那，2015-2022

目的法属圭亚那（FG）是位于亚马逊地区的法国海外领土，其特点是高度不稳定，可能有利于戊型肝炎病毒（HEV）的传播，但近期没有相关数据。患者和方法我们进行了一项回顾性研究，以确定2015年至2022年间在FG卡宴医院诊断的急性HEV感染的发生率。结果934例检测人群中，12例hev IgM抗体阳性，阳性率为1.28% （CI95[0.66-2.23]）。很少进行RT-PCR，无阳性结果。中位年龄为41岁，半数受试者为女性。未发生暴发性肝炎。2例患者出现神经系统症状。在研究期间，很少诊断出急性HEV感染。结论更早、更广泛地应用RT-PCR有助于更好地了解急性HEV感染的流行病学。HEV在FG的传播方式和基因型仍不确定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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