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STUDY OF POST SHELF LIFE AND MARKETED TABLETS OF CARVEDILOL BY RP-HPLC 反相高效液相色谱法研究卡维地洛市售片剂的保质期
INDIAN DRUGS Pub Date : 2023-10-28 DOI: 10.53879/id.60.10.13080
Rupali B. Giri, Shailesh J. Wadher, Tukaram M. Kalyankar
{"title":"STUDY OF POST SHELF LIFE AND MARKETED TABLETS OF CARVEDILOL BY RP-HPLC","authors":"Rupali B. Giri, Shailesh J. Wadher, Tukaram M. Kalyankar","doi":"10.53879/id.60.10.13080","DOIUrl":"https://doi.org/10.53879/id.60.10.13080","url":null,"abstract":"The purpose of this work was to determine the tablet content and carry out the dissolving test of expired and non-expired tablet as well as establish a simple, selective, linear, precise, accurate and sensitive RP-HPLC technique for the analysis of carvedilol tablets. The experiment was carried out using a mobile phase consisting of 20 mM phosphate buffer (PB) pH 2.5: acetonitrile (ACN) 55:45 (V/V) at a pH of 2.5 using a column (Oyster ODS 3,150-4.6 mm, 5m) and a L6 6AD pump. The sample had a volume of 20 µL, and it was injected at room temperature for a run period of 6 minutes at a flow rate of 1.0 mL min-1. Detection was carried out at 240 nm using an ultraviolet detector. The retention time of the sample was 2.92 minutes. At 37 o C ± 0.5 o C, the preliminary dissolution tests were performed on an Electro Lab dissolution tester. The results of this analysis revealed that there was no distinct shift in the amount of drug present. The percentage of non-expired tablets discovered in the test was 94.67 %, whereas the percentage of expired tablets was 91.71 %.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136232881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GLAUCARUBINONE - A LEAD MOLECULE FROM SIMAROUBA GLAUCA AS A POTENTIAL DRUG CANDIDATE, AN IN SILICO STUDY 青花紫红素-一种来自青花紫红素的先导分子，作为潜在的候选药物，一项计算机研究
INDIAN DRUGS Pub Date : 2023-09-28 DOI: 10.53879/id.60.09.13729
Suguna Rajendran, Jeya Jeyamani, Renuka Radhakrishnan
{"title":"GLAUCARUBINONE - A LEAD MOLECULE FROM SIMAROUBA GLAUCA AS A POTENTIAL DRUG CANDIDATE, AN IN SILICO STUDY","authors":"Suguna Rajendran, Jeya Jeyamani, Renuka Radhakrishnan","doi":"10.53879/id.60.09.13729","DOIUrl":"https://doi.org/10.53879/id.60.09.13729","url":null,"abstract":"Nature has always been a source of drug candidates. Since ancient times, people have been using plants and their metabolites for various medicinal purposes. Glaucarubinone is a quassinoid present in the family Simaroubaceae. Simarouba glauca, also known as Laxmitaru or paradise tree is grouped under the family Simaroubaceae, Glaucarubinone present in S. glauca is known for its medicinal property. Molecular docking methods are widely used to investigate the interactions between a drug candidate and its target, and to discern the therapeutic action to design new drug candidate with enhanced activities. The information generated from docking studies helps to obtain an insight into interactions of drug candidate with amino acid in the active site of the target proteins, and to predict the binding energy of ligands to the target. By molecular Dynamic Simulation, the flexibility and the conformational stability of target proteins-glaucarubinone complex is confirmed.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135470691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ETOPOSIDE AMORPHOUS SOLID DISPERSION FOR IMPROVED ORAL BIOAVAILABILITY: FORMULATION, CHARACTERIZATION, PHARMACOKINETIC AND CYTOTOXICITY STUDIES 改良口服生物利用度的依托泊苷无定形固体分散体:配方、表征、药代动力学和细胞毒性研究
INDIAN DRUGS Pub Date : 2023-09-28 DOI: 10.53879/id.60.09.13786
Prashant J. Ghule, Shripad M. Bairagi, Ritu M. Gilhotra
{"title":"ETOPOSIDE AMORPHOUS SOLID DISPERSION FOR IMPROVED ORAL BIOAVAILABILITY: FORMULATION, CHARACTERIZATION, PHARMACOKINETIC AND CYTOTOXICITY STUDIES","authors":"Prashant J. Ghule, Shripad M. Bairagi, Ritu M. Gilhotra","doi":"10.53879/id.60.09.13786","DOIUrl":"https://doi.org/10.53879/id.60.09.13786","url":null,"abstract":"Etoposide is a well-known anti-tumor agent used to treat a variety of cancers. Although it is a BCS class IV drug, applications are restricted due to poor solubility and bioavailability. Hence, the current research was designed to overcome these pitfalls. A total of 16 formulation batches were developed using the physical mixture and kneading method and optimized by Design-expert® software. A selected batch was evaluated using solubility, differential scanning calorimetry, X-ray diffraction, motic microscopy, scanning electron microscopy, Fourier transform infrared (FtIR), gastrointestinal distribution, pharmacokinetic and cytotoxicity study. the results showed that the saturated solubility of formulation was 19.76 mg mL -1. FtIR showed C-O=1646 cm -1, and C-H=2956 cm -1. the distribution study indicated 9.11, 5.39 and 4.23 μg mL-1 colon concentrations at 8h, 16h, and 24h, respectively. the Cmax and AUC were found at 741.17±12.29 ng mL-1 and 3089.23 ±34.69 ng mL -1 with less viability on HeLa cells. therefore, the study investigates the developed solid dispersions enhanced solubility and bioavailability with an antiproliferative effect.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135470680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CHEMOMETRIC ASSISTED UV SPECTROPHOTOMETRIC METHOD FOR QUANTIFICATION OF EMTRICITABINE AND TENOFOVIR DISOPROXIL FUMARATE 化学计量辅助紫外分光光度法定量测定恩曲他滨和富马酸替诺福韦二氧吡酯
INDIAN DRUGS Pub Date : 2023-09-28 DOI: 10.53879/id.60.09.13152
Santosh V. Gandhi, Smruti C. Shinde
{"title":"CHEMOMETRIC ASSISTED UV SPECTROPHOTOMETRIC METHOD FOR QUANTIFICATION OF EMTRICITABINE AND TENOFOVIR DISOPROXIL FUMARATE","authors":"Santosh V. Gandhi, Smruti C. Shinde","doi":"10.53879/id.60.09.13152","DOIUrl":"https://doi.org/10.53879/id.60.09.13152","url":null,"abstract":"The aim of this study was to verify the ability of the UV spectrophotometric method for the simultaneous determination of emtricitabine and tenofovir disoproxil fumarate in tablet dosage form using the principal Component Regression (pCR) and partial Least Squares (pLS) multivariate calibration methods. Double beam UV-Vis spectrophotometer (Jasco V-730) with 1 cm quartz cell with 1 nm data interval and scanning speed of 400 nm min -1 was used in the study. the optimized wavelength range selected was 225-275 nm. the data obtained was processed using Unscrambler X (10.5) (64bit) software. The developed models showed good results over the concentration range of 6-36 μg mL -1 for tenofovir disoproxil fumarate and 4-24 μg mL-1 for emtricitabine with co-relation coefficient greater than 0.995 and % RSD less than 2%. the accuracy studies show % recovery within limits. The method was validated as per ICH Q2(R1) guideline.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135428253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DESIGN AND STATISTICAL OPTIMIZATION OF CONCENTRATION OF SUBLIMATING AGENTS IN FORMULATING ORODISPERSIVE TABLETS 分散片剂配方中升华剂浓度的设计与统计优化
INDIAN DRUGS Pub Date : 2023-09-28 DOI: 10.53879/id.60.09.13088
Harani Avasarala, Rasi Nokku, Ratnam b. Pabbineedi, Mahalaxmi K. Palepu, Chandana S. Polimera, Niranjini Pragada, Mahima Puliga
{"title":"DESIGN AND STATISTICAL OPTIMIZATION OF CONCENTRATION OF SUBLIMATING AGENTS IN FORMULATING ORODISPERSIVE TABLETS","authors":"Harani Avasarala, Rasi Nokku, Ratnam b. Pabbineedi, Mahalaxmi K. Palepu, Chandana S. Polimera, Niranjini Pragada, Mahima Puliga","doi":"10.53879/id.60.09.13088","DOIUrl":"https://doi.org/10.53879/id.60.09.13088","url":null,"abstract":"Amlodipine is a BCS (biopharmaceutical Classification System) class I drug with high permeability and high solubility. It has a long half-life of 30-50h. It is a suitable model drug for formulating orodispersive tablets, as the orodispersive tablets can release the drug immediately. thus, formulation of amlodipine into orodispersible tablets will help in improved delivery of the drug at a faster rate. to achieve this, the orodispersive tablets were prepared by sublimation technique and the concentration of the sublimating agents was optimized by central composite design. based on the results, it was concluded that camphor and thymol when used at optimum concentrations can be used in the formulation of orodispersive tablets, the drug delivery systems for drugs with long half-life. they are potential delivery systems to improve palatability also for model drugs like amlodipine.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135428254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HEALTH JUSTICE AND HEALTH EQUALITY 卫生公正和卫生平等
INDIAN DRUGS Pub Date : 2023-09-28 DOI: 10.53879/id.60.09.p0005
{"title":"HEALTH JUSTICE AND HEALTH EQUALITY","authors":"","doi":"10.53879/id.60.09.p0005","DOIUrl":"https://doi.org/10.53879/id.60.09.p0005","url":null,"abstract":"Dear Reader, The Hathi Committee Report of 1975 on the Drugs & Pharmaceutical Industry, running into 278 pages, was widely discussed in India, both inside and outside Parliament, as well as in many other countries across the globe. The Hathi Committee Report was never implemented in India because of its bold and radical recommendations. However, this report inspired several other countries to frame their National Drug Policies much before India did. The then fledgling neighbour Bangladesh was the first country in the world which bravely enacted the Drug Control Ordinance Law in 1982, against huge resistance from several quarters. This law helped Bangladesh to control the cost and supplies of essential medications, especially for its poor and down trodden masses. The essential medicines list of the World Health Organisation owes a lot to Bangladesh for this revolutionary step. Taking the example of Bangladesh, several developing countries including India formulated their own essential medicines lists. This soon led to the availability of cheap essential medicines. The architect of the Bangladesh Ordinance of 1982 was Dr. Zafrullah Chowdhury, who had concluded by then that Bangladesh needed only 250 drugs while more than 5000 drugs were existing in the market.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135428262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FORMULATION AND EVALUATION OF AMISULPRIDE LOADED INTRANASAL MICROEMULSION 含氨硫脲鼻内微乳剂的研制与评价
INDIAN DRUGS Pub Date : 2023-09-28 DOI: 10.53879/id.60.09.13783
Sachin N. Kothawade, Vishal V. Pande
{"title":"FORMULATION AND EVALUATION OF AMISULPRIDE LOADED INTRANASAL MICROEMULSION","authors":"Sachin N. Kothawade, Vishal V. Pande","doi":"10.53879/id.60.09.13783","DOIUrl":"https://doi.org/10.53879/id.60.09.13783","url":null,"abstract":"The use of microemulsion as a delivery system for improving take-up across the nasal mucosa is cur-rently being studied. A mucoadhesive polymer is added to help extend the retention time on the mucosa.The primary goal of the current research was to create a nano-formulation of amisulpride with the intention of increasing the drug’s permeability and protecting it with a biocompatible lipid content, avoiding first-pass metabolism and efflux mechanisms, and selecting the route of administration to deliver amisulpride to the brain or CNS to increase the bioavailability of amisulpride at the targeted site of Schizophrenia. For calculating the percentage of transmittance, the release profile, and the levels of amisulpride in the brain and plasma, appropriate analytical methods were chosen, developed and validated. The results revealed that the residence time of me (microemulsion) was enhanced by the mucoadhesive agent and that a targeted site of action was achieved","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135470093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COMPARATIVE ANTI-INFLAMMATORY STUDIES ON TIMOLOL MALEATE AND DICLOFENAC SODIUM IN, IN VITRO AND IN VIVO MODELS BY ORAL ROUTES 马来酸替马洛尔与双氯芬酸钠口服抗炎模型的体外和体内对比研究
INDIAN DRUGS Pub Date : 2023-09-28 DOI: 10.53879/id.60.09.13913
Namrata P. Nailwal, Gaurav M. Doshi
{"title":"COMPARATIVE ANTI-INFLAMMATORY STUDIES ON TIMOLOL MALEATE AND DICLOFENAC SODIUM IN, IN VITRO AND IN VIVO MODELS BY ORAL ROUTES","authors":"Namrata P. Nailwal, Gaurav M. Doshi","doi":"10.53879/id.60.09.13913","DOIUrl":"https://doi.org/10.53879/id.60.09.13913","url":null,"abstract":"The present study was conducted on timolol maleate (a non-selective beta-blocker) using in vitro assays and in vivo models of rats. It was tested for its anti-inflammatory activity at three dose levels (1.028 mg kg-1 , 5.14 mg kg -1 and 10.28 mg kg -1). Furthermore, the investigation was supported by the estimation of tumor necrosis factor-alpha (tNF-α), interleukin-1 (IL- 1) and histopathological examination. It was observed that at 1.028 mg kg -1, 5.14 mg kg -1 and 10.28 mg kg -1 the drug showed anti-inflammatory activities. moreover, plasma levels of tNF-α and IL-1 showed inhibition. Histopathological examination confirmed the highest anti-inflammatory activity at 5.14 mg kg -1. Thus, the conducted studies revealed that timolol maleate, when given orally does possesses an anti-inflammatory potential.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135470693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IN SILICO STUDY OF NEW SCHIFF BASE-AND AMIDE-BORONIC ACID DERIVATIVES AS POTENTIAL INHIBITORS OF Β-LACTAMASES 新的希夫碱和酰胺硼酸衍生物作为Β-lactamases潜在抑制剂的硅研究
INDIAN DRUGS Pub Date : 2023-09-28 DOI: 10.53879/id.60.09.13937
Safaa P. Bahnam, Mahmood H. M. Jasim, Ahmed A. J. Mahmood
{"title":"IN SILICO STUDY OF NEW SCHIFF BASE-AND AMIDE-BORONIC ACID DERIVATIVES AS POTENTIAL INHIBITORS OF Β-LACTAMASES","authors":"Safaa P. Bahnam, Mahmood H. M. Jasim, Ahmed A. J. Mahmood","doi":"10.53879/id.60.09.13937","DOIUrl":"https://doi.org/10.53879/id.60.09.13937","url":null,"abstract":"Bacteria are becoming more and more resistant to β-lactam antibiotics. One approach to lower such resistance involves combining inhibitors of β-lactamase with β-lactams antibiotics. As such, the need for innovative inhibitors of β-lactamases is urgent. therefore, the aim of this research was to design and dock two new series of amides and Schiff bases of the cyclic and noncyclic boronate derivatives into four subtypes from two different classes of the β-lactamase enzymes. In silico prediction of the pharmacokinetic profile of the designed compounds was also performed. the results revealed possible enhanced activity of 15 out of the 82 compounds, when matched with 4 existing β-lactamase inhibitors (clavulanic acid, sulbactam, tazobactam and vaborbactam). the 15 compounds showed favorable docking interactions with the residues in the active site of all enzymes. the predicted pharmacokinetic characteristics also showed that the 15 compounds are promising as oral agents. the designed compounds have the potential to act as inhibitors of β-lactamase as shown by their docking results on 4 β-lactamase crystal structures. the pharmacokinetic profile of 15 compounds is also promising, making them suitable candidates for synthesis and in vitro testing.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135428080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DESIGNING, SYNTHESIS AND BIOLOGICAL EVALUATION OF PYRAZOLINE DERIVATIVES TARGETING PANCREATIC CANCER CELLS 靶向胰腺癌细胞的吡唑啉衍生物的设计、合成及生物学评价
INDIAN DRUGS Pub Date : 2023-09-28 DOI: 10.53879/id.60.09.13805
Sarita S. Shinkar, Sarvanti R. Bhairi, Priyanka M. Khedkar, Swati R. Dhande, Deepali M. Jagdale
{"title":"DESIGNING, SYNTHESIS AND BIOLOGICAL EVALUATION OF PYRAZOLINE DERIVATIVES TARGETING PANCREATIC CANCER CELLS","authors":"Sarita S. Shinkar, Sarvanti R. Bhairi, Priyanka M. Khedkar, Swati R. Dhande, Deepali M. Jagdale","doi":"10.53879/id.60.09.13805","DOIUrl":"https://doi.org/10.53879/id.60.09.13805","url":null,"abstract":"In continuation of the previous work based upon pyrazoline derivatives having cytotoxic activity, twenty-one 1,3,5-substituted pyrazoline derivatives were designed taking into consideration the important functional groups of methisazone, sorafenib and chalcone. the designed derivatives were screened using a preliminary molecular docking simulation study for evaluation of their binding interactions with receptor-2 of vascular endothelial growth factor, i.e., pDb ID: 3WZD. the synthesized derivatives were biologically evaluated for in vivo anti-angiogenic activity using adult zebrafish, its embryo, and in vitro anti-proliferative activity against pancreatic cancer mIA-pA-CA-2 cell line using the sulforhodamine b assay. Compound 5b emerged as a promising hit molecule as it manifested moderate in vitro cytotoxic activity. besides, its ability to inhibit zebrafish caudal fin regeneration with less phenotypical changes in zebrafish embryos suggests its promising potential against pancreatic cancer by VeGFR-2 inhibition as a mode of action.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135470084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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