INDIAN DRUGS最新文献

COMPUTATIONAL IDENTIFICATION OF SELECTED BIOACTIVE COMPOUNDS FROM CEDRUS DEODARA AS INHIBITORS AGAINST SARS-COV-2 MAIN PROTEASE: A PHARMACOINFORMATICS STUDY 计算鉴定雪松中可作为 SARS-COV-2 主要蛋白酶抑制剂的部分生物活性化合物：药物信息学研究

INDIAN DRUGS Pub Date : 2024-02-28 DOI: 10.53879/id.61.02.13859

Aminabee Shaik, L. R. Atmakuri

引用次数: 0

MECHANISTIC OUTCOMES OF LIPID CORE ON SOLID LIPID NANOPARTICLE CHARACTERIZATION 脂质核心对固体脂质纳米粒子特性的机理影响

INDIAN DRUGS Pub Date : 2024-02-28 DOI: 10.53879/id.61.02.13881

Juna B. Chacko, G. R. Vijayasankar, Bendi S. Venkateswarlu, Margret C. Rajappa

引用次数: 0

RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR QUANTITATIVE ESTIMATION OF TEMOZOLOMIDE AND (S) - PERILLYL ALCOHOL IN NANOPARTICULATE DOSAGE FORM 纳米微粒剂型中替莫唑胺和(s)-紫苏醇定量估算的 RP-HPLC 方法开发与验证

INDIAN DRUGS Pub Date : 2024-02-28 DOI: 10.53879/id.61.02.13782

N. Desai, M. Momin, Tabassum Khan

{"title":"RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR QUANTITATIVE ESTIMATION OF TEMOZOLOMIDE AND (S) - PERILLYL ALCOHOL IN NANOPARTICULATE DOSAGE FORM","authors":"N. Desai, M. Momin, Tabassum Khan","doi":"10.53879/id.61.02.13782","DOIUrl":"https://doi.org/10.53879/id.61.02.13782","url":null,"abstract":"A quick reverse-phase high-performance liquid chromatography (RP-HPLC) approach for the quantitative measurement of temozolomide (TMZ) and (s) - perillyl alcohol [(S)-POH] in a nanoparticulate system was developed and validated in the current work. The RP-HPLC method for the simultaneous estimation of TMZ and (S)-POH was developed using Agilent (Infinity 1260) HPLC system and ZorbaxC18 (4.6 x 150 mm i.d., 5µ; Agilent) as stationary phase. The optimized mobile phase comprised of ACN: water: MeOH (42:12:46 V/V/V; 42:08:50 V/V/V and 20:30:50 V/V/V) pumped at a flow rate of 0.8 mL min-1, 0.8 mL min-1 and 1 mL min-1, respectively. Drug separation was accomplished in an isocratic mode, and a PDA detector operating at 210 nm was used to track elution. The procedure was validated in accordance with ICH-Q2R1 standards. The responses of TMZ and (S)- POH were found to be linear at 50-175 μg mL-1 (ACN: water: MeOH 42:12:46 V/V/V and 42:08:50 V/V/V) and 50-175 μg mL-1 (ACN: water: MeOH 20:30:50 V/V/V) respectively. The percent recovery was determined to be between 97% and 103%, demonstrating that the method’s accuracy was adequate. The precision study’s percent relative standard deviation (% RSD) was less than 2, indicating the accuracy of the suggested procedure. It was discovered that the established method for the quantitative determination of TMZ and (S)- POH in bulk and in hollow gold nanoparticles was accurate, precise, and specific. The developed technique can be applied to TMZ and (S)- POH routine testing and quality control in bulk and nanoparticulate systems.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"111 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140422449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PREPARATION AND EVALUATION OF MELOXICAM CHEWABLE TABLETS FOR BETTER ORAL DELIVERY 制备和评估美洛昔康咀嚼片，提高口服给药效果

INDIAN DRUGS Pub Date : 2024-02-28 DOI: 10.53879/id.61.02.14061

Garima Sharma, Manish Dhall

引用次数: 0

PHYSICOCHEMICAL AND PHARMACOKINETIC ANALYSIS AND DOCKING OF DRUG REPOSITIONING AGAINST SARS-COV-2: AN IN SILICO STUDY 针对 SARS-COV-2 的药物重新定位的理化和药代动力学分析及对接：一项硅学研究

INDIAN DRUGS Pub Date : 2024-02-28 DOI: 10.53879/id.61.02.14233

Jackson A. Pereira, Eduardo D. Costa

{"title":"PHYSICOCHEMICAL AND PHARMACOKINETIC ANALYSIS AND DOCKING OF DRUG REPOSITIONING AGAINST SARS-COV-2: AN IN SILICO STUDY","authors":"Jackson A. Pereira, Eduardo D. Costa","doi":"10.53879/id.61.02.14233","DOIUrl":"https://doi.org/10.53879/id.61.02.14233","url":null,"abstract":"Studies on the development of effective and cost-effective oral drugs are the new priority of the pharmaceutical industry for the prevention and treatment of COVID-19. This work was based on the computational analysis of physicochemical parameters, pharmacokinetic and toxicological measurements, molecular docking and in silico measurement of the antiviral activity of 12 repositionable drugs. The Molinspiration platform (physical-chemical parameters), pkCSM® (absorption, distribution, metabolism and excretion), OSIRIS Property Explorer® (toxicological measurements), Seam® (Docking with the RdRp protein) and AVCpred server® (antiviral activity) were used. Considering the 12 selected repositionable drugs, molecular anchoring data with the RdRp protein, only the drug tilorone had lower binding energy than the control used in this study (Molnupiravir). Ledipasvir, daclatasvir and piperaquine showed the best percentage of antiviral inhibition considering the control pattern. ADMETox data showed that piperaquine has a high toxicological potential for mutagenesis, tumorigenesis and irritant effects. The findings of this study indicate that ledipasvir and daclatasvir showed greatest potential for inhibition RdRp and action against COVID-19.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"46 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140419156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NOVEL UV SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF MONTELUKAST SODIUM AND OLOPATADINE HYDROCHLORIDE USING ABSORBANCE CORRECTION PRINCIPLE 利用吸光度校正原理同时测定孟鲁司特钠和盐酸奥洛他定的新型紫外分光光度法

INDIAN DRUGS Pub Date : 2024-02-28 DOI: 10.53879/id.61.02.13426

Vidhi Bhanushali, Celina Nazareth, Rakshanda S. Khorjuwenkar

引用次数: 0

PREPARATION AND CHARACTERIZATION OF MICROSPHERES UTILIZING RATE-CONTROLLING MEMBRANES FOR THE MANAGEMENT OF DIABETES MELLITUS 利用速率控制膜制备和表征用于治疗糖尿病的微球

INDIAN DRUGS Pub Date : 2024-02-28 DOI: 10.53879/id.61.02.14270

Nitu Patidar, N. Farooqui, Darshan Jamindar, D. K. Mishra, Rajat Goyal, Hitesh Chopra, R. Gautam

{"title":"PREPARATION AND CHARACTERIZATION OF MICROSPHERES UTILIZING RATE-CONTROLLING MEMBRANES FOR THE MANAGEMENT OF DIABETES MELLITUS","authors":"Nitu Patidar, N. Farooqui, Darshan Jamindar, D. K. Mishra, Rajat Goyal, Hitesh Chopra, R. Gautam","doi":"10.53879/id.61.02.14270","DOIUrl":"https://doi.org/10.53879/id.61.02.14270","url":null,"abstract":"The present research work aimed at the formulation of film-coated microspheres incorporating glibenclamide drug and their evaluation for the management of diabetes mellitus (DM). Microspheres were prepared by solvent evaporation methodology by the usage of ethyl cellulose as polymer, ethanol and dichloromethane as solvents and Tween 80® as a non-ionic surfactant. The film-coated membrane was prepared by pan coating method, incorporating ethyl cellulose, isopropyl alcohol, diethyl phthalate and sodium lauryl sulfate. This film membrane was coated on microspheres with the help of a spray gun. The efficiency of entrapment of the film coated microspheres of F5* batch, among different formulations, is highest and comes out to be in the range of 76.65±0.58. The percentage yield was observed to be 73.32±0.14. Morphological studies conducted by scanning electron microscope show spherical microspheres of uniform size. In vitro drug release study conducted of the coated microspheres of glibenclamide shows the highest amount of release of 97.44% in the F5*batch. The best-fit model was determined by the highest R2 value. Further, the developed formulation helps in reduction in dose dumping, with better patient compliance, and also masks the bitter taste of the drug.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"237 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140417760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NEED/ROLE OF GENERATIVE AI IN PHARMACEUTICAL RESEARCH 生成性人工智能在药物研究中的需求/作用

INDIAN DRUGS Pub Date : 2024-02-28 DOI: 10.53879/id.61.02.p0005

引用次数: 0

THE GENUS LITSEA: A REVIEW OF ITS CYTOTOXIC POTENTIAL AND PHYTOCHEMISTRY 石莲花属：细胞毒性潜力和植物化学综述

INDIAN DRUGS Pub Date : 2024-02-28 DOI: 10.53879/id.61.02.12907

Sayali Churi, Tabassum Khan

{"title":"THE GENUS LITSEA: A REVIEW OF ITS CYTOTOXIC POTENTIAL AND PHYTOCHEMISTRY","authors":"Sayali Churi, Tabassum Khan","doi":"10.53879/id.61.02.12907","DOIUrl":"https://doi.org/10.53879/id.61.02.12907","url":null,"abstract":"The family Lauraceae includes various genus in which Litsea has around 200-400 varieties which are widely scattered in the tropical and semi-tropical zones. In China, Litsea species are used traditionally in many disease conditions such as bone pain, diarrhoea, edema, dyspepsia, gastroenteritis and colds. Litsea glutinosa has been traditionally used in the treatment of tumors by the local people of Chittagong Hill Tracts, Bangladesh. Also, 15 other Litsea species are reported to have cytotoxic activity against various cancer cell lines, making this genus a promising potential source of anticancer compounds. This review provides comprehensive information about the cytotoxicity potential of various species in the genus Litsea along with secondary metabolites responsible, and its potential utility in lung, breast, hepatocellular, ovarian, prostate, colon and cervical cancer therapeutics as a botanical product. The published cytotoxicity data of these plants are mainly based on in vitro studies with very few molecular levels and mechanistic studies conducted. The optimistic results of these 16 species open unexplored vistas of natural product chemistry and the anticancer potential of this genus.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"57 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140419784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ESTABLISHMENT AND AUTHENTICATION OF A UV SPECTROPHOTOMETRIC APPROACH FOR MEASURING EMBELIN CONTENT IN BULK AND FORMULATED SAMPLE 建立和验证紫外分光光度法测量散装和配制样品中的栓皮素含量

INDIAN DRUGS Pub Date : 2024-02-28 DOI: 10.53879/id.61.02.14489

Kritika R. Saboo, Rohit R. Ghadge, Dhanashree P. Sanap, Sneha A. Agrawal

引用次数: 0