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EVALUATION OF HERBOSOL SYRUP FOR ACUTE TOXICITY 草药糖浆急性毒性评价
INDIAN DRUGS Pub Date : 2023-10-28 DOI: 10.53879/id.60.10.13550
Sukeshini Lote, Deepak Khobragade, Mahendra Gunde, Kirti Sahu, Ashish Budhrani
{"title":"EVALUATION OF HERBOSOL SYRUP FOR ACUTE TOXICITY","authors":"Sukeshini Lote, Deepak Khobragade, Mahendra Gunde, Kirti Sahu, Ashish Budhrani","doi":"10.53879/id.60.10.13550","DOIUrl":"https://doi.org/10.53879/id.60.10.13550","url":null,"abstract":"Various diseases caused due to stress and tension lead to metabolic disorders and disturbed body functions. Herbosol is a combination of potential herbal drugs meant to balance the body’s metabolism and functions. The present study aims to evaluate the acute toxicity of polyherbal herbosol syrup in Wistar rats. Herbosol syrup formulation was administered orally at doses of 5, 50, 300, 2000 mL kg-1. Animals were divided into control and test groups, each with five animals. The control group was administered orally only with vehicle. After 14 days of study, all test animals were sacrificed and histopathology was done. During the study, four parameters were studied: cage side observation, change in body weight, hematology and histology. All animals survived till they were sacrificed. There were no changes in behavior, body weight, hematology or histological results. During the study, no toxicity was observed, so it can be safely used in human beings.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"81 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136232880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CGMP AND INNOVATION – TO BE PHARMA INDUSTRY CULTURE FOR THE COMING YEARS CGMP和创新——未来几年制药行业的文化
INDIAN DRUGS Pub Date : 2023-10-28 DOI: 10.53879/id.60.10.p0005
{"title":"CGMP AND INNOVATION – TO BE PHARMA INDUSTRY CULTURE FOR THE COMING YEARS","authors":"","doi":"10.53879/id.60.10.p0005","DOIUrl":"https://doi.org/10.53879/id.60.10.p0005","url":null,"abstract":"Dear Reader, Under the able youthful leadership of the IDMA National president, Dr. Viranchi Shah and his fully charged, motivated and committed colleagues, IDMA has led a hitherto not witnessed, roadshows and webinars on revised cGMP and Schedule M guidelines which was the need of the hour and which is the \"health-tonic\" or \"sanjeevani\" for the Pharma-Bio med-tech industry in years to come.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136232884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HPTLC METHOD DEVELOPMENT AND VALIDATION FOR THE QUANTIFICATION OF ALECTINIB HYDROCHLORIDE IN BULK POWDER AND CAPSULE PREPARATIONS hplc法测定盐酸阿勒替尼散装粉剂和胶囊制剂中含量的方法建立及验证
INDIAN DRUGS Pub Date : 2023-10-28 DOI: 10.53879/id.60.10.13519
Shaileshkumar K. Koradia, Rushik P. Thakkar, Ashok N. Mahajan, Falgun A. Mehta, Priyal R. Patel, Digvijaysinh G. Rana
{"title":"HPTLC METHOD DEVELOPMENT AND VALIDATION FOR THE QUANTIFICATION OF ALECTINIB HYDROCHLORIDE IN BULK POWDER AND CAPSULE PREPARATIONS","authors":"Shaileshkumar K. Koradia, Rushik P. Thakkar, Ashok N. Mahajan, Falgun A. Mehta, Priyal R. Patel, Digvijaysinh G. Rana","doi":"10.53879/id.60.10.13519","DOIUrl":"https://doi.org/10.53879/id.60.10.13519","url":null,"abstract":"The high performance thin layer chromatography method described here enables simple, accurate and precise estimation of alectinib hydrochloride content in capsule formulation. To achieve adequate separation, G60 - F254 pre-coated silica gel sheets of aluminium were used as the stationary phase. A mobile phase comprising a solvent mixture of methanol and water in a ratio of 80:20 (V/V) was utilized with a chamber saturation duration of 30 minutes. The retardation factor value was found to be 0.47 at the detection wavelength 341 nm. The method’s linearity was confirmed across a concentration range from 600 - 2100 ng band-1, exhibiting a high correlation coefficient of 0.9992. The accuracy range was observed between 98.50 % – 100.45 %. The lowest detection limits of drug were observed to be 17.49 ng band-1 and lowest quantitation limits of drug were found to be 53.01 ng band-1. This developed methodology was effectively employed for the quantification of alectinib hydrochloride in capsule preparations","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"7 3-4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136232879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DESIGN, CHARACTERIZATION AND EVALUATION OF NOVEL MUCOADHESIVE NASAL INSERTS FOR THE TREATMENT OF MIGRAINE 治疗偏头痛的新型黏液鼻植入物的设计、表征和评价
INDIAN DRUGS Pub Date : 2023-10-28 DOI: 10.53879/id.60.10.12854
Bindiya Amin, Jobin Jose, Lalit Kumar
{"title":"DESIGN, CHARACTERIZATION AND EVALUATION OF NOVEL MUCOADHESIVE NASAL INSERTS FOR THE TREATMENT OF MIGRAINE","authors":"Bindiya Amin, Jobin Jose, Lalit Kumar","doi":"10.53879/id.60.10.12854","DOIUrl":"https://doi.org/10.53879/id.60.10.12854","url":null,"abstract":"Recently, nasal administration has gained more attention as a safe way for delivering the active ingredients used to treat migraines. Strategies can be implemented by changing aspects like the medicines, delivery vehicle, and other components to get around the obstacles associated with conventional therapies. This research work aimed to explore the potential of lyophilized nasal inserts of eletriptan hydrobromide for the treatment of migraine attack. Here, the lyophilization technique is used for the nasal inserts preparation. The developed inserts were tested for various characterization studies,such as mucoadhesive examinations, water uptake, in vitro drug release, in vitro cytotoxicity, ex vivo investigations and stability. The inserts showed acceptable pH values, satisfactory mucoadhesion potential and excellent water uptake activity. In vitro release data for the formulations followed first-order kinetics. The cytotoxicity studies showed that there was a reduction in cell toxicity of drug embedded in the inserts when compared to the pure drug. When the prepared nasal inserts were used for treatment, there was no significant impact on the epithelium of nasal mucosa. The novel lyophilized nasal inserts of eletriptan hydrobromide could be a better alternative for the treatment of migraine","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"49 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136232888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DEVELOPMENT AND VALIDATION OF A NOVEL HPTLC METHOD FOR QUANTITATIVE ESTIMATION OF VINCAMINE FROM CATHARANTHUS ROSEUS LINN. LEAVES EXTRACT 长春花中长春胺的高效液相色谱定量测定方法的建立与验证。叶萃取精华
INDIAN DRUGS Pub Date : 2023-10-28 DOI: 10.53879/id.60.10.14128
Christina Viju, Sneha A. Agrawal, Aruna P. Jadhav
{"title":"DEVELOPMENT AND VALIDATION OF A NOVEL HPTLC METHOD FOR QUANTITATIVE ESTIMATION OF VINCAMINE FROM CATHARANTHUS ROSEUS LINN. LEAVES EXTRACT","authors":"Christina Viju, Sneha A. Agrawal, Aruna P. Jadhav","doi":"10.53879/id.60.10.14128","DOIUrl":"https://doi.org/10.53879/id.60.10.14128","url":null,"abstract":"Catharanthus roseus (Apocynaceae), commonly known as periwinkle, is a perennial plant that is mostly found in Southern Asia. Periwinkle is rich in indole alkaloids. This research work consists of the development and validation of one of the indole alkaloids, vincamine, by HPTLC. The chromatographic separation was achieved by using eluent chloroform, acetone, and formic acid in the ratio of 5:1:0.5 V/V/V at wavelength 222 nm. With an Rf value of 0.33±0.02, this method showed good separation of vincamine in the extract. Vincamine in the range of 200-1000 ng spot-1 showed a satisfactory linear relationship according to the regression analysis data, and the correlation coefficient (R2 ) was found to be 0.9957. ICH Q2 (R1) guidelines were followed for validation.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136232876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EXTRACTION AND ISOLATION OF Β-AMYRIN FROM FICUS ELASTICA 榕树中Β-amyrin的提取与分离
INDIAN DRUGS Pub Date : 2023-10-28 DOI: 10.53879/id.60.10.13408
Komalatha Nakkala, Vrushali Kulkarni, Kirti S. Laddha
{"title":"EXTRACTION AND ISOLATION OF Β-AMYRIN FROM FICUS ELASTICA","authors":"Komalatha Nakkala, Vrushali Kulkarni, Kirti S. Laddha","doi":"10.53879/id.60.10.13408","DOIUrl":"https://doi.org/10.53879/id.60.10.13408","url":null,"abstract":"There is a huge interest in medicinally active constituents isolated from plants. β-Amyrin is a member of the class of pentacyclic triterpenoids and it is oleanane substituted at the 3 β-position by a hydroxyl group and containing a double bond between positions 12 and 13. These triterpenoids are generally found in many medicinal plants. The β-amyrin is generally extracted and isolated from leaves and oleoresin (latex) exudates by bark incisions of the plant sources from many plant species. The β-amyrin isolation described in this article was by a novel method developed for isolation. Triterpenoids are constituents that have shown a great interest in recent years due to their pharmacological potential, with numerous therapeutic activities, such as anticancer, anti-inflammatory, antiviral, antibacterial, antifungal, anti-diuretic, and acetylcholinesterase inhibitory. Due to the wide range of activities of β-amyrin, research has been undertaken to isolate it in a simple way. The isolated β-amyrin was characterized, and confirmed by multiple analytical methods.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"23 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136232877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
QUALITY RISK ASSESSMENT AND DESIGNED EXPERIMENTS ORIENTED SIMULTANEOUS QUANTIFICATION OF ASPIRIN AND PANTOPRAZOLE SODIUM USING DRIFTS AND UFLC-DAD METHODS 采用漂移法和uflc-dad法同时定量阿司匹林和泮托拉唑钠的质量风险评估和设计实验
INDIAN DRUGS Pub Date : 2023-10-28 DOI: 10.53879/id.60.10.13194
Sagar S. Panda, Ravi Kumar V.V. Bera, Chandra Sekhar Patro
{"title":"QUALITY RISK ASSESSMENT AND DESIGNED EXPERIMENTS ORIENTED SIMULTANEOUS QUANTIFICATION OF ASPIRIN AND PANTOPRAZOLE SODIUM USING DRIFTS AND UFLC-DAD METHODS","authors":"Sagar S. Panda, Ravi Kumar V.V. Bera, Chandra Sekhar Patro","doi":"10.53879/id.60.10.13194","DOIUrl":"https://doi.org/10.53879/id.60.10.13194","url":null,"abstract":"Systematized and reliable analytical methods are always of great advantage for the quality control of new drug products. Two new analytical methods were developed and validated using the multivariate approach to quantify a unique combination of aspirin and pantoprazole sodium. In the first method, emphasis was on non-destructive identification with quantification of aspirin and pantoprazole at their characteristic diffused reflectance-based infrared absorption band at 1747cm-1(-C=O) and 1303cm-1 (-S-O), respectively. The second method relies on liquid chromatographic separation using a mobile phase of acetonitrile: phosphate buffer pH 3.5 (60:40 V/V) at a flow rate of 1.0 mL min-1 using a C-18 column. At 240 nm, the diode array detection was performed. Employing risk assessment revealed the risky method parameters that may influence the preciseness of the present methods. Nevertheless, these techniques were linear, sensitive and reliable for the quick and simultaneous measurement of the analytes in bulk and proposed fixed-dose commercial formulation.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"21 7","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136232882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DRUG-CYCLODEXTRIN COMPLEXES: CURRENT STATUS AND RECENT ADVANCEMENTS 药物-环糊精配合物:现状与最新进展
INDIAN DRUGS Pub Date : 2023-10-28 DOI: 10.53879/id.60.10.12952
Vikas S. Panwar, Lokesh Adhikari, Mona Semalty, Ajay Semalty
{"title":"DRUG-CYCLODEXTRIN COMPLEXES: CURRENT STATUS AND RECENT ADVANCEMENTS","authors":"Vikas S. Panwar, Lokesh Adhikari, Mona Semalty, Ajay Semalty","doi":"10.53879/id.60.10.12952","DOIUrl":"https://doi.org/10.53879/id.60.10.12952","url":null,"abstract":"Cyclodextrins are water-soluble oligosaccharides formed by the action of cyclodextrin glucosyl transferase enzyme (CGTase) on the medium containing starch. Cyclodextrins are proven to be a cost-effective breakthrough in the pharmaceutical industry by formulating them with polymers and drugs to improve the safety, bioavailability, and solubility of APIs. This review describes the current status and advancement of cyclodextrin research in drug delivery. The use of cyclodextrins to improve the solubility and dissolution properties of poor water-soluble products has been reviewed exhaustively with a specific focus on their physicochemical property, practical methods, toxicity, the drug-cyclodextrin compatibility and its applications.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136232886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IN SILICO, ANTIMICROBIAL AND CYTOTOXIC STUDIES OF CARBOXAMIDE DERIVATIVES AND THEIR GREEN SYNTHESIS 碳酰胺衍生物的硅、抗菌和细胞毒性研究及其绿色合成
INDIAN DRUGS Pub Date : 2023-10-28 DOI: 10.53879/id.60.10.14103
Swathi Thumula, Venkatesan Srinivasadesikan, Ravi K. Kottalanka, Ramu Samineni
{"title":"IN SILICO, ANTIMICROBIAL AND CYTOTOXIC STUDIES OF CARBOXAMIDE DERIVATIVES AND THEIR GREEN SYNTHESIS","authors":"Swathi Thumula, Venkatesan Srinivasadesikan, Ravi K. Kottalanka, Ramu Samineni","doi":"10.53879/id.60.10.14103","DOIUrl":"https://doi.org/10.53879/id.60.10.14103","url":null,"abstract":"5-Chloro-N-((2-oxo-3-(4-(3-oxomorpholino) phenyl) oxazolidin-5-yl) methyl) thiophene-2-carboxamide derivatives were synthesized in a simple and efficient approach using 2-(oxiran-2-ylmethyl) isoindoline-1, 3-dione, 4-(4-aminophenyl) morpholin-3-one, and 5-chlorothiophene-2-carbonyl chloride by stepwise synthesis. Three compounds 3, 4 and 7 were designed, prepared, and screened for anticancer activity against HeLa, MCF- 7, A-549 and K-562 and antibacterial activities against Gram +ve and Gram -ve strains. The carboxamide moieties proved to be capable for the development of new anticancer and anti-bacterial agents. Docking studies carried out on target receptors caspase-3 HeLa cell line and Staphylococcus aureus DNA-Gyrase also supported the anticancer and antimicrobial activity of compounds 3, 4 and 7","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"270 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136232889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SOLID DISPERSION SYSTEMS OF POORLY WATER SOLUBLE DRUG FEBUXOSTAT: PREPARATION, CHARACTERIZATION AND OPTIMIZATION 难水溶性药物非布司他的固体分散体系:制备、表征和优化
INDIAN DRUGS Pub Date : 2023-10-28 DOI: 10.53879/id.60.10.13648
Mangirish N. Deshpande, Shruti S. Dessai, Pearl Dighe
{"title":"SOLID DISPERSION SYSTEMS OF POORLY WATER SOLUBLE DRUG FEBUXOSTAT: PREPARATION, CHARACTERIZATION AND OPTIMIZATION","authors":"Mangirish N. Deshpande, Shruti S. Dessai, Pearl Dighe","doi":"10.53879/id.60.10.13648","DOIUrl":"https://doi.org/10.53879/id.60.10.13648","url":null,"abstract":"Febuxostat is a poor soluble drug used in the management of hyperuricemia and gout. The present study aims at increasing the solubility of febuxostat by solid dispersion technique with the aid of various polymers (Beta cyclodextrin, Soluplus®, HPMC E5, and Kolliphor® P 407) in various drug: carrier ratios employing the solvent evaporation method. Solid dispersions were evaluated for physical appearance, percentage yield, drug content, saturation solubility and dissolution properties. Saturation solubility data of the study depict an increased solubility of the solid dispersion compared to the pure drug. In in vitro release profiles revealed that formulation SD20, having drug: Kolliphor® P 407 in 1:9 ratio exhibited highest dissolution rate. The powder X-ray diffraction study and scanning electron microscopy (SEM) exhibited a crystalline to an amorphous transformation in the solid dispersion. The study demonstrated that solid dispersions are a highly effective technique to increase solubility and bioavailability of febuxostat.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"6 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136232878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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